고마바이오텍(주)

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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

프린트 제품 문의

CNS Target LeadHunter Panel (#PP280)  

  • CNS 연구에 관련된 94가지 assay를 제공합니다. 
  • Receptors, ionic channels, transporters, nuclear hormone receptors, enzyme에 대한 스크리닝 결과를 제공합니다.
  • Test Sample Requirements: 210 μl of a 10 mM stock or 1.5 mg pre-weighed powder (assuming FW≦500 and purity 100%)

 

GPCR 　 Ion Channel
200510 Adenosine A1 　 214510 Calcium Channel L-Type, Benzothiazepine
200610 Adenosine A2A 　 214600 Calcium Channel L-Type, Dihydropyridine
200650 Adenosine A2B 　 215000 Calcium Channel L-Type, Phenylalkylamine
200720 Adenosine A3 　 216000 Calcium Channel N-Type
203110 Adrenergic alpha1A 　 226810 GABAA, Chloride Channel, TBOB
203210 Adrenergic alpha1B 　 226600 GABAA, Flunitrazepam, Central
203630 Adrenergic alpha2A 　 232600 Glutamate, AMPA
203710 Adrenergic alpha2B 　 232710 Glutamate, Kainate
203810 Adrenergic alpha2C 　 232810 Glutamate, NMDA, Agonism
204010 Adrenergic beta1 　 233000 Glutamate, NMDA, Phencyclidine
204110 Adrenergic beta2 　 239000 Glycine, Strychnine-Sensitive
212620 Bradykinin B2 　 299031 Nicotinic Acetylcholine alpha4beta2, Cytisine
214020 Calcitonin Gene-Related Peptide CGRP1 　 299032 Nicotinic Acetylcholine alpha7, Bungarotoxin
217050 Cannabinoid CB1 　 265800 Potassium Channel [SKCA]
217100 Cannabinoid CB2 　 299036 Purinergic P2X
218030 Cholecystokinin CCK1 (CCKA) 　 271910 Serotonin (5-Hydroxytryptamine) 5-HT3
218130 Cholecystokinin CCK2 (CCKB) 　 279510 Sodium Channel, Site 2
219500 Dopamine D1 　 Nuclear Hormone Receptor
219600 Dopamine D2L 　 206000 Androgen (Testosterone)
219800 Dopamine D3 　 226010 Estrogen ERalpha
220000 Dopamine D4.4 　 232030 Glucocorticoid
224010 Endothelin ETA 　 Transporter
228710 GABAB1B 　 202000 Transporter, Adenosine
237000 Glutamate, Metabotropic, mGlu5 　 204410 Transporter, Norepinephrine (NET)
239610 Histamine H1 　 220320 Transporter, Dopamine (DAT)
239820 Histamine H3 　 226400 Transporter, GABA
251600 Melatonin MT1 　 274030 Transporter, Serotonin (5-Hydroxytryptamine) (SERT)
252610 Muscarinic M1 　 Enzyme
252710 Muscarinic M2 　 107710 ATPase, Na+/K+, Heart, Pig
252810 Muscarinic M3 　 112020 Carbonic Anhydrase II
252910 Muscarinic M4 　 199019 Catechol-O-Methyl Transferase (COMT)
253010 Muscarinic M5 　 104010 Cholinesterase, Acetyl, ACES
255520 Tachykinin NK1 　 118050 CYP450, 1A2
257010 Neuropeptide Y Y1 　 118070 CYP450, 2C19
257110 Neuropeptide Y Y2 　 118080 CYP450, 2D6
260130 Opiate delta1 (OP1, DOP) 　 118090 CYP450, 3A4
260210 Opiate kappa (OP2, KOP) 　 199015 GABA Transaminase
260430 Opiate mu (OP3, MOP) [3H]morphine 　 140010 Monoamine Oxidase MAO-A
299002 Orexin OX2 　 140120 Monoamine Oxidase MAO-B
299030 Orexin OX1 　 107310 Peptidase, Angiotensin Converting Enzyme
260900 Oxytocin 　 112250 Peptidase, CTSB (Cathepsin B)
271110 Serotonin (5-Hydroxytryptamine) 5-HT1A 　 112650 Peptidase, CTSL (Cathepsin L)
271230 Serotonin (5-Hydroxytryptamine) 5-HT1B 　 154420 Phosphodiesterase PDE4D2
271650 Serotonin (5-Hydroxytryptamine) 5-HT2A 　 176610 Protein Serine/Threonine Kinase, MAPK14 (p38alpha)
271700 Serotonin (5-Hydroxytryptamine) 5-HT2B 　 170020 Protein Tyrosine Kinase, EGF Receptor
271800 Serotonin (5-Hydroxytryptamine) 5-HT2C 　 174990 Protein Tyrosine Kinase, Insulin Receptor
272320 Serotonin (5-Hydroxytryptamine) 5-HT7 　 195010 Tyrosine Hydroxylase
287530 Vasopressin V1A 　 Mitochondrial Function
　 　 　 299008 BZDp (TSPO)
　 　 　 Transmembrane
　 　 　 278300 Sigma, Non-Selective

 

 

  

Drug Abuse Safety SafetyScreen Panel (#PP279) 

  • Drug Abuse (약물남용)에 관련된 48가지 assay 실험을 제공합니다.  
  • FDA의 Assessment of Abuse Potential of Drugs 가이드라인에 따른 시험법을 준수합니다. 
  • Dopamine, Serotonin, GABA, Opioid, Cannabinoid, NMDA, Ion channel complex (calcium, potassium, chloride등), transporter 타겟에 대해 검증합니다.  
  • Test Sample Requirements:120 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)

 

GPCR 　 Enzyme
203110 Adrenergic alpha1A 　 104010 Cholinesterase, Acetyl, ACES
203210 Adrenergic alpha1B 　 195010 Tyrosine Hydroxylase
203400 Adrenergic alpha1D 　 Ion Channel
203630 Adrenergic alpha2A 　 216000 Calcium Channel N-Type
203710 Adrenergic alpha2B 　 226600 GABAA, Flunitrazepam, Central
203810 Adrenergic alpha2C 　 232600 Glutamate, AMPA
204010 Adrenergic beta1 　 232710 Glutamate, Kainate
204110 Adrenergic beta2 　 232810 Glutamate, NMDA, Agonism
217050 Cannabinoid CB1 　 233000 Glutamate, NMDA, Phencyclidine
217100 Cannabinoid CB2 　 299032 Nicotinic Acetylcholine alpha7, Bungarotoxin
219500 Dopamine D1 　 258660 Nicotinic Acetylcholine alpha7, Methyllycaconitine
219700 Dopamine D2S 　 271910 Serotonin (5-Hydroxytryptamine) 5-HT3
228610 GABAB1A 　 Nuclear Hormone Receptor
228710 GABAB1B 　 226010 Estrogen ERalpha
236400 Glutamate, Metabotropic, mGlu2 　 226050 Estrogen ERbeta
252610 Muscarinic M1 　 232030 Glucocorticoid
252710 Muscarinic M2 　 Transporter
252810 Muscarinic M3 　 220320 Transporter, Dopamine (DAT)
252910 Muscarinic M4 　 226400 Transporter, GABA
253010 Muscarinic M5 　 204410 Transporter, Norepinephrine (NET)
260130 Opiate delta1 (OP1, DOP) 　 274030 Transporter, Serotonin (5-Hydroxytryptamine) (SERT)
260210 Opiate kappa (OP2, KOP) 　 　 　
260430 Opiate mu (OP3, MOP) [3H]morphine 　 　 　
299030 Orexin OX1 　 　 　
299002 Orexin OX2 　 　 　
271110 Serotonin (5-Hydroxytryptamine) 5-HT1A 　 　 　
271230 Serotonin (5-Hydroxytryptamine) 5-HT1B 　 　 　
271650 Serotonin (5-Hydroxytryptamine) 5-HT2A 　 　 　
271700 Serotonin (5-Hydroxytryptamine) 5-HT2B 　 　 　
271800 Serotonin (5-Hydroxytryptamine) 5-HT2C 　 　 　

 

  

  

Pain Target LeadHunter Panel (#PP273) 

  • Pain target에 관련된 44가지 assay 실험을 제공합니다.  
  • 모든 유형의 통증과 관련있는 GPCR, Ion channel, neurotransmitter, transporter, enzyme에 대한 스크리닝을 제공합니다. 
  • 통증치료에 대한 진통제 발굴 및 연구에 유용합니다. 
  • Test Sample Requirements: 120 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)

 

GPCR 　 Enzyme
200720 Adenosine A3 　 116030 Cyclooxygenase COX-1
203110 Adrenergic alpha1A 　 118030 Cyclooxygenase COX-2
203630 Adrenergic alpha2A 　 199008 Fatty Acid Amide Hydrolase (FAAH)
203810 Adrenergic alpha2C 　 142000 Nitric Oxide Synthase, Neuronal (nNOS)
210120 Angiotensin AT2 　 176610 Protein Serine/Threonine Kinase, MAPK14 (p38alpha)
212520 Bradykinin B1 　 175040 Protein Tyrosine Kinase, NTRK1 (TRKA)
212620 Bradykinin B2 　 Ion Channel
214020 Calcitonin Gene-Related Peptide CGRP1 　 216020 Calcium Channel Cav2.2, [3H]Gabapentin
217050 Cannabinoid CB1 　 226600 GABAA, Flunitrazepam, Central
217100 Cannabinoid CB2 　 232810 Glutamate, NMDA, Agonism
217550 Chemokine CCR2B 　 232910 Glutamate, NMDA, Glycine
239820 Histamine H3 　 233000 Glutamate, NMDA, Phencyclidine
258010 Neurotensin NT1 　 258730 Nicotinic Acetylcholine alpha3beta4
260130 Opiate delta1 (OP1, DOP) 　 258660 Nicotinic Acetylcholine alpha7, Methyllycaconitine
260210 Opiate kappa (OP2, KOP) 　 299036 Purinergic P2X
260410 Opiate mu (OP3, MOP) 　 271910 Serotonin (5-Hydroxytryptamine) 5-HT3
268110 Prostanoid EP1 　 279510 Sodium Channel, Site 2
268200 Prostanoid EP2 　 Transporter
299006 Prostanoid EP3 　 204410 Transporter, Norepinephrine (NET)
268420 Prostanoid EP4 　 274030 Transporter, Serotonin (5-Hydroxytryptamine) (SERT)
268820 Purinergic P2Y, Non-Selective 　 Transmembrane
271110 Serotonin (5-Hydroxytryptamine) 5-HT1A 　 299034 Sigma1
271230 Serotonin (5-Hydroxytryptamine) 5-HT1B 　
272320 Serotonin (5-Hydroxytryptamine) 5-HT7 　
255520 Tachykinin NK1 　 　 　

 

   

Neurodegeneration Phenotypic LeadHunter Panel (#PP283)  

  •  가장 흔한 신경퇴행성 질환인 알츠하이머병(AD)과 파킨슨병(PD)의 잠재적 화합물을 스크리닝하기 위한 3가지 cell-based assay 실험을 제공합니다.
  • 가족성 AD의 β-amyloid/과인산화 tau, 산발성 AD의 APOE4, PD 진행과 관련된 α-synuclein을 포함한 유전적 변이 관련 신경변성을 확인합니다. 
  • Test Sample Requirements: 240 μl of a 10 mM stock or 1.5 mg pre-weighed powder (assuming FW≦500 and purity 100%) 

 

Family
Name
Item
Protein
Organism
Assay Sub Type
Cell Based Phenotypic Alpha-Synuclein A53T Parkinson’s Disease Genetic Cell Based Agonist Neurite Outgrowth Assay, Panlabs 332400-0 SYUA_HUMAN Human Cell Based
Cell Based Phenotypic APOEε4 C130R Sporadic Alzheimer’s Disease Genetic Cell Based Agonist Neurite Outgrowth Assay, Panlabs 332440-0 APOE_HUMAN Human Cell Based
Cell Based Phenotypic APP- PS1- MAPT Familial Alzheimer’s Disease Genetic Cell Based Agonist Neurite Outgrowth Assay, Panlabs 332460-0 A4_HUMAN Human Cell Based

 

  

Alzheimer's MoA LeadHunter Panel (#PP284)

  • 신경전달, 글루타메이트 흥분독성, β-아밀로이드의 bioprocess, 타우 과인산화 및 신경염증을 포함한 MoA 기반 표적을 사용합니다.
  • 알츠하이머 치료제 discovery를 위한 41가지 assay를 제공합니다. 
  • Test Sample Requirements: 120 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)

 

Neurotransmission 　 Disease-modifying
Cholinergic 　 Glutamate Excitotoxicity
104010 AChE 　 279450 279510 Nav
104050 BuChE 　 200610 Adenosine A2AR
252610 M1 　 232600 AMPAR
258660 α7nAChR 　 237000 mGlu5
Monoaminergic 　 234000 NMDAR-ifenprodil
140010 MAO-A 　 233010 NMDAR-MK801
140120 MAO-B 　 299034 σ1R
199019 COMT 　 299007 σ2R
Serotonergic 　 b-amyloid
271120 5-HT1A 　 164700 BACE-1
272000 5-HT4 　 163950 ECE-1
272200 5-HT6 　 164010 NEP
Histaminergic 　 282910 SST4
239820 H3R 　 Phospho-tau
GABA 　 168040 CAMK2D
226630 GABA-A 　 172020 FYN
226400 GABA transporter 　 176500 GSK-3β
　 　 　 176610 p38-MAPK
　 　 　 Neuroinflammation
　 　 　 199020 15-LO
　 　 　 112250 CathB
　 　 　 116030 COX-1
　 　 　 118030 COX-2
　 　 　 244600 CX3CR1
　 　 　 189240 dusp22
　 　 　 199008 FAAH
　 　 　 125810 IDO
　 　 　 199010 iNOS 
　 　 　 121000 mpo
　 　 　 299037 PAF

   

 

Parkinson's MoA LeadHunter Panel (#PP285)   

  • 파킨슨병(PD)은 운동 장애를 특징으로 하는 진행성 신경퇴행성 질환입니다. Lewy body inclusion 및 진행성 도파민성 신경 세포 손실은 PD의 병리학적 특징입니다.
  • PP285에는 메커니즘의 다중 프로필을 이해하기 위해 도파민성 및 비도파민성 수용체, 수송체, 이온 채널, 운동 및 비운동 결손과 관련된 효소 분석 등, 27가지 assay를 제공합니다.
  • Test Sample Requirements:120 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)  

 

Motor 　 Non-Motor
200610 Adenosine A2AR 　 271120 5-HT1A
232600 AMPAR 　 271230 5-HT1B
216010 Cav2.2 　 271650 5-HT2A
199019 COMT 　 104010 AChE
219500 D1 　 104050 BuChE
219600 D2L 　 239820 H3R
219700 D2S 　 279450 Nav
219800 D3 　 274030 SET
220000 D4.4 　 299034 σ1R
220100 D4.7 　 299007 σ2R
220200 D5 　 　 　
220320 DAT 　 　 　
141010 MAO-A 　 　 　
140120 MAO-B 　 　 　
237000 mGlu5 　 　 　
234000 NMDAR-ifenprodil 　 　 　
233010 NMDAR-MK801 　 　 　

 

주문정보

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제품 문의

 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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