알츠하이머 인히비터 | Alzheimer's Disease Inhibitor

제품 상세

알츠하이머 인히비터 | Alzheimer's Disease Inhibitor

알츠하이머 병 (AD) 기전에 관련된 γ-Secretase와 Amyloid β Peptide의 Modulators & Inhibitors를 소개합니다.

프린트 제품 문의

Alzheimer's disease (AD)란?

알츠하이머병은 1907년 독일 정신과 의사인 Alois Alzheimer에 의해 보고된 증상으로, 전체 치매 환자의 60-70%를 차지하고 있는 대표적인 노인성 신경질환입니다.
인지 및 기능장애를 유발하는 비가역적이고 진행성인 신경퇴행성 장애로, 중추신경계(CNS)에서 단백질 응집체의 형성과 뉴런의 점진적인 손실을 유발하는 것이 특징입니다.
세포외부에 아밀로이드 플라크 형성, 뇌의 전반적인 위축, 뇌실확장, 타우 인산화 등의 병리학적인 특징을 가집니다.
알츠하이머의 발생원인은 아직 명확히 밝혀지지 않았으며 여러 가설을 바탕으로 집중적인 연구가 진행되고 있습니다.

주요 제품

γ-Secretase Modulators & Inhibitors
Cat. No.	Product	Activity
6363	Avagacestat	Highly potent γ-secretase inhibitor; orally bioavailable
2870	BMS 299897	Potent γ-secretase inhibitor
6476	Compound E	γ-secretase inhibitor; induces neuronal differentiation
2634	DAPT	γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling
4489	DBZ	γ-secretase inhibitor; inhibits Notch pathway
5550	E 2012	γ-secretase modulator; Notch-sparing
2627	L-685,458	Potent and selective γ-secretase inhibitor
6559	LY 450139	γ-secretase pseudo-inhibitor
4000	MRK 560	γ-secretase inhibitor; attenuates amyloid plaque deposition
5751	PF 3084014 hydrobromide	Potent γ-secretase inhibitor

Amyloid β Peptide Modulators & Inhibitors
Cat. No.	Product	Activity
5053	AC 186	Decreases Aβ levels in combination with ACP-105; ERβ agonist
1191	Amyloid β-Peptide (1-40) (human)	Amyloid β-protein fragment
1428	Amyloid β-Peptide (1-42) (human)	Predominant amyloid β-protein fragment
2425	Amyloid β-peptide (1-42) (rat)	Predominant amyloid β-protein fragment
1429	Amyloid β-peptide (25-35) (human)	Human amyloid β-protein fragment functionally required for neurotoxicity
6363	Avagacestat	Highly potent γ-secretase inhibitor; orally bioavailable
2870	BMS 299897	γ-secretase inhibitor; reduces Aβ levels
0427	Bromocriptine mesylate	Reduces Aβ levels; D2 and D3 receptor agonist
4924	CEP 1347	Neuroprotective; blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling
2442	CGP 53353	Inhibitor of de novo Aβ42 assembly
3945	Colivelin	Neuroprotective peptide; protects against β-amyloid neurotoxicity
4803	CRANAD 2	Near-infrared probe that detects Aβ40 aggregates
2634	DAPT	γ-secretase inhibitor; reduces Aβ42 levels
6779	Davunetide	Highly potent active component of ADNP; prevents amyloid β aggregation; active in vivo
4524	EGCG	β-secretase inhibitor; inhibits formation of amyloid fibrils
5081	J 147	Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
3144	K 114	Amyloid fibril-specific fluorescent dye
2627	L-685,458	Potent and selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42
6517	Liraglutide	Reduces Aβ and soluble amyloid levels in vivo; also highly potent GLP-1 receptor agonist
7081	LY 2886721 Hydrochloride	Inhibits Aβ1-40 and 1-42 production in vitro and in vivo; potent and selective β-secretase inhibitor
4920	Methoxy-X04	Fluorescent amyloid β detector; brain penetrant
4000	MRK 560	γ-secretase inhibitor; attenuates amyloid plaque deposition
5751	PF 3084014 hydrobromide	Potent γ-secretase inhibitor
2408	Ro 90-7501	Inhibitor of Aβ42 fibril formation
5343	TPPB	APP modulator; also high affinity PKC activator
1098	Tranilast	Antiallergic; binds to Aβ40 monomers
6762	Urolithin A	Inhibits amyloid-β fibrillation; also PI 3-K/Akt/mTOR signaling inhibitor
7659	Verubecestat	Potently reduces Aβ formation in vitro and in vivo; BACE1 and BACE2 inhibitor

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
Product	Cat.No.	Size	Maker
(+)-MK 801 maleate (50 mg)	0924	50 mg	TOCRIS
(R)-DRF053 dihydrochloride (50 mg)	3610	50 mg	TOCRIS
A 85380 dihydrochloride (10 mg)	5017	10 mg	TOCRIS
AC 186 (10 mg)	5053	10 mg	TOCRIS
AC 186 (50 mg)	5053	50 mg	TOCRIS
ACEA (25 mg)	1319	25 mg	TOCRIS
ACEA (5 mg)	1319	5 mg	TOCRIS
AR-A 014418 (50 mg)	3966	50 mg	TOCRIS
Avagacestat (25 MG)	6363	25 mg	TOCRIS
Avagacestat (5 MG)	6363	5 mg	TOCRIS
AZ 191 (10 mg)	5232	10 mg	TOCRIS
AZ 191 (50 mg)	5232	50 mg	TOCRIS
BF 2649 hydrochloride (10 MG)	3743	10 mg	TOCRIS
BF 2649 hydrochloride (50 MG)	3743	50 mg	TOCRIS
BIO (10 mg)	3194	10 mg	TOCRIS
BIO (50 mg)	3194	50 mg	TOCRIS
BMS 299897 (10 mg)	2870	10 mg	TOCRIS
Cevimeline hydrochloride (10 mg)	3689	10 mg	TOCRIS
Cevimeline hydrochloride (50 mg)	3689	50 mg	TOCRIS
CGP 53353 (10 mg)	2442	10 mg	TOCRIS
CHIR 99021 trihydrochloride (10 mg)	4953	10 mg	TOCRIS
CHIR 99021 trihydrochloride (50 mg)	4953	50 mg	TOCRIS
Curcumin (50 mg)	2841	50 mg	TOCRIS
D 4476 (50 mg)	2902	50 mg	TOCRIS
D-AP5 (10 mg)	0106	10 mg	TOCRIS
D-AP5 (100 mg)	0106	100 mg	TOCRIS
D-AP5 (50 mg)	0106	50 mg	TOCRIS
DBZ (50 mg)	4489	50 mg	TOCRIS
Desformylflustrabromine hydrochloride (50 mg)	3328	50 mg	TOCRIS
Dihydro-b-erythroidine hydrobromide (50 mg)	2349	50 mg	TOCRIS
E 2012 (10 MG)	5550	10 mg	TOCRIS
E 2012 (50 MG)	5550	50 mg	TOCRIS
HU 308 (10 mg)	3088	10 mg	TOCRIS
HU 308 (50 mg)	3088	50 mg	TOCRIS
J 147 (10 mg)	5081	10 mg	TOCRIS
J 147 (50 mg)	5081	50 mg	TOCRIS
JWH 133	1343	10 mg	TOCRIS
JWH 133	1343	10 mg	TOCRIS
LY 2886721 Hydrochloride (50 MG)	7081	50 mg	TOCRIS
LY 450139 (25 MG)	6559	25 mg	TOCRIS
LY 450139 (5 MG)	6559	5 mg	TOCRIS
Methyllycaconitine citrate (25 mg)	1029	25 mg	TOCRIS
Methyllycaconitine citrate (5 mg)	1029	5 mg	TOCRIS
MRK 560 (50 mg)	4000	50 mg	TOCRIS
NADA (5 mg)	1568	5 mg	TOCRIS
PF 3084014 hydrobromide (10 mg)	5751	10 mg	TOCRIS
PF 3084014 hydrobromide (50 mg)	5751	50 mg	TOCRIS
PF 670462 (10 mg)	3316	10 mg	TOCRIS
PF 670462 (50 mg)	3316	50 mg	TOCRIS
PHA 543613 hydrochloride (10 mg)	3092	10 mg	TOCRIS

전체보기

1
Maker	TOCRIS
Cat.No.	0924
Product	(+)-MK 801 maleate (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

2
Maker	TOCRIS
Cat.No.	3610
Product	(R)-DRF053 dihydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

3
Maker	TOCRIS
Cat.No.	5017
Product	A 85380 dihydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

4
Maker	TOCRIS
Cat.No.	5053
Product	AC 186 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

5
Maker	TOCRIS
Cat.No.	5053
Product	AC 186 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

6
Maker	TOCRIS
Cat.No.	1319
Product	ACEA (25 mg)
Size	25 mg
Qty
Data Sheet
MSDS

7
Maker	TOCRIS
Cat.No.	1319
Product	ACEA (5 mg)
Size	5 mg
Qty
Data Sheet
MSDS

8
Maker	TOCRIS
Cat.No.	3966
Product	AR-A 014418 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

9
Maker	TOCRIS
Cat.No.	6363
Product	Avagacestat (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

10
Maker	TOCRIS
Cat.No.	6363
Product	Avagacestat (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

11
Maker	TOCRIS
Cat.No.	5232
Product	AZ 191 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

12
Maker	TOCRIS
Cat.No.	5232
Product	AZ 191 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

13
Maker	TOCRIS
Cat.No.	3743
Product	BF 2649 hydrochloride (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

14
Maker	TOCRIS
Cat.No.	3743
Product	BF 2649 hydrochloride (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

15
Maker	TOCRIS
Cat.No.	3194
Product	BIO (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

16
Maker	TOCRIS
Cat.No.	3194
Product	BIO (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

17
Maker	TOCRIS
Cat.No.	2870
Product	BMS 299897 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

18
Maker	TOCRIS
Cat.No.	3689
Product	Cevimeline hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

19
Maker	TOCRIS
Cat.No.	3689
Product	Cevimeline hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

20
Maker	TOCRIS
Cat.No.	2442
Product	CGP 53353 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

21
Maker	TOCRIS
Cat.No.	4953
Product	CHIR 99021 trihydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

22
Maker	TOCRIS
Cat.No.	4953
Product	CHIR 99021 trihydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

23
Maker	TOCRIS
Cat.No.	2841
Product	Curcumin (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

24
Maker	TOCRIS
Cat.No.	2902
Product	D 4476 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

25
Maker	TOCRIS
Cat.No.	0106
Product	D-AP5 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

26
Maker	TOCRIS
Cat.No.	0106
Product	D-AP5 (100 mg)
Size	100 mg
Qty
Data Sheet
MSDS

27
Maker	TOCRIS
Cat.No.	0106
Product	D-AP5 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

28
Maker	TOCRIS
Cat.No.	4489
Product	DBZ (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

29
Maker	TOCRIS
Cat.No.	3328
Product	Desformylflustrabromine hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

30
Maker	TOCRIS
Cat.No.	2349
Product	Dihydro-b-erythroidine hydrobromide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

31
Maker	TOCRIS
Cat.No.	5550
Product	E 2012 (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

32
Maker	TOCRIS
Cat.No.	5550
Product	E 2012 (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

33
Maker	TOCRIS
Cat.No.	3088
Product	HU 308 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

34
Maker	TOCRIS
Cat.No.	3088
Product	HU 308 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

35
Maker	TOCRIS
Cat.No.	5081
Product	J 147 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

36
Maker	TOCRIS
Cat.No.	5081
Product	J 147 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

37
Maker	TOCRIS
Cat.No.	1343
Product	JWH 133
Size	10 mg
Qty
Data Sheet
MSDS

38
Maker	TOCRIS
Cat.No.	1343
Product	JWH 133
Size	10 mg
Qty
Data Sheet
MSDS

39
Maker	TOCRIS
Cat.No.	7081
Product	LY 2886721 Hydrochloride (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

40
Maker	TOCRIS
Cat.No.	6559
Product	LY 450139 (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

41
Maker	TOCRIS
Cat.No.	6559
Product	LY 450139 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

42
Maker	TOCRIS
Cat.No.	1029
Product	Methyllycaconitine citrate (25 mg)
Size	25 mg
Qty
Data Sheet
MSDS

43
Maker	TOCRIS
Cat.No.	1029
Product	Methyllycaconitine citrate (5 mg)
Size	5 mg
Qty
Data Sheet
MSDS

44
Maker	TOCRIS
Cat.No.	4000
Product	MRK 560 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

45
Maker	TOCRIS
Cat.No.	1568
Product	NADA (5 mg)
Size	5 mg
Qty
Data Sheet
MSDS

46
Maker	TOCRIS
Cat.No.	5751
Product	PF 3084014 hydrobromide (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

47
Maker	TOCRIS
Cat.No.	5751
Product	PF 3084014 hydrobromide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

48
Maker	TOCRIS
Cat.No.	3316
Product	PF 670462 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

전체보기

자료

Alzheimer’s Disease Neuropathology and Epidemiology

고마뉴스 자료신청 [TOCRIS]

알츠하이머의 신경 병리 및 역학에 대한 포스터입니다.
Alzheimer's Disease Research Product Guide

고마뉴스 자료신청 [TOCRIS]

Alzheimer's Disease 연구에 필요한 제품을 소개합니다.
Neurodegeneration Research Product Guide

[TOCRIS]

Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Diseases 연구에 관련된 small molecule 정보가 수록되어 있습니다.
Alzheimer's Poster

[TOCRIS]

Alzheimer's Disease pathway poster 입니다.
Alzheimer's Disease

[ARIGO]

알츠하이머병에서 생성되는 Amyloid beta의 기전에 대한 포스터 입니다.
Neuronal Probes

[BIOTIUM]

신경세포 염색 dye에 대한 안내입니다.
Inhibitor Book Vol.4

고마뉴스 자료신청 [KOMA]

다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

알츠하이머 인히비터 | Alzheimer's Disease Inhibitor | 고마바이오텍

알츠하이머 인히비터 | Alzheimer's Disease Inhibitor

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