γ-Secretase Modulators & Inhibitors |
|
Cat. No. |
Product |
Activity |
6363 |
Avagacestat |
Highly potent
γ-secretase inhibitor; orally bioavailable |
2870 |
BMS 299897 |
Potent γ-secretase
inhibitor |
6476 |
Compound E |
γ-secretase
inhibitor; induces neuronal differentiation |
2634 |
DAPT |
γ-secretase
inhibitor; induces neuronal differentiation; blocks Notch signaling |
4489 |
DBZ |
γ-secretase
inhibitor; inhibits Notch pathway |
5550 |
E 2012 |
γ-secretase
modulator; Notch-sparing |
2627 |
L-685,458 |
Potent and
selective γ-secretase inhibitor |
6559 |
LY 450139 |
γ-secretase
pseudo-inhibitor |
4000 |
MRK 560 |
γ-secretase
inhibitor; attenuates amyloid plaque deposition |
5751 |
PF 3084014
hydrobromide |
Potent γ-secretase
inhibitor |
|
|
|
Amyloid
β Peptide Modulators & Inhibitors |
|
Cat. No. |
Product |
Activity |
5053 |
AC 186 |
Decreases Aβ levels
in combination with ACP-105; ERβ agonist |
1191 |
Amyloid β-Peptide
(1-40) (human) |
Amyloid β-protein
fragment |
1428 |
Amyloid β-Peptide
(1-42) (human) |
Predominant amyloid
β-protein fragment |
2425 |
Amyloid β-peptide
(1-42) (rat) |
Predominant amyloid
β-protein fragment |
1429 |
Amyloid β-peptide
(25-35) (human) |
Human amyloid
β-protein fragment functionally required for neurotoxicity |
6363 |
Avagacestat |
Highly potent
γ-secretase inhibitor; orally bioavailable |
2870 |
BMS 299897 |
γ-secretase
inhibitor; reduces Aβ levels |
0427 |
Bromocriptine
mesylate |
Reduces Aβ levels;
D2 and D3 receptor agonist |
4924 |
CEP 1347 |
Neuroprotective;
blocks Aβ-induced cortical neuron apoptosis. Also inhibitor of JNK signaling |
2442 |
CGP 53353 |
Inhibitor of de
novo Aβ42 assembly |
3945 |
Colivelin |
Neuroprotective
peptide; protects against β-amyloid neurotoxicity |
4803 |
CRANAD 2 |
Near-infrared probe
that detects Aβ40 aggregates |
2634 |
DAPT |
γ-secretase
inhibitor; reduces Aβ42 levels |
6779 |
Davunetide |
Highly potent
active component of ADNP; prevents amyloid β aggregation; active in vivo |
4524 |
EGCG |
β-secretase
inhibitor; inhibits formation of amyloid fibrils |
5081 |
J 147 |
Neuroprotective and
neurotrophic compound; reduces Aβ40 and Aβ42 levels |
3144 |
K 114 |
Amyloid
fibril-specific fluorescent dye |
2627 |
L-685,458 |
Potent and
selective γ-secretase inhibitor; inhibits Aβ40 and Aβ42 |
6517 |
Liraglutide |
Reduces Aβ and
soluble amyloid levels in vivo; also highly potent GLP-1 receptor agonist |
7081 |
LY 2886721
Hydrochloride |
Inhibits Aβ1-40 and
1-42 production in vitro and in vivo; potent and selective β-secretase
inhibitor |
4920 |
Methoxy-X04 |
Fluorescent amyloid
β detector; brain penetrant |
4000 |
MRK 560 |
γ-secretase
inhibitor; attenuates amyloid plaque deposition |
5751 |
PF 3084014
hydrobromide |
Potent γ-secretase
inhibitor |
2408 |
Ro 90-7501 |
Inhibitor of Aβ42
fibril formation |
5343 |
TPPB |
APP modulator; also
high affinity PKC activator |
1098 |
Tranilast |
Antiallergic; binds
to Aβ40 monomers |
6762 |
Urolithin A |
Inhibits amyloid-β
fibrillation; also PI 3-K/Akt/mTOR signaling inhibitor |
7659 |
Verubecestat |
Potently reduces Aβ
formation in vitro and in vivo; BACE1 and BACE2 inhibitor |