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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

배 경

  

  • GABA Receptor는 중추신경계의 주요 억제성 신경전달물질인 GABA에 반응하는 수용체 군으로, GABA A와 GABA B 두가지 그룹이 있습니다. 
  • GABA A Receptor는 이온성 수용체 (ionotropic receptor)로 ligand-gated channel 이라고도 하며 Cl-의 개폐를 조정하고, GABA B Receptor는 대사성 수용체 (metabotropic receptor)로, K+ 채널의 개폐를 조정합니다. 



GABAA Receptor 주요 제품 

  GABAA Receptor Agonists  
  Cat. No. Product Name Activity
  0344 GABA Endogenous agonist
  0235 Isoguvacine hydrochloride Selective GABAA agonist
  3250 L-838,417 GABAA partial agonist; displays subtype selectivity
  4415 MK 0343 GABAA partial agonist; displays subtype selectivity
  0289 Muscimol Potent GABAA agonist; also GABAA-ρ partial agonist
  4709 RuBi GABA trimethylphosphine Caged GABA; inhibits neural activity
  0181 TACA GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
  0807 THIP hydrochloride GABAA agonist
       
  GABAA Receptor Inverse Agonists  
  Cat. No. Product Name Activity
  3817 MRK 016 α5-selective GABAA inverse agonist
  2905 TB 21007 α5-selective GABAA inverse agonist
       
  GABAA Receptor Antagonists  
  Cat. No. Product Name Activity
  2503 (-)-Bicuculline methiodide GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
  0109 (-)-Bicuculline methobromide GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
  0131 (-)-Bicuculline methochloride GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
  0130 (+)-Bicuculline Potent GABAA antagonist
  3109 Furosemide GABAA antagonist; also Na+/2Cl-/K+ cotransporter blocker
  4466 PHP 501 trifluoroacetate Potent GABAA antagonist
  1128 Picrotoxin GABAA antagonist
  2143 SCS Potent GABAA antagonist; β1-subunit selective
  1262 SR 95531 hydrobromide Competitive and selective GABAA antagonist
       
  Benzodiazepines  
  Cat. No. Product Name Activity
  3568 Bretazenil Benzodiazepine partial agonist
  0456 Chlormezanone Positive allosteric modulator of benzodiazepine site
  1709 CL 218872 Benzodiazepine agonist
  2805 Diazepam Acts at the benzodiazepine modulatory site
  3083 DMCM hydrochloride Benzodiazepine inverse agonist
  0554 FG 7142 Benzodiazepine inverse agonist
  0658 FGIN-1-27 Potent ligand for mitochondrial DBI receptor; GABAreceptor modulator
  1328 Flumazenil Benzodiazepine antagonist
  1327 L-655,708 Benzodiazepine inverse agonist; selective for α5-containing GABAreceptors
  2832 Midazolam hydrochloride Benzodiazepine agonist
  1997 Ro 15-4513 Benzodiazepine partial inverse agonist
  4414 TP 003 GABAA partial agonist; acts at benzodiazepine site
  0405 β-CCB Benzodiazepine inverse agonist; putative endogenous ligand
       
GABAA Receptor Modulators
  Cat. No. Product Name Activity
  2681 17-PA Antagonist of neurosteroid potentiation and direct gating of GABAA
  3972 AA 29504 Positive allosteric modulator of GABAA receptors
  3653 Allopregnanolone Positive allosteric modulator of GABAA receptors
  3679 DS2 Positive allosteric modulator of GABAA receptors; displays subunit selectivity
  3113 Etifoxine hydrochloride GABAA potentiator; anxiolytic
  1471 Etomidate GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
  2867 Flupirtine maleate GABAA modulator; also indirect NMDA antagonist and Kv7 channel activator
  2531 Ganaxolone Potent positive allosteric modulator of GABAA receptors
  1295 Loreclezole hydrochloride Subtype-selective GABAA modulator
  4949 MaxiPost Negative modulator of GABAA receptors; also potassium channel modulator
  4410 Ocinaplon GABAA modulator; anxiolytic
  2738 Org 20599 Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
  3652 Pregnanolone Postitive allosteric modulator of GABAA receptors
  5376 Pregnenolone sulfate sodium salt GABAA inhibitor; displays some subunit selectivity; NMDA potentiator; also activates TRPM3 channels
  6192 PZ-II-029 α6β3γ2-selective GABAA positive allosteric modulator
  1512 SB 205384 GABAA modulator; slows current decay
  6334 THDOC Positive modulator of GABAA receptors; endogenous neurosteroid
  3620 Topiramate Positive allosteric modulator of GABAA receptors; GluK1 antagonist; also inhibits carbonic anhydrase (CA) II and IV
  1558 Tracazolate hydrochloride Allosteric modulator of GABAA receptors
  2734 U 89843A Positive allosteric modulator of GABAA receptors




GABAB Receptors 주요 제품

GABAB Receptor Agonists
  Cat. No. Product Name Activity
  0796 (R)-Baclofen Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
  0417 (RS)-Baclofen Selective GABAB agonist
  0344 GABA Endogenous agonist
  4709 RuBi GABA trimethylphosphine Caged GABA; inhibits neural activity
  3400 RuBi-GABA Caged GABA; excitable at visible wavelengths
  0379 SKF 97541 Highly potent GABAB agonist; also GABAA-ρ antagonist
       
  GABAB Receptor Antagonists  
  Cat. No. Product Name Activity
  0245 2-Hydroxysaclofen Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
  1245 CGP 35348 Selective GABAB antagonist; brain penetrant
  3219 CGP 36216 hydrochloride GABAB antagonist; displays activity at presynaptic receptors
  1247 CGP 46381 Selective GABAB antagonist; brain penetrant
  1246 CGP 52432 Potent and selective GABAB antagonist
  1088 CGP 54626 hydrochloride Potent and selective GABAB antagonist
  1248 CGP 55845 hydrochloride Potent and selective GABAB antagonist
  0246 Saclofen Selective GABAB antagonist
  0984 SCH 50911 Selective and competitive GABAB antagonist; orally bioavailable
       
  GABAB Receptor Modulators  
  Cat. No. Product Name Activity
  1514 CGP 13501 Positive allosteric modulator of GABAB receptors
  1513 CGP 7930 Positive allosteric modulator of GABAB receptors
  2001 GS 39783 Positive allosteric modulator of GABAB receptors
  3313 rac BHFF Potent and selective postitive allosteric modulator of GABAB receptors
   
  Other    
  Cat. No. Product Name Activity
  0386 3-Methyl-GABA Activator of GABA amino-transferase
  1811 Modafinil Psychostimulant
  4579 Pentobarbital sodium salt Enhances GABAergic activity
  2687 Pentylenetetrazole CNS stimulant
  2815 Valproic acid, sodium salt Increases GABA levels; anticonvulsant
  2625 Zonisamide Modulates GABA neurotransmission; anticonvulsant


 





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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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