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GABAA Receptor Agonists |
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|
Cat. No. |
Product Name |
Activity |
|
0344 |
GABA |
Endogenous agonist |
|
0235 |
Isoguvacine hydrochloride |
Selective
GABAA agonist |
|
3250 |
L-838,417 |
GABAA partial agonist; displays
subtype selectivity |
|
4415 |
MK 0343 |
GABAA partial agonist; displays
subtype selectivity |
|
0289 |
Muscimol |
Potent
GABAA agonist; also GABAA-ρ partial agonist |
|
4709 |
RuBi GABA trimethylphosphine |
Caged GABA; inhibits neural activity |
|
0181 |
TACA |
GABAA agonist; also GABA-T
substrate and GABA uptake inhibitor |
|
0807 |
THIP hydrochloride |
GABAA agonist |
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GABAA Receptor Inverse Agonists |
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|
Cat. No. |
Product Name |
Activity |
|
3817 |
MRK 016 |
α5-selective GABAA inverse agonist |
|
2905 |
TB 21007 |
α5-selective
GABAA inverse agonist |
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|
|
|
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GABAA Receptor Antagonists |
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|
Cat. No. |
Product Name |
Activity |
|
2503 |
(-)-Bicuculline methiodide |
GABAA antagonist; more water soluble version of
(+)-bicuculline (Cat. No. 0130) |
|
0109 |
(-)-Bicuculline methobromide |
GABAA antagonist; more water soluble version of
(+)-bicuculline (Cat. No. 0130) |
|
0131 |
(-)-Bicuculline methochloride |
GABAA antagonist; more water soluble version of
(+)-bicuculline (Cat. No. 0130) |
|
0130 |
(+)-Bicuculline |
Potent
GABAA antagonist |
|
3109 |
Furosemide |
GABAA antagonist; also Na+/2Cl-/K+ cotransporter
blocker |
|
4466 |
PHP 501 trifluoroacetate |
Potent
GABAA antagonist |
|
1128 |
Picrotoxin |
GABAA antagonist |
|
2143 |
SCS |
Potent
GABAA antagonist;
β1-subunit selective |
|
1262 |
SR 95531 hydrobromide |
Competitive
and selective GABAA antagonist |
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|
|
|
|
Benzodiazepines |
|
|
Cat. No. |
Product Name |
Activity |
|
3568 |
Bretazenil |
Benzodiazepine partial agonist |
|
0456 |
Chlormezanone |
Positive allosteric modulator of benzodiazepine site |
|
1709 |
CL 218872 |
Benzodiazepine agonist |
|
2805 |
Diazepam |
Acts at the benzodiazepine modulatory site |
|
3083 |
DMCM hydrochloride |
Benzodiazepine inverse agonist |
|
0554 |
FG 7142 |
Benzodiazepine inverse agonist |
|
0658 |
FGIN-1-27 |
Potent
ligand for mitochondrial DBI receptor; GABAA receptor modulator |
|
1328 |
Flumazenil |
Benzodiazepine antagonist |
|
1327 |
L-655,708 |
Benzodiazepine
inverse agonist; selective for α5-containing GABAA receptors |
|
2832 |
Midazolam hydrochloride |
Benzodiazepine agonist |
|
1997 |
Ro 15-4513 |
Benzodiazepine partial inverse agonist |
|
4414 |
TP 003 |
GABAA partial agonist; acts at
benzodiazepine site |
|
0405 |
β-CCB |
Benzodiazepine inverse agonist; putative endogenous
ligand |
|
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|
|
GABAA Receptor Modulators |
|
|
Cat. No. |
Product Name |
Activity |
|
2681 |
17-PA |
Antagonist
of neurosteroid potentiation and direct gating of GABAA |
|
3972 |
AA 29504 |
Positive
allosteric modulator of GABAA receptors |
|
3653 |
Allopregnanolone |
Positive
allosteric modulator of GABAA receptors |
|
3679 |
DS2 |
Positive
allosteric modulator of GABAA receptors;
displays subunit selectivity |
|
3113 |
Etifoxine hydrochloride |
GABAA potentiator; anxiolytic |
|
1471 |
Etomidate |
GABA-mimetic;
selectively interacts with β2- and β3-subunit containing GABAA receptors |
|
2867 |
Flupirtine maleate |
GABAA modulator; also indirect NMDA
antagonist and Kv7
channel activator |
|
2531 |
Ganaxolone |
Potent
positive allosteric modulator of GABAA receptors |
|
1295 |
Loreclezole hydrochloride |
Subtype-selective
GABAA modulator |
|
4949 |
MaxiPost |
Negative
modulator of GABAA receptors;
also potassium channel modulator |
|
4410 |
Ocinaplon |
GABAA modulator; anxiolytic |
|
2738 |
Org 20599 |
Positive
allosteric modulator of GABAA receptors;
direct agonist at higher concentrations |
|
3652 |
Pregnanolone |
Postitive
allosteric modulator of GABAA receptors |
|
5376 |
Pregnenolone sulfate sodium salt |
GABAA inhibitor; displays some
subunit selectivity; NMDA potentiator; also activates TRPM3 channels |
|
6192 |
PZ-II-029 |
α6β3γ2-selective
GABAA positive allosteric
modulator |
|
1512 |
SB 205384 |
GABAA modulator; slows current
decay |
|
6334 |
THDOC |
Positive
modulator of GABAA receptors;
endogenous neurosteroid |
|
3620 |
Topiramate |
Positive
allosteric modulator of GABAA receptors;
GluK1 antagonist; also inhibits carbonic anhydrase (CA) II and IV |
|
1558 |
Tracazolate hydrochloride |
Allosteric
modulator of GABAA receptors |
|
2734 |
U 89843A |
Positive
allosteric modulator of GABAA receptors |