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GABA 수용체 연구 | GPCR GABA Receptor Agonist & Antagonist 이미지

GABA 수용체 연구 | GPCR GABA Receptor Agonist & Antagonist

GABA Receptor 연구에 이용되는 Agonist & Antagonist를 소개합니다.

프린트 제품 문의

특징

  

  • GABA Receptor는 중추신경계의 주요 억제성 신경전달물질인 GABA에 반응하는 수용체 군으로, GABA A와 GABA B 두가지 그룹이 있습니다. 
  • GABA A Receptor는 이온성 수용체 (ionotropic receptor)로 ligand-gated channel 이라고도 하며 Cl-의 개폐를 조정하고, GABA B Receptor는 대사성 수용체 (metabotropic receptor)로, K+ 채널의 개폐를 조정합니다. 


주요 제품 
GABAA Receptor Agonists, Antagonists, Modulators
Cat. No. Product  Activity
2503 (-)-Bicuculline methiodide GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
0109 (-)-Bicuculline methobromide GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
0131 (-)-Bicuculline methochloride GABAA antagonist; more water soluble version of (+)-bicuculline (Cat. No. 0130)
0130 (+)-Bicuculline Potent GABAA antagonist
2681 17-PA Antagonist of neurosteroid potentiation and direct gating of GABAA
3972 AA 29504 Positive allosteric modulator of GABAA receptors
3653 Allopregnanolone Positive allosteric modulator of GABAA receptors
3679 DS2 Positive allosteric modulator of GABAA receptors; displays subunit selectivity
3113 Etifoxine hydrochloride GABAA potentiator; anxiolytic
1471 Etomidate GABA-mimetic; selectively interacts with β2- and β3-subunit containing GABAA receptors
2867 Flupirtine maleate GABAA modulator; also indirect NMDA antagonist and Kv7 channel activator
3109 Furosemide GABAA antagonist; also Na+/2Cl-/K+ cotransporter blocker
0344 GABA Endogenous agonist
2531 Ganaxolone Potent positive allosteric modulator of GABAA receptors
0235 Isoguvacine hydrochloride Selective GABAA agonist
3250 L-838,417 GABAA partial agonist; displays subtype selectivity
1295 Loreclezole hydrochloride Subtype-selective GABAA modulator
4949 MaxiPost Negative modulator of GABAA receptors; also potassium channel modulator
4415 MK 0343 GABAA partial agonist; displays subtype selectivity
3817 MRK 016 α5-selective GABAA inverse agonist
0289 Muscimol Potent GABAA agonist; also GABAA-ρ partial agonist
4410 Ocinaplon GABAA modulator; anxiolytic
2738 Org 20599 Positive allosteric modulator of GABAA receptors; direct agonist at higher concentrations
4466 PHP 501 trifluoroacetate Potent GABAA antagonist
1128 Picrotoxin GABAA antagonist
3652 Pregnanolone Postitive allosteric modulator of GABAA receptors
5376 Pregnenolone sulfate sodium salt GABAA inhibitor; displays some subunit selectivity; NMDA potentiator; also activates TRPM3 channels
6192 PZ-II-029 α6β3γ2-selective GABAA positive allosteric modulator
4709 RuBi GABA trimethylphosphine Caged GABA; inhibits neural activity
1512 SB 205384 GABAA modulator; slows current decay
2143 SCS Potent GABAA antagonist; β1-subunit selective
1262 SR 95531 hydrobromide Competitive and selective GABAA antagonist
0181 TACA GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
2905 TB 21007 α5-selective GABAA inverse agonist
6334 THDOC Positive modulator of GABAA receptors; endogenous neurosteroid
0807 THIP hydrochloride GABAA agonist
3620 Topiramate Positive allosteric modulator of GABAA receptors; GluK1 antagonist; also inhibits carbonic anhydrase (CA) II and IV
1558 Tracazolate hydrochloride Allosteric modulator of GABAA receptors
2734 U 89843A Positive allosteric modulator of GABAA receptors
Benzodiazepines
Cat. No. Product  Activity
3568 Bretazenil Benzodiazepine partial agonist
0456 Chlormezanone Positive allosteric modulator of benzodiazepine site
1709 CL 218872 Benzodiazepine agonist
2805 Diazepam Acts at the benzodiazepine modulatory site
3083 DMCM hydrochloride Benzodiazepine inverse agonist
0554 FG 7142 Benzodiazepine inverse agonist
0658 FGIN-1-27 Potent ligand for mitochondrial DBI receptor; GABAA receptor modulator
1328 Flumazenil Benzodiazepine antagonist
1327 L-655,708 Benzodiazepine inverse agonist; selective for α5-containing GABAA receptors
2832 Midazolam hydrochloride Benzodiazepine agonist
1997 Ro 15-4513 Benzodiazepine partial inverse agonist
4414 TP 003 GABAA partial agonist; acts at benzodiazepine site
0405 β-CCB Benzodiazepine inverse agonist; putative endogenous ligand
GABAB Receptor Agonists, Antagonists, Modulators
Cat. No. Product  Activity
0796 (R)-Baclofen Selective GABAB agonist; active enantiomer of (RS)-Baclofen (Cat. No. 0417)
0417 (RS)-Baclofen Selective GABAB agonist
0245 2-Hydroxysaclofen Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246)
0386 3-Methyl-GABA Activator of GABA amino-transferase
1514 CGP 13501 Positive allosteric modulator of GABAB receptors
1245 CGP 35348 Selective GABAB antagonist; brain penetrant
3219 CGP 36216 hydrochloride GABAB antagonist; displays activity at presynaptic receptors
1247 CGP 46381 Selective GABAB antagonist; brain penetrant
1246 CGP 52432 Potent and selective GABAB antagonist
1088 CGP 54626 hydrochloride Potent and selective GABAB antagonist
1248 CGP 55845 hydrochloride Potent and selective GABAB antagonist
1513 CGP 7930 Positive allosteric modulator of GABAB receptors
0344 GABA Endogenous agonist
2001 GS 39783 Positive allosteric modulator of GABAB receptors
1811 Modafinil Psychostimulant
4579 Pentobarbital sodium salt Enhances GABAergic activity
2687 Pentylenetetrazole CNS stimulant
3313 rac BHFF Potent and selective postitive allosteric modulator of GABAB receptors
4709 RuBi GABA trimethylphosphine Caged GABA; inhibits neural activity
3400 RuBi-GABA Caged GABA; excitable at visible wavelengths
0246 Saclofen Selective GABAB antagonist
0984 SCH 50911 Selective and competitive GABAB antagonist; orally bioavailable
0379 SKF 97541 Highly potent GABAB agonist; also GABAA-ρ antagonist
2815 Valproic acid, sodium salt Increases GABA levels; anticonvulsant
2625 Zonisamide Modulates GABA neurotransmission; anticonvulsant

 





주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
b-Alanine (1 g) 0206 1 g TOCRIS
CI 966 hydrochloride (10 mg) 1296 10 mg TOCRIS
CI 966 hydrochloride (50 mg) 1296 50 mg TOCRIS
CLP 257 (50 mg) 5242 50 mg TOCRIS
OX 04528 8131 50 mg TOCRIS
OX 04528 8131 10 mg TOCRIS
SKF 89976A hydrochloride (10 mg) 1081 10 mg TOCRIS
SKF 89976A hydrochloride (50 mg) 1081 50 mg TOCRIS
THDOC (10 MG) 6334 10 mg TOCRIS
Tiagabine hydrochloride (10 mg) 4256 10 mg TOCRIS
Tiagabine hydrochloride (50 mg) 4256 50 mg TOCRIS
VU 0463271 (50 mg) 4719 50 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
0206
Product
b-Alanine (1 g)
Size
1 g
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1296
Product
CI 966 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1296
Product
CI 966 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5242
Product
CLP 257 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
8131
Product
OX 04528
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
8131
Product
OX 04528
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1081
Product
SKF 89976A hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1081
Product
SKF 89976A hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6334
Product
THDOC (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4256
Product
Tiagabine hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4256
Product
Tiagabine hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4719
Product
VU 0463271 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
전체보기

추천제품

관련제품

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

자료

  • GABA Receptors

    GABA Receptors 이미지

    [TOCRIS]

    GABA receptor subtypes과 ligands의 구조와 기능에 대한 review를 제공합니다.

  • Inhibitor Book Vol.4

    Inhibitor Book Vol.4 이미지

    고마뉴스 자료신청 [KOMA]

    다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

웨비나/Video

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제품 문의

 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet
MSDS

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