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SARS-CoV-2 Inhibitors 이미지

SARS-CoV-2 Inhibitors

Maker : TOCRIS

SARS-CoV-2의 cell entry, 복제, 감염 등의 매커니즘 연구와 관련된 small molecule을 소개합니다. ACE2 inhibitor, TMPRSS2 inhibitor, Coronavirus PLpro inhibitor, Furin Inhibitor등, SARS-CoV-2의 메카니즘에 관련된 inhibitor를 제공합니다.

프린트 제품 문의

SARS-CoV-2 세포 침입 및 복제 매커니즘 

 

숙주세포 진입은 nucleocapsid의 spike 단백질의 receptor binding domain (RBD)이 숙주 세포 표면의 protease인 ACE2에 결합함으로써 영향을 받습니다. ACE2에 대한 S단백질의 결합은 또 다른 숙주세포 protease인 TMPRSS2에 의해 촉진됩니다. S 단백질의 결합에 따라 바이러스는 내재화 됩니다. 내재화된 바이러스는 코팅되지 않고 SARS-CoV-2 genome이 세포질로 방출됩니다. 그런 다음 바이러스 RNA가 복제되고 translation됩니다. 이것은 두개의 다단백질인 PP1A와 PP1AB를 생성합니다.  이들 단백질은 서열내에 Papain-like protease (PLpro)와  coronavirus main protease (Mpro, 3CLpro)를 함유하고 있어 polyprotein을 다양한 다른 기능적 단백질로 절단합니다.  바이러스 RNA는 또한 바이러스의 구조적 구성요소, 즉 spke, nucleocapsid, membrane, envelop 단백질을 암호화 합니다. 모든 바이러스 구성요소가 재생산 되면 coronavirus가 조립되고 vesicular exocytosis를 통해 방출됩니다.  

 


 

 

  

 SARS-CoV와 SARS-CoV-2 세포 침입 매커니즘 비교  

 

ACE2는 transmembrane protease이며 주요 기능은 renin-angiotensin system의 vasoactive peptide를 절단하는 것입니다. S1 ectodomain에 위치하는 S protein의 RBD는 ACE2의 세포외 enzymatic domain에 결합하여 virus 및 ACE2의 세포내 이입 및 숙주 세포 내로의 전위를 초래합니다. SARS-CoV 및 SARS-CoV-2 모두에 대해 S2 domain의 priming은 숙주 세포에 융합할때 필요하며, TMPRSS2에 의해 유도됩니다. Camostat (#3193)과 같은 protease inhibitor는 TMPRSS2를 억제함으로써 시험관내에서 SARS-CoV-2가 폐세포로 유입되는 것을 부분적으로 차단할 수 있는 것으로 보고되었습니다.  다른 Coronavirus는 다른 종류의 transmembrane protease를 host cell receptor로 이용합니다. 예를 들어 MERS-CoV는 dipeptidyl protease 4 (DPP-IV, CD26)에 결합하고 HCoV-229E는 aminopeptidase N에 결합합니다.  숙주 세포막에 융합된 후 virus genome은 세포질로 방출됩니다. 이 시점에서 virus는 자신을 복제하기 위해 숙주 세포의 transcription 및 translation 프로세스를 이용합니다.  

 

 


  

 

주요 제품  

 

Coronavirus Antivirals  
Cat. No. Product Name Activity
4499 (+)-JQ1 Inhibits ACE2 and TMPRSS2 transcription and blocks infection by SARS-CoV-2; potent and selective BET bromodomain inhibitor
4274 AP 24534 Identified as targeting human proteins in the SARS-CoV-2 interactome; potent multi-kinase and pan-Bcr-Abl inhibitor
7283 Apilimod dimesylate Inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions; potent and selective PIKfyve inhibitor
7235 Arbidol Inhibits replication of SARS-CoV-2 in vitro; broad spectrum antiviral
7755 Asunaprevir Inhibits SARS-CoV-2 Mpro activity; also inhibits hepatitis C virus NS3 protease
3771 Azithromycin Predicted to disrupt binding of SARS-CoV-2 spike protein to ACE2
7222 Baricitinib In silico modelling predicts inhibition of SARS-CoV-2 cell entry; highly potent JAK inhibitor
3193 Camostat mesylate Inhibits entry of SARS-Cov-2 into lung cells; TMPRSS2 inhibitor
4109 Chloroquine diphosphate Inhibits SARS-CoV-2 infection in vitro
7485 Covidcil-19 Inhibits viral propagation and viral infectivity of SARS-CoV-2
970 Cycloheximide Exhibits anti-MERS-CoV activity in vitro; protein synthesis inhibitor
1101 Cyclosporin A Inhibits coronavirus replication; cyclophilin inhibitor
7223 Dabrafenib mesylate Targets human proteins in the SARS-CoV-2 interactome; potent and selective B-Raf, CDK16 and NEK9 inhibitor
6793 Dasatinib Inhibits replication of SARS-CoV and MERS-CoV in vitro; potent pan-Src/Bcr-Abl inhibitor
1467 Daunorubicin hydrochloride Identified as targeting human proteins in the SARS-CoV-2 interactome; DNA topoisomerase II inhibitor
4583 Digoxin Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
7336 Dinaciclib Exhibits antiviral activity against SARS-CoV-2 in vitro; potent and selective inhibitor of CDK2, CDK5, CDK1 and CDK9
3807 Disulfiram SARS-CoV-2 Mpro inhibitor; also reversibly stimulates SERCA Ca2+-ATPase
4545 E 64d Inhibts entry of SARS-CoV-2 into lung cells in combination with Camostat (Cat. No. 3193); cathepsin inhibitor
5245 Ebselen Inhibits SARS-CoV-2 Mpro in vitro; glutathione peroxidase mimic
6986 EG 00229 trifluoroacetate Inhibits binding of cleaved spike protein of SARS-CoV-2 to neuropilin 1 (NRP1); neuropilin 1 antagonist
7231 EIDD 1931 Inhibits MERS-CoV and SARS-CoV-2 replication in vitro; viral RNA-dependent RNA polymerase (RdRP) inhibitor
7225 Favipiravir Reduces infection rate of SARS-CoV-2 in vitro; viral RNA polymerase inhibitor
3631 FK 506 Identified as targeting human proteins in the SARS-CoV-2 interactome; potent calcineurin inhibitor
7229 Galidesivir dihydrochloride Broad spectrum antiviral nucleotide; inhibits coronavirus replication in vitro
3259 Gemcitabine hydrochloride Inhibits replication of coronaviruses; DNA synthesis inhibitor
7280 GRL 0617 Coronavirus PLpro inhibitor
7227 GS 441524 Displays antiviral activity against MERS-CoV, SARS-CoV and SARS-CoV-2; viral RNA-dependent RNA polymerase (RdRp) inhibitor; active metabolite of Remdesivir (Cat. No. 7226)
5303 GSK 2194069 Inhibits SARS-CoV-2 infection in vitro; human FASN inhibitor
4618 GW 6471 Blocks SARS-CoV-2 infection in vitro and reduces viral RNA; PPARα antagonist
1416 Homoharringtonine Inhibits SARS-CoV-2 infection in vitro; inhibits protein synthesis
5648 Hydroxychloroquine sulfate Inhibits SARS-CoV-2 viral infection in vitro
5906 Imatinib mesylate Inhibits replication of SARS-CoV and MERS-CoV in vitro; potent and selective v-Abl tyrosine kinase inhibitor
1708 Indomethacin Identified as targeting human proteins in the SARS-CoV-2 interactome
5213 LL 37 Inhibits interaction between SAR-CoV-2 S1 protein and ACE2; human cathelicidin peptide derivative
7052 Lopinavir Inhibits SARS-CoV-2 replication in vitro; highly potent and selective HIV-1 protease inhibitor
7705 Masitinib SARS-CoV-2 Mpro inhibitor
6819 Mefloquine hydrochloride Exhibits antiviral activities against SARS-CoV-2; also Cx36 and Cx50 gap channel blocker
2864 Metformin hydrochloride Identified as targeting human proteins in the SARS-CoV-2 interactome; antidiabetic
7586 Molnupiravir Prodrug of antiviral nucleoside analog; inhibits SARS-CoV, SARS-CoV-2 and MERS-CoV infection
7853 Mpro 13b-H Negative control for Mpro 13b-K (Cat. No. 7228)
7228 Mpro 13b-K Coronavirus Mpro inhibitor
7695 Mpro 61 Potent non-covalent inhibitor of SARS-CoV-2 main protease
7230 MPro N3 Coronavirus Mpro inhibitor
8126 Mpro Tracer SARS-CoV-2 main protease fluorescent ligand; TR-FRET acceptor
3081 Nafamostat mesylate Inhibits SARS-CoV-2 infection in vitro; serine protease inhibitor
3766 Nelfinavir mesylate Exhibits anti-MERS-CoV activity in vitro; potent HIV-1 protease inhibitor
4079 Niclosamide Inhibits SARS-CoV-2 spike protein induced syncytia formation and viral replication in vitro; also STAT3 inhibitor
7234 Nitazoxanide Inhibits SARS-CoV-2 infection in vitro; Pyruvate flavodoxin/ferredoxin oxidoreductase (PFOR) inhibitor
1076 Ouabain Exhibits anti-MERS-CoV activity in vitro; Na+/K+ ATPase inhibitor
7416 Plitidepsin  Inhibits SARS-CoV-2 replication. Also potent antitumor and protein synthesis inhibitor.
7505 PLpro inhibitor 19 SARS-CoV-2 PLpro and viral replication inhibitor
7357 PLpro inhibitor 6 SARS-CoV and SARS-CoV-2 PLpro inhibitor
4107 Probenecid Inhibits SARS-CoV-2 replication and influenza A infection; MRP and OAT3 inhibitor
1125 Quercetin Inhibits SARS-CoV Mpro; also non-selective PI 3-kinase inhibitor
1292 Rapamycin Inhibits MERS-CoV infection; mTOR inhibitor and immunosuppressant
7226 Remdesivir Displays antiviral activity against MERS-CoV, SARS-CoV and SARS-CoV-2; viral RNA-dependent RNA polymerase (RdRp) inhibitor
4501 Ribavirin Inhibits cytopathic effect of SARS-CoV in vitro; guanosine analog and IMPDH inhibitor
5856 Ritonavir Improves outcome in an animal model of MERS-CoV infection; HIV protease inhibitor
7064 Ruxolitinib Targets human proteins in the SARS-CoV-2 interactome; potent and selective JAK1/JAK2 inhibitor
7191 Santacruzamate A Identified as targeting human host proteins that interact with SARS-CoV-2
7189 Saracatinib Inhibits MERS-CoV, other coronaviruses and dengue virus
7760 Selinexor Potent inhibitor of SARS-CoV-2 replication in vitro
7192 SMIP 004 S-phase kinase-associated protein 2 (SKP2) inhibitor; inhibits MERS-CoV replication and induces autophagy in infected cells
7554 SSYA10-001 Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6
1138 Thapsigargin Inhibits SARS-CoV-2 infection in vitro; SERCA inhibitor
2815 Valproic acid, sodium salt Identified as targeting human proteins in the SARS-CoV-2 interactome; HDAC inhibitor
0654 Verapamil hydrochloride Targets human proteins in the SARS-CoV-2 interactome; CaV1.x blocker
ACE2
Cat. No. Product Name Activity
1158 Angiotensin II Potent endogenous vasoconstrictor peptide; substrate for ACE2
5213 LL 37 Inhibitor of SARS-CoV-2 S1 spike protein and ACE2 interaction
3345 MLN 4760 Potent and selective angiotensin-converting enzyme 2 (ACE2) inhibitor
7629 Panobinostat Suppresses ACE2 and ABO expression
7486 Roxadustat Reduces ACE2 expression; orally bioavailable
Furin Inhibitor
Cat. No. Product Name Activity
3501 Decanoyl-RVKR-CMK Furin inhibitor; blocks SARS-CoV-2 spike protein cleavage and blocks viral cell entry
5253 SSM 3 trifluoroacetate Potent furin inhibitor

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
(+/-)-Eriodictyol (5 MG) 7199 5 mg TOCRIS
Angiotensin II (5 mg) 1158 5 mg TOCRIS
Apilimod dimesylate (25 MG) 7283 25 mg TOCRIS
Apilimod dimesylate (5 MG) 7283 5 mg TOCRIS
Arbidol (50 MG) 7235 50 mg TOCRIS
Auranofin (10 mg) 4600 10 mg TOCRIS
Auranofin (50 mg) 4600 50 mg TOCRIS
Azithromycin (50 mg) 3771 50 mg TOCRIS
Baricitinib 11-074 250 mg PROSCI
Baricitinib (50 MG) 7222 50 mg TOCRIS
Camostat mesylate (10 mg) 3193 10 mg TOCRIS
Camostat mesylate (50 mg) 3193 50 mg TOCRIS
Chloroquine diphosphate (50 mg) 4109 50 mg TOCRIS
Ciclesonide (25 MG) 6357 25 mg TOCRIS
Ciclesonide (5 MG) 6357 5 mg TOCRIS
Covidcil-19 7485 10 mg TOCRIS
Covidcil-19 7485 50 mg TOCRIS
Dabrafenib mesylate (50 MG) 7223 50 mg TOCRIS
Decanoyl-RVKR-CMK (1 mg) 3501 1 mg TOCRIS
Dinaciclib 7336 10 mg TOCRIS
Dinaciclib 7336 50 mg TOCRIS
Dinaciclib (10 MG) 7336 10 MG TOCRIS
Dinaciclib (50 MG) 7336 50 MG TOCRIS
E 64d (1 mg) 4545 1 mg TOCRIS
EG 00229 trifluoroacetate (10 MG) 6986 10 mg TOCRIS
GRL 0617 (25 MG) 7280 25 mg TOCRIS
GRL 0617 (5 MG) 7280 5 mg TOCRIS
Homoharringtonine (10 mg) 1416 10 mg TOCRIS
Ivermectin (100 mg) 1260 100 mg TOCRIS
Linezolid (10 mg) 3765 10 mg TOCRIS
Lopinavir (50 MG) 7052 50 mg TOCRIS
Mefloquine hydrochloride (50 MG) 6819 50 mg TOCRIS
Metformin hydrochloride (100 mg) 2864 100 mg TOCRIS
MLN 4760 3345 2 mg TOCRIS
MPro 13b (5 mg) 7228 5 mg TOCRIS
Mpro 13b-H 7853 5 mg TOCRIS
MPro N3 (25 MG) 7230 25 mg TOCRIS
MPro N3 (5 MG) 7230 5 mg TOCRIS
Nafamostat mesylate (10 mg) 3081 10 mg TOCRIS
Nafamostat mesylate (50 mg) 3081 50 mg TOCRIS
Nelfinavir mesylate (10 mg) 3766 10 mg TOCRIS
Nelfinavir mesylate (50 mg) 3766 50 mg TOCRIS
Niclosamide (50 mg) 4079 50 mg TOCRIS
PLpro inhibitor 6 (25 MG) 7357 25 mg TOCRIS
PLpro inhibitor 6 (5 MG) 7357 5 mg TOCRIS
Quercetin (100 mg) 1125 100 mg TOCRIS
Ritonavir (50 mg) 5856 50 mg TOCRIS
Ruxolitinib (50 MG) 7064 50 mg TOCRIS
Saracatinib (50 MG) 7189 50 mg TOCRIS
SMIP 004 (10 mg) 7192 10 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
7199
Product
(+/-)-Eriodictyol (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1158
Product
Angiotensin II (5 mg)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7283
Product
Apilimod dimesylate (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7283
Product
Apilimod dimesylate (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7235
Product
Arbidol (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4600
Product
Auranofin (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4600
Product
Auranofin (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3771
Product
Azithromycin (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
PROSCI
Cat.No.
11-074
Product
Baricitinib
Size
250 mg
Qty
Data Sheet
Maker
TOCRIS
Cat.No.
7222
Product
Baricitinib (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3193
Product
Camostat mesylate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3193
Product
Camostat mesylate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4109
Product
Chloroquine diphosphate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6357
Product
Ciclesonide (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6357
Product
Ciclesonide (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7485
Product
Covidcil-19
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7485
Product
Covidcil-19
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7223
Product
Dabrafenib mesylate (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3501
Product
Decanoyl-RVKR-CMK (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7336
Product
Dinaciclib
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7336
Product
Dinaciclib
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7336
Product
Dinaciclib (10 MG)
Size
10 MG
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7336
Product
Dinaciclib (50 MG)
Size
50 MG
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4545
Product
E 64d (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6986
Product
EG 00229 trifluoroacetate (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7280
Product
GRL 0617 (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7280
Product
GRL 0617 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1416
Product
Homoharringtonine (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1260
Product
Ivermectin (100 mg)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3765
Product
Linezolid (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7052
Product
Lopinavir (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6819
Product
Mefloquine hydrochloride (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2864
Product
Metformin hydrochloride (100 mg)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3345
Product
MLN 4760
Size
2 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7228
Product
MPro 13b (5 mg)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7853
Product
Mpro 13b-H
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7230
Product
MPro N3 (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7230
Product
MPro N3 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3081
Product
Nafamostat mesylate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3081
Product
Nafamostat mesylate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3766
Product
Nelfinavir mesylate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3766
Product
Nelfinavir mesylate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4079
Product
Niclosamide (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7357
Product
PLpro inhibitor 6 (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7357
Product
PLpro inhibitor 6 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1125
Product
Quercetin (100 mg)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5856
Product
Ritonavir (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7064
Product
Ruxolitinib (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7189
Product
Saracatinib (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7192
Product
SMIP 004 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
전체보기

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주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

자료

  • Life cycle of SARS-CoV-2

    Life cycle of SARS-CoV-2 이미지

    [ARIGO]

    코로나바이러스의 구조와 life cycle에 대한 포스터 입니다.

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet
MSDS

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