SARS-CoV-2 변이 단백질과 항체 | 고마바이오텍

SARS-CoV-2 Alpha to Delta Antibody Map 

 

종 류 

 

 

	SARS-CoV-2 Spike 681P Antibodies (Wild Type: WT)
	Product	Cat. No.	Application	Clonality	Species	WT
	SARS-CoV-2 Spike 681P Antibody	PM-9365	E, WB	Monoclonal	Mouse	++++
	SARS-CoV-2 Spike 681P Antibody	PM-9366	E, WB	Monoclonal	Mouse	++++
	SARS-CoV-2 Spike 681P Antibody	PM-9367	E, WB	Monoclonal	Mouse	++++
	SARS-CoV-2 Alpha Variant (B.1.1.7, U.K.) Specific Antibodies
	Product	Cat. No.	Application	Clonality	Species	WT
	SARS-CoV-2 Alpha Variant (B.1.1.7, U.K.) Spike P681H Antibody	9359	E, WB	Polyclonal	Rabbit	-
	SARS-CoV-2 Alpha Variant (B.1.1.7, U.K.) Spike P681H Antibody	PM-9371	E, WB	Monoclonal	Mouse	-
	SARS-CoV-2 Alpha Variant (B.1.1.7, U.K.) Spike P681H Antibody	PM-9373	E, WB	Monoclonal	Mouse	-
	SARS-CoV-2 Alpha Variant (B.1.1.7, U.K.) Spike P681H Antibody	PM-9374	E, WB	Monoclonal	Mouse	-
	SARS-CoV-2 Alpha Variant (B.1.1.7, U.K.) Spike P681H Antibody	PM-9375	E, WB	Monoclonal	Mouse	-
	SARS-CoV-2 Delta Variant Antibodies
	Product	Cat. No.	Application	Clonality	Species
	SARS-CoV-2 (COVID-19) Spike 156-157EF Antibody	9685	E, WB	Polyclonal	Mouse
	SARS-CoV-2 (COVID-19) Spike 156-157EFdel Antibody (Delta Variant)	9689	E, WB	Polyclonal	Mouse
	SARS-CoV-2 (COVID-19) Spike L452R Antibody (Delta Variant)	9463	E, WB	Polyclonal	Mouse
	SARS-CoV-2 Gamma Variant Antibodies
	Product	Cat. No.	Application	Clonality	Species
	SARS-CoV-2 (COVID-19) Spike P26S Antibody (Gamma Variant)	9573	E, WB	Polyclonal	Rabbit
	SARS-CoV-2 (COVID-19) Spike 26P Antibody	PM-9583	E, WB	Monoclonal	Mouse
	SARS-CoV-2 (COVID-19) Spike P26S Antibody (Gamma Variant)	PM-9590	E, WB	Monoclonal	Mouse
	Other SARS-CoV-2 Variant Related Antibodies
	Product	Cat. No.	WT	Alpha Variant (B.1.1.7)	Beta Variant (B.1.135)	Gamma Variant (P.1)	Comment
	SARS-CoV-2 (COVID-19) Spike S1 Antibody	9083	++++	++++	++++	-	9083 cannot detect Brazil Variant
	SARS-CoV-2 (COVID-19) Spike S1 Antibody [SP185]	10-351	++++	++++	-	-	10-351 cannot detect S.A. and Brazil Variants
	SARS-CoV-2 (COVID-19) Spike S1 Antibody [SP422]	10-350	++++	++++	++	++	10-350 has a lower affinity for S.A. and Brazil Variants
	SARS-CoV-2 (COVID-19) Spike RBD Antibody	9087	++++	+++	++	+	9087 has a lower affinity for all variants
	SARS-CoV-2 (COVID-19) Spike S1 Antibody (cleavage)	9091	++++	++	N/A	N/A	9091 has a lower affinity for UK variant
	SARS-CoV-2 Variants Recombinant Proteins
	Product	Cat. No.	Source	Fusion Tag	Sequence
	SARS-CoV-2 (COVID-19) Alpha S RBD RP	11-064	Mammalian Cells	C-His	N501Y
	SARS-CoV-2 (COVID-19) Beta S RBD RP	11-065	Mammalian Cells	C-His	K417N, E484K, N501Y
	SARS-CoV-2 (COVID-19) Gamma S RBD RP	11-066	Mammalian Cells	C-His	E484K, K417T, N501Y
	Delta Variant Spike S1 Recombinant Protein (His-Avi tag)	95-127	HEK293 cells	C-His	Val 16 - Arg 685 (T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R)-His-Avi
	SARS-CoV-2 (COVID-19) Alpha/Beta Spike Trimer	11-067	Mammalian Cells	C-His	E484K
	SARS-CoV-2 (COVID-19) D614G Spike RP	92-748	Human Cells	C-His	D614G
	SARS-CoV-2 (COVID-19) D614G Spike S1 RP	92-746	Human Cells	C-His	D614G
	SARS CoV-2 spike protein in LMNG detergent	21-815	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS CoV-2 spike protein in DIBMA Glycerol	21-816	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS CoV-2 spike protein nanodisc complex	21-817	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS-CoV-2 (COVID-19) full-length Spike S1 Alpha (United Kingdom, Sept 2020) B.1.1.7 Variant RP	21-818	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS-CoV-2 (COVID-19) full-length Spike S1 Beta (South Africa, May 2020) B.1.351 Variant RP	21-819	HEK293	C-Terminal Rho1D4	Del 144; K417N; E484K; N501Y; A570D; D614G; P681H; T716I; S982A; D1118H; more…
	SARS-CoV-2 (COVID-19) full-length Spike S1 Gamma (Brazil, Nov 2020) P.1 Variant RP	21-820	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS-CoV-2 (COVID-19) full-length Spike S1 Eta (United Kingdom, Dec 2020) B.1.525 Variant RP	21-821	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS-CoV-2 (COVID-19) full-length Spike S1 Epsilon (California) B.1.429 Variant RP	21-822	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS-CoV-2 (COVID-19) full-length Spike S1 Kappa (India, Dec 2020) B.1.617.1 Variant RP	21-823	HEK293	C-Terminal Rho1D4	AA 1-1273
	SARS-CoV-2 (COVID-19) Spike RBD Alpha (United Kingdom, Sept 2020) B.1.1.7 Variant RP	21-824	HEK293	C-Terminal His Tag	AA 319-537 (N501Y)
	SARS-CoV-2 (COVID-19) Spike RBD Beta (South Africa, May 2020) B.1.351 Variant RP	21-825	HEK293	C-Terminal His Tag	AA 319-537 (N501Y)
	SARS-CoV-2 (COVID-19) Spike RBD Gamma (Brazil, Nov 2020) P.1 Variant RP	21-826	HEK293	C-Terminal His Tag	AA 319-537 (K417T; E484K; N501Y)

 

 

  

 

배 경 

 

• SARS-CoV-2 바이러스는 게놈 복제 과정에서 유전자 코드 변화(유전 돌연변이)가 발생하면서 다양한 변이체를 생성합니다. 
  
• SARS-CoV-2의 변이 분류 체계는 4가지 class로 정의됩니다.

 

How Variants Are Classified	WHO Label	Pango Lineage
모니터링 중인 변이(Variants Being Monitored / VBM) :	Alpha	B.1.1.7 and Q lineages
	Beta	B.1.351 and descendent lineages
	Gamma	P.1and descendent lineages
	Epsilon	B.1.427
		B.1.429
	Eta	B.1.525
	Iota	B.1.526
	Kappa	B.1.617.1
	N/A	B.1.617.3
	Zeta	P.2
	Mu	B.1.621, B.1.621.1
관심 변이 (Variant of Interest / VOI) :	없음	-
우려 변이 (Variant of Concern / VOC) :	Delta	B.1.617.2 and AY lineages Spike Protein Substitutions: T19R, (V70F*), T95I, G142D, E156-, F157-, R158G, (A222V*), (W258L*), (K417N*), L452R, T478K, D614G, P681R, D950N
	Omicron	B.1.1.529 and BA lineages Spike Protein Substitutions:  A67V, del69-70, T95I, del142-144, Y145D, del211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
고위험 변이 (Variant of High Consequence / VOHC) :	없음	-

 

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