고마바이오텍(주)
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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

Addiction 이란?

  

  • WHO에 따르면 중독은 충동적 행동에 대한 통제력을 상실하여 강박적으로 약물을 찾고 복용하는 것을 특징으로 하는 중추신경계의 만성 질환입니다.
  • 중독은 약물 남용이 신경 기능을 세포 및 분자적으로 변경하는 복잡한 신경적응 과정으로, 뇌회로는 약물의 다양한 행동 효과를 중재합니다.
  • 세포 수준에서의 약물 감작은 신경 및 시냅스 가소성 및 수상돌기의 구조적 변화와 관련 있습니다. 
  • 도파민은 약물 중독의 긍정적 보상에 직접적으로 관련됩니다. 

 

 

 

타 겟

 

  • 5-HT Receptors
  • 5-HT Transporters
  • Acetylcholine Nicotinic Receptors
  • Cannabinoid Receptors
  • CRF Receptors
  • Dopamine Receptors
  • Dopamine Transporters
  • GABAA and GABAA-ρ Receptors
  • Glutamate (EAAT) Transporters
  • Glutamate (Ionotropic) Receptors
  • Opioid Receptors

 

 

 

주요 제품 

  

Cannabinoid receptors
Cannabinoid receptor는 central (CB1), peripheral(CB2), GPR55로 크게 세 분류로 나뉘며, 모두 G-protein couple receptor입니다. 
CB1 Receptor 
CB1 수용체는 주로 중추 신경 말단과 말초 신경 말단에 위치합니다. 
Target Cat. No. Product Name Activity
CB1 Receptor Agonists 1319 ACEA Potent and highly selective CB1 agonist
0878 Oleamide CB1 agonist
CB1 Receptor Inverse Agonists 1115 AM 281 Potent and selective CB1 inverse agonist
3791 Hemopressin (human, mouse) Selective CB1 inverse agonist
1764 Hemopressin (rat) Selective CB1 inverse agonist
2387 LY 320135 Selective CB1 inverse agonist
0923 SR 141716A Selective CB1 inverse agonist
4345 TC-C 14G High affinity and potent CB1 inverse agonist
7131 TM 38837 Highly potent CB1 inverse agonist; peripherally restricted
CB1 Receptor Antagonists 1117 AM 251 Potent CB1 antagonist; also GPR55 agonist
6193 AM 4113 High affinity and selective CB1 antagonist
5443 AM 6545 High affinity and selective CB1 antagonist
6763 AVE 1625 Potent and selective CB1 receptor antagonist
4236 CP 945598 hydrochloride CB1 antagonist
5746 NESS 0327 Ultra-high affinity and selective CB1 antagonist
4605 (±)-SLV 319 High affinity and selective CB1 antagonist
CB1 Receptor Modulators 2957 Org 27569 Potent allosteric modulator of CB1 receptors
5321 PSNCBAM-1 Negative allosteric modulator of CB1 receptors
Other 1655 O-2050 Putative CB1 antagonist; displays mixed activity at CB receptors
2540 Tocrifluor T1117 Fluorescent cannabinoid ligand; fluorescent form of AM 251 (Cat. No. 1117)
CB2 Receptors
CB2 수용체는 비신경 조직에 대부분 존재하며, 특히 사이토카인 분비와 세포 이동을 조절하는 면역 세포에 존재합니다. 최근 논문에서는 중추 신경계에도 발현될 것이라 보고 있습니다.
Target Cat. No. Product Name Activity
CB2 Receptor Agonists 2663 CB 65 High affinity, selective CB2 agonist
3088 HU 308 Potent and selective CB2 agonist
1343 JWH 133 Potent and selective CB2 agonist
5826 LEI 101 hydrochloride Potent and selective CB2 partial agonist; orally biovailable
6220 PM 226 Potent and selective CB2 receptor agonist; BBB permeable; neuroprotective
CB2 Receptor Inverse Agonists 1120 AM 630 Selective CB2 inverse agonist
4756 COR 170 Selective CB2 receptor inverse agonist
2764 GP 1a CB2 receptor inverse agonist
2479 JTE 907 Selective CB2 receptor inverse agonist
5815 SCH 336 Highly potent and selective CB2 inverse agonist
5039 SR 144528 High affinity and selective CB2 inverse agonist
CB2 Receptor Modulators 6832 Ec2la Positive allosteric modulator of CB2  receptors; active in vivo
GPR55
내인성, 식물 및 합성 카나비노이드뿐만 아니라 내인성 리간드로 제안되는 리소포스파티딜이노시톨(LPI)에 대해 친화성을 나타내는 수용체입니다.
Target Cat. No. Product Name Activity
GPR55 Agonists 1297 Abn-CBD Selective GPR55 agonist; neurobehaviorally inactive
1117 AM 251 GPR55 agonist; also CB1 antagonist
6668 ML 184 Selective GPR55 agonist; also promotes NSC proliferation and differentiation
2797 O-1602 Potent GPR55 agonist
1484 Oleylethanolamide GPR55 agonist; also PPARα agonist
0879 Palmitoylethanolamide Selective GPR55 agonist. FAAH and PAA substrate
GPR55 Antagonists 4959 CID 16020046 Selective GPR55 antagonist
4860 ML 193 Potent, selective GPR55 antagonist
Other 2540 Tocrifluor T1117 Novel fluorescent cannabinoid ligand; displays GPR55 binding activity
Opioid Receptor
Opioid receptor는 κ, δ and μ receptors로 구분됩니다.
κ opioid Receptor (KOP 또는 KOR)
Target Cat. No. Product Name Activity
κ Opioid Receptor Agonists 0699 BRL 52537 hydrochloride Potent and selective κ agonist
3195 Dynorphin A Endogenous κ agonist
1483 GR 89696 fumarate Subtype-selective κ agonist
7541 Helianorphin-19 Opioid receptor (KOR) agonist
0778 ICI 199,441 hydrochloride Potent κ agonist
0822 ICI 204,448 hydrochloride κ agonist, acts peripherally
0471 (+)-U-50488 hydrochloride Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)
0495 (±)-U-50488 hydrochloride Selective κ agonist
0496 (-)-U-50488 hydrochloride Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
κ Opioid Receptor Antagonists 0794 DIPPA hydrochloride Selective and irreversible κ antagonist
4866 ML 190 Selective κ opioid receptor antagonist
Other 5611 Salvinorin B Activates the κ-opioid DREADD (KORD)
δ opioid receptor (DOP 또는 DOR)
Target Cat. No. Product Name Activity
δ Opioid Receptor Agonists 4335 AR-M 1000390 hydrochloride Low-internalizing δ agonist
1663 BW 373U86 Potent, selective non-peptide δ agonist
3790 DADLE Prototypical δ agonist
1180 [D-Ala2]-Deltorphin II Selective δ agonist peptide
1431 DPDPE Selective δ agonist
0921 SB 205607 dihydrobromide Selective, high affinity non-peptide δ1 agonist
1529 SNC 162 Potent, selective non-peptide δ agonist
0764 SNC 80 Highly selective non-peptide δ agonist
δ Opioid Receptor Antagonists 0827 ICI 154,129 δ selective peptide antagonist
0820 ICI 174,864 δ selective peptide antagonist
6729 TAN 452 Potent and selective peripherally acting δ opioid antagonist; antianalgesic.
δ Opioid Receptor Modulators 5983 BMS 986187 Potent positive allosteric modulator of δ receptors
μ Opioid Receptor
Target Cat. No. Product Name Activity
μ Opioid Receptor Agonists 1171 DAMGO Selective μ agonist
1055 Endomorphin-1 Potent and selective μ agonist
1056 Endomorphin-2 Potent and selective μ agonist
0840 Loperamide hydrochloride Peripherally acting μ agonist; Ca2+ channel blocker
7218 PZM21 Selective μ receptor agonist
μ Opioid Receptor Antagonists 0898 Clocinnamox mesylate Irreversible μ antagonist
1560 CTAP Potent and selective μ antagonist
1578 CTOP Potent and selective μ antagonist
2601 Cyprodime hydrochloride Selective μ antagonist
0926 β-Funaltrexamine hydrochloride Irreversible and selective μ antagonist
6109 Methylnaltrexone bromide μ antagonist; peripherally restricted

  

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
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제품 문의

0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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