뇌전증 연구 | Epilepsy Small Molecules

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Category 전체보기: 전기영동 > 단백질 전기영동 전기영동 > 헥산 전기영동

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뇌전증 연구 | Epilepsy Small Molecules

Epilepsy(뇌전증)기전 연구에 관련된 Tocris Inhibitors & Activators를 안내합니다.

프린트 제품 문의

Epilepsy란?

뇌전증(간질)은 뇌의 비정상적이거나 과도하거나 동시적인 신경 활동으로 인한 징후로 가장 흔한 뇌 질환 중 하나입니다. Epileptogenesis은 뇌전증이 생기는 메커니즘으로, 그중 중요한 단계는 신경 손상입니다. Initial insult 단계에서는 뉴런 및 신경교 네트워크의 분자 및 세포구성 요소를 변경하는 일련의 유전자 발현 변화를 시작합니다.
뇌전증은 Glutamamatergic excitation과 GBAergic inhibition의 균형을 조절하는 시스템에 장애가 있을때 발생합니다. 신경세포의 휴식전위 (resting potential)를 조절하는 것이 중요하고, Na-K ATPase는 휴식 잠재력을 유지하는데 필수적이며 중요합니다.
뇌전증은 항경련제(anticonvulsant drug)로 약리학적으로 조절할 수 있습니다. 현재 항경련제의 주요 표적은 voltage-gated sodium channel, GABA inhibitory system (including benzodiazepines), voltage-gated calcium channel 을 포함합니다. 발작이 발생하는 다양한 기전을 치료하기 위한 antiepileptic agent 개발에 대한 집중적인 연구가 진행되고 있습니다.

주요 제품

Target	Cat. No.	Product
Ca2+-Activated Potassium Channels	1041	1-EBIO
Ca2+-Activated Potassium Channels	1652	Apamin
Ca2+-ATPase	2006	Paxilline
Ca2+-ATPase	1138	Thapsigargin
CB1 Receptors	1319	ACEA
Cyclooxygenase	1418	Resveratrol
Gap Channels	5353	Gap19
GABA Receptors	0131	(-)-Bicuculline methochloride
	0796	(R)-Baclofen
	1248	CGP 55845 hydrochloride
	2867	Flupirtine maleate
	3109	Furosemide
	2531	Ganaxolone
	3250	L-838,417
	0289	Muscimol
	3400	RuBi-GABA
	1262	SR 95531 hydrobromide
	2815	Valproic acid, sodium salt
	0808	Vigabatrin
	2625	Zonisamide
GABA Transporters	1561	(S)-SNAP 5114
GABA Transporters	0768	Riluzole hydrochloride
Glutamate (Ionotropic) Receptors	0924	(+)-MK 801 maleate
	1045	CNQX disodium salt
	1454	GYKI 52466 dihydrochloride
	0773	Memantine hydrochloride
	1044	NBQX disodium salt
Glutamate (Metabotropic) Receptors	0805	(S)-3,5-DHPG
	0972	CPPG
	4062	LY 341495 disodium salt
	5064	LY 379268 disodium salt
	1212	MPEP hydrochloride
	4323	VU 0360172 hydrochloride
Glutamate Transporters	1223	DL-TBOA
HMG-CoA Reductase	1965	Simvastatin
Na+/Ca2+ Exchanger	2184	SN-6
PPAR Receptors	1677	GW 7647
PPAR Receptors	5325	Rosiglitazone
Translocation, Exocytosis & Endocytosis	2839	Levetiracetam
Voltage-gated Calcium Channels	1544	(±)-Bay K 8644
	2004	Isradipine
	0601	Nitrendipine
Voltage-gated Chloride Channels	4877	CaCCinh-A01
Voltage-gated Potassium Channels	2000	XE 991 dihydrochloride
Voltage-gated Sodium Channels	4098	Carbamazepine
	2313	QX 314 chloride
	0768	Riluzole hydrochloride
	2918	Veratridine

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
Product	Cat.No.	Size	Maker
(-)-Bicuculline methochloride (10 mg)	0131	10 mg	TOCRIS
(-)-Bicuculline methochloride (50 mg)	0131	50 mg	TOCRIS
(R)-Baclofen (10 mg)	0796	10 mg	TOCRIS
(R)-Baclofen (50 mg)	0796	50 mg	TOCRIS
(S)-3,5-DHPG (10 mg)	0805	10 mg	TOCRIS
(S)-3,5-DHPG (5 mg)	0805	5 mg	TOCRIS
(S)-SNAP 5114 (10 mg)	1561	10 mg	TOCRIS
(S)-SNAP 5114 (50 mg)	1561	50 mg	TOCRIS
1-EBIO (10 mg)	1041	10 mg	TOCRIS
1-EBIO (50 mg)	1041	50 mg	TOCRIS
Apamin (1 mg)	1652	1 mg	TOCRIS
CaCCinh-A01 (10 mg)	4877	10 mg	TOCRIS
CaCCinh-A01 (50 mg)	4877	50 mg	TOCRIS
CGP 55845 hydrochloride (10 mg)	1248	10 mg	TOCRIS
CGP 55845 hydrochloride (50 mg)	1248	50 mg	TOCRIS
CNQX disodium salt (1 mg)	1045	1 mg	TOCRIS
CNQX disodium salt (10 mg)	1045	10 mg	TOCRIS
CNQX disodium salt (50 mg)	1045	50 mg	TOCRIS
Felbamate (10 mg)	0869	10 mg	TOCRIS
Felbamate (50 mg)	0869	50 mg	TOCRIS
Flupirtine maleate (10 mg)	2867	10 mg	TOCRIS
Flupirtine maleate (50 mg)	2867	50 mg	TOCRIS
Furosemide (50 mg)	3109	50 mg	TOCRIS
Ganaxolone (10 mg)	2531	10 mg	TOCRIS
Ganaxolone (50 mg)	2531	50 mg	TOCRIS
Gap19 (1 mg)	5353	1 mg	TOCRIS
GW 7647 (50 mg)	1677	50 mg	TOCRIS
GYKI 52466 dihydrochloride (10 mg)	1454	10 mg	TOCRIS
GYKI 52466 dihydrochloride (50 mg)	1454	50 mg	TOCRIS
Isradipine (10 mg)	2004	10 mg	TOCRIS
Isradipine (50 mg)	2004	50 mg	TOCRIS
L-838,417 (10 mg)	3250	10 mg	TOCRIS
L-838,417 (50 mg)	3250	50 mg	TOCRIS
Levetiracetam (10 mg)	2839	10 mg	TOCRIS
Levetiracetam (50 mg)	2839	50 mg	TOCRIS
LY 379268 disodium salt (10 mg)	5064	10 mg	TOCRIS
Muscimol (1 mg)	0289	1 mg	TOCRIS
Muscimol (10 mg)	0289	10 mg	TOCRIS
Muscimol (50 mg)	0289	50 mg	TOCRIS
NBQX disodium salt (1 mg)	1044	1 mg	TOCRIS
NBQX disodium salt (10 mg)	1044	10 mg	TOCRIS
NBQX disodium salt (50 mg)	1044	50 mg	TOCRIS
QX 314 chloride (50 mg)	2313	50 mg	TOCRIS
Retigabine	6233	50 mg	TOCRIS
Retigabine	6233	10 mg	TOCRIS
Rosiglitazone (50 mg)	5325	50 mg	TOCRIS
SN-6 (10 mg)	2184	10 mg	TOCRIS
SN-6 (50 mg)	2184	50 mg	TOCRIS
SR 95531 hydrobromide (10 mg)	1262	10 mg	TOCRIS
SR 95531 hydrobromide (50 mg)	1262	50 mg	TOCRIS

전체보기

1
Maker	TOCRIS
Cat.No.	0131
Product	(-)-Bicuculline methochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

2
Maker	TOCRIS
Cat.No.	0131
Product	(-)-Bicuculline methochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

3
Maker	TOCRIS
Cat.No.	0796
Product	(R)-Baclofen (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

4
Maker	TOCRIS
Cat.No.	0796
Product	(R)-Baclofen (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

5
Maker	TOCRIS
Cat.No.	0805
Product	(S)-3,5-DHPG (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

6
Maker	TOCRIS
Cat.No.	0805
Product	(S)-3,5-DHPG (5 mg)
Size	5 mg
Qty
Data Sheet
MSDS

7
Maker	TOCRIS
Cat.No.	1561
Product	(S)-SNAP 5114 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

8
Maker	TOCRIS
Cat.No.	1561
Product	(S)-SNAP 5114 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

9
Maker	TOCRIS
Cat.No.	1041
Product	1-EBIO (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

10
Maker	TOCRIS
Cat.No.	1041
Product	1-EBIO (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

11
Maker	TOCRIS
Cat.No.	1652
Product	Apamin (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

12
Maker	TOCRIS
Cat.No.	4877
Product	CaCCinh-A01 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

13
Maker	TOCRIS
Cat.No.	4877
Product	CaCCinh-A01 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

14
Maker	TOCRIS
Cat.No.	1248
Product	CGP 55845 hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

15
Maker	TOCRIS
Cat.No.	1248
Product	CGP 55845 hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

16
Maker	TOCRIS
Cat.No.	1045
Product	CNQX disodium salt (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

17
Maker	TOCRIS
Cat.No.	1045
Product	CNQX disodium salt (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

18
Maker	TOCRIS
Cat.No.	1045
Product	CNQX disodium salt (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

19
Maker	TOCRIS
Cat.No.	0869
Product	Felbamate (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

20
Maker	TOCRIS
Cat.No.	0869
Product	Felbamate (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

21
Maker	TOCRIS
Cat.No.	2867
Product	Flupirtine maleate (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

22
Maker	TOCRIS
Cat.No.	2867
Product	Flupirtine maleate (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

23
Maker	TOCRIS
Cat.No.	3109
Product	Furosemide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

24
Maker	TOCRIS
Cat.No.	2531
Product	Ganaxolone (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

25
Maker	TOCRIS
Cat.No.	2531
Product	Ganaxolone (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

26
Maker	TOCRIS
Cat.No.	5353
Product	Gap19 (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

27
Maker	TOCRIS
Cat.No.	1677
Product	GW 7647 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

28
Maker	TOCRIS
Cat.No.	1454
Product	GYKI 52466 dihydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

29
Maker	TOCRIS
Cat.No.	1454
Product	GYKI 52466 dihydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

30
Maker	TOCRIS
Cat.No.	2004
Product	Isradipine (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

31
Maker	TOCRIS
Cat.No.	2004
Product	Isradipine (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

32
Maker	TOCRIS
Cat.No.	3250
Product	L-838,417 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

33
Maker	TOCRIS
Cat.No.	3250
Product	L-838,417 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

34
Maker	TOCRIS
Cat.No.	2839
Product	Levetiracetam (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

35
Maker	TOCRIS
Cat.No.	2839
Product	Levetiracetam (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

36
Maker	TOCRIS
Cat.No.	5064
Product	LY 379268 disodium salt (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

37
Maker	TOCRIS
Cat.No.	0289
Product	Muscimol (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

38
Maker	TOCRIS
Cat.No.	0289
Product	Muscimol (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

39
Maker	TOCRIS
Cat.No.	0289
Product	Muscimol (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

40
Maker	TOCRIS
Cat.No.	1044
Product	NBQX disodium salt (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

41
Maker	TOCRIS
Cat.No.	1044
Product	NBQX disodium salt (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

42
Maker	TOCRIS
Cat.No.	1044
Product	NBQX disodium salt (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

43
Maker	TOCRIS
Cat.No.	2313
Product	QX 314 chloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

44
Maker	TOCRIS
Cat.No.	6233
Product	Retigabine
Size	50 mg
Qty
Data Sheet
MSDS

45
Maker	TOCRIS
Cat.No.	6233
Product	Retigabine
Size	10 mg
Qty
Data Sheet
MSDS

46
Maker	TOCRIS
Cat.No.	5325
Product	Rosiglitazone (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

47
Maker	TOCRIS
Cat.No.	2184
Product	SN-6 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

48
Maker	TOCRIS
Cat.No.	2184
Product	SN-6 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

전체보기

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