고마바이오텍(주)

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전기영동 > 단백질 전기영동 전기영동 > 헥산 전기영동
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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

프린트 제품 문의

특징

 

  • 이온채널은 원형질막을 통해 세포 안팎으로 이온의 통과를 허용하는 pore-forming membrane 단백질로,  생명에 필수적이며, 근육 수추, 영양소 수송과 같은 생리적 과정에 관여합니다. 많은 질병이 정상적인 이온채널 기능의 붕괴로 인해 발생합니다. 
  • 매커니즘, 이온선택성 등에 따라 수백가지 유형의 이온채널이 존재합니다. 
  • Classification by gating mechanism:
    • Voltage-gated ion channels
    • Ligand-gated ion channels (also known as ionotropic receptors)
    • Light-gated ion channels
    • Mechanosensitive ion channels
    • Cyclic nucleotide-gated ion channels
    • Calcium-gated ion channels
  •  Classification by ion selectivity:
    • Calcium
    • Potassium
    • Sodium
    • Chloride
    • Proton
    • Non-selective (let any type of ion pass)

 

 

주요 제품 

Aquaporins
Cat. No. Product  Activity
2611 IMD 0354 Selective aquaporin 4 (AQP4) inhibitor
5412 TC AQP1 1 Aquaporin 1 (AQP1) channel blocker
5425 TGN 020 Aquaporin 4 (AQP4) channel blocker
Calcium Channels
Cat. No. Product  Activity
1280 (-)-Xestospongin C Reported inhibitor of IP3-dependent Ca2+ release
1544 (±)-Bay K 8644 CaV1.x activator
1545 (R)-(+)-Bay K 8644 CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also TMEM176B inhibitor
1546 (S)-(-)-Bay K 8644 CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644
1224 2-APB IP3 receptor antagonist. Also TRP channel modulator
1224 2-APB Increases STIM-Orai channel conductivity and reduces selectivity
5490 5J 4 CRAC channel blocker; anti-inflammatory
6770 ABT 639 CaV3.2 and CaV3.1 channel blocker; orally bioavailable
2571 Amlodipine besylate CaV1.x blocker
7909 ARN 11391  Potentiator of the IP3-gated calcium channel ITPR1
2793 Caffeine Mobilizes calcium from intracellular stores
6210 ci-IP3/PM Caged inositol triphosphate
2629 Cilnidipine Dual CaV1.x and CaV2.x blocker
6170 Cinacalcet hydrochloride CaV1.x blocker; also CaSR allosteric agonist and CYP2D2 inhibitor
0507 Dantrolene, sodium salt Ca2+ release inhibitor
0685 Diltiazem hydrochloride CaV1.x blocker
6407 Fendiline Hydrochloride CaV1.x blocker; also K-Ras inhibitor
1403 FPL 64176 Potent CaV1.x activator
2004 Isradipine CaV1.x blocker
4564 JTV 519 fumarate Ryanodine receptor (RyR) inhibitor
4055 L-Ascorbic acid Selective CaV3.2 blocker
0840 Loperamide hydrochloride CaV1.x and CaV2.x blocker; also peripherally acting μ agonist
2198 Mibefradil dihydrochloride CaV3.x blocker
4507 ML 218 hydrochloride CaV3.x blocker
0431 ML 9 hydrochloride STIM1-plasma membrane interaction inhibitor. Also MLCK inhibitor
3905 NAADP tetrasodium salt Ca2+ mobilizing agent
2851 Nefiracetam CaV1.x and CaV2.2 activator; cognitive enhancer
1075 Nifedipine CaV1.x blocker
0600 Nimodipine CaV1.x blocker
0601 Nitrendipine CaV1.x blocker
2268 NNC 55-0396 dihydrochloride Highly selective CaV3.x blocker
1439 Ruthenium Red Inhibits ryanodine-sensitive Ca2+ release
1439 Ruthenium Red Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels
1329 Ryanodine Ca2+ release inhibitor
6239 SAK 3 Potent CaV3.1 and 3.3 activator; orally bioavailable
1147 SKF 96365 hydrochloride STIM1-mediated Ca2+ influx inhibitor
2945 SNX 482 Potent and selective CaV2.3 blocker
0654 Verapamil hydrochloride CaV1.x blocker
3939 YM 58483 Inhibits CRAC channels
6367 Z 944 CaV3.x blocker
2799 ω-Agatoxin IVA CaV2.1 blocker
2802 ω-Agatoxin TK CaV2.1 blocker
1085 ω-Conotoxin GVIA CaV2.2 blocker
Chloride Channels
Cat. No. Product  Activity
6076 Ani 9 Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker
4877 CaCCinh-A01 Calcium-activated chloride channel (CaCC) inhibitor
3430 CFTRinh 172 Voltage-independent, selective CFTR chloride channel blocker
1412 Chromanol 293B Blocks ICFTR; also IKs blocker
1422 DCEBIO Activates Cl- conductance and hKCa3.1 channels
5948 DMNPE-4 AM-caged-calcium Caged calcium; cell permeable
4876 Eact Activator of Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)
4522 Flufenamic acid Calcium-activated chloride channel blocker; NSAID. Also activates TRPC6
0911 Glibenclamide Blocks CFTR chloride channels; also KATP blocker
5485 GlyH 101 Reversible, voltage-dependent CFTR chloride channel blocker
1646 Lonidamine CFTR Cl- channel blocker; also mitochondrial hexokinase inhibitor
5770 MONNA Potent TMEM16A (Anoctamin-1) blocker
4079 Niclosamide TMEM16F inhibitor; also STAT3 inhibitor
0593 NPPB Inhibits calcium-sensitive chloride currents
4303 PPQ 102 Potent, voltage-independent CFTR chloride channel inhibitor
4538 T16Ainh - A01 Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor
Potassium Channels
Cat. No. Product  Activity
1475 (-)-[3R,4S]-Chromanol 293B IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412)
1041 1-EBIO Epithelial KCa channel activator
0940 4-Aminopyridine Non-selective KV channel blocker
6972 A 1899 Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker
5462 AAQ chloride Photoswitchable Kv channel blocker
6086 AMP PNP Kir6 blocker; non-hydrolyzable AMP analog
6481 AP 14145 hydrochloride Negative allosteric modulator of KCa2 (SK) channels
1652 Apamin KCa2 (SK) channel blocker
3489 Astemizole Potent KV11.1 (hERG) channel blocker. Also histamine H1 antagonist
6318 Azimilide dihydrochloride Kv11.1 (hERG) channel blocker
2787 BAPTA AM hKV11.1 (hERG), hKV1.3 and hKV1.5 channel blocker. Also Ca2+ chelator
3797 BL 1249 K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
2665 BMS 191011 Potent KCa1.1 (BK) channel opener
8007 C 101248  Selective and potent inhibitor of both mouse and human THIK-1
1513 CGP 7930 Blocks G protein-coupled inwardly rectifying K+ (GIRK) channels
1412 Chromanol 293B IKs blocker. Also blocks ICFTR
2953 CyPPA KCa2.2 and KCa2.3 (SK) channel activator
1422 DCEBIO Activates Cl- secretion via hKCa3.1 (IK) channel; more potent analog of 1-EBIO (Cat. No. 1041).
1540 DCPIB Modulator of K2P channels; activates TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3
0964 Diazoxide Kir6 (KATP) channel opener
5948 DMNPE-4 AM-caged-calcium Caged calcium; cell permeable
3757 Dofetilide KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
2533 DPO-1 Blocker of KV1.5 channel and IKur current
1808 E-4031 dihydrochloride KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier K+ current (IKr)
2867 Flupirtine maleate KV7 channel activator; also GABAA modulator and indirect NMDA antagonist
2007 Fluticasone propionate Selective glucocorticoid agonist; KV1 potentiator
6689 GI 530159 K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator
0911 Glibenclamide Kir6 (KATP) channel blocker
5814 GoSlo SR 5-69 KCa1.1 (BK) channel activator
5676 Guangxitoxin 1E Potent Kv2.1 and Kv2.2 channel blocker
4311 GW 542573X Selective KCa2.1 (SK) channel activator
5011 HMR 1556 Potent and selective Iks channel blocker
1086 Iberiotoxin KCa (BK) channel blocker
4305 ICA 069673 KV7.2/KV7.3 channel opener
4950 ICA 110381 KV7.2/7.3 activator; displays anticonvulsant properties
3899 JNJ 303 Potent and selective IKs blocker
4130 KN 92 K+ channel (Kv) blocker. Inactive analog of KN 93
1278 KN 93 K+ channel blocker (KV); also inhibitor of CaM Kinase II
1378 Levcromakalim Kir6 (KATP) channel opener; active enantiomer of Cromakalim
1999 Linopirdine dihydrochloride KV7 (KCNQ) channel blocker
3563 Margatoxin Potent KV1.3 channel blocker
4949 MaxiPost Potassium channel modulator; exerts subtype-specific effects
0583 Minoxidil Kir6 channel (KATP) opener
4549 ML 133 hydrochloride Kir2 channel blocker
4519 ML 213 KV7.2 and KV7.4 channel opener
4687 ML 252 Potent and selective KV7.2 inhibitor; brain penetrant
4777 ML 277 Selective KV7.1 (KCNQ1) potassium channel activator; augments IKs current
5380 ML 297 Selective Kir3.1/3.2 (GIRK1/2) channel activator
6887 ML 335 Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
5337 ML 365 Potent and selective K2P3.1 (TASK-1) channel blocker
6888 ML 402 Selective TREK channel activator
6889 ML 418 Kir 7.1 inhibitor; also inhibits Kir 6.2
6886 ML 67-33 K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel activator
4231 Nateglinide Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2 channels
4788 NS 11021 KCa1.1 (BK) channel activator
3804 NS 1619 KCa1.1 (BK) channel activator
3062 NS 1643 KV11.1 (hERG) channel activator; antiarrhythmic
5276 NS 19504 KCa1.1 (BK) channel activator
3895 NS 309 Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels
4462 NS 3623 KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic
4166 NS 5806 KV4.3 channel activator
4597 NS 8593 hydrochloride Selective negative modulator of KCa2 (SK) channels; inhibits SK currents
2006 Paxilline Potent KCa1.1 (BK) channel blocker
7868 PE 22-28  Potent inhibitor of TREK-1 channels
4617 Penitrem A Potent and selective KCa1.1 (BK) channel blocker
6087 Perifosine Modulates Kv2.1current; also PKB/Akt inhibitor
5338 PK-THPP Potent K2P9.1 (TASK-3) channel blocker
2095 PNU 37883 hydrochloride Vascular Kir6 (KATP) channel blocker
4367 Psora 4 Potent KV1.3 channel blocker
5470 QAQ dichloride Photoswitchable Nav, Kv and Cav channel blocker
5083 QO 58 Kv7 channel opener
7129 RA 2 Potent negative modulator of KCa2.3 and KCa3.1 channels
3805 Repaglinide Kir6 (KATP) channel blocker
6233 Retigabine KV7 channel activator
7486 Roxadustat Inhibitor of peak and late components of delayed rectifier potassium currents
0925 SCH 23390 hydrochloride Kir3 channel blocker; also potent dopamine D1-like antagonist and 5-HT2C agonist
3220 ShK-Dap22 Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
6398 SKA 121 Positive allosteric modulator of KCa3.1 (IK) channels
3670 SKA 31 KCa3.1 (IK) and KCa2 (SK) channel activator
5594 Spadin Potent K2P2.1 (TREK-1) channel blocker
2580 Tenidap Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor
6484 Terbinafine hydrochloride Selective K2P9.1 (TASK-3) activator; also inhibits fungal squalene epoxidase
3948 Terfenadine KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1 antagonist
1316 Tertiapin-Q Selective blocker of inward-rectifier K+ channels
3068 Tetraethylammonium chloride Non-selective K+ channel blocker
2946 TRAM 34 Potent and highly selective KCa3.1 (IK) channel blocker
4952 TRAM 39 Potent KCa3.1 (IK) blocker
1310 UCL 1684 Highly potent KCa2 (SK) channel blocker
3829 UK 78282 hydrochloride Blocker of KV1.3 and KV1.4 channels
7057 VU 0071063 Selective activator of SUR1 Kir6.2 channels
6877 VU 0134992 Kir4.1 blocker
2000 XE 991 dihydrochloride Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents
2076 Y-26763 Kir6 (KATP) channel opener
Sodium Channels
Cat. No. Product  Activity
6159 4,9-Anhydrotetrodotoxin Potent and selective Nav1.6 channel blocker
2976 A 803467 Selective NaV1.8 channel blocker
4249 A 887826 Potent voltage-dependent NaV1.8 channel blocker
0890 Amiloride hydrochloride Na+ channel blocker; also I2 imidazoline ligand
4804 APETx2 NaV1.8 and NaV1.2 blocker; also blocks ASIC3 channels
4098 Carbamazepine Inhibitor of neuronal NaV channels; anticonvulsant
1470 Flecainide acetate Cardiac Na+ channel blocker. Antiarrhythmic
7029 GX 201 Potent and selective Nav1.7 blocker; analgesic
5066 ICA 121431 Potent and selective NaV1.3 and NaV1.1 channel blocker
4913 Jingzhaotoxin III Selective NaV1.5 channel blocker
3865 Licarbazepine Active metabolite of oxcarbazepine (Cat. No. 3864)
3057 Lidocaine Na+ channel blocker
2596 Mexiletine hydrochloride Na+ channel blocker; antiarrhythmic agent
4691 NAV 26 Selective Nav1.7 channel blocker
5927 NS 383 ASIC blocker; active in vivo
5941 OD1 Potent hNav1.4, rNav1.6 and rNav1.7 channel activator
3864 Oxcarbazepine Anticonvulsant; inhibits Na+ channel activity
4916 PF 04885614 Potent and selective NaV1.8 channel blocker; active in vivo
5931 PF 05089771 Potent and selective Nav1.7 channel blocker
4914 Phrixotoxin 3 Potent blocker of NaV1.2, NaV1.3 and NaV1.5 channels
4023 ProTx II Selective NaV1.7 channel blocker
1014 QX 314 bromide Na+ channel blocker
2313 QX 314 chloride Na+ channel blocker
0768 Riluzole hydrochloride Na+ channel blocker; also inhibits GABA uptake and glutamate release
4044 Sipatrigine NaV blocker; neuroprotective
4435 TC-N 1752 NaV channel blocker
1078 Tetrodotoxin Na+ channel blocker
1069 Tetrodotoxin citrate Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078)
2815 Valproic acid, sodium salt Blocks voltage-gated Na+ channels
2918 Veratridine Voltage-gated Na+ channel opener

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
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관련제품

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자료

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제품 문의

 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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