| Aquaporins |
|
|
| Cat. No. |
Product |
Activity |
| 2611 |
IMD 0354 |
Selective aquaporin 4 (AQP4) inhibitor |
| 5412 |
TC AQP1 1 |
Aquaporin 1 (AQP1) channel blocker |
| 5425 |
TGN 020 |
Aquaporin 4 (AQP4) channel blocker |
|
|
|
| Calcium
Channels |
|
| Cat. No. |
Product |
Activity |
| 1280 |
(-)-Xestospongin C |
Reported inhibitor of IP3-dependent Ca2+ release |
| 1544 |
(±)-Bay K 8644 |
CaV1.x activator |
| 1545 |
(R)-(+)-Bay K 8644 |
CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644; also
TMEM176B inhibitor |
| 1546 |
(S)-(-)-Bay K 8644 |
CaV1.x activator; (S)-(-)-enantiomer of (±)-Bay K 8644 |
| 1224 |
2-APB |
IP3 receptor antagonist. Also TRP channel modulator |
| 1224 |
2-APB |
Increases STIM-Orai channel conductivity and reduces selectivity |
| 5490 |
5J 4 |
CRAC channel blocker; anti-inflammatory |
| 6770 |
ABT 639 |
CaV3.2 and CaV3.1 channel blocker; orally bioavailable |
| 2571 |
Amlodipine besylate |
CaV1.x blocker |
| 7909 |
ARN 11391 |
Potentiator of the IP3-gated calcium channel ITPR1 |
| 2793 |
Caffeine |
Mobilizes calcium from intracellular stores |
| 6210 |
ci-IP3/PM |
Caged inositol triphosphate |
| 2629 |
Cilnidipine |
Dual CaV1.x and CaV2.x blocker |
| 6170 |
Cinacalcet hydrochloride |
CaV1.x blocker; also CaSR allosteric agonist and CYP2D2
inhibitor |
| 0507 |
Dantrolene, sodium salt |
Ca2+ release inhibitor |
| 0685 |
Diltiazem hydrochloride |
CaV1.x blocker |
| 6407 |
Fendiline Hydrochloride |
CaV1.x blocker; also K-Ras inhibitor |
| 1403 |
FPL 64176 |
Potent CaV1.x activator |
| 2004 |
Isradipine |
CaV1.x blocker |
| 4564 |
JTV 519 fumarate |
Ryanodine receptor (RyR) inhibitor |
| 4055 |
L-Ascorbic acid |
Selective CaV3.2 blocker |
| 0840 |
Loperamide hydrochloride |
CaV1.x and CaV2.x blocker; also peripherally acting μ agonist |
| 2198 |
Mibefradil dihydrochloride |
CaV3.x blocker |
| 4507 |
ML 218 hydrochloride |
CaV3.x blocker |
| 0431 |
ML 9 hydrochloride |
STIM1-plasma membrane interaction inhibitor. Also MLCK inhibitor |
| 3905 |
NAADP tetrasodium salt |
Ca2+ mobilizing agent |
| 2851 |
Nefiracetam |
CaV1.x and CaV2.2 activator; cognitive enhancer |
| 1075 |
Nifedipine |
CaV1.x blocker |
| 0600 |
Nimodipine |
CaV1.x blocker |
| 0601 |
Nitrendipine |
CaV1.x blocker |
| 2268 |
NNC 55-0396 dihydrochloride |
Highly selective CaV3.x blocker |
| 1439 |
Ruthenium Red |
Inhibits ryanodine-sensitive Ca2+ release |
| 1439 |
Ruthenium Red |
Non-selective CaV2.1 and 2.2 blocker; also blocks TRPV channels |
| 1329 |
Ryanodine |
Ca2+ release inhibitor |
| 6239 |
SAK 3 |
Potent CaV3.1 and 3.3 activator; orally bioavailable |
| 1147 |
SKF 96365 hydrochloride |
STIM1-mediated Ca2+ influx inhibitor |
| 2945 |
SNX 482 |
Potent and selective CaV2.3 blocker |
| 0654 |
Verapamil hydrochloride |
CaV1.x blocker |
| 3939 |
YM 58483 |
Inhibits CRAC channels |
| 6367 |
Z 944 |
CaV3.x blocker |
| 2799 |
ω-Agatoxin IVA |
CaV2.1 blocker |
| 2802 |
ω-Agatoxin TK |
CaV2.1 blocker |
| 1085 |
ω-Conotoxin GVIA |
CaV2.2 blocker |
|
|
|
| Chloride
Channels |
|
| Cat. No. |
Product |
Activity |
| 6076 |
Ani 9 |
Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker |
| 4877 |
CaCCinh-A01 |
Calcium-activated chloride channel (CaCC) inhibitor |
| 3430 |
CFTRinh 172 |
Voltage-independent, selective CFTR chloride channel blocker |
| 1412 |
Chromanol 293B |
Blocks ICFTR; also IKs blocker |
| 1422 |
DCEBIO |
Activates Cl- conductance and hKCa3.1 channels |
| 5948 |
DMNPE-4 AM-caged-calcium |
Caged calcium; cell permeable |
| 4876 |
Eact |
Activator of Ca2+-activated Cl- channel transmembrane protein
16A (TMEM16A) |
| 4522 |
Flufenamic acid |
Calcium-activated chloride channel blocker; NSAID. Also
activates TRPC6 |
| 0911 |
Glibenclamide |
Blocks CFTR chloride channels; also KATP blocker |
| 5485 |
GlyH 101 |
Reversible, voltage-dependent CFTR chloride channel blocker |
| 1646 |
Lonidamine |
CFTR Cl- channel blocker; also mitochondrial hexokinase
inhibitor |
| 5770 |
MONNA |
Potent TMEM16A (Anoctamin-1) blocker |
| 4079 |
Niclosamide |
TMEM16F inhibitor; also STAT3 inhibitor |
| 0593 |
NPPB |
Inhibits calcium-sensitive chloride currents |
| 4303 |
PPQ 102 |
Potent, voltage-independent CFTR chloride channel inhibitor |
| 4538 |
T16Ainh - A01 |
Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A)
inhibitor |
|
|
|
| Potassium
Channels |
|
| Cat. No. |
Product |
Activity |
| 1475 |
(-)-[3R,4S]-Chromanol 293B |
IKs blocker. Enantiomer of Chromanol 293B (Cat. No. 1412) |
| 1041 |
1-EBIO |
Epithelial KCa channel activator |
| 0940 |
4-Aminopyridine |
Non-selective KV channel blocker |
| 6972 |
A 1899 |
Potent K2P3.1 (TASK-1) and K2P9.1 (TASK-3) blocker |
| 5462 |
AAQ chloride |
Photoswitchable Kv channel blocker |
| 6086 |
AMP PNP |
Kir6 blocker; non-hydrolyzable AMP analog |
| 6481 |
AP 14145 hydrochloride |
Negative allosteric modulator of KCa2 (SK) channels |
| 1652 |
Apamin |
KCa2 (SK) channel blocker |
| 3489 |
Astemizole |
Potent KV11.1 (hERG) channel blocker. Also histamine H1
antagonist |
| 6318 |
Azimilide dihydrochloride |
Kv11.1 (hERG) channel blocker |
| 2787 |
BAPTA AM |
hKV11.1 (hERG), hKV1.3 and hKV1.5 channel blocker. Also Ca2+
chelator |
| 3797 |
BL 1249 |
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator |
| 2665 |
BMS 191011 |
Potent KCa1.1 (BK) channel opener |
| 8007 |
C 101248 |
Selective and potent inhibitor of both mouse and human THIK-1 |
| 1513 |
CGP 7930 |
Blocks G protein-coupled inwardly rectifying K+ (GIRK) channels |
| 1412 |
Chromanol 293B |
IKs blocker. Also blocks ICFTR |
| 2953 |
CyPPA |
KCa2.2 and KCa2.3 (SK) channel activator |
| 1422 |
DCEBIO |
Activates Cl- secretion via hKCa3.1 (IK) channel; more potent
analog of 1-EBIO (Cat. No. 1041). |
| 1540 |
DCPIB |
Modulator of K2P channels; activates TREK1 and TRAAK, inhibits
TRESK, TASK1 and TASK3 |
| 0964 |
Diazoxide |
Kir6 (KATP) channel opener |
| 5948 |
DMNPE-4 AM-caged-calcium |
Caged calcium; cell permeable |
| 3757 |
Dofetilide |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier
K+ current (IKr) |
| 2533 |
DPO-1 |
Blocker of KV1.5 channel and IKur current |
| 1808 |
E-4031 dihydrochloride |
KV11.1 (hERG) channel blocker; inhibits rapid delayed rectifier
K+ current (IKr) |
| 2867 |
Flupirtine maleate |
KV7 channel activator; also GABAA modulator and indirect NMDA
antagonist |
| 2007 |
Fluticasone propionate |
Selective glucocorticoid agonist; KV1 potentiator |
| 6689 |
GI 530159 |
K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator |
| 0911 |
Glibenclamide |
Kir6 (KATP) channel blocker |
| 5814 |
GoSlo SR 5-69 |
KCa1.1 (BK) channel activator |
| 5676 |
Guangxitoxin 1E |
Potent Kv2.1 and Kv2.2 channel blocker |
| 4311 |
GW 542573X |
Selective KCa2.1 (SK) channel activator |
| 5011 |
HMR 1556 |
Potent and selective Iks channel blocker |
| 1086 |
Iberiotoxin |
KCa (BK) channel blocker |
| 4305 |
ICA 069673 |
KV7.2/KV7.3 channel opener |
| 4950 |
ICA 110381 |
KV7.2/7.3 activator; displays anticonvulsant properties |
| 3899 |
JNJ 303 |
Potent and selective IKs blocker |
| 4130 |
KN 92 |
K+ channel (Kv) blocker. Inactive analog of KN 93 |
| 1278 |
KN 93 |
K+ channel blocker (KV); also inhibitor of CaM Kinase II |
| 1378 |
Levcromakalim |
Kir6 (KATP) channel opener; active enantiomer of Cromakalim |
| 1999 |
Linopirdine dihydrochloride |
KV7 (KCNQ) channel blocker |
| 3563 |
Margatoxin |
Potent KV1.3 channel blocker |
| 4949 |
MaxiPost |
Potassium channel modulator; exerts subtype-specific effects |
| 0583 |
Minoxidil |
Kir6 channel (KATP) opener |
| 4549 |
ML 133 hydrochloride |
Kir2 channel blocker |
| 4519 |
ML 213 |
KV7.2 and KV7.4 channel opener |
| 4687 |
ML 252 |
Potent and selective KV7.2 inhibitor; brain penetrant |
| 4777 |
ML 277 |
Selective KV7.1 (KCNQ1) potassium channel activator; augments
IKs current |
| 5380 |
ML 297 |
Selective Kir3.1/3.2 (GIRK1/2) channel activator |
| 6887 |
ML 335 |
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator |
| 5337 |
ML 365 |
Potent and selective K2P3.1 (TASK-1) channel blocker |
| 6888 |
ML 402 |
Selective TREK channel activator |
| 6889 |
ML 418 |
Kir 7.1 inhibitor; also inhibits Kir 6.2 |
| 6886 |
ML 67-33 |
K2P2.1 (TREK-1), K2P10.1 (TREK-2) and K2P4.1 (TRAAK) channel
activator |
| 4231 |
Nateglinide |
Kir6 (KATP) blocker; displays high affinity for SUR1/Kir6.2
channels |
| 4788 |
NS 11021 |
KCa1.1 (BK) channel activator |
| 3804 |
NS 1619 |
KCa1.1 (BK) channel activator |
| 3062 |
NS 1643 |
KV11.1 (hERG) channel activator; antiarrhythmic |
| 5276 |
NS 19504 |
KCa1.1 (BK) channel activator |
| 3895 |
NS 309 |
Positive modulator of KCa2 (SK) and KCa3.1 (IK) channels |
| 4462 |
NS 3623 |
KV11.1 (hERG) and KV4.3 channel activator; antiarrhythmic |
| 4166 |
NS 5806 |
KV4.3 channel activator |
| 4597 |
NS 8593 hydrochloride |
Selective negative modulator of KCa2 (SK) channels; inhibits SK
currents |
| 2006 |
Paxilline |
Potent KCa1.1 (BK) channel blocker |
| 7868 |
PE 22-28 |
Potent inhibitor of TREK-1 channels |
| 4617 |
Penitrem A |
Potent and selective KCa1.1 (BK) channel blocker |
| 6087 |
Perifosine |
Modulates Kv2.1current; also PKB/Akt inhibitor |
| 5338 |
PK-THPP |
Potent K2P9.1 (TASK-3) channel blocker |
| 2095 |
PNU 37883 hydrochloride |
Vascular Kir6 (KATP) channel blocker |
| 4367 |
Psora 4 |
Potent KV1.3 channel blocker |
| 5470 |
QAQ dichloride |
Photoswitchable Nav, Kv and Cav channel blocker |
| 5083 |
QO 58 |
Kv7 channel opener |
| 7129 |
RA 2 |
Potent negative modulator of KCa2.3 and KCa3.1 channels |
| 3805 |
Repaglinide |
Kir6 (KATP) channel blocker |
| 6233 |
Retigabine |
KV7 channel activator |
| 7486 |
Roxadustat |
Inhibitor of peak and late components of delayed rectifier
potassium currents |
| 0925 |
SCH 23390 hydrochloride |
Kir3 channel blocker; also potent dopamine D1-like antagonist
and 5-HT2C agonist |
| 3220 |
ShK-Dap22 |
Extremely potent and selective KV1.3 blocker; suppresses T cell
activation in vitro |
| 6398 |
SKA 121 |
Positive allosteric modulator of KCa3.1 (IK) channels |
| 3670 |
SKA 31 |
KCa3.1 (IK) and KCa2 (SK) channel activator |
| 5594 |
Spadin |
Potent K2P2.1 (TREK-1) channel blocker |
| 2580 |
Tenidap |
Opener of Kir2.3. Also cyclooxygenase (COX-1) inhibitor |
| 6484 |
Terbinafine hydrochloride |
Selective K2P9.1 (TASK-3) activator; also inhibits fungal
squalene epoxidase |
| 3948 |
Terfenadine |
KV11.1 (hERG) and Kir6 (KATP) channel blocker. Also H1
antagonist |
| 1316 |
Tertiapin-Q |
Selective blocker of inward-rectifier K+ channels |
| 3068 |
Tetraethylammonium chloride |
Non-selective K+ channel blocker |
| 2946 |
TRAM 34 |
Potent and highly selective KCa3.1 (IK) channel blocker |
| 4952 |
TRAM 39 |
Potent KCa3.1 (IK) blocker |
| 1310 |
UCL 1684 |
Highly potent KCa2 (SK) channel blocker |
| 3829 |
UK 78282 hydrochloride |
Blocker of KV1.3 and KV1.4 channels |
| 7057 |
VU 0071063 |
Selective activator of SUR1 Kir6.2 channels |
| 6877 |
VU 0134992 |
Kir4.1 blocker |
| 2000 |
XE 991 dihydrochloride |
Potent, selective KV7 (KCNQ) channel blocker; blocks M-currents |
| 2076 |
Y-26763 |
Kir6 (KATP) channel opener |
|
|
|
| Sodium
Channels |
|
| Cat. No. |
Product |
Activity |
| 6159 |
4,9-Anhydrotetrodotoxin |
Potent and selective Nav1.6 channel blocker |
| 2976 |
A 803467 |
Selective NaV1.8 channel blocker |
| 4249 |
A 887826 |
Potent voltage-dependent NaV1.8 channel blocker |
| 0890 |
Amiloride hydrochloride |
Na+ channel blocker; also I2 imidazoline ligand |
| 4804 |
APETx2 |
NaV1.8 and NaV1.2 blocker; also blocks ASIC3 channels |
| 4098 |
Carbamazepine |
Inhibitor of neuronal NaV channels; anticonvulsant |
| 1470 |
Flecainide acetate |
Cardiac Na+ channel blocker. Antiarrhythmic |
| 7029 |
GX 201 |
Potent and selective Nav1.7 blocker; analgesic |
| 5066 |
ICA 121431 |
Potent and selective NaV1.3 and NaV1.1 channel blocker |
| 4913 |
Jingzhaotoxin III |
Selective NaV1.5 channel blocker |
| 3865 |
Licarbazepine |
Active metabolite of oxcarbazepine (Cat. No. 3864) |
| 3057 |
Lidocaine |
Na+ channel blocker |
| 2596 |
Mexiletine hydrochloride |
Na+ channel blocker; antiarrhythmic agent |
| 4691 |
NAV 26 |
Selective Nav1.7 channel blocker |
| 5927 |
NS 383 |
ASIC blocker; active in vivo |
| 5941 |
OD1 |
Potent hNav1.4, rNav1.6 and rNav1.7 channel activator |
| 3864 |
Oxcarbazepine |
Anticonvulsant; inhibits Na+ channel activity |
| 4916 |
PF 04885614 |
Potent and selective NaV1.8 channel blocker; active in vivo |
| 5931 |
PF 05089771 |
Potent and selective Nav1.7 channel blocker |
| 4914 |
Phrixotoxin 3 |
Potent blocker of NaV1.2, NaV1.3 and NaV1.5 channels |
| 4023 |
ProTx II |
Selective NaV1.7 channel blocker |
| 1014 |
QX 314 bromide |
Na+ channel blocker |
| 2313 |
QX 314 chloride |
Na+ channel blocker |
| 0768 |
Riluzole hydrochloride |
Na+ channel blocker; also inhibits GABA uptake and glutamate
release |
| 4044 |
Sipatrigine |
NaV blocker; neuroprotective |
| 4435 |
TC-N 1752 |
NaV channel blocker |
| 1078 |
Tetrodotoxin |
Na+ channel blocker |
| 1069 |
Tetrodotoxin citrate |
Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No.
1078) |
| 2815 |
Valproic acid, sodium salt |
Blocks voltage-gated Na+ channels |
| 2918 |
Veratridine |
Voltage-gated Na+ channel opener |