[TOCRIS] 표적단백질 분해기술 | PROTAC® Degraders & Linkers

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[TOCRIS] 표적단백질 분해기술 | PROTAC® Degraders & Linkers

Maker : TOCRIS

PROTAC은 특정단백질의 분해를 유도하는 bi-valent bifunctional small molecule로, Ubiquitin-Proteasome system (UPS)를 이용하여 특정 질병 단백질을 분해하는 새로운 약물 작용 원리입니다. PROTAC 연구에 이용되는 linker, degrader를 소개합니다.

프린트 제품 문의

특징

PROTAC은 특정 표적 단백질의 분해를 유도하는 system입니다.
분해하려는 단백질에 붙는 Target protein ligand(1), E3 Ligase에 붙는 E3 Ligase Ligand(2) 부분과, 둘을 연결하는 Linker(3)로 구성됩니다.
CRISPR/Cas9이나 RNA interference를 이용한 유전자 방법에 비해 사용이 간편하고, 처리량에 대한 optimization이 가능합니다.
PROTAC은 recycle 됩니다.
Tocris에서 제공하는 PROTAC은 모두 개발자의 license를 취득하여 제공되고 있습니다.
많은 질병 관련 단백질을 약물 표적으로 이용함으로써 질병 치료제의 개발에 응용되고 있습니다.
관심있는 ligand/linker에 쉽게 conjugation될 수 있도록 디자인되었습니다.
잘 알려진 linker를 이용한 linker-functionalized E3 Ligase ligand를 제공합니다.
Custom design도 가능합니다.

원리

표적 단백질과 단백질 분해 촉진 효소인 E3 Ligase를 가깝게 연결해 주는 역할로 PROTAC이 작용합니다.
PROTAC에 의해 연결이 되면, 표적단백질이 Ubiquitination되면서 Proteasome에 의해 degradation 됩니다.

주요 제품

1. Active Degraders

Active Degrader는 E3 ligase와 target protein ligand가 linker로 연결된 PROTAC 입니다.
Proteasome에 의한 표적 단백질의 선택적 분해를 유도하고 단백질 knockdown의 다운스트림 효과를 조사하거나 특정 신호 전달 경로를 방해하는데 사용할 수 있습니다.

Cat. No.	Product	Action
7254	ARCC 4	Potent and selective androgen receptor PROTAC®
7256	ARV 771	Potent BET bromodomain PROTAC®; also degrades BRD-tagged chimeric antigen receptors (CAR) in T cells
6356	AT 1	(+)-JQ1 based PROTAC® with selectivity for BRD4
7699	AUTAC4	Mitochondrial targeting AUTAC Degrader
7319	BRD PHOTAC-I-3	Photoswitchable BET bromodomain Degrader (PHOTAC)
6921	BSJ-03-123	Selective Cdk6 Degrader (PROTAC®)
6938	BSJ-03-204	Selective Cdk4/6 Degrader (PROTAC®)
6937	BSJ-04-132	Selective Cdk4 Degrader (PROTAC®)
7528	BSJ-4-116	Selective CDK12 PROTAC® Degrader
7425	CG 428	Potent tropomyosin receptor kinase (TRK) degrader
7427	CG 858	Selective BRAF-V600E protein Degrader (uSMITE™)
6416	CM 11	Homo-PROTAC® for self-degradation of pVHL30
7800	CPS2	Potent and selective CDK2 Degrader (PROTAC®)
7219	CRBN PROTAC® 14a	Cereblon Degrader (PROTAC®)
6948	CRBN-6-5-5-VHL	Potent and selective cereblon Degrader (PROTAC®); cell-permeable
7745	CST 905	Potent and selective BRAFV600E Degrader (PROTAC®)
6327	dBET1	(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
6945	dBET6	Potent and selective (+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
6606	dBRD9	Potent and selective BRD9 Degrader (PROTAC®)
6943	dBRD9-A	Potent BRD9 Degrader (PROTAC®)
7160	DD 03-171	Potent and selective BTK Degrader (PROTAC®)
6607	dTRIM 24	TRIM24 Degrader (PROTAC®)
7306	FC 11	Highly potent focal adhesion kinase (FAK) Degrader (PROTAC®)
7258	Gefitinib-based PROTAC® 3	Potent EGFR PROTAC®
7265	GMB 475	BCR-ABL1 kinase PROTAC®
7818	GSK 215	Potent and selective focal adhesion kinase (FAK) degrader
7882	HDAC4 CHDI Degrader 11	Potent and selective HDAC4 Degrader (PROTAC®)
7837	JB 300	Aurora A Degrader (PROTAC®)
7304	JH-XI-10-02	CDK8 Degrader (PROTAC®)
8029	JNJ 1013	Interleukin 1 Receptor Associated Kinase 1 (IRAK1) PROTAC®
7682	JQAD1	Potent and selective EP300 Degrader
7420	LC 2	Selective KRAS PROTAC®
7813	LL-K9-3	Selective HyT-based degrader of the CDK9-cyclin T1 complex
7503	MD13	Potent MIF Degrader (PROTAC®)
7395	MS 154	Potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant EGFR
7397	MS 39	Potent and selective VHL-recruiting Degrader (PROTAC®) of mutant EGFR
6154	MZ 1	(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4
7842	NAMPT PROTAC® A7	Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)
7388	ND1-YL2	SRC-1 peptide-based PROTAC®; active in vivo
7177	NR 7h	Potent and selective p38α and p38β Degrader (PROTAC®); active in vivo
8004	PROTAC®(H-PGDS)-7	Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)
7651	PT-65	Potent GSK3 Degrader (PROTAC®)
7432	SIM1	Potent and selective trivalent BET Bromodomain Degrader (PROTAC®)
7675	SJ 1008030	Selective JAK2 Degrader (PROTAC®)
7727	SJ 10542	Potent and selective JAK2/3 Degrader (PROTAC®)
7721	SJ 11646	Potent and selective LCK Degrader (PROTAC®)
7463	SJF 0628	Potent BRAF PROTAC®
7261	SJF 1521	Selective EGFR PROTAC®
7262	SJF 1528	Potent EGFR PROTAC®; also degrades HER2
7266	SJF 8240	c-MET PROTAC®; also degrades exon-14-deleted c-MET
7268	SJFα	Potent and selective p38α PROTAC®
7267	SJFδ	Potent and selective p38δ PROTAC®
7583	SK 575	Potent PARP1 Degrader (PROTAC®)
7120	SNIPER(ER)-87	Potent and selective ERα Degrader (SNIPER)
8053	STING Degrader SP23	Selective STING Degrader (PROTAC®)
7259	TBK1 PROTAC® 3i	Potent TANK-binding kinase 1 (TBK1) PROTAC®
6532	THAL SNS 032	Potent and selective Cdk9 Degrader (PROTAC®)
6524	TL 12-186	Multikinase Degrader (PROTAC®)
6745	TL 13-112	Selective ALK Degrader (PROTAC®)
6744	TL 13-12	Selective ALK Degrader (PROTAC®)
7816	UNC 6852	Polycomb repressive complex 2 (PRC2) Degrader PROTAC®
6936	VZ 185	Potent and selective BRD7/9 Degrader (PROTAC®)
7298	xStAx-VHLL	Selective peptide-based β-catenin Degrader (PROTAC®)
7240	ZNL 02-096	Potent and selective Wee1 Degrader (PROTAC®)
7278	α1A-AR Degrader 9c	Selective α1A adrenergic receptor Degrader (PROTAC®)
8951	NX 2127	Potent BTK Degrader (PROTAC®)

2. Degrader Building Blocks

Tocris는 Degrader 연구 및 개발을 지원하기 위해 Degrader Building Block을 제공합니다.
Degrader Building Block은 Reactive handle을 포함한 linker에 E3 ligase ligand가 붙은 형태로, E3 ligase ligand (CRBN, VHL, IAP), exit vector 유형 및 위치, linker의 길이와 유형 등을 스크리닝하는데 유용합니다.

VHL Targeting Ligands Plus Linkers

Cat. No.	Product Name	Linker Type	Number of Units	Conjugation Functionality
7106	VH 032 amide-alkylC2-acid	Alkyl	2	Carboxylic Acid
6852	VH 032 amide-alkylC2-amine	Alkyl	2	Amine
7216	VH 032 amide-alkylC3-acid	Alkyl	3	Acid
7073	VH 032 amide-alkylC3-amine	Alkyl	3	Amine
6680	VH 032 amide-alkylC4-acid	Alkyl	4	Carboxylic Acid
6465	VH 032 amide-alkylC4-amine	Alkyl	4	Amine
7217	VH 032 amide-alkylC5-acid	Alkyl	5	Acid
6985	VH 032 amide-alkylC5-amine	Alkyl	5	Amine
7867	VH 032 amide-alkylC5-azide	Alkyl	5	Azide
7107	VH 032 amide-alkylC6-acid	Alkyl	6	Carboxylic Acid
6853	VH 032 amide-alkylC6-amine	Alkyl	6	Amine
7925	VH 032 amide-alkylC7-acid	Alkyl	7	Carboxylic Acid
7074	VH 032 amide-alkylC7-amine	Alkyl	7	Amine
7108	VH 032 amide-alkylC8-acid	Alkyl	8	Carboxylic Acid
6890	VH 032 amide-alkylC8-amine	Alkyl	8	Amine
7404	VH 032 amide-alkylC9-acid	Alkyl	9	Carboxylic Acid
7566	VH 032 amide-alkylC9-amine	Alkyl	9	Amine
6880	VH 032 amide-alkylC10-amine	Alkyl	10	Amine
7104	VH 032 amide-PEG1-acid	PEG	1	Acid
6879	VH 032 amide-PEG1-amine	PEG	1	Amine
6907	VH 032 amide-PEG2-amine	PEG	2	Amine
6684	VH 032 amide-PEG2-alkyne	PEG	2	Alkyne
6679	VH 032 amide-PEG3-acid	PEG	3	Carboxylic Acid
6463	VH 032 amide-PEG3-amine	PEG	3	Amine
7215	VH 032 amide-PEG4-acid	PEG	4	Carboxylic Acid
6464	VH 032 amide-PEG4-amine	PEG	4	Amine
7105	VH 032 amide-PEG5-acid	PEG	5	Acid
7568	VH 032 amide-PEG6-amine	PEG	6	Amine
6909	VH 032 phenol-alkylC4-amine	Alkyl	4	Amine
6910	VH 032 phenol-alkylC6-amine	Alkyl	6	Amine
7293	VH 101 phenol-alkylC4-amine	Alkyl	4	Amine

Cereblon Targeting Ligands Plus Linkers

Cat. No.	Product Name	E3 Ligase Exit Vector	Linker Type	Number of Units	Conjugation Functionality
7516	Lenalidomide 4'-alkylC3-azide	-	alkyl	3	Azide
7517	Lenalidomide 4'-alkylC5-azide	-	alkyl	5	Azide
7075	Lenalidomide 4'-PEG1-amine	-	PEG	1	Amine
7513	Lenalidomide 4'-PEG1-azide	-	PEG	1	Azide
7093	Lenalidomide 4'-PEG2-amine	-	PEG	2	Amine
7514	Lenalidomide 4'-PEG2-azide	-	PEG	2	Azide
7076	Lenalidomide 4'-PEG3-amine	-	PEG	3	Amine
7515	Lenalidomide 4'-PEG3-azide	-	PEG	3	Azide
7472	Lenalidomide 5'-piperazine	Piperazine	-	-	Amine
7473	Lenalidomide 5'-piperazine-4-methylpiperidine	Piperazine	Methyl-piperidine	1	Amine
7998	PAG 4'-piperazine	Piperazine	-	-	Amine
7999	PAG 4'-piperazine-4-methylpiperidine	Piperazine	Methyl-piperidine	1	Amine
6851	Pomalidomide 4'-alkylC2-amine	-	Alkyl	2	Amine
7439	Pomalidomide 4'-alkylC2-azide	-	Alkyl	2	Azide
7096	Pomalidomide 4'-alkylC3-acid	-	Alkyl	3	Carboxylic Acid
7205	Pomalidomide 4'-alkylC3-amine	-	Alkyl	3	Amine
7440	Pomalidomide 4'-alkylC3-azide	-	Alkyl	3	Azide
7209	Pomalidomide 4'-alkylC4-acid	-	Alkyl	4	Carboxylic Acid
7441	Pomalidomide 4'-alkylC4-azide	-	Alkyl	4	Azide
6682	Pomalidomide 4'-alkylC5-acid	-	Alkyl	5	Carboxylic Acid
6716	Pomalidomide 4'-alkylC5-amine	-	Alkyl	5	Amine
7442	Pomalidomide 4'-alkylC5-azide	-	Alkyl	5	Azide
7210	Pomalidomide 4'-alkylC6-acid	-	Alkyl	6	Carboxylic Acid
7923	Pomalidomide 4'-alkylC6-amine	-	Alkyl	6	Amine
7443	Pomalidomide 4'-alkylC6-azide	-	Alkyl	6	Azide
7097	Pomalidomide 4'-alkylC7-acid	-	Alkyl	7	Carboxylic Acid
7208	Pomalidomide 4'-alkylC7-amine	-	Alkyl	7	Amine
7211	Pomalidomide 4'-alkylC8-acid	-	Alkyl	8	Carboxylic Acid
6944	Pomalidomide 4'-alkylC8-amine	-	Alkyl	8	Amine
7732	Pomalidomide 4'-alkylC10-amine	-	Alkyl	10	Amine
7094	Pomalidomide 4'-PEG1-acid	-	PEG	1	Acid
7203	Pomalidomide 4'-PEG1-amine	-	PEG	1	Ethylamine
7434	Pomalidomide 4'-PEG1-azide	-	PEG	1	Azide
7212	Pomalidomide 4'-PEG2-acid	-	PEG	2	Acid
6637	Pomalidomide 4'-PEG2-amine	-	PEG	2	Amine
7307	Pomalidomide 4'-PEG2-azide	-	PEG	2	Azide
6681	Pomalidomide 4'-PEG3-acid	-	PEG	3	Carboxylic Acid
7204	Pomalidomide 4'-PEG3-amine	-	PEG	3	Ethylamine
7435	Pomalidomide 4'-PEG3-azide	-	PEG	3	Azide
7213	Pomalidomide 4'-PEG4-acid	-	PEG	4	Acid
6963	Pomalidomide 4'-PEG4-amine	-	PEG	4	Ethylamine
7436	Pomalidomide 4'-PEG4-azide	-	PEG	4	Azide
7095	Pomalidomide 4'-PEG5-acid	-	PEG	5	Acid
7437	Pomalidomide 4'-PEG5-azide	-	PEG	5	Azide
7438	Pomalidomide 4'-PEG6-azide	-	PEG	6	Azide
7468	Pomalidomide 5'-piperazine	Piperazine	-	-	Amine
7469	Pomalidomide 5'-piperazine-4-methylpiperidine	Piperazine	Methyl-piperidine	1	Amine
7470	Pomalidomide 5'-fluoro-6-piperazine	Piperazine	-	-	Amine
7471	Pomalidomide 5'-fluoro-6-piperazine-4-methylpiperidine	Piperazine	Methyl-piperidine	1	Amine
7329	Thalidomide 4'-ether-alkylC2-acid		Alkyl	2	Acid
6850	Thalidomide 4'-ether-alkylC2-amine		Alkyl	2	Amine
7330	Thalidomide 4'-ether-alkylC3-acid		Alkyl	3	Acid
7521	Thalidomide 4'-ether-alkylC3-azide		Alkyl	3	Azide
7331	Thalidomide 4'-ether-alkylC4-acid		Alkyl	4	Acid
6917	Thalidomide 4'-ether-alkylC4-amine		Alkyl	4	Amine
7332	Thalidomide 4'-ether-alkylC5-acid		Alkyl	5	Acid
7522	Thalidomide 4'-ether-alkylC5-azide		Alkyl	5	Azide
6627	Thalidomide 4'-ether-alkylC6-amine		Alkyl	6	Amine
7333	Thalidomide 4'-ether-alkylC6-acid		Alkyl	6	Acid
7829	Thalidomide 4'-ether-alkylC6-azide		Alkyl	6	Azide
7334	Thalidomide 4'-ether-alkylC7-acid		Alkyl	7	Acid
7335	Thalidomide 4'-ether-alkylC8-acid		Alkyl	8	Acid
7403	Thalidomide 4'-ether-alkylC8-amine		Alkyl	8	Amine
7518	Thalidomide 4'-ether-PEG1-azide		PEG	1	Azide
6686	Thalidomide 4'-ether-PEG2-alkyne		PEG	2	Alkyne
7519	Thalidomide 4'-ether-PEG2-azide		PEG	2	Azide
6950	Thalidomide 4'-ether-PEG3-amine		PEG	3	Ethylamine
7520	Thalidomide 4'-ether-PEG3-azide		PEG	3	Azide
6951	Thalidomide 4'-ether-PEG5-amine		PEG	5	Ethylamine
6949	Thalidomide 4'-oxyacetamide-alkylC2-amine		Alkyl	2	Amine
6469	Thalidomide 4'-oxyacetamide-alkylC4-amine		Alkyl	4	Amine
6968	Thalidomide 4'-oxyacetamide-alkylC6-amine		Alkyl	6	Amine
6946	Thalidomide 4'-oxyacetamide-alkylC8-amine		Alkyl	2	Amine
6300	Thalidomide 4'-oxyacetamide-alkylC4-azide		Alkyl	4	Azide
6966	Thalidomide 4'-oxyacetamide-PEG1-amine		PEG	1	Ethylamine
6967	Thalidomide 4'-oxyacetamide-PEG2-amine		PEG	2	Ethylamine
6467	Thalidomide 4'-oxyacetamide-PEG3-amine		PEG	3	Amine
6468	Thalidomide 4'-oxyacetamide-PEG4-amine		PEG	4	Amine
6913	Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine		Alkyl-PEG-Alkyl	1-3-3	Amine
7988	Thalidomide 5'-amine-alkylc6-amine		Alkyl	6	Ethylamine
7557	Thalidomide 5'-amine-alkylc8-amine		Alkyl	8	Ethylamine
7733	Thalidomide 5'-amine-alkylC10-amine		Alkyl	10	Ethylamine
7735	Thalidomide 5'-amine-PEG1-amine		alkyl	10	Ethylamine
7736	Thalidomide 5'-amine-PEG2-amine		PEG	2	Ethylamine
7737	Thalidomide 5'-amine-PEG3-amine		PEG	3	Ethylamine

IAP Targeting Ligands Plus Linkers

Cat. No.	Product Name	Linker Type	Number of Units	Conjugation Functionality
6474	A 410099.1 amide-alkylC4-amine	Amide-Alkyl	4	Amine
6473	A 410099.1 amide-PEG2-amine	Amide-PEG	2	Amine
6472	A 410099.1 amide-PEG3-amine	Amide-PEG	3	Amine
7220	A 410099.1 amide-PEG4-amine	Amide-PEG	4	Amine
7221	A 410099.1 amide-PEG5-amine	Amide-PEG	5	Amine

Functionalized E3 Ligase Ligands

Cat. No.	Product Name	E3 Ligase Ligand	Target E3	Reactive Handle	Reaction Chemistry
8066	CST 530, Phenol	CST 530	IAP	Alcohol	Mitsunobu reaction
6471	A 410099.1, amine	A 410099.1	IAP	Primary Amine	Amide coupling
7178	LCL 161, phenol	LCL 161	IAP	Alcohol	Mitsunobu reaction
7677	Lenalidomide 5'-amine	Lenalidomide	Cereblon	Primary Amine	Amide Coupling
7858	PD 4'-oxyacetic acid	Phenyl Dihydrouracil	Cereblon	Carboxylic Acid	Amide Coupling
7859	PD 4'-piperazine	Phenyl Dihydrouracil	Cereblon	Cyclic Amine	Amide Coupling
7670	Phenyl-glutarimide 4'-oxyacetic acid	Phenyl-glutarimide	Cereblon	Carboxylic Acid	Amide Coupling
6466	TC E3 5031	Thalidomide	Cereblon	Carboxylic acid	Amide coupling
6628	TC E3 5032	Pomalidomide	Cereblon	Fluorine	Nucleophilic aromatic substitution
7456	Thalidomide, 5'-fluoro	Thalidomide	Cereblon	Fluoro	Nucleophilic aromatic substitution
6685	Thalidomide, propargyl	Thalidomide	Cereblon	Alkyne	Click chemistry
6462	VH 032, amine	VH 032	VHL	Primary amine	Amide coupling
6969	cis VH 032, amine dihydrochloride	VH 032	VHL	Primary amine	Amide coupling
7634	Me VH 032, amine	VH 032	VHL	Primary amine	Amide coupling
6911	VH 032, phenol	VH 032	VHL	Alcohol	Mitsunobu reaction
6683	VH 032, propargyl	VH 032	VHL	Alkyne	Click chemistry
7861	VH 032, thiol	VH 032	VHL	Thiol	Nucleophilic substitution
6952	VH 101, phenol	VH 101	VHL	Alcohol	Mitsunobu reaction
7884	VH 101, thiol	VH 101	VHL	Thiol	Nucleophilic substitution

Functionalized Warhead Ligands

Cat. No.	Product Name	Ligand	Target Protein	Reactive Handle	Reaction Chemistry
7689	(+)-JQ1 bump, acid functionalized	JQ1 analog	BET Bromodomains	Carboxylic acid	Amide coupling
6588	(+)-JQ1 carboxylic acid	JQ1	BET Bromodomains	Carboxylic acid	Amide coupling
7576	(+)-JQ1 maleimide	JQ1	BET Bromodomains	Maleimide	Sulfhydryl coupling
6589	(+)-JQ1 PA	JQ1	BET Bromodomains	Alkyne	Click chemistry

3. Negative Controls

Cat. No.	Product	Action
7255	ARCC 4 negative control	Negative control for ARCC 4 (Cat. No. 7254)
7529	BSJ-4-116-NC	Negative control for BSJ-4-116 (Cat. No. 7528).
6922	BSJ-Bump	Negative control for BSJ-03-123 (Cat. No. 6921)
7426	CG 428-Neg	Negative control for CG 428 (Cat. No. 7425)
7428	CG 858-Neg	Negative control for CG 858 (Cat. No. 7427)
6155	cis MZ 1	Negative Control for MZ 1 (Cat. No. 6154)
7433	cis-SIM1	Negative control for SIM1 (Cat. No. 7432)
6939	cis-VZ 185	Negative control for VZ 185 (Cat. No. 6936)
7421	LC 2 Epimer	Negative control for LC 2 (Cat. No. 7420)
7504	MD15	Negative control for MD13 (Cat. No. 7503)
7396	MS 154N	Negative control for MS 154 (Cat No. 7395)
7398	MS 39N	Negative control for MS 39 (Cat. No. 7397)
8005	PROTAC®(H-PGDS)-8	Negative control for PROTAC®(H-PGDS)-7 (Cat. No. 8004)
7464	SJF 0661	Negative control for SJF 0628 (Cat. No. 7463)
7588	SK 575-NEG	Negative control for SK 575 (Cat. No. 7583)
8054	STING Degrader N-Me-SP23	Negative control for STING Degrader SP23 (Cat. No. 8053)
7260	TBK1 control PROTAC® 4	Negative control for TBK1 PROTAC® 3i (Cat. No. 7259)
6746	TL 13-110	Negative control for TL 13-112 (Cat. No. 6745)
6747	TL 13-22	Negative control for TL 13-12 (Cat. No. 6744)
6525	TL 13-27	Negative control for TL 12-186 (Cat. No. 6524)

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
Product	Cat.No.	Size	Maker
PD 4'-oxyacetic acid	7858	50 mg	TOCRIS
NX 2127	8951	5 mg	TOCRIS
(+)-JQ1 bump, acid functionalized	7689	50 mg	TOCRIS
(+)-JQ1 bump-N, acid functionalized	8827	25 mg	TOCRIS
(+)-JQ1 maleimide	7576	10 mg	TOCRIS
5-Amino-Thalidomide	7678	100 mg	TOCRIS
5-Ph-IAA-AM	7893	10 mg	TOCRIS
5-Ph-IAA-AM	7893	50 mg	TOCRIS
A 410099.1 amide-alkylC4-amine (25 MG)	6474	25 mg	TOCRIS
A 410099.1 amide-PEG2-amine (25 MG)	6473	25 mg	TOCRIS
A 410099.1 amide-PEG3-amine (25 MG)	6472	25 mg	TOCRIS
A 410099.1 amide-PEG4-amine (25 MG)	7220	25 mg	TOCRIS
A 410099.1 amide-PEG5-amine (25 MG)	7221	25 mg	TOCRIS
A 410099.1, amine (100 MG)	6471	100 mg	TOCRIS
a-Synuclein Degrader 2b	8040	5 mg	TOCRIS
a-Synuclein Degrader 2bn	8041	5 mg	TOCRIS
a-Synuclein Degrader 2bn	8041	5 mg	TOCRIS
a1A-AR Degrader 9c	7278	5 mg	TOCRIS
Active Degraders	8118	5 mg	TOCRIS
AP 1867	6207	50 mg	TOCRIS
AP 1867	6207	10 mg	TOCRIS
ARCC 4 negative control (5 MG)	7255	5 mg	TOCRIS
ARV 771 (5 MG)	7256	5 MG	TOCRIS
AT 1 (5 MG)	6356	5 mg	TOCRIS
AUTAC4	7699	5 mg	TOCRIS
AZ 3137	8833	5 mg	TOCRIS
BRD PHOTAC-I-3 (5 mg)	7319	5 mg	TOCRIS
BSJ-03-123 (5 MG)	6921	5 mg	TOCRIS
BSJ-03-204 (5 MG)	6938	5 mg	TOCRIS
BSJ-04-132 (5 MG)	6937	5 mg	TOCRIS
BSJ-4-116	7528	5 mg	TOCRIS
BSJ-4-116-NC	7529	5 mg	TOCRIS
CG 428	7425	5 mg	TOCRIS
CG 428-Neg	7426	5 mg	TOCRIS
CG 858	7427	5 mg	TOCRIS
CG 858-Neg	7428	5 mg	TOCRIS
cis MZ 1 (5 MG)	6155	5 mg	TOCRIS
cis VH 032, amine dihydrochloride (50 MG)	6969	50 mg	TOCRIS
cis-SIM1	7433	2 mg	TOCRIS
cis-VZ 185 (5 MG)	6939	5 mg	TOCRIS
CM 11 (5 MG)	6416	5 mg	TOCRIS
CPS2	7800/2	2 mg	TOCRIS
CRBN PROTAC 14a (5 MG)	7219	5 mg	TOCRIS
CRBN-6-5-5-VHL (5 MG)	6948	5 mg	TOCRIS
CSN5i-3-NEG	7532	2 mg	TOCRIS
CST 530, Phenol	8066	50 mg	TOCRIS
CST 626	8021	2 mg	TOCRIS
CST 905	7745	5 mg	TOCRIS
CST 967	7801	5 mg	TOCRIS
dBET1 (5 MG)	6327	5 mg	TOCRIS

전체보기

1
Maker	TOCRIS
Cat.No.	7858
Product	PD 4'-oxyacetic acid
Size	50 mg
Qty
Data Sheet
MSDS

2
Maker	TOCRIS
Cat.No.	8951
Product	NX 2127
Size	5 mg
Qty
MSDS

3
Maker	TOCRIS
Cat.No.	7689
Product	(+)-JQ1 bump, acid functionalized
Size	50 mg
Qty
Data Sheet
MSDS

4
Maker	TOCRIS
Cat.No.	8827
Product	(+)-JQ1 bump-N, acid functionalized
Size	25 mg
Qty
Data Sheet
MSDS

5
Maker	TOCRIS
Cat.No.	7576
Product	(+)-JQ1 maleimide
Size	10 mg
Qty
Data Sheet
MSDS

6
Maker	TOCRIS
Cat.No.	7678
Product	5-Amino-Thalidomide
Size	100 mg
Qty
Data Sheet
MSDS

7
Maker	TOCRIS
Cat.No.	7893
Product	5-Ph-IAA-AM
Size	10 mg
Qty
Data Sheet
MSDS

8
Maker	TOCRIS
Cat.No.	7893
Product	5-Ph-IAA-AM
Size	50 mg
Qty
Data Sheet
MSDS

9
Maker	TOCRIS
Cat.No.	6474
Product	A 410099.1 amide-alkylC4-amine (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

10
Maker	TOCRIS
Cat.No.	6473
Product	A 410099.1 amide-PEG2-amine (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

11
Maker	TOCRIS
Cat.No.	6472
Product	A 410099.1 amide-PEG3-amine (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

12
Maker	TOCRIS
Cat.No.	7220
Product	A 410099.1 amide-PEG4-amine (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

13
Maker	TOCRIS
Cat.No.	7221
Product	A 410099.1 amide-PEG5-amine (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

14
Maker	TOCRIS
Cat.No.	6471
Product	A 410099.1, amine (100 MG)
Size	100 mg
Qty
Data Sheet
MSDS

15
Maker	TOCRIS
Cat.No.	8040
Product	a-Synuclein Degrader 2b
Size	5 mg
Qty
Data Sheet
MSDS

16
Maker	TOCRIS
Cat.No.	8041
Product	a-Synuclein Degrader 2bn
Size	5 mg
Qty
Data Sheet
MSDS

17
Maker	TOCRIS
Cat.No.	8041
Product	a-Synuclein Degrader 2bn
Size	5 mg
Qty
Data Sheet
MSDS

18
Maker	TOCRIS
Cat.No.	7278
Product	a1A-AR Degrader 9c
Size	5 mg
Qty
Data Sheet
MSDS

19
Maker	TOCRIS
Cat.No.	8118
Product	Active Degraders
Size	5 mg
Qty
Data Sheet
MSDS

20
Maker	TOCRIS
Cat.No.	6207
Product	AP 1867
Size	50 mg
Qty
Data Sheet
MSDS

21
Maker	TOCRIS
Cat.No.	6207
Product	AP 1867
Size	10 mg
Qty
Data Sheet
MSDS

22
Maker	TOCRIS
Cat.No.	7255
Product	ARCC 4 negative control (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

23
Maker	TOCRIS
Cat.No.	7256
Product	ARV 771 (5 MG)
Size	5 MG
Qty
Data Sheet
MSDS

24
Maker	TOCRIS
Cat.No.	6356
Product	AT 1 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

25
Maker	TOCRIS
Cat.No.	7699
Product	AUTAC4
Size	5 mg
Qty
Data Sheet
MSDS

26
Maker	TOCRIS
Cat.No.	8833
Product	AZ 3137
Size	5 mg
Qty
Data Sheet
MSDS

27
Maker	TOCRIS
Cat.No.	7319
Product	BRD PHOTAC-I-3 (5 mg)
Size	5 mg
Qty
Data Sheet
MSDS

28
Maker	TOCRIS
Cat.No.	6921
Product	BSJ-03-123 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

29
Maker	TOCRIS
Cat.No.	6938
Product	BSJ-03-204 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

30
Maker	TOCRIS
Cat.No.	6937
Product	BSJ-04-132 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

31
Maker	TOCRIS
Cat.No.	7528
Product	BSJ-4-116
Size	5 mg
Qty
Data Sheet
MSDS

32
Maker	TOCRIS
Cat.No.	7529
Product	BSJ-4-116-NC
Size	5 mg
Qty
Data Sheet
MSDS

33
Maker	TOCRIS
Cat.No.	7425
Product	CG 428
Size	5 mg
Qty
Data Sheet
MSDS

34
Maker	TOCRIS
Cat.No.	7426
Product	CG 428-Neg
Size	5 mg
Qty
Data Sheet
MSDS

35
Maker	TOCRIS
Cat.No.	7427
Product	CG 858
Size	5 mg
Qty
Data Sheet
MSDS

36
Maker	TOCRIS
Cat.No.	7428
Product	CG 858-Neg
Size	5 mg
Qty
Data Sheet
MSDS

37
Maker	TOCRIS
Cat.No.	6155
Product	cis MZ 1 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

38
Maker	TOCRIS
Cat.No.	6969
Product	cis VH 032, amine dihydrochloride (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

39
Maker	TOCRIS
Cat.No.	7433
Product	cis-SIM1
Size	2 mg
Qty
Data Sheet
MSDS

40
Maker	TOCRIS
Cat.No.	6939
Product	cis-VZ 185 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

41
Maker	TOCRIS
Cat.No.	6416
Product	CM 11 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

42
Maker	TOCRIS
Cat.No.	7800/2
Product	CPS2
Size	2 mg
Qty
Data Sheet
MSDS

전체보기

자료

표적 단백질 분해 PRODUCT GUIDE

[TOCRIS]

Targeted Protein Degradation에 대한 PRODUCT GUIDE 한글판 입니다.
Targeted Protein Degradation Research Product Guide

[TOCRIS]

PROTAC 연구에 필요한 linker 및 degrader를 제공합니다.
Advance Emerging Therapeutics for Undruggable Targets

[EUROFINS DISCOVERX]

PROTAC을 이용한 Targeted Protein Degradation Drug Discovery Solutions을 안내합니다.
Targeted Protein Degradation Assays

[EUROFINS DISCOVERX]

PROTAC에 의해 유도된 Protein의 turnover를 측정하기 위한 assay platform에 대한 안내입니다.
Inhibitor Book Vol.4

고마뉴스 자료신청 [KOMA]

다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

웨비나/Video

[TOCRIS] Tools for Targeted Protein Degradation

PROTAC 기술에 대한 안내 영상입니다.

동영상 보기
[TOCRIS] New Frontiers in Targeted Protein Degradation and Degrader Development

PROTAC 기술에 대한 안내입니다.

동영상 보기
[TOCRIS] dTAG - A Powerful New Tag-Based Degradation System

dTAG 기술에 대한 안내입니다.

동영상 보기
[EUROFINS DISCOVERY] Next-Generation Drug Discovery: Leveraging E3 Ligases for Targeted Protein Degradation

PROTAC 스크리닝에 대한 웨비나 입니다.

동영상 보기

[TOCRIS] 표적단백질 분해기술 | PROTAC® Degraders & Linkers | 고마바이오텍

[TOCRIS] 표적단백질 분해기술 | PROTAC® Degraders & Linkers

주문정보

추천제품

관련제품

자료

웨비나/Video

[TOCRIS] Tools for Targeted Protein Degradation

[TOCRIS] New Frontiers in Targeted Protein Degradation and Degrader Development

[TOCRIS] dTAG - A Powerful New Tag-Based Degradation System

[EUROFINS DISCOVERY] Next-Generation Drug Discovery: Leveraging E3 Ligases for Targeted Protein Degradation

제품 문의

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