| Cat.
No. |
Product Name |
Biological
Activity |
| TB2939-RMU |
A 83-01 |
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5
kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A 83-01
blocks phosphorylation of Smad2 and inhibits TGF-β-induced
epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6
and MAPK activity. More potent than SB 431542 (Cat. No. 1614). A 83-01
inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and
increases clonal expansion efficiency. Helps maintain homogeneity and
long-term in vitro self-renewal of human iPSCs. Also promotes neural
differentiation of hPSCs as part of a chemical cocktail. |
| TB5758-RMU |
AGN 193109 |
AGN
193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (Kd
values are 2, 2 and 3 nM at RARα, RARβ and RARγ, respectively). Exhibits no
significant affinity for retinoic X receptors. AGN 193109
promotes the differentiation from mouse embryonic stem cells into paraxial
mesoderm. AGN 193109 suppresses primary human
cardiovascular smooth muscle cell calcification. |
| TB0760-RMU |
AM 580 |
AM
580 is an analog of retinoic acid that acts as a selective RARα agonist (EC50
values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively).
Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFNγ
synthesis, and induces cell differentiation with over 7
times the activity of retinoic acid in vitro. |
| TB2634-RMU |
DAPT |
DAPT
is a γ-secretase inhibitor. DAPT reduces Aβ40 and Aβ42 levels in human
primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and
Aβ42 respectively) and in brain extract, cerebrospinal fluid and plasma in
vivo. DAPT has no effect on APPα and APPβ levels. DAPT blocks Notch signaling
in hybrid human-mouse fetal thymus organ culture (FTOC) and causes ESCs to
commit to neuronal differentiation. DAPT can be used in a
small molecule cocktail to derive cortical neurons from hPSCs and to maintain
hepatocytes in culture. DAPT also promotes the
formation of cone photoreceptors in retinal organoids. |
| TB4489-RMU |
DBZ |
DBZ
is an inhibitor of γ-secretase aspartyl protease. DBZ blocks amyloid
precursor protein-like (APPL) and Notch cleavage (IC50 values are 2.6 nM and
1.7-2.9 nM, respectively). By inhibiting Notch and the Notch pathway, DBZ improves efficiency of iPSC generation and production of
iPSCs from mouse and human keratinocytes without KLF4 and CMYC. In an animal model of Alzheimer's disease, DBZ inhibits the
cleavage of amyloid precursor protein into Aβ40. DBZ promotes cochlear
supporting cell proliferation and hair cell mitotic regeneration in neonatal
mice. DBZ in combination with iDOT1L enables maintenance of human naïve-state
pluripotency in non-hypoxic conditions. |
| TB4703-RMU |
DZNep HCl |
3-Deazaneplanocin
A hydrochloride is a histone methyltransferase inhibitor; decreases global
histone methylation. 3-Deazaneplanocin A hydrochloride inhibits EZH2 histone
methyltransferase and s-adenosylhomocysteine (SAH) hydrolase activity. Blocks
trimethylation of lysine 27 on histone H3 and lysine 20 on histone H4 in
vitro. 3-Deazaneplanocin A hydrochloride induces apoptosis in multiple cancer
cell lines and has no apoptotic effect on normal cells. Enhances
Oct4 expression in chemically induced pluripotent stem cells (CiPSCs). |
| TB1099-RMU |
Forskolin |
Forskolin,
or coleonol, is a cell-permeable, potent, reversible and rapid activator of
adenylyl cyclase, an enzyme that converts ATP to cAMP and pyrophosphate (EC50
= 0.5 μM). In combination with 5 other compounds, forskolin
enables chemical reprogramming of mouse embryonic fibroblasts to pluripotent
stem cells, without genetic factors: Valproic
acid, sodium salt (Cat. No. 2815), RepSox (Cat. No. 3742), Tranylcypromine
hydrochloride (Cat. No. 3852), CHIR 99021 (Cat. No. 4423) and
3-Deazaneplanocin A hydrochloride (Cat. No. 4703). In combination with IBMX
(Cat. No. 2845), forskolin induces neural differentiation of mesenchymal stem
cells by downregulating neuron restrictive silencer factor. In a rat model of
Huntington's disease-like neurodegeneration, forskolin also exhibits
neuroprotective effects. Hypotensive and vasodilatory agent. |
| TB3000-RMU |
Gefitinib |
TB3000-RMU
is an Ancillary Material Grade version of product Iressa (Cat. No. 3000). Suitable for use as an ancillary reagent in
the further manufacturing of cell therapies. |
| TB4439-RMU |
ISX 9 |
ISX
9 is a neurogenic agent. Mediates neuroD reporter gene induction via
activation of Ca2+ influx; increases expression of
neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal
differentiation in human cortical neuronal cells (HCN), adult mouse whole
brain (MWB) and subventricular zone (SVZ) progenitors. Also shown to induce cardiomyogenic differentiation of
Notch-activated epicardium-derived cells in vitro. |
| TB6053-RMU |
LDN 193189 |
LDN
193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor
(IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8
activation. Exhibits >200-fold selectivity for BMP signaling over TGF-β
signaling. Also exhibits selectivity over AMPK, PDGFR and MAPK signaling. Promotes neural induction of hPSCs in combination with SB
431542 (Cat.No. 1614). Also induces differentiation of hPSCs into nociceptive
sensory neurons in combination with SB 431542 (Cat.No. 1614), SU 5402
(Cat.No.3300), CHIR 99021 (Cat.No. 4423) and DAPT (Cat.No. 2634). |
| TB3742-RMU |
RepSox |
RepSox
is a potent and selective inhibitor of the TGF-β type I receptor/ALK5 (IC50
values are 4 and 23 nM for TGF-β type I receptor autophosphorylation and
binding respectively). Selective for TGF-β type I receptor over a range of
kinases, including p38 MAPK, JNK1 and GSK3 (IC50 > 16 μM). Enhances the efficiency of cellular reprogramming; replaces
Sox2 by inducing Nanog expression. |
| TB6666-RMU |
T3 |
T3 is a thyroid hormone. Promotes
differentiation of oligodendroglial precursor cells in neonatal rats and
promotes maturation of hiPSC-derived cardiomyocytes. Also specifies cone cell
subtype in retinal cell differentiation protocols. T3 is used in protocols to
generate cortical spheroids from hPSCs. |
| TB4855-RMU |
WIKI4 |
WIKI4
is an inhibitor of Wnt/β-catenin signaling (EC50 ~ 75 nM). Inhibits
auto-ADP-ribosylation of tankyrase 2 (TNKS2) (IC50 ~15 nM); prevents the
ubiquitination and degradation of axin. WIKI4 inhibits
expression of β-catenin target genes in cancer cell lines as well as in human
embryonic stem cells (ESC). |