Immune Checkpoint Inhibitors | Cytokine Inhibitor

Immune Checkpoints

Immune checkpoint molecule은 면역억제 신호경로에 관여하여 면역세포의 활성을 유도합니다.
indoleamine 2,3-dioxygenase (IDO), tryptophan 2,3 dioxygenase (TDO), arginase 와 같은 특정 대사 효소도 면역세포 기능에 필수적인 아미노산을 국소적으로 고갈시키는 역할을 하므로 Immune checkpoint molecule로 간주됩니다.

Cat. No.	Product Name	Activity
6515	(D)-PPA 1	PD-1/PD-L1 interaction inhibitor
1545	(R)-(+)-Bay K 8644	TMEM176B inhibitor; activates inflammasomes; also CaV1.x blocker
5698	1-Methyl-D-tryptophan	Indoleamine 2,3-dioxygenase (IDO) inhibitor
4392	680C91	Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor
7831	AUNP 12	Peptide inhibitor of the PD-1 signaling pathway
6007	INCB 024360-analog	Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
6068	Lin28 1632	Lin28 inhibitor; suppresses PD-L1 expression and enhances T cell-mediated antitumor immunity; also bromodomain inhibitor
8119	ML T7	Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
6370	Nor NOHA monoacetate	Arginase inhibitor
8050	SA-15-P	Dual inhibitor of LAG3 interaction with both MHCII and FGL1
6979	SEN 177	Disrupts binding of SIRP-α to CD47; potent glutaminyl cyclase inhibitor.
7533	ZE 132	Potent and selective PD-1/PD-L1 interaction inhibitor

Checkpoint Control Kinases

Checkpoint control kinase는 세포 주기를 통해 세포의 진행을 조절하는 효소 그룹을 말합니다. 이전 단계가 완료되기 전에 세포주기의 다음 단계로 진행되면 치명적인 유전적 손상이 발생할 수 있습니다.

Cat. No.	Product	Activity
5198	AZ 20	Potent and selective ATR kinase inhibitor; antitumor
3994	AZ 3146	Potent and selective Mps1 inhibitor
6330	AZ 5704	Potent and selective ATM kinase inhibitor; orally bioavailable.
5199	AZD 7762 hydrochloride	Potent and selective ATP-competitive inhibitor of Chk1 and Chk2
4968	CCT 241533 dihydrochloride	Potent Chk2 inhibitor
4840	KU 0060648	Dual DNA-PK and PI 3-K inhibitor
3544	KU 55933	Potent and selective ATM kinase inhibitor
6454	LY 2603618	Potent and selective Chk1 inhibitor
3190	Mirin	MRN-ATM pathway inhibitor
5142	Mps1-IN-1 dihydrochloride	Selective Mps1 kinase inhibitor
3034	NSC 109555 ditosylate	Selective Chk2 inhibitor
2828	NU 7026	Selective DNA-PK inhibitor
3712	NU 7441	Potent and selective DNA-PK inhibitor
3785	PD 166285 dihydrochloride	Wee1 inhibitor; also inhibits Src, FGFR and PDGFRβ
2694	PD 407824	Potent and selective inhibitor of Chk1 and Wee1
4277	PF 477736	Selective Chk1 inhibitor
2930	PI 103 hydrochloride	Inhibitor of DNA-PK, mTOR and PI 3-kinase
2560	SB 218078	Chk1 inhibitor
4750	TC Mps1 12	Potent and selective Mps1 kinase inhibitor; orally active
3038	TCS 2312	Potent Chk1 inhibitor

mTOR

mTOR는 세포 신호 전달 경로를 조정하는데 중요한 역할을 합니다.
mTOR는 분자량 280kD이상의 large multidomain protein으로 kinase domain과 FKBP12 binding domain을 갖고 있습니다.

Cat. No.	Product Name	Activity
5615	AZD 3147	Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
6791	BC-LI-0186	Inhibits mTORC1 activity; TRS/Ras-related GTP-binding protein D (RagD) interaction inhibitor
5955	eCF 309	Potent mTOR inhibitor
4702	ETP 45658	mTOR inhibitor; also inhibits PI 3-K and DNA-PK
6188	Everolimus	mTOR inhibitor; Immunosuppressant
3725	KU 0063794	Selective mTOR inhibitor
4079	Niclosamide	STAT3 inhibitor; also inhibits mTORC1 signaling
6792	Omipalisib	High affinity mTOR inhibitor; also highly potent PI 3-kinase and potent DNA-PK inhibitor
4820	PF 04691502	Dual PI 3-K/mTOR inhibitor
4823	PF 05212384	Potent and selective dual PI 3-kinase/mTOR inhibitor
2930	PI 103 hydrochloride	Inhibitor of mTOR, PI 3-kinase and DNA-PK
3894	PP 121	Dual kinase inhibitor; inhibits PI 3K family kinases
4257	PP 242	Dual mTORC1/mTORC2 inhibitor
1292	Rapamycin	mTOR inhibitor; immunosuppressant
6036	STK16-IN-1	mTOR kinase inhibitor; also inhibits PI 3Kδ, PI 3Kγ and STK16 kinases
5264	Temsirolimus	mTOR inhibitor; antitumor
4247	Torin 1	Potent and selective mTOR inhibitor
4248	Torin 2	Potent and selective mTOR inhibitor
4282	WYE 687 dihydrochloride	Potent and selective mTOR inhibitor
4893	XL 388	Potent and selective mTOR inhibitor; antitumor

Akt(Protein Kinase B)

Akt (Protein kinase B, PKB)는 세포의 생존, 혈관 신생, 종양 형성을 조절하는데 중요한 역할을 하는 serine/threonine kinase 입니다.

Cat. No.	Product Name	Activity
2558	10-DEBC hydrochloride	Selective Akt/PKB inhibitor
5985	AKT Inhibitor IV	Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
1353	Akt/SKG Substrate Peptide	Akt/PKB substrate (synthetic)
5773	Akti-1/2	Potent and selective dual Akt1 and 2 inhibitor
3897	API-1	Selective Akt/PKB inhibitor. Antitumor
2151	API-2	Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
7001	AT 7867	Potent pan-Akt and PKA inhibitor
6978	AZD 5363	Potent pan-AKT inhibitor
2926	FPA 124	Akt/PKB inhibitor
4144	GSK 690693	Akt kinase inhibitor. Antitumor
5682	OSU 03012	Akt signaling inhibitor; inhibits PDPK1 (PDK1)
6087	Perifosine	PKB/Akt inhibitor; also modulates Kv2.1 current
4598	PHT 427	Dual Akt and PDK1 inhibitor; antitumor
4398	SC 66	Allosteric Akt inhibitor
4635	SC 79	Akt activator
6762	Urolithin A	PI 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

Cytokines

Cytokine은 면역반응의 주요 매개체인 단백질성 신호 화합물 입니다.
증식, 분화, 세포생존 및 apoptosis를 포함하여 다양한 세포 기능을 제어하며, 여러 병리생리학적 과정에도 관여합니다.

Cat. No.	Product Name	Activity
4400	(±)-CPSI 1306	Reported macrophage migration inhibitory factor (MIF) inhibitor
4656	(D)-(+)-Neopterin	Stimulated by IFN-γ; marker of immune activation
6829	(R)-Shikonin	Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
3429	4-IPP	Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
7283	Apilimod dimesylate	Inhibits production of IL-12 and IL-23; potent and selective PIKfyve inhibitor
2446	AS 101	Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
5430	AS 2444697	Potent and selective IRAK4 inhibitor
6438	BRD 6989	IL-10 production enhancer; Cdk8 inhibitor
4316	Bropirimine	Immunomodulatory and antitumor compound
4204	BTZO 1	MIF binder
5484	C 87	TNF-α inhibitor
0846	Chicago Sky Blue 6B	MIF inhibitor; also inhibits L-glutamate uptake into synaptic vesicles
6107	CP 424174	Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
5479	CRID3 sodium salt	Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production
2471	ER 27319 maleate	Inhibits TNF-α production
1798	Gabexate mesylate	Inhibits TNF-α production. Also antithrombotic agent
3270	GIT 27	Immunomodulator; reduces production of pro-inflammatory cytokines
5126	iMDK	Suppressor of MDK expression; inhibits PI 3-K signaling
4288	ISO 1	Macrophage migration inhibitory factor (MIF) inhibitor
5185	JTE 607 dihydrochloride	Cytokine release inhibitor; anti-inflammatory
6305	Lenalidomide	TNF-α inhibitor; inhibits angiogenesis; also cereblon binder
6373	PF 06650833	Potent and selective IRAK4 inhibitor
1093	Pirfenidone	Antifibrotic agent; regulates cytokine levels in vivo
6302	Pomalidomide	TNF-α inhibitor; also cereblon ubiquitination inhibitor and antiangiogenic
7066	RCGD 423	gp130 modulator; activates JAK/STAT signaling
4963	SC 144 hydrochloride	gp130 inhibitor; blocks cytokine-triggered gp130 signaling
0652	Thalidomide	TNF-α synthesis inhibitor; also binds cereblon
6583	UCLA GP130 2	gp130 agonist; brain penetrant and neuroprotectant

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	Product	Cat.No.	Size	Maker	Qty	Data Sheet	MSDS

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Immune Checkpoint Inhibitors | Cytokine Inhibitor | 고마바이오텍

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