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Immune Checkpoint Inhibitors | Cytokine Inhibitor 이미지

Immune Checkpoint Inhibitors | Cytokine Inhibitor

Maker : TOCRIS

Immune Checkpoints, mTOR, Cytokines, Checkpoint Control Kinases에 대한 small molecule을 소개합니다.

프린트 제품 문의

Immune Checkpoints 

 

  • Immune checkpoint molecule은 면역억제 신호경로에 관여하여 면역세포의 활성을 유도합니다.
  • indoleamine 2,3-dioxygenase (IDO), tryptophan 2,3 dioxygenase (TDO), arginase 와 같은 특정 대사 효소도 면역세포 기능에 필수적인 아미노산을 국소적으로 고갈시키는 역할을 하므로 Immune checkpoint molecule로 간주됩니다. 

 

Cat. No. Product Name Activity
1545 (R)-(+)-Bay K 8644 TMEM176B inhibitor; activates inflammasomes; also CaV1.x blocker
5698 1-Methyl-D-tryptophan Indoleamine 2,3-dioxygenase (IDO) inhibitor
4392 680C91 Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor
7831 AUNP 12 Peptide inhibitor of the PD-1 signaling pathway
6007 INCB 024360-analog Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
8119 ML T7 Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
6370 Nor NOHA monoacetate Arginase inhibitor
8050 SA-15-P Dual inhibitor of LAG3 interaction with both MHCII and FGL1
6979 SEN 177 Disrupts binding of SIRP-α to CD47; potent glutaminyl cyclase inhibitor.
7533 ZE 132 Potent and selective PD-1/PD-L1 interaction inhibitor

 

 

 

Checkpoint Control Kinases

 

  • Checkpoint control kinase는 세포 주기를 통해 세포의 진행을 조절하는 효소 그룹을 말합니다. 이전 단계가 완료되기 전에 세포주기의 다음 단계로 진행되면 치명적인 유전적 손상이 발생할 수 있습니다.

Cat. No. Product Name Activity
7589 Adavosertib Potent and selective Wee1 inhibitor
5198 AZ 20 Potent and selective ATR kinase inhibitor; antitumor
3994 AZ 3146 Potent and selective Mps1 inhibitor
6330 AZ 5704 Potent and selective ATM kinase inhibitor; orally bioavailable.
7549 BAY 1816032 Potent and selective BUB1 kinase inhibitor
3544 KU 55933 Potent and selective ATM kinase inhibitor
6454 LY 2603618 Potent and selective Chk1 inhibitor
3190 Mirin MRN-ATM pathway inhibitor
3712 NU 7441 Potent and selective DNA-PK inhibitor
3785 PD 166285 dihydrochloride Wee1 inhibitor; also inhibits Src, FGFR and PDGFRβ
2694 PD 407824 Potent and selective inhibitor of Chk1 and Wee1
2930 PI 103 hydrochloride Inhibitor of DNA-PK, mTOR and PI 3-kinase
2560 SB 218078 Chk1 inhibitor

  

mTOR


  • mTOR는 세포 신호 전달 경로를 조정하는데 중요한 역할을 합니다.
  • mTOR는 분자량 280kD이상의 large multidomain protein으로 kinase domain과 FKBP12 binding domain을 갖고 있습니다.

Cat. No. Product Name Activity
7840 AZD 8055 Highly potent and selective mTOR inhibitor
6791 BC-LI-0186 Inhibits mTORC1 activity; leucyl-tRNA synthase (TRS)/RagD interaction inhibitor
6188 Everolimus mTOR inhibitor; Immunosuppressant
3725 KU 0063794 Selective mTOR inhibitor
4079 Niclosamide STAT3 inhibitor; also inhibits mTORC1 signaling
6792 Omipalisib High affinity mTOR inhibitor; also highly potent PI 3-kinase and potent DNA-PK inhibitor
2930 PI 103 hydrochloride Inhibitor of mTOR, PI 3-kinase and DNA-PK
4257 PP 242 Dual mTORC1/mTORC2 inhibitor
1292 Rapamycin mTOR inhibitor; immunosuppressant
5264 Temsirolimus mTOR inhibitor; antitumor
4247 Torin 1 Potent and selective mTOR inhibitor
4248 Torin 2 Potent and selective mTOR inhibitor
4282 WYE 687 dihydrochloride Potent and selective mTOR inhibitor

 

Akt(Protein Kinase B)

 

  • Akt (Protein kinase B, PKB)는 세포의 생존, 혈관 신생, 종양 형성을 조절하는데 중요한 역할을 하는 serine/threonine kinase 입니다.

Cat. No. Product Name Activity
2558 10-DEBC hydrochloride Selective Akt/PKB inhibitor
5773 Akti-1/2 Potent and selective dual Akt1 and 2 inhibitor
2151 API-2 Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
7001 AT 7867 Potent pan-Akt and PKA inhibitor
6978 AZD 5363 Potent pan-AKT inhibitor
4144 GSK 690693 Akt kinase inhibitor. Antitumor
7850 MK 2206 dihydrochloride Potent and selective allosteric Akt1, Akt2 and Akt3 inhibitor
8081 MS 143 AKT kinase Degrader (PROTAC®)
6087 Perifosine PKB/Akt inhibitor; also modulates Kv2.1 current
4635 SC 79 Akt activator

 

Cytokines

 

  • Cytokine은 면역반응의 주요 매개체인 단백질성 신호 화합물 입니다.
  • 증식, 분화, 세포생존 및 apoptosis를 포함하여 다양한 세포 기능을 제어하며, 여러 병리생리학적 과정에도 관여합니다. 

 

Cat. No. Product Name Activity
5430 AS 2444697 Potent and selective IRAK4 inhibitor
6965 CGI 1746 Blocks production of cytokines IL-1β TNFα and IL-6; potent inhibitor of BTK
7820 CU-76 Selective cGAS-STING pathway inhibitor
4288 ISO 1 Macrophage migration inhibitory factor (MIF) inhibitor
7503 MD13 Potent MIF Degrader (PROTAC®)
7504 MD15 Negative control for MD13 (Cat. No. 7503)
4963 SC 144 hydrochloride gp130 inhibitor; blocks cytokine-triggered gp130 signaling
6583 UCLA GP130 2 gp130 agonist; brain penetrant and neuroprotectant

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
AUNP 12 7831 1 mg TOCRIS
BAY 1816032 7549 10 mg TOCRIS
(+/-)-CPSI 1306 (10 mg) 4400 10 mg TOCRIS
(R)-(+)-Bay K 8644 (10 mg) 1545 10 mg TOCRIS
(R)-(+)-Bay K 8644 (50 mg) 1545 50 mg TOCRIS
10-DEBC hydrochloride (10 mg) 2558 10 mg TOCRIS
10-DEBC hydrochloride (50 mg) 2558 50 mg TOCRIS
4-IPP (10 mg) 3429 10 mg TOCRIS
4-IPP (50 mg) 3429 50 mg TOCRIS
Adavosertib 7589 10 mg TOCRIS
Adavosertib 7589 50 mg TOCRIS
AKT Inhibitor IV 5985 5 mg TOCRIS
AM 9022 8969 5 mg TOCRIS
API-2 (10 mg) 2151 10 mg TOCRIS
AS 2444697 (10 mg) 5430 10 mg TOCRIS
AS 2444697 (50 mg) 5430 50 mg TOCRIS
AT 7867 (10 MG) 7001 10 mg TOCRIS
AT 7867 (50 MG) 7001 50 mg TOCRIS
AZ 20 (10 mg) 5198 10 mg TOCRIS
AZ 20 (50 mg) 5198 50 mg TOCRIS
AZ 3146 (10 mg) 3994 10 mg TOCRIS
AZ 3146 (50 mg) 3994 50 mg TOCRIS
AZ 5704 (25 MG) 6330 25 mg TOCRIS
AZ 5704 (5 MG) 6330 5 mg TOCRIS
AZD 5363 (25 MG) 6978 25 mg TOCRIS
AZD 5363 (5 MG) 6978 5 mg TOCRIS
BBI 2779 8955 2 mg TOCRIS
BRD 6989 (10 MG) 6438 10 mg TOCRIS
BRD 6989 (50 MG) 6438 50 mg TOCRIS
Bropirimine (10 mg) 4316 10 mg TOCRIS
Bropirimine (50 mg) 4316 50 mg TOCRIS
BTZO 1 (10 mg) 4204 10 mg TOCRIS
BTZO 1 (50 mg) 4204 50 mg TOCRIS
Compound 401 (10 mg) 3271 10 mg TOCRIS
CRID3 sodium salt (10 mg) 5479 10 mg TOCRIS
CRID3 sodium salt (50 mg) 5479 50 mg TOCRIS
Dexamethasone 11-082 5 g PROSCI
ER 27319 maleate (10 mg) 2471 10 mg TOCRIS
ER 27319 maleate (50 mg) 2471 50 mg TOCRIS
Everolimus (10 MG) 6188 10 mg TOCRIS
FPA 124 (50 mg) 2926 50 mg TOCRIS
Gabexate mesylate (10 mg) 1798 10 mg TOCRIS
Gabexate mesylate (50 mg) 1798 50 mg TOCRIS
GSK 690693 (10 mg) 4144 10 mg TOCRIS
iMDK (10 mg) 5126 10 mg TOCRIS
iMDK (50 mg) 5126 50 mg TOCRIS
ISO 1 (10 mg) 4288 10 mg TOCRIS
ISO 1 (50 mg) 4288 50 mg TOCRIS
JTE 607 dihydrochloride (10 mg) 5185 10 mg TOCRIS
JTE 607 dihydrochloride (50 mg) 5185 50 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
7831
Product
AUNP 12
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7549
Product
BAY 1816032
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4400
Product
(+/-)-CPSI 1306 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1545
Product
(R)-(+)-Bay K 8644 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1545
Product
(R)-(+)-Bay K 8644 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2558
Product
10-DEBC hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2558
Product
10-DEBC hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3429
Product
4-IPP (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3429
Product
4-IPP (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7589
Product
Adavosertib
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7589
Product
Adavosertib
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5985
Product
AKT Inhibitor IV
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
8969
Product
AM 9022
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2151
Product
API-2 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5430
Product
AS 2444697 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5430
Product
AS 2444697 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7001
Product
AT 7867 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7001
Product
AT 7867 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5198
Product
AZ 20 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5198
Product
AZ 20 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3994
Product
AZ 3146 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3994
Product
AZ 3146 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6330
Product
AZ 5704 (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6330
Product
AZ 5704 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6978
Product
AZD 5363 (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6978
Product
AZD 5363 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
8955
Product
BBI 2779
Size
2 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6438
Product
BRD 6989 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6438
Product
BRD 6989 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4316
Product
Bropirimine (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4316
Product
Bropirimine (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4204
Product
BTZO 1 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4204
Product
BTZO 1 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3271
Product
Compound 401 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5479
Product
CRID3 sodium salt (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5479
Product
CRID3 sodium salt (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
PROSCI
Cat.No.
11-082
Product
Dexamethasone
Size
5 g
Qty
Data Sheet
Maker
TOCRIS
Cat.No.
2471
Product
ER 27319 maleate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2471
Product
ER 27319 maleate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6188
Product
Everolimus (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2926
Product
FPA 124 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1798
Product
Gabexate mesylate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1798
Product
Gabexate mesylate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4144
Product
GSK 690693 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5126
Product
iMDK (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5126
Product
iMDK (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4288
Product
ISO 1 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4288
Product
ISO 1 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5185
Product
JTE 607 dihydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5185
Product
JTE 607 dihydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
전체보기

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주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Cat.No.
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MSDS

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