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Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

Immune Checkpoints 

 

  • Immune checkpoint molecule은 면역억제 신호경로에 관여하여 면역세포의 활성을 유도합니다.
  • indoleamine 2,3-dioxygenase (IDO), tryptophan 2,3 dioxygenase (TDO), arginase 와 같은 특정 대사 효소도 면역세포 기능에 필수적인 아미노산을 국소적으로 고갈시키는 역할을 하므로 Immune checkpoint molecule로 간주됩니다.

Cat. No.Product Activity
6515(D)-PPA 1PD-1/PD-L1 interaction inhibitor
1545(R)-(+)-Bay K 8644TMEM176B inhibitor; activates inflammasomes; also CaV1.x blocker
56981-Methyl-D-tryptophanIndoleamine 2,3-dioxygenase (IDO) inhibitor
4392680C91Potent and selective tryptophan 2,3-dioxygenase (TDO) inhibitor
6007INCB 024360-analogPotent indoleamine 2,3-dioxygenase (IDO) inhibitor
6068Lin28 1632Lin28 inhibitor; suppresses PD-L1 expression and enhances T cell-mediated antitumor immunity
5794LM 10Selective tryptophan 2,3-dioxygenase (TDO) inhibitor
6370Nor NOHA monoacetateArginase inhibitor

 

 

Checkpoint Control Kinases

 

  • Checkpoint control kinase는 세포 주기를 통해 세포의 진행을 조절하는 효소 그룹을 말합니다. 이전 단계가 완료되기 전에 세포주기의 다음 단계로 진행되면 치명적인 유전적 손상이 발생할 수 있습니다.

Cat. No.Product Activity
5198AZ 20Potent and selective ATR kinase inhibitor; antitumor
3994AZ 3146Potent and selective Mps1 inhibitor
6330AZ 5704Potent and selective ATM kinase inhibitor; orally bioavailable.
5199AZD 7762 hydrochloridePotent and selective ATP-competitive inhibitor of Chk1 and Chk2
4968CCT 241533 dihydrochloridePotent Chk2 inhibitor
4840KU 0060648Dual DNA-PK and PI 3-K inhibitor
3544KU 55933Potent and selective ATM kinase inhibitor
6454LY 2603618Potent and selective Chk1 inhibitor
3190MirinMRN-ATM pathway inhibitor
5142Mps1-IN-1 dihydrochlorideSelective Mps1 kinase inhibitor
3034NSC 109555 ditosylateSelective Chk2 inhibitor
2828NU 7026Selective DNA-PK inhibitor
3712NU 7441Potent and selective DNA-PK inhibitor
3785PD 166285 dihydrochlorideWee1 inhibitor; also inhibits Src, FGFR and PDGFRβ
2694PD 407824Potent and selective inhibitor of Chk1 and Wee1
4277PF 477736Selective Chk1 inhibitor
2930PI 103 hydrochlorideInhibitor of DNA-PK, mTOR and PI 3-kinase
2560SB 218078Chk1 inhibitor
4750TC Mps1 12Potent and selective Mps1 kinase inhibitor; orally active
3038TCS 2312Potent Chk1 inhibitor

 

  

mTOR


  • mTOR는 세포 신호 전달 경로를 조정하는데 중요한 역할을 합니다.
  • mTOR는 분자량 280kD이상의 large multidomain protein으로 kinase domain과 FKBP12 binding domain을 갖고 있습니다.

Cat. No.Product NameActivity
5615AZD 3147Potent and selective dual mTORC1 and 2 inhibitor; orally bioavailable
6791BC-LI-0186Inhibits mTORC1 activity; TRS/Ras-related GTP-binding protein D (RagD) interaction inhibitor
5955eCF 309Potent mTOR inhibitor
4702ETP 45658mTOR inhibitor; also inhibits PI 3-K and DNA-PK
6188EverolimusmTOR inhibitor; Immunosuppressant
3725KU 0063794Selective mTOR inhibitor
4079NiclosamideSTAT3 inhibitor; also inhibits mTORC1 signaling
6792OmipalisibHigh affinity mTOR inhibitor; also highly potent PI 3-kinase and potent DNA-PK inhibitor
4820PF 04691502Dual PI 3-K/mTOR inhibitor
4823PF 05212384Potent and selective dual PI 3-kinase/mTOR inhibitor
2930PI 103 hydrochlorideInhibitor of mTOR, PI 3-kinase and DNA-PK
3894PP 121Dual kinase inhibitor; inhibits PI 3K family kinases
4257PP 242Dual mTORC1/mTORC2 inhibitor
1292RapamycinmTOR inhibitor; immunosuppressant
6036STK16-IN-1mTOR kinase inhibitor; also inhibits PI 3Kδ, PI 3Kγ and STK16 kinases
5264TemsirolimusmTOR inhibitor; antitumor
4247Torin 1Potent and selective mTOR inhibitor
4248Torin 2Potent and selective mTOR inhibitor
4282WYE 687 dihydrochloridePotent and selective mTOR inhibitor
4893XL 388Potent and selective mTOR inhibitor; antitumor
 

 

Akt(Protein Kinase B)

 

  • Akt (Protein kinase B, PKB)는 세포의 생존, 혈관 신생, 종양 형성을 조절하는데 중요한 역할을 하는 serine/threonine kinase 입니다.

Cat. No.Product NameActivity
255810-DEBC hydrochlorideSelective Akt/PKB inhibitor
5985AKT Inhibitor IV Promotes Akt hyperphosphorylation; decreases phosphorylation of Akt substrates
1353Akt/SKG Substrate PeptideAkt/PKB substrate (synthetic)
5773Akti-1/2Potent and selective dual Akt1 and 2 inhibitor
3897API-1Selective Akt/PKB inhibitor. Antitumor
2151API-2Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral
7001AT 7867Potent pan-Akt and PKA inhibitor
6978AZD 5363Potent pan-AKT inhibitor
2926FPA 124Akt/PKB inhibitor
4144GSK 690693Akt kinase inhibitor. Antitumor
5682OSU 03012Akt signaling inhibitor; inhibits PDPK1 (PDK1)
6087PerifosinePKB/Akt inhibitor; also modulates Kv2.1 current
4598PHT 427Dual Akt and PDK1 inhibitor; antitumor
4398SC 66Allosteric Akt inhibitor
4635SC 79Akt activator
6762Urolithin API 3-K/Akt/mTOR signaling inhibitor; blocks phosphorylation of Akt and p70S6K in vitro

  

 

Cytokines

 

  • Cytokine은 면역반응의 주요 매개체인 단백질성 신호 화합물 입니다.
  • 증식, 분화, 세포생존 및 apoptosis를 포함하여 다양한 세포 기능을 제어하며, 여러 병리생리학적 과정에도 관여합니다.

Cat. No.Product NameActivity
4400(±)-CPSI 1306Reported macrophage migration inhibitory factor (MIF) inhibitor
4656(D)-(+)-NeopterinStimulated by IFN-γ; marker of immune activation
6829(R)-ShikoninBlocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
34294-IPPInhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
7283Apilimod dimesylateInhibits production of IL-12 and IL-23; potent and selective PIKfyve inhibitor
2446AS 101Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1α, IL-2 and TNF-α release
5430AS 2444697Potent and selective IRAK4 inhibitor
6438BRD 6989IL-10 production enhancer; Cdk8 inhibitor
4316BropirimineImmunomodulatory and antitumor compound
4204BTZO 1MIF binder
5484C 87TNF-α inhibitor
0846Chicago Sky Blue 6BMIF inhibitor; also inhibits L-glutamate uptake into synaptic vesicles
6107CP 424174Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3
5479CRID3 sodium saltPotent NLRP3 inflammasome inhibitor; inhibits IL-1β production
2471ER 27319 maleateInhibits TNF-α production
1798Gabexate mesylateInhibits TNF-α production. Also antithrombotic agent
3270GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines
5126iMDKSuppressor of MDK expression; inhibits PI 3-K signaling
4288ISO 1Macrophage migration inhibitory factor (MIF) inhibitor
5185JTE 607 dihydrochlorideCytokine release inhibitor; anti-inflammatory
6305LenalidomideTNF-α inhibitor; inhibits angiogenesis; also cereblon binder
6373PF 06650833Potent and selective IRAK4 inhibitor
1093PirfenidoneAntifibrotic agent; regulates cytokine levels in vivo
6302PomalidomideTNF-α inhibitor; also cereblon ubiquitination inhibitor and antiangiogenic
7066RCGD 423gp130 modulator; activates JAK/STAT signaling
4963SC 144 hydrochloridegp130 inhibitor; blocks cytokine-triggered gp130 signaling
0652ThalidomideTNF-α synthesis inhibitor; also binds cereblon
6583UCLA GP130 2gp130 agonist; brain penetrant and neuroprotectant
 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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