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제품 상세
SPRINTer Ready-to-use Assays | 표적단백질분해 확인 이미지

SPRINTer Ready-to-use Assays | 표적단백질분해 확인

SPRINTer™ eXpress™ ready-to-use assay kit은 표적 단백질 분해(TPD)를 정량적으로 검출할 수 있는 kit 입니다.

프린트 제품 문의

특징 

 

  • 소분자 치료제를 신속하게 스크리닝하고 질병관련 세포 모델에서 내인성 단백질 수준의 변화를 정량화하기 위한 키트 입니다.
  • PROTAC과 같은 표적 분해 분자에 의해 유도된 단백질 전환을 감지합니다. 



타겟  

 

  • c-Myc : oncogenesis가 일어나는 동안 master regulator 역할
  • BRD4 : c-Myc의 핵심 transcriptional modulator
  • IKZF1 : 혈액암에서 중요한 transcriptional factor
  • CDKN1A(p21) : p53등의 단백질에 의해 조절되는 핵심 cell cycle node
  • BTK : B-cell과 관련된 악성 종양에 대한 중요한 약물 타겟
  • BRAF(V600E) : 여러 종양에서의 일반적인 missense 돌연변이
  • KRAS(G12C) : 폐암, 대장암 및 여러 고형암에서의 일반적인 돌연변이 

    

 

분석 원리

  




Kit 구성

 

  • SPRINTer™ eXpress Endogenous Protein Turnover Biosensor Cells
  • Assay Complete™ Cell Plating Reagent
  • PathHunter® PL/PK Detection Kit
    • EA Reagent 
    • Lysis Buffer
    • Substrate Reagent 
    • Positive Control Peptide (ED) 
  • 96-well white-walled clear-bottom tissue culture treated plate

 



분석 과정

 


 


 

주요 제품  

 

Cat. No. Product  Size
91-1008E057CP0M SPRINTer™ eXpress BRAF(V600E) Protein Turnover Biosensor Assay (A375) 200dp (2x96well)
91-1008E057CP0L SPRINTer™ eXpress BRAF(V600E) Protein Turnover Biosensor Assay (A375) 1000dp (10x96well)
91-1004E047CP0M SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (HCT-116) 200dp (2x96well)
91-1004E047CP0L SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (HCT-116) 1000dp (10x96well)
91-1002E042CP0M SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (K562) 200dp (2x96well)
91-1002E042CP0L SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (K562) 1000dp (10x96well)
91-1005E042CP0M SPRINTer™ eXpress BTK Protein Turnover Biosensor Assay (K562) 200dp (2x96well)
91-1005E042CP0L SPRINTer™ eXpress BTK Protein Turnover Biosensor Assay (K562) 1000dp (10x96well)
91-1006E047CP0M SPRINTer™ eXpress CDKN1A (p21) Protein Turnover Biosensor Assay (HCT-116) 200dp (2x96well)
91-1006E047CP0L SPRINTer™ eXpress CDKN1A (p21) Protein Turnover Biosensor Assay (HCT-116) 1000dp (10x96well)
91-1003E047CP0M SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (HCT-116) 200dp (2x96well)
91-1003E047CP0L SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (HCT-116) 1000dp (10x96well)
91-1001E042CP0M SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (K562) 200dp (2x96well)
91-1001E042CP0L SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (K562) 1000dp (10x96well)
91-1007E042CP0M SPRINTer™ eXpress IKZF1 Protein Turnover Biosensor Assay (K562) 200dp (2x96well)
91-1007E042CP0L SPRINTer™ eXpress IKZF1 Protein Turnover Biosensor Assay (K562) 1000dp (10x96well)
91-1009E015CP0M SPRINTer™ eXpress KRAS(G12C) Protein Turnover Biosensor Assay (A549) 200dp (2x96well)
91-1009E015CP0L SPRINTer™ eXpress KRAS(G12C) Protein Turnover Biosensor Assay (A549) 1000dp (10x96well)

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
SPRINTer™ eXpress BRAF(V600E) Protein Turnover Biosensor Assay (A375) 91-1008E057CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BRAF(V600E) Protein Turnover Biosensor Assay (A375) 91-1008E057CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (HCT-116) 91-1004E047CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (HCT-116) 91-1004E047CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (K562) 91-1002E042CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (K562) 91-1002E042CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BTK Protein Turnover Biosensor Assay (K562) 91-1005E042CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress BTK Protein Turnover Biosensor Assay (K562) 91-1005E042CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (HCT-116) 91-1003E047CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (HCT-116) 91-1003E047CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (K562) 91-1001E042CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (K562) 91-1001E042CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress CDKN1A (p21) Protein Turnover Biosensor Assay (HCT-116) 91-1006E047CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress CDKN1A (p21) Protein Turnover Biosensor Assay (HCT-116) 91-1006E047CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress IKZF1 Protein Turnover Biosensor Assay (K562) 91-1007E042CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress IKZF1 Protein Turnover Biosensor Assay (K562) 91-1007E042CP0M 200dp (2x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress KRAS(G12C) Protein Turnover Biosensor Assay (A549) 91-1009E015CP0L 1000dp (10x96well) EUROFINS DISCOVERX
SPRINTer™ eXpress KRAS(G12C) Protein Turnover Biosensor Assay (A549) 91-1009E015CP0M 200dp (2x96well) EUROFINS DISCOVERX
전체보기
Maker
EUROFINS DISCOVERX
Cat.No.
91-1008E057CP0M
Product
SPRINTer™ eXpress BRAF(V600E) Protein Turnover Biosensor Assay (A375)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1008E057CP0L
Product
SPRINTer™ eXpress BRAF(V600E) Protein Turnover Biosensor Assay (A375)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1004E047CP0L
Product
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (HCT-116)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1004E047CP0M
Product
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (HCT-116)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1002E042CP0L
Product
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (K562)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1002E042CP0M
Product
SPRINTer™ eXpress BRD4 Protein Turnover Biosensor Assay (K562)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1005E042CP0L
Product
SPRINTer™ eXpress BTK Protein Turnover Biosensor Assay (K562)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1005E042CP0M
Product
SPRINTer™ eXpress BTK Protein Turnover Biosensor Assay (K562)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1003E047CP0L
Product
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (HCT-116)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1003E047CP0M
Product
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (HCT-116)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1001E042CP0L
Product
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (K562)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1001E042CP0M
Product
SPRINTer™ eXpress c-Myc Protein Turnover Biosensor Assay (K562)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1006E047CP0M
Product
SPRINTer™ eXpress CDKN1A (p21) Protein Turnover Biosensor Assay (HCT-116)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1006E047CP0L
Product
SPRINTer™ eXpress CDKN1A (p21) Protein Turnover Biosensor Assay (HCT-116)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1007E042CP0L
Product
SPRINTer™ eXpress IKZF1 Protein Turnover Biosensor Assay (K562)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1007E042CP0M
Product
SPRINTer™ eXpress IKZF1 Protein Turnover Biosensor Assay (K562)
Size
200dp (2x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1009E015CP0L
Product
SPRINTer™ eXpress KRAS(G12C) Protein Turnover Biosensor Assay (A549)
Size
1000dp (10x96well)
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
91-1009E015CP0M
Product
SPRINTer™ eXpress KRAS(G12C) Protein Turnover Biosensor Assay (A549)
Size
200dp (2x96well)
Qty
Data Sheet
전체보기

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주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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