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생물학적 노화에 의한 염증 연구 | Senescence-Induced Inflammation antibodies 이미지

생물학적 노화에 의한 염증 연구 | Senescence-Induced Inflammation antibodies

생물학적 노화에 의한 염증 연구에 이용되는 cGAS-STING-NFkB signaling 항체 (anti-cGAS, anti-TMEM173/STING) 와 SASP factors 용 ELISA Kit을 소개합니다.

특징 


  • 생물학적 노화(senescnece)에 의해 유도된 염증은 암, 퇴행성신경계 질환, 심혈관 질환, 노화(aging) 등과 같은 나이와 관련된 다양한 질병과 관련됩니다.
  • 생물학적으로 노화된세포는 염증 사이토카인, 면역 조절제, SASP(senescence-associated secretory phenotype)라고 알려진 단백질 분해효소 등을 분비하여 만성적이고 무균인 염증을 일으킵니다
  • cGAS(Cyclic GMP–AMP synthase)는 선천성 면역을 활성화하는 세포질 DNA센서로 SASP 유도 핵심 조절자입니다
  • cGAS 신호와 SASP 유도의 조절은 생물학적 노화 관련 질환을 치료하는 새로운 전략으로 고려되고 있습니다.
  • senescnece에 의해 유도된 염증을 detection하기 위한 anti-cGAS, anti-TMEM173 / STING, anti-NFkB p65 phospho (Ser536)에 대한 항체를 제공합니다. 

 

 

 

 

  •  /종양
  • 퇴행성 신경계 질환
  • 2종 당뇨
  • 면역계 질환
  • 녹내장

 

 

 

cGAS-STING-NFkB signaling 항체

 

anti-cGAS antibody (#ARG54961)
Product Description Rabbit Polyclonal antibody recognizes cGAS
Tested Reactivity Hu
Tested Application FACS, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name cGAS
Antigen Species Human
Immunogen KLH-conjugated synthetic peptide corresponding to aa. 266-295 (Center) of Human cGAS.
Conjugation Un-conjugated
Alternate Names cGAMP synthase; Cyclic GMP-AMP synthase; Mab-21 domain-containing protein 1; C6orf150; EC 2.7.7.86; cGAS; h-cGAS
   
anti-TMEM173 / STING phospho (Ser366) antibody (#ARG43199)
Product Description Rabbit Polyclonal antibody recognizes TMEM173 / STING phospho (Ser366)
Tested Reactivity Hu, Ms
Tested Application WB
Specificity The antibody detects endogenous levels of TMEM173 / STING only when phosphorylated at Ser366.
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name TMEM173 / STING
Antigen Species Human
Immunogen Phosphospecific peptide around Ser366 of Human TMEM173 / STING.
Conjugation Un-conjugated
Alternate Names MPYS; hSTING; hMITA; Transmembrane protein 173; ERIS; STING; Stimulator of interferon genes protein; Mediator of IRF3 activation; SAVI; Endoplasmic reticulum interferon stimulator; NET23; MITA
anti-NFkB p65 phospho (Ser536) antibody (#ARG51518)
Product Description Rabbit Polyclonal antibody recognizes NFkB p65 phospho (Ser536)
Tested Reactivity Hu, Ms, Rat
Tested Application ICC/IF, IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name NFkB p65
Antigen Species Human
Immunogen Peptide sequence around phosphorylation site of serine 536 (F-S-S(p)-I-A) derived from Human NFκB-p65.
Conjugation Un-conjugated
Alternate Names Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; NFKB3; p65; Transcription factor p65

 

 

 


 

SASP factors 용 ELISA Kits

 

  •  IL-1 alpha:Human (ARG80191), Mouse (ARG80204), Rat (ARG80237)
  • IL-6:Human (ARG80110), Mouse (ARG80199), Rat (ARG80233)
  • IL-8:Human (ARG80111)
  • CXCL1:Human (ARG81631), Mouse (ARG80208), Rat (ARG80236)
  • CXCL12:Human (ARG82247), Mouse (ARG82061)
  • HMGB1:Human (ARG81185), Mouse/Rat (ARG81310)
  • IGFBP3:Human (ARG80494)
  • Fibronectin:Human (ARG81301), Mouse (ARG82323), Rat (ARG81644)
  • MMP1:Human (ARG80145), Mouse (ARG82074), Rat (ARG82075)
  • MMP3:Human (ARG81267), Mouse (ARG81662), Rat (ARG82625) 

 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
anti-BRD4 antibody ARG56161 100 ul ARIGO
anti-cGAS antibody ARG54961 100 ul ARIGO
anti-cGAS antibody ARG43036 100 ul ARIGO
anti-cGAS antibody ARG40192 100 ul ARIGO
anti-GATA4 antibody ARG41629 100 ul ARIGO
anti-HMGB2 antibody ARG57506 100 ul ARIGO
anti-TMEM173 / STING phospho (Ser366) antibody ARG43199 50 ul ARIGO
Human CXCL1 (GRO alpha) ELISA Kit ARG81631 96 wells ARIGO
Human Fibronectin ELISA Kit ARG81301 96 wells ARIGO
Human IGFBP3 ELISA Kit ARG80494 96 wells ARIGO
Human IL-1 alpha ELISA Kit ARG80191 96 wells ARIGO
Human IL-6 ELISA Kit ARG80110 96 wells ARIGO
Human IL-8 ELISA Kit ARG80111 96 wells ARIGO
Mouse Cxcl1 ELISA Kit ARG80208 96 wells ARIGO
Mouse CXCL12 / SDF1 ELISA Kit ARG82061 96 wells ARIGO
Mouse Fibronectin ELISA Kit ARG82323 96 wells ARIGO
Mouse IL-1 alpha ELISA Kit ARG80204 96 wells ARIGO
Mouse IL-6 ELISA Kit ARG80199 96 wells ARIGO
Rat CXCL1 / CINC1 ELISA Kit ARG80236 96 wells ARIGO
Rat Fibronectin ELISA Kit ARG81644 96 wells ARIGO
Rat IL-1 alpha ELISA Kit ARG80237 96 wells ARIGO
Rat IL-6 ELISA Kit ARG80233 96 wells ARIGO
전체보기
Maker
ARIGO
Cat.No.
ARG56161
Product
anti-BRD4 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG54961
Product
anti-cGAS antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG43036
Product
anti-cGAS antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG40192
Product
anti-cGAS antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG41629
Product
anti-GATA4 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57506
Product
anti-HMGB2 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG43199
Product
anti-TMEM173 / STING phospho (Ser366) antibody
Size
50 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG81631
Product
Human CXCL1 (GRO alpha) ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG81301
Product
Human Fibronectin ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80494
Product
Human IGFBP3 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80191
Product
Human IL-1 alpha ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80110
Product
Human IL-6 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80111
Product
Human IL-8 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80208
Product
Mouse Cxcl1 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG82061
Product
Mouse CXCL12 / SDF1 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG82323
Product
Mouse Fibronectin ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80204
Product
Mouse IL-1 alpha ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80199
Product
Mouse IL-6 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80236
Product
Rat CXCL1 / CINC1 ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG81644
Product
Rat Fibronectin ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80237
Product
Rat IL-1 alpha ELISA Kit
Size
96 wells
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG80233
Product
Rat IL-6 ELISA Kit
Size
96 wells
Qty
Data Sheet
전체보기

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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Cat.No.
Product
Size
Qty
Data Sheet
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