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아드레날린 수용체 연구 | GPCR Adrenergic Receptor Agonist & Antagonist 이미지

아드레날린 수용체 연구 | GPCR Adrenergic Receptor Agonist & Antagonist

Adrenergic Receptor 연구에 필요한 Agonist와 Antagonist를 소개합니다. Adrenergic Receptor (Adrenoceptors) 는 catecholamines like norepinephrine (noradrenaline)과 epinephrine (adrenaline)에 작용합니다

특징 

  

  • Adrenergic receptor (Adrenoceptor)는 α와 β의 주요 그룹으로 분리되며, Adrenaline/epinephrine이라는 신경전달물질(호르몬)과 작용하는 수용체 입니다. 
  • α그룹은 α1, α2로, 그리고 좀더 세분화된 α1A, α1B, α1D, α2A, α2B, α2C로 나뉘어 지고, β 그룹은 β1, β2, β3 subgroup으로, β 그룹은 β1, β2, β3 subgroup으로 나뉘어 지며, 각 subtype은 여러 장기에서 근육, 혈관 수축 등의 기능에 관여합니다. 

 

 

주요 제품 

Adrenergic α1 Receptors
Cat. No. Product  Activity
2838 (R)-(-)-Phenylephrine hydrochloride α1 agonist
1052 A 61603 hydrobromide α1A agonist
2685 Carvedilol Potent α1 antagonist; also potent and non-selective β antagonist
0888 Cirazoline hydrochloride Selective α1 agonist
2964 Doxazosin mesylate α1 antagonist
0535 HEAT hydrochloride Highly selective α1 antagonist
0545 Ifenprodil hemitartrate α1 antagonist. Also NMDA antagonist and σ ligand
0597 Naftopidil hydrochloride α1 antagonist
0623 Prazosin hydrochloride α1 and α2B antagonist; also MT3 antagonist
1325 RS 100329 hydrochloride Potent, subtype-selective α1A antagonist
0985 RS 17053 hydrochloride α1A antagonist
6663 Silodosin Selective α1A antagonist
3050 Tamsulosin hydrochloride Selective α1A antagonist
1506 Terazosin hydrochloride α1 and α2B antagonist (α1 > α2B). Orally active
6336 Trazodone hydrochloride 5-HT2A and α1 adrenoceptor antagonist; also enhances neural differentiation
Adrenergic α2 Receptors
Cat. No. Product  Activity
0928 ARC 239 dihydrochloride α2B antagonist
2937 Atipamezole hydrochloride Selective α2 antagonist
2758 B-HT 933 dihydrochloride Selective α2 agonist
1133 BRL 44408 maleate Selective α2A antagonist
0690 Clonidine hydrochloride α2 agonist. Also I1 ligand
2749 Dexmedetomidine hydrochloride Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)
0885 Guanabenz acetate α2 agonist. Also I2 selective ligand
1030 Guanfacine hydrochloride α2A agonist
0986 Imiloxan hydrochloride Highly selective α2B antagonist
2666 JP 1302 dihydrochloride Potent and selective α2C antagonist
5160 Medetomidine hydrochloride Potent and highly selective α2 agonist
2018 Mirtazapine α2 antagonist; also potent 5-HT2, 5-HT3 and H1 antagonist; antidepressant
0623 Prazosin hydrochloride α2B and α1 antagonist; also MT3 antagonist
0790 Rilmenidine hemifumarate I1 ligand. Also α2 agonist.
0987 RS 79948 hydrochloride Potent and selective α2 antagonist
1324 RX 821002 hydrochloride Potent, selective α2D antagonist
3866 SKF 86466 hydrochloride Potent and selective α2 antagonist
3609 Tizanidine hydrochloride α2 agonist
0425 UK 14,304 α2 agonist
2466 UK 14,304 tartrate α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)
1127 Yohimbine hydrochloride Selective α2 antagonist
Adrenergic β1 Receptors
Cat. No. Product  Activity
0906 Betaxolol hydrochloride Selective β1 antagonist
1024 CGP 20712 dihydrochloride Highly potent and selective β1 antagonist
3256 Metoprolol tartrate Selective β1 antagonist
3517 Nebivolol hydrochloride Highly selective β1-adrenoceptor antagonist
0950 Xamoterol hemifumarate Selective β1 partial agonist
Adrenergic β2 Receptors
Cat. No. Product  Activity
6219 Arformoterol tartrate Long-acting β2 agonist (LABA)
1448 Formoterol hemifumarate Potent and selective β2 agonist
0821 ICI 118,551 hydrochloride Highly selective β2 inverse agonist
1102 Procaterol hydrochloride Potent β2 agonist
0634 Salbutamol hemisulfate β2-adrenoceptor agonist
4712 Salmeterol xinafoate Long-acting β2 agonist; bronchodilator
1051 Zinterol hydrochloride Selective β2 agonist
Adrenergic β3 Receptors
Cat. No. Product  Activity
1060 (S)-(-)-Pindolol β3 partial agonist; also 5-HT1A and 5-HT1B antagonist; more active enantiomer of pindolol
0948 BRL 37344, sodium salt β3 agonist
1134 CGP 12177 hydrochloride β3 partial agonist. β1/β2 antagonist
1499 CL 316243 disodium salt Highly selective β3 agonist
2760 L-748,337 Selective β3 antagonist
2197 L-755,507 Very potent and selective β3 partial agonist
7070 Mirabegron Potent and selective β3 agonist
3986 SR 58611A hydrochloride β3 agonist; displays anxiolytic and antidepressant effects
1511 SR 59230A hydrochloride Potent and selective β3 antagonist

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
(R)-(+)-Propranolol hydrochloride (100 mg) 0835 100 mg TOCRIS
(S)-(-)-Propranolol hydrochloride (100 mg) 0834 100 mg TOCRIS
Arformoterol tartrate (10 MG) 6219 10 mg TOCRIS
Arformoterol tartrate (50 MG) 6219 50 mg TOCRIS
Betaxolol hydrochloride (10 mg) 0906 10 mg TOCRIS
Betaxolol hydrochloride (50 mg) 0906 50 mg TOCRIS
BRL 37344, sodium salt (10 mg) 0948 10 mg TOCRIS
BRL 37344, sodium salt (50 mg) 0948 50 mg TOCRIS
Carvedilol (50 mg) 2685 50 mg TOCRIS
CGP 12177 hydrochloride (10 mg) 1134 10 mg TOCRIS
CGP 12177 hydrochloride (50 mg) 1134 50 mg TOCRIS
Desipramine hydrochloride (50 mg) 3067 50 mg TOCRIS
Dobutamine hydrochloride (50 mg) 0515 50 mg TOCRIS
L-748,337 (10 mg) 2760 10 mg TOCRIS
L-748,337 (50 mg) 2760 50 mg TOCRIS
Mirabegron (25 MG) 7070 25 mg TOCRIS
Mirabegron (5 MG) 7070 5 mg TOCRIS
Nebivolol hydrochloride (10 mg) 3517 10 mg TOCRIS
Nebivolol hydrochloride (50 mg) 3517 50 mg TOCRIS
Nisoxetine hydrochloride (10 mg) 1025 10 mg TOCRIS
Nisoxetine hydrochloride (50 mg) 1025 50 mg TOCRIS
Noradrenaline bitartrate (50 mg) 5169 50 mg TOCRIS
Phentolamine Mesylate (100 MG) 6431 100 mg TOCRIS
Procaterol hydrochloride (10 mg) 1102 10 mg TOCRIS
Procaterol hydrochloride (50 mg) 1102 50 mg TOCRIS
Salbutamol hemisulfate (250 mg) 0634 250 mg TOCRIS
Silodosin (10 MG) 6663 10 mg TOCRIS
Silodosin (50 MG) 6663 50 mg TOCRIS
Sotalol hydrochloride (10 mg) 0952 10 mg TOCRIS
Sotalol hydrochloride (50 mg) 0952 50 mg TOCRIS
SR 59230A hydrochloride (10 mg) 1511 10 mg TOCRIS
SR 59230A hydrochloride (50 mg) 1511 50 mg TOCRIS
Talopram hydrochloride (10 mg) 3145 10 mg TOCRIS
Talopram hydrochloride (50 mg) 3145 50 mg TOCRIS
Xamoterol hemifumarate (10 mg) 0950 10 mg TOCRIS
Xamoterol hemifumarate (50 mg) 0950 50 mg TOCRIS
ZD 2079 (10 mg) 2154 10 mg TOCRIS
ZD 2079 (50 mg) 2154 50 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
0835
Product
(R)-(+)-Propranolol hydrochloride (100 mg)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0834
Product
(S)-(-)-Propranolol hydrochloride (100 mg)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6219
Product
Arformoterol tartrate (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6219
Product
Arformoterol tartrate (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0906
Product
Betaxolol hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0906
Product
Betaxolol hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0948
Product
BRL 37344, sodium salt (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0948
Product
BRL 37344, sodium salt (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2685
Product
Carvedilol (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1134
Product
CGP 12177 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1134
Product
CGP 12177 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3067
Product
Desipramine hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0515
Product
Dobutamine hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2760
Product
L-748,337 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2760
Product
L-748,337 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7070
Product
Mirabegron (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7070
Product
Mirabegron (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3517
Product
Nebivolol hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3517
Product
Nebivolol hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1025
Product
Nisoxetine hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1025
Product
Nisoxetine hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5169
Product
Noradrenaline bitartrate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6431
Product
Phentolamine Mesylate (100 MG)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1102
Product
Procaterol hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1102
Product
Procaterol hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0634
Product
Salbutamol hemisulfate (250 mg)
Size
250 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6663
Product
Silodosin (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6663
Product
Silodosin (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0952
Product
Sotalol hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0952
Product
Sotalol hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1511
Product
SR 59230A hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1511
Product
SR 59230A hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3145
Product
Talopram hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3145
Product
Talopram hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0950
Product
Xamoterol hemifumarate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0950
Product
Xamoterol hemifumarate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2154
Product
ZD 2079 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2154
Product
ZD 2079 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
전체보기

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