우울증 연구 | Depression Research Small Molecules

시약 및 기기 상세

우울증 연구 | Depression Research Small Molecules

우울증 연구에 관련된 Tocris Inhibitors & Activators를 안내합니다.

프린트 제품 문의

Depression 이란?

우울장애는 복잡하고 다양한 신경생물학적 병인을 가진 이질적인 상태입니다. 우울증 원인의 40-050%는 유전적이며, 나머지는 환경적 스트레스 요인에 의해 발생합니다.
전통적으로 우울증은 뇌 내 monoamine 기능의 저하로 야기되었다고 알려져 있습니다. (모노아민 가설) 특히 관련된 뇌 영역은 해마, 전두엽 및 대상피질, 편도체를 포함하는 것으로 여겨지며, 도파민성 보상 경로에는 시상하부가 관련될 수 있습니다.
우울증은 또한 생물학적 스트레스 반응 기전, 특히 시상하부-뇌하수체-아드레날 (HPA) 축의 강화로 발생할 수 있으며, 이는 뇌척수액과 시상하부에서 CRF (corticotrophin releasing factor)의 발현 증가와 관련이 있습니다.
우울증의 약물 치료는 모노아민 시스템의 강화에 중점을 둡니다. monoamine oxidase (MAO) inhibitor는 serotonin, noradrenalin, dopamine 효소 분해를 감소시킵니다.
CRF antagonists, GR antagonists, cytokines, melatonin receptor agonists, TrkB agonists, histone deacetylase (HDAC) inhibitors, κ-opioid receptor antagonists 같은 비 모노아민 시스템에 촛점을 맞춘 새로운 약리학적 타겟에 대한 연구가 활발히 진행중입니다.

주요 제품

Target	Cat. No	Product
Adrenergic Receptors (α1-AR)	2838	(R)-(-)-Phenylephrin
	1052	A 61603
	0888	Cirazoline
	0623	Prazosin
Adrenergic Receptors (α2-AR)	2749	Dexmedetomidine
	0986	Imiloxan
	0987	RS 79948
Adrenergic Receptors (β-AR)	1747	Isoproterenol
	0624	Propranolol
	3986	SR 58611A
CRF-R	2391	Astressin 2B
	3212	CP 376395
	1151	CRF (human, rat)
	3100	NBI 35965
	1608	Stressin I
Dopamine Receptors (D1/D5)	0925	SCH 23390
	2299	SCH 39166
	1447	SKF 81297
Dopamine Receptors (D2)	1003	L-741,626
	1061	(-)-Quinpirole
	2773	Sumanirole
FGFR	3044	PD 173074
	3300	SU 5402
	3335	SU 6668
Glutamate Receptors	1611	Lamotrigine
Glutamate Receptors	0768	Riluzole
Glutamate Receptors (AMPA)	0254	(S)-AMPA
	2980	CX 546
	0713	Cyclothiazide
	2555	GYKI 53655
	2766	Naspm
Glutamate Receptors (mGlu1/5)	5000	FTIDC
	2333	JNJ 16259685
	5275	LSN 2463359
	1237	LY 367385
	1212	MPEP
	2921	MTEP
	4346	Ro 67-7476
Glutamate Receptors (mGlu2)	1209	LY 341495
	3246	LY 354740
	2453	LY 379268
	3283	LY 487379
Glutamate Receptors (NMDA)	0106	D-AP5
	0286	5,7-Dichlorokynurenic acid
	4491	DQP 1105
	0545	Ifenprodil
	0742	L-689,560
	0773	Memantine
	0924	(+)-MK 801
	1594	Ro 25-6981
GR	2007	Fluticasone
GR	1479	Mifepristone
Ion Channels (ASIC)	5042	Psalmotoxin 1
Ion Channels (Cav)	2198	Mibefradil
Ion Channels (Cav)	2945	SNX 482
Ion Channels (TASK-3)	5337	ML 365
Ion Channels (TREK)	3797	BL 1249
Ion Channels (TREK)	5594	Spadin
Monoamine Oxidase	2460	Lazabemide
	4395	Moclobemide
	0724	Pirlindole
Muscarinic Receptors	1414	Scopolamine
	3569	Xanomeline
	3727	VU 0255035
Neurotransmitter Transporters (DAT)	2831	Bupropion
Neurotransmitter Transporters (DAT)	0421	GBR 12909
Neurotransmitter Transporters (NET)	1982	Reboxetine
Neurotransmitter Transporters (NET)	2011	Tomoxetine
Neurotransmitter Transporters (EAAT)	0111	Dihydrokainic
	1223	DL-TBOA
	2532	TFB-TBOA
Neurotransmitter Transporters (SERT)	1427	Citalopram
	0927	Fluoxetine
	2395	Sertraline
Serotonin Receptors (5-HT1A)	0529	8-Hydroxy-DPAT
Serotonin Receptors (5-HT2)	0444	Clozapine
	4173	MDL 100907
	2592	TCB-2
Serotonin Receptors (5-HT4)	4374	BIMU 8
	1322	GR 113808
	1658	GR 125487
Serotonin Receptors (5-HT5)	3188	SB 699551
Serotonin Receptors (5-HT7)	1968	AS 19
	2726	SB 258719
	1612	SB 269970
TrkB Receptor	4781	ANA 12
	2837	BDNF
	4607	LM 22A4
Signal Transduction (AC)	1099	Forskolin
	1603	NKH 477
	1435	SQ 22536
Signal Transduction (Akt)	2558	10-DEBC
	3897	API-1
	4144	GSK 690693
Signal Transduction (Ca2+ Signaling)	1234	A23187
Signal Transduction (Ca2+ Signaling)	2092	Ionomycin
Signal Transduction (CAMK)	4483	A 484954
	1278	KN 93
	1551	STO-609
Signal Transduction (DNMTs)	2624	Decitabine
	5155	SGI 1027
	2293	Zebularine
Signal Transduction (GSK-3)	3194	BIO
	1616	SB 216763
	1617	SB 415286
Signal Transduction (HDACs)	3515	FK 228
	4652	SAHA
	1406	Trichostatin A
Signal Transduction (MEK)	4842	BIX 02189
	4192	PD 0325901
	1213	PD 98059
	1969	SL 327
	1144	U0126
Signal Transduction (mTOR)	3725	KU 0063794
	1292	Rapamycin
	5264	Temsirolimus
	4247	Torin 1
Signal Transduction (NO)	1200	Nω-Propyl-L-arginine
Signal Transduction (NO)	0598	SNAP
Signal Transduction (PDE)	2845	IBMX
Signal Transduction (PDE)	0905	Rolipram
Signal Transduction (PI3K)	1130	LY 294002
	1983	740 Y-P
	1232	Wortmannin
Signal Transduction (PKA)	2910	H 89
	1288	KT 5720
	2546	PKI 14-22
Signal Transduction (PLC)	1437	D609
Signal Transduction (PLC)	1268	U 73122
Signal Transduction (Raf)	1381	GW 5074
Signal Transduction (Raf)	2650	SB 590885
Tachykinin Receptors	1669	GR 73632
	1145	L-733,060
	1635	RP 67580
Vasopressin Receptors	2935	[Arg8]-Vasopressin
Vasopressin Receptors	2310	SR 49059

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
Product	Cat.No.	Size	Maker
(-)-Quinpirole hydrochloride (10 mg)	1061	10 mg	TOCRIS
(-)-Quinpirole hydrochloride (50 mg)	1061	50 mg	TOCRIS
(R)-(-)-Phenylephrine hydrochloride (100 mg)	2838	100 mg	TOCRIS
(S)-AMPA (1 mg)	0254	1 mg	TOCRIS
(S)-AMPA (10 mg)	0254	10 mg	TOCRIS
(S)-AMPA (50 mg)	0254	50 mg	TOCRIS
5,7-Dichlorokynurenic acid (10 mg)	0286	10 mg	TOCRIS
5,7-Dichlorokynurenic acid (50 mg)	0286	50 mg	TOCRIS
740 Y-P (1 mg)	1983	1 mg	TOCRIS
A 484954 (10 mg)	4483	10 mg	TOCRIS
A 484954 (50 mg)	4483	50 mg	TOCRIS
A 61603 hydrobromide (10 mg)	1052	10 mg	TOCRIS
A 61603 hydrobromide (50 mg)	1052	50 mg	TOCRIS
Aniracetam (250 mg)	0867	250 mg	TOCRIS
Aniracetam (50 mg)	0867	50 mg	TOCRIS
AS 19 (10 mg)	1968	10 mg	TOCRIS
AS 19 (50 mg)	1968	50 mg	TOCRIS
Astressin 2B (500 ug)	2391	500 ug	TOCRIS
BDNF (human) (10 ug)	2837	10 ug	TOCRIS
BIMU 8 (25 MG)	4374	25 mg	TOCRIS
BIMU 8 (5 MG)	4374	5 mg	TOCRIS
BL 1249 (10 mg)	3797	10 mg	TOCRIS
BL 1249 (50 mg)	3797	50 mg	TOCRIS
Bupropion hydrochloride (50 mg)	2831	50 mg	TOCRIS
Cirazoline hydrochloride (10 mg)	0888	10 mg	TOCRIS
Citalopram hydrobromide (10 mg)	1427	10 mg	TOCRIS
Citalopram hydrobromide (50 mg)	1427	50 mg	TOCRIS
Clozapine (50 mg)	0444	50 mg	TOCRIS
Clozapine (500 mg)	0444	500 mg	TOCRIS
CP 376395 hydrochloride (10 mg)	3212	10 mg	TOCRIS
CP 376395 hydrochloride (50 mg)	3212	50 mg	TOCRIS
CRF (human, rat) (200 ug)	1151	200 ug	TOCRIS
CX 546 (10 mg)	2980	10 mg	TOCRIS
CX 546 (50 mg)	2980	50 mg	TOCRIS
Cyclothiazide (10 mg)	0713	10 mg	TOCRIS
Cyclothiazide (50 mg)	0713	50 mg	TOCRIS
Decitabine (10 mg)	2624	10 mg	TOCRIS
Decitabine (50 mg)	2624	50 mg	TOCRIS
Dexmedetomidine hydrochloride (10 mg)	2749	10 mg	TOCRIS
Dexmedetomidine hydrochloride (50 mg)	2749	50 mg	TOCRIS
Dihydrokainic acid (1 mg)	0111	1 mg	TOCRIS
Dihydrokainic acid (10 mg)	0111	10 mg	TOCRIS
Dihydrokainic acid (50 mg)	0111	50 mg	TOCRIS
DL-TBOA (10 mg)	1223	10 mg	TOCRIS
DL-TBOA (50 mg)	1223	50 mg	TOCRIS
DQP 1105 (10 mg)	4491	10 mg	TOCRIS
DQP 1105 (50 mg)	4491	50 mg	TOCRIS
Fluoxetine hydrochloride (10 mg)	0927	10 mg	TOCRIS
Fluoxetine hydrochloride (50 mg)	0927	50 mg	TOCRIS
Fluticasone propionate (10 mg)	2007	10 mg	TOCRIS

전체보기

1
Maker	TOCRIS
Cat.No.	1061
Product	(-)-Quinpirole hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

2
Maker	TOCRIS
Cat.No.	1061
Product	(-)-Quinpirole hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

3
Maker	TOCRIS
Cat.No.	2838
Product	(R)-(-)-Phenylephrine hydrochloride (100 mg)
Size	100 mg
Qty
Data Sheet
MSDS

4
Maker	TOCRIS
Cat.No.	0254
Product	(S)-AMPA (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

5
Maker	TOCRIS
Cat.No.	0254
Product	(S)-AMPA (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

6
Maker	TOCRIS
Cat.No.	0254
Product	(S)-AMPA (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

7
Maker	TOCRIS
Cat.No.	0286
Product	5,7-Dichlorokynurenic acid (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

8
Maker	TOCRIS
Cat.No.	0286
Product	5,7-Dichlorokynurenic acid (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

9
Maker	TOCRIS
Cat.No.	1983
Product	740 Y-P (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

10
Maker	TOCRIS
Cat.No.	4483
Product	A 484954 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

11
Maker	TOCRIS
Cat.No.	4483
Product	A 484954 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

12
Maker	TOCRIS
Cat.No.	1052
Product	A 61603 hydrobromide (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

13
Maker	TOCRIS
Cat.No.	1052
Product	A 61603 hydrobromide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

14
Maker	TOCRIS
Cat.No.	0867
Product	Aniracetam (250 mg)
Size	250 mg
Qty
Data Sheet
MSDS

15
Maker	TOCRIS
Cat.No.	0867
Product	Aniracetam (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

16
Maker	TOCRIS
Cat.No.	1968
Product	AS 19 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

17
Maker	TOCRIS
Cat.No.	1968
Product	AS 19 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

18
Maker	TOCRIS
Cat.No.	2391
Product	Astressin 2B (500 ug)
Size	500 ug
Qty
Data Sheet
MSDS

19
Maker	TOCRIS
Cat.No.	2837
Product	BDNF (human) (10 ug)
Size	10 ug
Qty
Data Sheet
MSDS

20
Maker	TOCRIS
Cat.No.	4374
Product	BIMU 8 (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

21
Maker	TOCRIS
Cat.No.	4374
Product	BIMU 8 (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

22
Maker	TOCRIS
Cat.No.	3797
Product	BL 1249 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

23
Maker	TOCRIS
Cat.No.	3797
Product	BL 1249 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

24
Maker	TOCRIS
Cat.No.	2831
Product	Bupropion hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

25
Maker	TOCRIS
Cat.No.	0888
Product	Cirazoline hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

26
Maker	TOCRIS
Cat.No.	1427
Product	Citalopram hydrobromide (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

27
Maker	TOCRIS
Cat.No.	1427
Product	Citalopram hydrobromide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

28
Maker	TOCRIS
Cat.No.	0444
Product	Clozapine (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

29
Maker	TOCRIS
Cat.No.	0444
Product	Clozapine (500 mg)
Size	500 mg
Qty
Data Sheet
MSDS

30
Maker	TOCRIS
Cat.No.	3212
Product	CP 376395 hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

31
Maker	TOCRIS
Cat.No.	3212
Product	CP 376395 hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

32
Maker	TOCRIS
Cat.No.	1151
Product	CRF (human, rat) (200 ug)
Size	200 ug
Qty
Data Sheet
MSDS

33
Maker	TOCRIS
Cat.No.	2980
Product	CX 546 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

34
Maker	TOCRIS
Cat.No.	2980
Product	CX 546 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

35
Maker	TOCRIS
Cat.No.	0713
Product	Cyclothiazide (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

36
Maker	TOCRIS
Cat.No.	0713
Product	Cyclothiazide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

37
Maker	TOCRIS
Cat.No.	2624
Product	Decitabine (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

38
Maker	TOCRIS
Cat.No.	2624
Product	Decitabine (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

39
Maker	TOCRIS
Cat.No.	2749
Product	Dexmedetomidine hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

40
Maker	TOCRIS
Cat.No.	2749
Product	Dexmedetomidine hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

41
Maker	TOCRIS
Cat.No.	0111
Product	Dihydrokainic acid (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

42
Maker	TOCRIS
Cat.No.	0111
Product	Dihydrokainic acid (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

43
Maker	TOCRIS
Cat.No.	0111
Product	Dihydrokainic acid (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

44
Maker	TOCRIS
Cat.No.	1223
Product	DL-TBOA (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

45
Maker	TOCRIS
Cat.No.	1223
Product	DL-TBOA (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

46
Maker	TOCRIS
Cat.No.	4491
Product	DQP 1105 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

47
Maker	TOCRIS
Cat.No.	4491
Product	DQP 1105 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

48
Maker	TOCRIS
Cat.No.	0927
Product	Fluoxetine hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

전체보기

자료

Metabotropic Glutamate Receptors

[TOCRIS]

mGluR의 pharmacological review를 제공합니다.
Depression Poster

[TOCRIS]

Depression pathway poster 입니다.
Inhibitor Book Vol.4

고마뉴스 자료신청 [KOMA]

다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

우울증 연구 | Depression Research Small Molecules | 고마바이오텍

우울증 연구 | Depression Research Small Molecules

주문정보

추천제품

관련제품

자료

웨비나/Video

제품 문의

로그인