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GPCR Pharmacology Inhibitors & Activators 이미지

GPCR Pharmacology Inhibitors & Activators

GPCR 매커니즘에 관련된 inhibitor & activator를 안내합니다.

프린트 제품 문의

특징 

 

  • G protein-coupled receptors (GPCR)은 7-Transmembrane receptor (7-TM receptor)라고도 하며, 7개의 막을 가로지르는 나선을 포함하는 통합 막 단백질입니다. 이들은 막의 세포내 측면에 있는 heterotrimeric G protein과 결합됩니다. 리간드 결합 시, GPCR은 형태가 변형되며 G 단백질로 신호를 전달하여 활성화시킵니다. 
  • GPCRs/7-TM receptors는 빛, 후각 자극제, 펩타이드, 호르몬 및 신경 전달 물질을 포함한 다양한 리간드에 의해 활성화되며 6가지 class로 분류됩니다. 
    • Class A (or 1) (Rhodopsin-like)
    • Class B (or 2) (Secretin receptor family)
    • Class C (or 3) (Metabotropic glutamate/pheromone)
    • Class D (or 4) (Fungal mating pheromone receptors)
    • Class E (or 5) (Cyclic AMP receptors)
    • Class F (or 6) (Frizzled/Smoothened)

 

 

GPCR 종류 

 

  • 5-HT Receptors
  • Acetylcholine Muscarinic Receptors
  • Adenosine Receptors
  • Adrenergic Receptors
  • Calcium-Sensing Receptor
  • Cannabinoid Receptors
  • Chemokine Receptors
  • Dopamine Receptors
  • Estrogen (GPER) Receptors
  • Free Fatty Acid Receptors
  • GABAB Receptors
  • Glutamate (Metabotropic) Receptors
  • GPBA Receptors
  • GPR119
  • GPR35
  • GPR55
  • Histamine Receptors
  • Hydroxycarboxylic Acid Receptors
  • Leukotriene and Related Receptors
  • Lysophosphatidic Acid Receptors
  • Melatonin Receptors
  • Opioid Receptors
  • Orphan 7-TM Receptors
  • Peptide Receptors
  • Platelet-Activating Factor (PAF) Receptors
  • Prostanoid Receptors
  • Purinergic (P2Y) Receptors
  • Smoothened Receptors
  • Sphingosine-1-Phosphate Receptors
  • Trace Amine 1 Receptor

  

 

주요 제품

 

Target Cat. No. Product
5-HT Receptors 1612 SB 269970 hydrochloride
2854 Tandospirone hydrochloride
5589 WAY 181187 oxalate
Muscarinic Receptors 1067 Oxotremorine M
3634 VU 0238429
4295 VU 0357017 hydrochloride
4404 VU 0365114
3141 VU 10010
3383 VU 152100
Adenosine A1 Receptors
 3576 (±)-5′-Chloro-5′-deoxy-ENBA 
1363 PD 81723
C5a receptor  3333 NDT 9513727 
5196 PMX 205
Canabinoid Receptors 3088 HU 308
2957 Org 27569
5321 PSNCBAM-1
Calcium-Sensing Receptor  6165 AC 265347 
4387 Calhex 231 hydrochloride
6170 Cinacalcet hydrochloride
3626 NPS 2143 hydrochloride
3815 R 568 hydrochloride
CRF1 receptor 3212 CP 376395 hydrochloride
1591 NBI 27914 hydrochloride
1608 Stressin I
Dopamine Receptors 1659 Fenoldopam hydrochloride
1003 L-741,626
5041 PAOPA
1447 SKF 81297 hydrobromide
GABAB Receptors  0796 (R)-Baclofen 
1514 CGP 13501
1248 CGP 55845 hydrochloride
1513 CGP 7930
2001 GS 39783
3817 MRK 016 
3313 rac BHFF 
4414 TP 003 
Free Fatty Acid Receptors  4642 4-CMTB 
6082 AMG 837 hemicalcium salt
5903 CATPB
5621 GLPG 0974 
Mas-Related G Protein-Coupled Receptors  1763 BAM (8-22)
5738 ML 382 
6642 QWF
mGlu1 Receptors  0805 (S)-3,5-DHPG 
2501 Bay 36-7620
6859 FITM 
5000 FTIDC
2333 JNJ 16259685 
4346 Ro 67-7476
5379 VU 0469650 hydrochloride
mGlu2 Receptors 4048 BINA
1209 LY 341495
2453 LY 379268
3283 LY 487379 hydrochloride
4388 MNI 137 
mGlu3 Receptors  4969 LY 2389575 hydrochloride
1209 LY 341495 
2453 LY 379268
4982 ML 337
mGlu4 Receptors  1209 LY 341495 
1212 MPEP hydrochloride
mGlu5 Receptors 0805 (S)-3,5-DHPG 
4416 ADX 10059 hydrochloride
3235 CDPPB
2386 Fenobam
1212 MPEP hydrochloride
4323 VU 0360172 hydrochloride
5693 VU 0409551 
mGlu7 Receptor 5715 (±)-ADX 71743
2385 AMN 082 dihydrochloride
1209 LY 341495 
2963 MMPIP hydrochloride
mGlu8 Receptor  1302 (S)-3,4-DCPG
1209 LY 341495
NPY Receptors  2412 BIBO 3304 trifluoroacetate 
1153 Neuropeptide Y (human, rat) 
6411 tBPC
Opioid Receptors  5983 BMS 986187 
0764 SNC 80 
Protease-Activated Receptors  1592 SCH 79797 dihydrochloride
1464 TFLLR-NH2 
Purinergic Receptors  4080 ATPγS tetralithium salt 
6078 BPTU
5545 BX 430
2159 MRS 2500 tetraammonium salt
Sphingosine-1-phosphate Receptors  5418 CYM 5520
4897 CYM 5541
2392 JTE 013 
1370 Sphingosine-1-phosphate 

 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
(+/-)-5'-Chloro-5'-deoxy-ENBA (10 mg) 3576 10 mg TOCRIS
(+/-)-5'-Chloro-5'-deoxy-ENBA (50 mg) 3576 50 mg TOCRIS
(+/-)-ADX 71743 (10 mg) 5715 10 mg TOCRIS
(+/-)-ADX 71743 (50 mg) 5715 50 mg TOCRIS
4-CMTB (10 mg) 4642 10 mg TOCRIS
4-CMTB (50 mg) 4642 50 mg TOCRIS
AC 265347 (10 MG) 6165 10 mg TOCRIS
AC 265347 (50 MG) 6165 50 mg TOCRIS
AMD 3100 octahydrochloride (10 mg) 3299 10 mg TOCRIS
AMD 3100 octahydrochloride (50 mg) 3299 50 mg TOCRIS
AMG 837 hemicalcium salt (10 MG) 6082 10 mg TOCRIS
AMG 837 hemicalcium salt (50 MG) 6082 50 mg TOCRIS
AS2717638 7730 10 mg TOCRIS
ATPgammaS tetralithium salt (10 mg) 4080 10 mg TOCRIS
BAM (8-22) (1 mg) 1763 1 mg TOCRIS
BMS 986187 (10 mg) 5983 10 mg TOCRIS
BMS 986187 (50 mg) 5983 50 mg TOCRIS
BPTU (10 MG) 6078 10 mg TOCRIS
BPTU (50 MG) 6078 50 mg TOCRIS
BX 430 (10 mg) 5545 10 mg TOCRIS
BX 430 (50 mg) 5545 50 mg TOCRIS
Calhex 231 hydrochloride (10 mg) 4387 10 mg TOCRIS
Calhex 231 hydrochloride (50 mg) 4387 50 mg TOCRIS
Cannabigerol 3021 10 mg TOCRIS
CATPB (10 mg) 5903 10 mg TOCRIS
CATPB (50 mg) 5903 50 mg TOCRIS
CBMR 0083 7890 10 mg TOCRIS
CBMR 0083 7890 50 mg TOCRIS
Cinacalcet hydrochloride (10 MG) 6170 10 mg TOCRIS
Cinacalcet hydrochloride (50 MG) 6170 50 mg TOCRIS
CITFA 7811 10 mg TOCRIS
CYM 5520 (10 mg) 5418 10 mg TOCRIS
CYM 5520 (50 mg) 5418 50 mg TOCRIS
CYM 5541 (10 mg) 4897 10 mg TOCRIS
CYM 5541 (50 mg) 4897 50 mg TOCRIS
FITM (10 MG) 6859 10 mg TOCRIS
FITM (50 MG) 6859 50 mg TOCRIS
GLP-2 (3-33) 7725 1 mg TOCRIS
GLPG 0974 (10 mg) 5621 10 mg TOCRIS
Hh-Ag1.5 7807 1 mg TOCRIS
Hh-Ag1.5 7807 5 mg TOCRIS
JTE 013 (10 mg) 2392 10 mg TOCRIS
KISS1 305 7490 1 mg TOCRIS
Laropiprant 7343 10 mg TOCRIS
Laropiprant 7343 50 mg TOCRIS
LEI 101 hydrochloride (10 MG) 5826 10 MG TOCRIS
LIH 383 8095 1 mg TOCRIS
ML 382 (10 mg) 5738 10 mg TOCRIS
ML 382 (50 mg) 5738 50 mg TOCRIS
MRS 2500 tetraammonium salt (1 mg) 2159 1 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
3576
Product
(+/-)-5'-Chloro-5'-deoxy-ENBA (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3576
Product
(+/-)-5'-Chloro-5'-deoxy-ENBA (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5715
Product
(+/-)-ADX 71743 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5715
Product
(+/-)-ADX 71743 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4642
Product
4-CMTB (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4642
Product
4-CMTB (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6165
Product
AC 265347 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6165
Product
AC 265347 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3299
Product
AMD 3100 octahydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3299
Product
AMD 3100 octahydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6082
Product
AMG 837 hemicalcium salt (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6082
Product
AMG 837 hemicalcium salt (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7730
Product
AS2717638
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4080
Product
ATPgammaS tetralithium salt (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1763
Product
BAM (8-22) (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5983
Product
BMS 986187 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5983
Product
BMS 986187 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6078
Product
BPTU (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6078
Product
BPTU (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5545
Product
BX 430 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5545
Product
BX 430 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4387
Product
Calhex 231 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4387
Product
Calhex 231 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3021
Product
Cannabigerol
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5903
Product
CATPB (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5903
Product
CATPB (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7890
Product
CBMR 0083
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7890
Product
CBMR 0083
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6170
Product
Cinacalcet hydrochloride (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6170
Product
Cinacalcet hydrochloride (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7811
Product
CITFA
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5418
Product
CYM 5520 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5418
Product
CYM 5520 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4897
Product
CYM 5541 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4897
Product
CYM 5541 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6859
Product
FITM (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6859
Product
FITM (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7725
Product
GLP-2 (3-33)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5621
Product
GLPG 0974 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7807
Product
Hh-Ag1.5
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7807
Product
Hh-Ag1.5
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2392
Product
JTE 013 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7490
Product
KISS1 305
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7343
Product
Laropiprant
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7343
Product
Laropiprant
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5826
Product
LEI 101 hydrochloride (10 MG)
Size
10 MG
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
8095
Product
LIH 383
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5738
Product
ML 382 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5738
Product
ML 382 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2159
Product
MRS 2500 tetraammonium salt (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
전체보기

추천제품

관련제품

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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    Neuronal 5-HT Receptors and SERT 이미지

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    GPCR연구와 관련된 small molecule 정보가 수록되어 있습니다.

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    Pain Poster 이미지

    [TOCRIS]

    Pain pathway poster 입니다.

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    GPCR Efficacy and Biased Agonisom 이미지

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    GPCR Efficacy and Biased Agonisom poster 입니다.

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    Cardiovascular Poster 이미지

    [TOCRIS]

    Cardiovascular pathway poster 입니다.

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    Allosteric GPCR Pharmacology 이미지

    [TOCRIS]

    Allosteric GPCR Pharmacology에 대한 poster 입니다.

  • Inhibitor Book Vol.4

    Inhibitor Book Vol.4 이미지

    고마뉴스 자료신청 [KOMA]

    다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

웨비나/Video

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Cat.No.
Product
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Data Sheet
MSDS

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