GPCR Pharmacology Inhibitors & Activators | 고마바이오텍

특징 

• G protein-coupled receptors (GPCR)은 7-Transmembrane receptor (7-TM receptor)라고도 하며, 7개의 막을 가로지르는 나선을 포함하는 통합 막 단백질입니다. 이들은 막의 세포내 측면에 있는 heterotrimeric G protein과 결합됩니다. 리간드 결합 시, GPCR은 형태가 변형되며 G 단백질로 신호를 전달하여 활성화시킵니다. 
• GPCRs/7-TM receptors는 빛, 후각 자극제, 펩타이드, 호르몬 및 신경 전달 물질을 포함한 다양한 리간드에 의해 활성화되며 6가지 class로 분류됩니다. 
  
• Class A (or 1) (Rhodopsin-like)
• Class B (or 2) (Secretin receptor family)
• Class C (or 3) (Metabotropic glutamate/pheromone)
• Class D (or 4) (Fungal mating pheromone receptors)
• Class E (or 5) (Cyclic AMP receptors)
• Class F (or 6) (Frizzled/Smoothened)

GPCR 종류 

• 5-HT Receptors
• Acetylcholine Muscarinic Receptors
• Adenosine Receptors
• Adrenergic Receptors
• Calcium-Sensing Receptor
• Cannabinoid Receptors
• Chemokine Receptors
• Dopamine Receptors
• Estrogen (GPER) Receptors
• Free Fatty Acid Receptors
• GABAB Receptors
• Glutamate (Metabotropic) Receptors
• GPBA Receptors
• GPR119
• GPR35
• GPR55
• Histamine Receptors
• Hydroxycarboxylic Acid Receptors
• Leukotriene and Related Receptors
• Lysophosphatidic Acid Receptors
• Melatonin Receptors
• Opioid Receptors
• Orphan 7-TM Receptors
• Peptide Receptors
• Platelet-Activating Factor (PAF) Receptors
• Prostanoid Receptors
• Purinergic (P2Y) Receptors
• Smoothened Receptors
• Sphingosine-1-Phosphate Receptors
• Trace Amine 1 Receptor

주요 제품