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제품 상세
통증 수용체 연구 | GPCR Opioid Receptor Agonist & Antagonist 이미지

통증 수용체 연구 | GPCR Opioid Receptor Agonist & Antagonist

δ Opioid Receptors, κ Opioid Receptors, μ Opioid Receptors, NOP Receptors등의 Opioid receptor 연구에 필요한 CTOP, DPDPE, Naltriben, BNTX maleate, DIPPA, Nociceptin 등과 같은 small molecule을 소개합니다.

특징

 

  • Opioid Receptor는 통증완화에 관련되며 κ, δ, μ 수용체 그룹으로 분류됩니다. 각 그룹내의 하위 유형은  μ1, μ2, δ1, δ2, κ1, κ2 및 κ3 입니다.
  • κ, δ, μ opioid receptor와 높은 수준의 상동성을 갖는 opioid-like receptor는 Orphan opioid receptor (NOP, ORL1)으로 불립니다. 이 수용체는 고전적인 opioid receptor와 동일한 약리학적 프로파일을 가지며 내인성 리간드인 nociceptin (orphanin FQ)가 확인되었습니다. 


주요 제품
Receptor Subtype μ (MOP, OP3) δ (DOP, OP1) κ (KOP, OP2) NOP (ORL1, OP4)
G protein Gi/o Gi/o Gi/o Gi/o
Transduction Mechanism Activation of inwardly rectifying K+ channels, inhibition of Ca2+ channels, inhibition of adenylyl cyclase
Localization in CNS Anterior cingulate cortex, neocortex, amygdala, hippocampus, ventral dentate gyrus, presubiculum, nucleus accumbens, caudate putamen, thalamus, habenula, interpeduncular nucleus, pars compacta of the substantia nigra, superior and inferior colliculi, raphe nuclei Medial habenula, hypothalamus, pons, medulla, dorsal root ganglion, caudate putamen, medial habenula, tegmentum, trigeminal nucleus Claustrum, endopiriform nucleus, caudate putamen, nucleus accumbens, midline nuclear group of the thalamus, superficial grey layer of the superior colliculus, central grey, caudate putamen, nucleus accumbens, amygdala, thalamus, interpeduncular nuclei Cortex, olfactory bulb, suprachiasmatic nucleus, amygdala, nucleus accumbens, thalamic nuclei, hypothalamus, hippocampus, septum, superior colliculus
Likely Physiological Roles Respiration, cardiovascular functions, feeding, learning and memory, intestinal transit, locomotor activity, thermoregulation, hormone secretion, immune functions Analgesia, motor integration, gastrointestinal motility, olfaction, respiration, cognitive function, mood driven behavior Regulation of nociception, diuresis, feeding, neuroendocrine secretions Motor and balance control, reinforcement and reward, nociception, the stress response, sexual behavior, aggression, autonomic control of physiological processes
Key Selective Agonists Endomorphin-1 (1055) SNC 80 (0764) (±)-U-50488 (0495) Nociceptin (0910)
Endomorphin-2 (1056) SB 205607 (0921) BRL 52537 (0699) MCOPPB (3763) 
DAMGO (1171) DPDPE (1431) Dynorphin A (3195) SCH 221510 (3240)
Key Selective Antagonists β-Funaltrexamine (0926) Naltrindole (0740) nor-Binaltorphimine (0347) UFP-101 (1552)
CTOP (1578) Naltriben (0892) DIPPA (0794) (±)-J 113397 (2598)
Cyprodime (2601) BNTX maleate (0899) GNTI (1282) JTC 801 (2481)

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
(+)-U-50488 hydrochloride (10 mg) 0471 10 mg TOCRIS
(+)-U-50488 hydrochloride (50 mg) 0471 50 mg TOCRIS
(-)-U-50488 hydrochloride (10 mg) 0496 10 mg TOCRIS
(-)-U-50488 hydrochloride (50 mg) 0496 50 mg TOCRIS
BNTX maleate (10 mg) 0899 10 mg TOCRIS
BNTX maleate (50 mg) 0899 50 mg TOCRIS
BRL 52537 hydrochloride (10 mg) 0699 10 mg TOCRIS
BRL 52537 hydrochloride (50 mg) 0699 50 mg TOCRIS
CTAP (1 mg) 1560 1 mg TOCRIS
DADLE (5 mg) 3790 5 mg TOCRIS
Deltorphin I (1 mg) 4591 1 mg TOCRIS
DIPPA hydrochloride (10 mg) 0794 10 mg TOCRIS
DIPPA hydrochloride (50 mg) 0794 50 mg TOCRIS
DPDPE (1 mg) 1431 1 mg TOCRIS
GR 89696 fumarate (10 mg) 1483 10 mg TOCRIS
GR 89696 fumarate (50 mg) 1483 50 mg TOCRIS
Helianorphin-19 7541 1 mg TOCRIS
ICI 174,864 (1 mg) 0820 1 mg TOCRIS
ICI 174,864 (5 mg) 0820 5 mg TOCRIS
ICI 199,441 hydrochloride (10 mg) 0778 10 mg TOCRIS
ICI 199,441 hydrochloride (50 mg) 0778 50 mg TOCRIS
ICI 204,448 hydrochloride (10 mg) 0822 10 mg TOCRIS
ICI 204,448 hydrochloride (50 mg) 0822 50 mg TOCRIS
ML 190 (10 mg) 4866 10 mg TOCRIS
ML 190 (50 mg) 4866 50 mg TOCRIS
Naloxonazine dihydrochloride (10 mg) 0591 10 mg TOCRIS
Naloxonazine dihydrochloride (50 mg) 0591 50 mg TOCRIS
Naltriben mesylate (10 mg) 0892 10 mg TOCRIS
Naltriben mesylate (50 mg) 0892 50 mg TOCRIS
NNC 63-0532 (10 mg) 1780 10 mg TOCRIS
NNC 63-0532 (50 mg) 1780 50 mg TOCRIS
Nociceptin (1 mg) 0910 1 mg TOCRIS
Nocistatin (bovine) (1 mg) 1118 1 mg TOCRIS
SB 612111 hydrochloride (10 mg) 3573 10 mg TOCRIS
SB 612111 hydrochloride (50 mg) 3573 50 mg TOCRIS
SDM25N hydrochloride (10 mg) 1410 10 mg TOCRIS
SDM25N hydrochloride (50 mg) 1410 50 mg TOCRIS
SNC 162 (10 mg) 1529 10 mg TOCRIS
SNC 162 (50 mg) 1529 50 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
0471
Product
(+)-U-50488 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0471
Product
(+)-U-50488 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0496
Product
(-)-U-50488 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0496
Product
(-)-U-50488 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0899
Product
BNTX maleate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0899
Product
BNTX maleate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0699
Product
BRL 52537 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0699
Product
BRL 52537 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1560
Product
CTAP (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3790
Product
DADLE (5 mg)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4591
Product
Deltorphin I (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0794
Product
DIPPA hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0794
Product
DIPPA hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1431
Product
DPDPE (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1483
Product
GR 89696 fumarate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1483
Product
GR 89696 fumarate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7541
Product
Helianorphin-19
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0820
Product
ICI 174,864 (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0820
Product
ICI 174,864 (5 mg)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0778
Product
ICI 199,441 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0778
Product
ICI 199,441 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0822
Product
ICI 204,448 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0822
Product
ICI 204,448 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4866
Product
ML 190 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4866
Product
ML 190 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0591
Product
Naloxonazine dihydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0591
Product
Naloxonazine dihydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0892
Product
Naltriben mesylate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0892
Product
Naltriben mesylate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1780
Product
NNC 63-0532 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1780
Product
NNC 63-0532 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
0910
Product
Nociceptin (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1118
Product
Nocistatin (bovine) (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3573
Product
SB 612111 hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3573
Product
SB 612111 hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1410
Product
SDM25N hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1410
Product
SDM25N hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1529
Product
SNC 162 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
1529
Product
SNC 162 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
전체보기

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