In Vitro Tumor Sensitivity Assay Kit | 고마바이오텍

특징

 

• 화학민감성 (chemosensitivity)를 테스트하기 위해 특별히 고안된 soft agar colony를 이용하여 anchorage-independent growth를 모니터링하고 잠재적인 항암제를 스크리닝합니다. 
• 6-8일  후 colorimetric microplate reader로 cell colony를 정량합니다. 

구성

 

• 10x CytoSelect™ Agar Matrix Solution 
  
• CytoSelect™ Matrix Diluent 
• 5x DMEM Solution 
• 1x Matrix Solubilization Buffer 
  
• Detergent Solution 
• MTT Solution 

적용

 

• Anchorageindependent model for chemosensitivity testing
• Potential anticancer drug screening

 

 

 

사용 논문

 

CBA-150 CBA-150-5

Xie, X. et al. (2021). Babao Dan is a robust anti-tumor agent via inhibiting wnt/β-catenin activation and cancer cell stemness. J Ethnopharmacol. doi: 10.1016/j.jep.2021.114449. Dehghanian, S.Z. et al. (2021). ABT-751 Induces Multiple Anticancer Effects in Urinary Bladder Urothelial Carcinoma-Derived Cells: Highlighting the Induction of Cytostasis through the Inhibition of SKP2 at Both Transcriptional and Post-Translational Levels. Int J Mol Sci. 22(2):945. doi: 10.3390/ijms22020945. Fujimura, T. et al. (2020). Enhanced antitumor effect of alectinib in combination with cyclin-dependent kinase 4/6 inhibitor against RET-fusion-positive non-small cell lung cancer cells. Cancer Biol Ther. doi: 10.1080/15384047.2020.1806643. Chandrasekaran, B. et al. (2020). Chronic exposure to cadmium induces a malignant transformation of benign prostate epithelial cells. Oncogenesis. 9(2):23. doi: 10.1038/s41389-020-0202-7. Tyagi, A. et al. (2019). Combination of androgen receptor inhibitor and cisplatin, an effective treatment strategy for urothelial carcinoma of the bladder. Urol Oncol. pii: S1078-1439(19)30101-2. doi: 10.1016/j.urolonc.2019.03.008. Wei, R.J. et al. (2019). Inhibition of the formation of autophagosome but not autolysosome augments ABT-751-induced apoptosis in TP53-deficient Hep-3B cells. J Cell Physiol. 234(6):9551-9563. doi: 10.1002/jcp.27643. Wang, L. et al. (2018). Effects of ebv-miR-BART7 on tumorigenicity, metastasis, and TRAIL sensitivity of non-small cell lung cancer. J Cell Biochem. doi: 10.1002/jcb.28289. von Frowein, J. et al. (2018). MiR-492 regulates metastatic properties of hepatoblastoma via CD44. Liver Int. 38(7):1280-1291. doi: 10.1111/liv.13687. Pal, D. et al. (2018). Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer. Cell Death Dis. 9(8):798. doi: 10.1038/s41419-018-0810-8. Chandrasekaran, B. et al. (2017). Molecular insights: Suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer. Genes Cancer. 8(9-10):713-724. doi: 10.18632/genesandcancer.154. Pal, D. et al. (2017). Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis. Br. J. Cancer. 117(1):56-64. doi: 10.1038/bjc.2017.143. Kato, K. et al. (2017). Opposite effects of tumor protein D (TPD) 52 and TPD54 on oral squamous cell carcinoma cells. Int J Oncol. doi: 10.3892/ijo.2017.3929 Wei, R. J. et al. (2016). A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol. Appl Pharmacol. doi:10.1016/j.taap.2016.09.021. Mukudai, Y. et al. (2016). Methanol and butanol extracts of Paeonia lutea leaves repress metastasis of squamous cell carcinoma. Evid Based Complement Alternat Med. doi:10.1155/2016/6087213. Damodaran, C. et al. (2016). miR-301a expression: A prognostic marker for prostate cancer. Urol Oncol. Doi:10.1016/j.urolonc.2016.03.009. Zheng, Y. et al. (2016). Glioma-derived platelet-derived growth factor-BB recruits oligodendrocyte progenitor cells via platelet-derived growth factor receptor-α and remodels cancer stroma. Am J Pathol. doi:10.1016/j.ajpath.2015.12.020. Joshi, P. et al. (2015). MicroRNA-148a reduces tumorigenesis and increases TRAIL-induced apoptosis in NSCLC.  Proc Natl Acad Sci U S A. 112:8650-8655. Meador, C. B. et al. (2015). Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer. Mol Cancer Ther. 14:542-552. Peng, Y. T. et al. (2015). Upregulation of cyclin-dependent kinase inhibitors CDKN1B and CDKN1 C in hepatocellular carcinoma-derived cells via goniothalamin-mediated protein stabilization and epigenetic modifications. Toxicol Rep. doi:10.1016/j.toxrep.2015.01.010. Akl, M. R. et al. (2015). Araguspongine C induces autophagic death in breast cancer cells through suppression of c-Met and HER2 receptor tyrosine kinase signaling. Mar Drugs. 13:288-311. Suman, S. et al. (2014). The pro-apoptotic role of autophagy in breast cancer. Bri J Cancer. 111:309-317. Suman, S. et al. (2014). Activation of AKT signaling promotes epithelial–mesenchymal transition and tumor growth in colorectal cancer cells. Mol Carcinog. 53:E151-E160. Bard-Chapeau, E. et al. (2013). EVI1 Oncoprotein Interacts with a Large and Complex Network of Proteins and Integrates Signals through Protein Phosphorylation. PNAS. 110:E2885-E2894. Takezawa. K. et al. (2012). HER2 Amplification: A Potential Mechanism of Acquired Resistance to EGFR Inhibition in EGFR-Mutant Lung Cancers That Lack the Second-Site EGFRT790M Mutation. Cancer Discovery. 2: 922-933. Li, C. et al. (2012).The Root Bark of Paeonia moutan is a Potential Anticancer Agent in Human Oral Squamous Cell Carcinoma Cells. Anticancer Res. 32:2625-2630. Itamochi, H. et al. (2011). Inhibiting the mTOR Pathway Synergistically Enhances Cytotoxicity in Ovarian Cancer Cells Induced by Etoposide through Upregulation of c-Jun. Clin. 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