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제품 상세
Tumor Transendothelial Migration Assay Kit 이미지

Tumor Transendothelial Migration Assay Kit

CytoSelect™ Tumor Transendothelial Migration Assay Kit은 Tumor cell과 endothelium cell의 interaction정도를 확인하는 kit 입니다.

프린트 제품 문의

특징

 

  • 암전이는 여러단계로 구성됩니다. 혈류로 흘러들어가 혈액에서 순환하고 마지막으로 혈관밖으로 유출되여 신체의 새로운 위치로 이동합니다. 초기 종양 세포의 혈관 내피에 대한 정착(arrest) 및 부착(attachement)은 종양 전이성 cascade에서 매우 중요한 단계 입니다. 
  • CytoSelect™ Tumor Transendothelial Migration Assay는 종양-내피 상호작용 및 전이를 정량적으로 측정합니다. 






구성

  • 24-well Migration Plate
  • 500 X CytoTracker™ Solution 
  • 4 X Lysis Buffer
  • TNFα 
  • Cotton Swabs 
  • Forceps



사용 논문

CBA-216 　
    1. Sasahira, T. et al. (2021). SERPINE2 is an oral cancer-promoting factor that induces angiogenesis and lymphangiogenesis. Int J Clin Oncol. doi: 10.1007/s10147-021-01970-4.
    2. Sasahira, T. et al. (2021). Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO. J Cancer Res Clin Oncol. doi: 10.1007/s00432-021-03568-9.
    3. Kong, J. et al. (2020). ICAM-1 Activates Platelets and Promotes Endothelial Permeability through VE- Cadherin after Insufficient Radiofrequency Ablation. Adv. Sci. doi: 10.1002/advs.202002228.
    4. Park, G.B. et al. (2020). GLUT5 regulation by AKT1/3-miR-125b-5p downregulation induces migratory activity and drug resistance in TLR-modified colorectal cancer cells. Carcinogenesis. doi: 10.1093/carcin/bgaa074.
    5. Shimomura, H. et al. (2019). Non-SMC Condensin I Complex Subunit H (NCAPH) Is Associated with Lymphangiogenesis and Drug Resistance in Oral Squamous Cell Carcinoma. J Clin Med. 9(1). pii: E72. doi: 10.3390/jcm9010072.
    6. Park, G.B. et al. (2019). Modified TLR-mediated downregulation of miR-125b-5p enhances CD248 (endosialin)-induced metastasis and drug resistance in colorectal cancer cells. Mol Carcinog. doi: 10.1002/mc.23137.
    7. Wang, S.Y. et al. (2019). High Expression of MicroRNA-196a is Associated with Progression of Hepatocellular Carcinoma in Younger Patients. Cancers (Basel). 11(10). pii: E1549. doi: 10.3390/cancers11101549.
    8. Park, G.B. et al. (2019). MicroRNA-503-5p Inhibits the CD97-Mediated JAK2/STAT3 Pathway in Metastatic or Paclitaxel-Resistant Ovarian Cancer Cells. Neoplasia. 21(2):206-215. doi: 10.1016/j.neo.2018.12.005.
    9. Fukushima, R. et al. (2018). Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer. 9(18):3326-3333. doi: 10.7150/jca.25666.
    10. Toeda, Y. et al. (2018). FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway. Mol Carcinog. 57(12):1690-1697. doi: 10.1002/mc.22889.
    11. Sasahira, T. et al. (2018). NIPA-like domain containing 1 is a novel tumor-promoting factor in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 144(5):875-882. doi: 10.1007/s00432-018-2612-x.
    12. Park, G.B. et al. (2017). Insulin-like growth factor-1 activates different catalytic subunits p110 of PI3K in a cell-type-dependent manner to induce lipogenesis-dependent epithelial-mesenchymal transition through the regulation of ADAM10 and ADAM17. Mol Cell Biochem. doi: 10.1007/s11010-017-3148-0.
    13. Choong L.Y. et al. (2017). Lee WH, et al. (2017). TRPV4 plays a role in breast cancer cell migration via Ca2+-dependent activation of AKT and downregulation of E-cadherin cell cortex protein. Oncogenesis. 6(5):e338. doi: 10.1038/oncsis.2017.39.
    14. Park, G.B. et al. (2017). PI3K Catalytic Isoform Alteration Promotes the LIMK1-related Metastasis Through the PAK1 or ROCK1/2 Activation in Cigarette Smoke-exposed Ovarian Cancer Cells. Anticancer Res. 37(4):1805-1818.
    15. Fife, C. M. et al. (2016). Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration. Oncogene. doi:10.1038/onc.2016.220.
    16. Waghray, M. et al. (2016). GM-CSF mediates mesenchymal-epithelial crosstalk in pancreatic cancer. Cancer Discov. Doi:10.1158/2159-8290.CD-15-0947.
    17. Park, G. B. et al. (2015). Regulation of ADAM10 and ADAM17 by sorafenib inhibits epithelial-to-mesenchymal transition in Epstein-Barr virus–infected retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 56:5162-5173.
    18. Park, G. B. et al. (2015). Silencing of galectin-3 represses osteosarcoma cell migration and invasion through inhibition of FAK/Src/Lyn activation and β-catenin expression and increases susceptibility to chemotherapeutic agents.Int J Oncol. 46:185-194.
    19. Choi, S. H. et al. (2014). MMP9 processing of HSPB1 regulates tumor progression. PLoS One.  9:e85509.
    20. Haidari, M. et al. (2014). Disruption of endothelial adherens junctions by high glucose is mediated by protein kinase C-β-dependent vascular endothelial cadherin tyrosine phosphorylation. Cardiovasc Diabetol. 13:112.
    21. Park, G.B. et al. (2014). The Epstein-Barr virus causes epithelial-mesenchymal transition in human corneal epithelial cells via Syk/Src and Akt/Erk signaling pathways.Invest. Ophthalmol. Vis. Sci. 55:1770-1779.
    22. Xu, Z. et al. (2010). Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis. Am. J. Pathol., 177:2585-2596.
    23. Yang, H. and H.E. Grossniklaus (2010). Constitutive Overexpression of Pigment Epithelium Derived Factor Inhibition of Ocular Melanoma Growth and Metastasis. Invest. Ophthalmol. Vis. Sci. 51:28-34.
    24. Liu, K. et al. (2007). Lentivirus Mediated Gene Transfer of PEDF Results in Decreased Uveal Melanoma Transendothelial Migration. Invest. Opthalmol. Vis. Sci. 48:5244.


주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
CytoSelect™ Tumor Transendothelial Migration Assay CBA-216 24 assays CELL BIOLABS
Maker
CELL BIOLABS
Cat.No.
CBA-216
Product
CytoSelect™ Tumor Transendothelial Migration Assay
Size
24 assays
Qty
Data Sheet
MSDS

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주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

자료

  • Tumor microenvironment (TME)

    Tumor microenvironment (TME) 이미지

    [ARIGO]

    종양미세환경과 관련된 marker와 pathway에 대한 포스터 입니다.

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
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Data Sheet
MSDS

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