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제품 상세
Chemogenetics Small Molecules 이미지

Chemogenetics Small Molecules

Chemogenetics의 타겟이 되는 DREADD 및 PSEMs ligand에 대한 agonist, activator등을 소개합니다.

프린트 제품 문의

특징

 

  • Chemogenetics (화학유전학)은 세포내 신호 전달 경로를 제어하고 조사하는데 있어 강력하고 구체적인 툴로, 특히 신경과학에서 신경세포나 신경교세포의 활성을 제어하기 위해 가장 널리 사용됩니다.
  • 광섬유를 이식해야 하는 Optogenetics (광유전학)에 비해, 타겟 receptor에 대한 ligand를 intracerebral infusion, intraperitoneal injection, drinking water등의 방법으로 uptake시킬 수 있어 실험이 수월합니다.
  • 유전적으로 변형된 GPCR에 대한 DREADD ligand 및 키메라 이온 채널(PSAM)을 선택적으로 타겟팅하는 PSAM ligand에 대한 agonist, antagonist를 제공합니다.

 



주요 제품

 

DREADDs and DREADD Ligands Agonist & Antagonist 

 

Cat. No. Product Activity
4936 Clozapine N-oxide Activator of hM3Dq and hM4Di DREADDs
6329 Clozapine N-oxide dihydrochloride Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide 
7193 Deschloroclozapine High affinity and highly potent activator of hM3Dq and hM4Di DREADDs; blood brain barrier penetrant
5548 DREADD agonist 21 Potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
6422 DREADD agonist 21 dihydrochloride Potent hM3Dq and hM4Di DREADD agonist; water soluble version of DREADD agonist 21
7197 JHU 37152 High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
7198 JHU 37160 High affinity and highly potent hM3Dq and hM4Di DREADD agonist; blood brain barrier penetrant
7926 MOMBA Selective orthostatic agonist of hFFA2-DREADDs
4349 Olanzapine Highly potent hM4Di activator; also 5-HT2A and D2 antagonist
5549 Perlapine Potent hM3Dq and hM4Di DREADD agonist in vitro
5611 Salvinorin B Activator of κ-opioid DREADD (KORD)
7119 Sorbic acid Activator of hFFA2-DREADDs

 

 


 

     

PSAMs and PSEMs Agonist  

 

Cat. No. Product  Activity
6425 PSEM 308 hydrochloride PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
6426 PSEM 89S PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
2459 Tropisetron hydrochloride Activates α7Q79G-GlyR; also potent 5-HT3 antagonist and α7 nAChR partial agonist
6865 uPSEM 792 hydrochloride Highly potent PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
6866 uPSEM 817 tartrate Highly potent and selective PSAM4-GlyR and PSAM4-5-HT3 chimeric ion channel agonist; brain-penetrant
3754 Varenicline tartrate Potent activator of PSAM4-5-HT3 and PSAM4-GlyR; also selective α4β2 nAChR partial agonist

 


 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
Clozapine N-oxide (50 mg) 4936 50 mg TOCRIS
Clozapine N-oxide dihydrochloride (50 MG) 6329 50 mg TOCRIS
Deschloroclozapine (10 MG) 7193 10 mg TOCRIS
Deschloroclozapine (50 MG) 7193 50 mg TOCRIS
DREADD agonist 21 (10 mg) 5548 10 mg TOCRIS
DREADD agonist 21 (50 mg) 5548 50 mg TOCRIS
DREADD agonist 21 dihydrochloride (10 MG) 6422 10 mg TOCRIS
DREADD agonist 21 dihydrochloride (50 MG) 6422 50 mg TOCRIS
JHU 37152 (10 MG) 7197 10 mg TOCRIS
JHU 37152 (50 MG) 7197 50 mg TOCRIS
JHU 37160 (10 MG) 7198 10 mg TOCRIS
JHU 37160 (50 MG) 7198 50 mg TOCRIS
MOMBA 7926 250 mg TOCRIS
Olanzapine (10 mg) 4349 10 mg TOCRIS
Olanzapine (50 mg) 4349 50 mg TOCRIS
Perlapine (10 mg) 5549 10 mg TOCRIS
Perlapine (50 mg) 5549 50 mg TOCRIS
PSEM 308 hydrochloride (25 MG) 6425 25 mg TOCRIS
PSEM 308 hydrochloride (5 MG) 6425 5 mg TOCRIS
PSEM 89S (25 MG) 6426 25 mg TOCRIS
PSEM 89S (5 MG) 6426 5 mg TOCRIS
Salvinorin B (1 mg) 5611 1 mg TOCRIS
Sorbic acid (100 MG) 7119 100 mg TOCRIS
uPSEM 792 hydrochloride (25 MG) 6865 25 mg TOCRIS
uPSEM 792 hydrochloride (5 MG) 6865 5 mg TOCRIS
uPSEM 817 tartrate (25 MG) 6866 25 mg TOCRIS
uPSEM 817 tartrate (5 MG) 6866 5 mg TOCRIS
Varenicline tartrate (10 mg) 3754 10 mg TOCRIS
Varenicline tartrate (50 mg) 3754 50 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
4936
Product
Clozapine N-oxide (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6329
Product
Clozapine N-oxide dihydrochloride (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7193
Product
Deschloroclozapine (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7193
Product
Deschloroclozapine (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5548
Product
DREADD agonist 21 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5548
Product
DREADD agonist 21 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6422
Product
DREADD agonist 21 dihydrochloride (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6422
Product
DREADD agonist 21 dihydrochloride (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7197
Product
JHU 37152 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7197
Product
JHU 37152 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7198
Product
JHU 37160 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7198
Product
JHU 37160 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7926
Product
MOMBA
Size
250 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4349
Product
Olanzapine (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4349
Product
Olanzapine (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5549
Product
Perlapine (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5549
Product
Perlapine (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6425
Product
PSEM 308 hydrochloride (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6425
Product
PSEM 308 hydrochloride (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6426
Product
PSEM 89S (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6426
Product
PSEM 89S (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5611
Product
Salvinorin B (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7119
Product
Sorbic acid (100 MG)
Size
100 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6865
Product
uPSEM 792 hydrochloride (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6865
Product
uPSEM 792 hydrochloride (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6866
Product
uPSEM 817 tartrate (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6866
Product
uPSEM 817 tartrate (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3754
Product
Varenicline tartrate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3754
Product
Varenicline tartrate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
전체보기

추천제품

관련제품

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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  • Neurotransmission Product Guide

    Neurotransmission Product Guide 이미지

    [TOCRIS]

    Neurotransmission 연구에 관련된 small molecule 정보가 수록되어 있습니다.

  • Ion Channel Product Listings

    Ion Channel Product Listings 이미지

    [TOCRIS]

    Ion Channel 연구에 관련된 small molecule 정보가 수록되어 있습니다.

  • GPCR Product Listings

    GPCR Product Listings 이미지

    [TOCRIS]

    GPCR연구와 관련된 small molecule 정보가 수록되어 있습니다.

  • Inhibitor Book Vol.4

    Inhibitor Book Vol.4 이미지

    고마뉴스 자료신청 [KOMA]

    다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

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제품 문의

 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet
MSDS

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