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제품 상세
Y-27632 dihydrochloride | ROCK inhibitor 이미지

Y-27632 dihydrochloride | ROCK inhibitor

Y-27632는 ROCK (Rho-associated coiled-coil forming protein serine/threonine kinase) 경로를 억제하는 화합물로, 세포 극성, 증식, 이동, 대사, 분화, 세포질 분열 및 세포 사멸과 같은 세포 기능에서 중요한 역할을 합니다.

특징

 

  • Y-27632는 선택적 ROCK 억제제로, PRK2도 억제합니다.
  • 냉동보존 중인 인간배아줄기세포(hES)와 iPSC의 생존율을 높여줍니다.
  • CHIR99021, RepSox, Forskolin, SP 600125, Go 6983 및 VPA와 함께 사용하여 섬유아세포를 성숙한 뉴런으로 리프로그래밍합니다.
  • Naive human stem cell medium (NHSM)를 사용하여 프라이밍된 ESC 및 iPSC로 부터 순수 세포 유도 후 순수 인간 다능성 줄기 세포 성장 및 생존력을 최적화합니다.
  • 요로상피 오가노이드의 growth media 구성요소로 사용됩니다.
  • 인간 iPSC에서 뇌 오가노이드를 생성하는 프로토콜에도 사용됩니다. 

 

 

적용별 프로토콜   


  

 

Technical Data 

 

M. Wt 320.26
Formula C14H21N3O.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 129830-38-2
PubChem ID 14801906
InChI Key VJGZNBYDSDEOED-FJSYBICCSA-N
Smiles N[C@H](C)[C@@]1([H])CC[C@H]([C@](NC2=CC=NC=C2)=O)CC1.Cl.Cl

 

 

Solubility Data  

 

Solubility Solvent Max Conc. mg/mL Max Conc. mM
DMSO 32.03 100
water 32.03 100

 

 

  

 

사용 논문

 

Citations are publications that use Tocris products. Selected citations for Y-27632 dihydrochloride include:

Wilke et al (2019) A Stem-Cell-Derived Platform Enables Complete Cryptosporidium Development In Vitro and Genetic Tractability. Cell Host Microbe 26 123 PMID: 31231046

Rehbach et al (2019) Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons. Sci Rep 9 9615 PMID: 31270336

Lee et al (2019) Entosis Controls a Developmental Cell Clearance in C. elegans. Cell Rep 26 3212 PMID: 30893595

Montel-Hagen et al (2019) Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells. Cell Stem Cell 24 376 PMID: 30661959

Li et al (2019) A Non-canonical Pathway with Potential for Safer Modulation of Transforming Growth Factor-β1 in Steroid-Resistant Airway Diseases. iScience 12 232 PMID: 30711747

Maguire et al (2019) Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol 48 e64 PMID: 30358158

Frith and Tsakiridis (2019) Efficient Generation of Trunk Neural Crest and Sympathetic Neurons from Human Pluripotent Stem Cells Via a Neuromesodermal Axial Progenitor Intermediate. Curr Protoc Stem Cell Biol e81 PMID: 30688409

Yin et al (2019) Chemical conversion of human fetal astrocytes into neurons through modulation of multiple signaling pathways. Stem Cell Reports 12 488 PMID: 30745031

Benedicto (2017) Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun 8 15374 PMID: 28524846

Tchieu et al (2017) A modular platform for differentiation of human PSCs into all major ectodermal lineages. Cell Stem Cell. 31 399 PMID:  28886367

Shi (2017) The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress. Mol Brain 10 38 PMID: 28800762

Xi (2017) In Vivo Human Somitogenesis Guides Somite Development from hPSCs. Cell Rep 18 1573 PMID: 28178531

Hall (2017) Mesoderm-specific Stat3 deletion affects expression of Sox9 yielding Sox9-dependent phenotypes. PLoS Genet 13 e1006610 PMID: 28166224

Kotton et al (2017) Differentiation of human pluripotent stem cells into functional lung alveolar epithelial cells. Cell Stem Cell. 21 472 PMID: 28965766

Shao (2017) A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nat Commun 8 208 PMID: 28785084

Rath et al (2016) ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells. Sci Data 3 160101 PMID: 27824338

Hien et al (2016) Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization. J Biol Chem 291 3552 PMID: 26683376

Manno et al (2016) Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells. Cell 167 566 PMID: 27716510

Koopmans et al (2016) Regulation of actin dynamics by WNT-5A: implications for human airway smooth muscle contraction. Sci Rep 6 30676 PMID: 27468699

Yu and Fernandez-Gonzalez (2016) Local mechanical forces promote polarized junctional assembly and axis elongation in Drosophila. Elife 5 PMID: 26747941

Rempel et al (2015) A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol 89 1599 PMID: 26272509

Goldspink et al (2013) The microtubule end-binding protein EB2 is a central regulator of microtubule reorganisation in apico-basal epithelial differentiation. J Cell Sci 126 4000 PMID: 23813963

Lian et al (2013) Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc 8 162 PMID: 23257984

Li et al (2013) Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation. Proc Natl Acad Sci U S A 110 E1452 PMID: 23576731

Matsumoto et al (2013) Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet J Rare Dis 8 190 PMID: 24321451

Roller et al (2012) Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma. Mol Cancer Ther 11 2505 PMID: 22962324

Harel et al (2012) ZFX controls the self-renewal of human embryonic stem cells. PLoS One 7 e42302 PMID: 22879936

Paige et al (2012) A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell 151 221 PMID: 22981225

Beers et al (2012) Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc 7 2029 PMID: 23099485

Díez et al (2010) STAT inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. PLoS One 5 e14145 PMID: 21152444

Gjorevski and Nelson (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Stroke 2 424 PMID: 20717570

Rajnicek et al (2006) Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field. J Cell Sci 119 1723 PMID: 16595546

Hartmann et al (2005) CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells. Oncogene 24 4462 PMID: 15806155

Rodríguez-Vita et al (2005) Endothelin-1, via ETA receptor and independently of transforming growth factor-β, increases the connective tissue growth factor in vascular smooth muscle cells. Am J Physiol Cell Physiol 97 125 PMID: 15976312

Nguyen et al (2019) Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells. Stem Cells Int 2019 3298432 PMID: 31191670

Ranganathan et al (2019) Evaluating Shigella flexneri pathogenesis in the human enteroid model. Infect Immun 87 PMID: 30642900

Bertero et al (2019) Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory. Nat Commun 10 1538 PMID: 30948719

Aureille et al (2019) Nuclear envelope deformation controls cell cycle progression in response to mechanical force. EMBO Rep 20 e48084 PMID: 31368207

Bryant et al (2019) Repurposed quinacrine synergizes with CIS. reducing the effective dose required for treatment of head and neck squamous cell carcinoma. Oncotarget 10 5229 PMID: 31497252

Schwedhelm et al (2019) Automated real-time monitoring of human pluripotent stem cell aggregation in stirred tank reactors. Sci Rep 9 12297 PMID: 31444389

Crowell et al (2019) Expansion of Luminal Progenitor Cells in the Aging Mouse and Human Prostate. Cell Rep 28 1499 PMID: 31390564

Sharma et al (2019) Exosomes regulate neurogenesis and circuit assembly. Proc Natl Acad Sci U S A 116 16086 PMID: 31320591

Vattulainen et al (2019) Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential. Stem Cell Res Ther 10 236 PMID: 31383008

Wang et al (2019) Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway. Biosci Rep 39 PMID: 31262973

Hladik et al (2019) Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. Stem Cell Res Ther 10 218 PMID: 31358047

Bonan et al (2017) Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget 8 1304 PMID: 27901489

Subramanian et al (2017) Dynamic behaviour of human neuroepithelial cells in the developing forebrain. Nat Commun 8 14167 PMID: 28139695

Lee et al (2017) Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations. Cell Stem Cell 21 179 PMID: 28777944

Rath et al (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med 9 198 PMID: 28031255

Cossette et al (2014) Sucrose non-fermenting related kinase enzyme is essential for cardiac metabolism. Biol Open 4 48 PMID: 25505152

Feng et al (2014) Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry. Cancer Cell 25 831 PMID: 24882515

Muñoz-García et al (2006) Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by AtoVas. Proc Natl Acad Sci U S A 37 2044 PMID: 16809572

Guillemot and Citi (2006) Cingulin regulates claudin-2 expression and cell proliferation through the small GTPase RhoA. Mol Biol Cell 17 3569 PMID: 16723500

Wyckoff et al (2006) ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol 16 1515 PMID: 16890527

Bantounas et al (2018) Generation of functioning nephrons by implanting human pluripotent stem cell-derived kidney progenitors. Stem Cell Reports 10 766 PMID: 29429961

Pattabiraman et al (2015) RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork. Autophagy 185 496 PMID: 25499974

Tyson et al (2015) Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells. Stem Cells 142 1267 PMID: 25804737

Balcioglu et al (2015) The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions. Nat Biotechnol 128 1316 PMID: 25663698

Morizane et al (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Commun 33 1193 PMID: 26458176

Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. Brain 6 6364 PMID: 25695512

Iovino et al (2015) Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations. Development 138 3345 PMID: 26220942

Jönsson et al (2015) Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor. Int J Nanomedicine 142 3166 PMID: 26395143

Tai et al (2015) SimV. enhances Rho/actin/cell rigidity pathway contributing to mesenchymal stem cells' osteogenic differentiation. Nat Commun 10 5881 PMID: 26451103

Sakaguchi et al (2015) Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Mol Vis 6 8896 PMID: 26573335

Su et al (2015) Phenotypes of trypsin- and Col. -prepared bovine corneal endothelial cells in the presence of a selective Rho kinase inhibitor, Y-27632. PLoS Comput Biol 21 633 PMID: 26097378

Ziv et al (2015) Quantitative Live Imaging of Human Embryonic Stem Cell Derived Neural Rosettes Reveals Structure-Function Dynamics Coupled to Cortical Development. Stem Cell Reports 11 e1004453 PMID: 26473351

Fernandes et al (2015) Comparison of Human Embryonic Stem Cell-Derived Cardiomyocytes, Cardiovascular Progenitors, and Bone Marrow Mononuclear Cells for Cardiac Repair. Bone Res NULL PMID: 26607951

Maharam et al (2015) Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation. Stem Cell Res Ther 3 15015 PMID: 26509098

Luzzani et al (2015) A therapy-grade protocol for differentiation of pluripotent stem cells into mesenchymal stem cells using platelet lysate as supplement. Int J Cancer 6 6 PMID: 25582222

Choi et al (2015) SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. Stem Cell Reports 136 E219 PMID: 25137150

Höfner et al (2015) Defined conditions for the isolation and expansion of basal prostate progenitor cells of mouse and human origin. PLoS One 4 503 PMID: 25702639

Härmä et al (2015) Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development. Stem Cell Reports 10 e0126111 PMID: 25965345

Lachmann et al (2015) Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. Nat Commun 4 282 PMID: 25680479

Abraham et al (2015) A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis. Stem Cell Reports 6 7286 PMID: 26129894

Arbab et al (2015) Cloning-free CRISPR. Cell 5 908 PMID: 26527385

Ruprecht et al (2015) Cortical contractility triggers a stochastic switch to fast amoeboid cell motility. Int J Mol Sci 160 673 PMID: 25679761

Vergara et al (2015) Transgenic plants as low-cost platform for chemotherapeutic drugs screening. J Biol Chem 16 2174 PMID: 25608652

Lee et al (2015) Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. Toxicol Sci 290 14740 PMID: 25911094

Kirschstein et al (2014) Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin 35 74 PMID: 24122009

Dickover et al (2014) The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev Biol 389 182 PMID: 24607366

Walker et al (2012) Intra-axonal translation of RhoA promotes axon growth inhibition by CSPG. J Cell Sci 32 14442 PMID: 23055514

Guo et al (2012) Slug and Sox9 cooperatively determine the mammary stem cell state. J Cell Sci 148 1015 PMID: 22385965

Neely et al (2012) DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. Proc Natl Acad Sci U S A 3 482 PMID: 22860217

Gomez et al (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. ACS Chem Neurosci 110 44 PMID: 20336666

Kim et al (2010) PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. FEBS Lett 107 17206 PMID: 20858732

Cao et al (2010) Cortical actin dynamics facilitate early-stage centrosome separation. J Pharmacol Exp Ther 20 770 PMID: 20409712

Bhadriraju et al (2007) Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy. J Biol Chem 8 43 PMID: 17941977

Schaafsma et al (2007) Ins induces airway smooth muscle contraction. Cell Rep 150 136 PMID: 17160007

Panciera et al (2020) Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties. Nat Mater 19 797 PMID: 32066931

Leibel et al (2020) Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation Curr Protoc Stem Cell Biol 54 e118 PMID: 32640120

Sharma et al (2018) Use of human induced pluripotent stem cell-derived cardiomyocytes to assess drug cardiotoxicity. Nat Protoc 13 3018 PMID: 30413796

Mehta et al (2018) Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation. Cell Rep 25 1081 PMID: 30355486

Lynch et al (2018) Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell 22 653 PMID: 29656941

Gupta et al (2018) CRISPR/Cas9-based Targeted Genome Editing for the Development of Monogenic Diseases Models with Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol 45 e50 PMID: 30040245

McCauley et al (2018) Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Curr Protoc Stem Cell Biol 45 e51 PMID: 30040246

Asumda et al (2018) Differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules. Differentiation 101 16 PMID: 29626713

Sharma et al (2018) Human Induced Pluripotent Stem Cell Production and Expansion from Blood using a Non-Integrating Viral Reprogramming Vector. Curr Protoc Mol Biol 122 e58 PMID: 29851250

Schaffer et al (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep 25 2470 PMID: 30485813

Fazakas et al (2018) Rho-Kinase Inhibition Ameliorates D.nib-Induced Endothelial Dysfunction and Pulmonary Hypertension. Front Physiol 9 537 PMID: 29867576

Ronaldson-Bouchard et al (2018) Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature 556 239 PMID: 29618819

Tidball et al (2016) Genomic Instability Associated with p53 Knockdown in the Generation of Huntington's Disease Human Induced Pluripotent Stem Cells. PLoS One 11 e0150372 PMID: 26982737

Kellner et al (2016) Nogo-A controls structural plasticity at dendritic spines by rapidly modulating actin dynamics. Hippocampus 6 816 PMID: 26748478

Borgs et al (2016) DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Scientific Reports 6 33377 PMID: 27640816

Chal et al (2016) Generation of human muscle fibers and satellite-like cells from human pluripotent stem cells in vitro. Nat.Protoc. 11 1833 PMID: 27583644

Jardé et al (2016) Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids Nature Communications 7 13207 PMID: 27782124

Palpant et al (2016) Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using humanpluripotent stem cells. Nature Protocols 12 15 PMID: 27906170

Keimpema et al (2014) GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain. Cereb Cortex 24 3277 PMID: 23897649

Moon et al (2014) Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis. Mucosal Immunol 7 818 PMID: 24220295

Orgaz et al (2014) Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun 5 4255 PMID: 24963846

McNary et al (2014) Transforming growth factor β-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A 20 921 PMID: 24116978

Williams et al (2014) An in vivo role for Rho kinase activation in the tumour vascular disrupting activity of combretastatin A-4 3-O-phosphate. Br J Pharmacol 171 4902 PMID: 24930520

Huang et al (2014) Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat Biotechnol 32 84 PMID: 24291815

Sun et al (2014) Induction of entosis by epithelial cadherin expression. Cell Res 24 1288 PMID: 25342558

Liu and Chen (2014) Cryopreservation of human pluripotent stem cells in defined medium. Curr Protoc Stem Cell Biol 31 1C.17.1 PMID: 25366897

Luo et al (2014) Generation of GFP Reporter Human Induced Pluripotent Stem Cells Using AAVS1 Safe Harbor Transcription Activator-Like Effector Nuclease. Curr Protoc Stem Cell Biol 29 5A.7.1 PMID: 24838915

Mich et al (2014) Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife 3 e02669 PMID: 24843006

Pavlov et al (2014) Role of Rho GDP dissociation inhibitor α in control of epithelial sodium channel (ENaC)-mediated sodium reabsorption. J Biol Chem 289 28651 PMID: 25164814

Wile et al (2014) Molecular beacon-enabled purification of living cells by targeting cell type-specific mRNAs. Nat Protoc 9 2411 PMID: 25232937

Sun et al (2014) Competition between human cells by entosis. Cell Res 24 1299 PMID: 25342560

Vallenius et al (2011) An association between NUAK2 and MRIP reveals a novel mechanism for regulation of actin stress fibers. Integr Biol (Camb) 124 384 PMID: 21242312

Lee et al (2011) The Relaxing Effect of α-Defensin 1 on the Adrenergic Responses of Rat Bladder. Dev Biol 15 143 PMID: 21860592

Ruiz and Chen (2008) Emergence of patterned stem cell differentiation within multicellular structures. J Cell Sci 26 2921 PMID: 18703661

Inan and Büyükafşar (2008) Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. Am J Pathol 155 44 PMID: 18536751

Surendran et al (2022) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells STAR Protoc 3 101803 PMID: 36386870

Zhan et al (2022) Pancreatic islet cryopreservation by vitrification achieves high viability, function, recovery and clinical scalability for transplantation. Nat.Med. 28 798 PMID: 35288694

Wong et al (2018) α-Tubulin Acetyltransferase Is a Novel Target Mediating Neurite Growth Inhibitory Effects of Chondroitin Sulfate Proteoglycans and Myelin-Associated Glycoprotein. Eneuro 5 PMID: 29497702

Ho et al (2018) Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci 59 1969 PMID: 29677358

Sima et al (2018) Neural stem cells for disease modeling and evaluation of therapeutics for infantile (CLN1/PPT1) and late infantile (CLN2/TPP1) neuronal ceroid lipofuscinoses. Orphanet J Rare Dis 13 54 PMID: 29631617

Medelnik et al (2018) Signaling-Dependent Control of Apical Membrane Size and Self-Renewal in Rosette-Stage Human Neuroepithelial Stem Cells. Stem Cell Reports 10 1751 PMID: 29779899

Levardon et al (2018) Expansion of Airway Basal Cells and Generation of Polarized Epithelium. Bio Protoc 8 PMID: 30009215

McHugh et al (2018) Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity. Oncotarget 9 20265 PMID: 29755650

Hepburn et al (2018) Targeting the spliceosome for cutaneous squamous cell carcinoma therapy: a role for c-MYC and wild-type p53 in determining the degree of tumour selectivity. Oncotarget 9 23029 PMID: 29796170

Vu et al (2018) Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease. Orphanet J Rare Dis 13 152 PMID: 30220252

Tidball et al (2018) Generating Loss-of-function iPSC Lines with Combined CRISPR Indel Formation and Reprogramming from Human Fibroblasts. Bio Protoc 8 PMID: 30320153

Ng-Blichfeldt et al (2018) Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine 36 461 PMID: 30236449

McKown et al (2018) Impaired adhesion of induced pluripotent stem cell-derived cardiac progenitor cells (iPSC-CPCs) to isolated extracellular matrix from failing hearts. Heliyon 4 e00870 PMID: 30364772

Pirie et al (2018) Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet 14 e1007732 PMID: 30372444

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Y-27632 dihydrochloride (1 mg) 1254 1 mg TOCRIS
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Y-27632 in solution 7000 4 mg TOCRIS
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1254
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Y-27632 dihydrochloride (1 mg)
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1 mg
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1254
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Y-27632 dihydrochloride (10 mg)
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10 mg
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7000
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Y-27632 in solution
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4 mg
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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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