제품 상세 Antibody 6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며, 최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다. 프린트 제품 문의 배경 Neurotransmitter transporter는 biological membrane을 가로질러 특정 세포 및 subcelluar 위치로 신경 전달 물질을 운반하는 막횡단 단백질 그룹입니다. 이들은 뉴런과 glia의 원형질막에서 발견되며 대부분이 나트륨 의존적입니다. 종종 신경 전달 물질 수송을 위한 에너지를 제공하기 위해 막을 가로지르는 전기화학적 gradient에 의존하는데, 예를 들어 Na + cotransport는 글루타메이트 수송에 필요한 에너지를 제공합니다. 신경 전달 물질 수송체는 신경 전달 물질을 틈새에서 제거함으로써 신경전달 물질의 효과를 종료시키는 작용을 하는 시냅스 갈라진 틈에서 고농도로 발견됩니다. 신경 전달 물질 수송체는 우울증, 간질 및 정신분열증 등의 치료에서 약물의 표적으로 삼고 있습니다. 또한 코카인 등의 마약도 이러한 수송체에 대한 작용을 통해 효과를 냅니다. 타겟 5-HT Transporters : 뇌 전체에 널리 분포되어 있는 solute carrier family 6 (SLC6) 중 sodium- 및 chloride-의존적인 transporter입니다. 5-HT의 재흡수를 담당하며 분자의 이동을 위해 구조적 변화를 거칩니다.Acetylcholine Transporters : vesicular monoamine transporters (VMAT) 1와 VMAT2를 포함하는 ATP 의존 수송체이며, solute carrier family 18 (SLC18) 중 하나 입니다.Adrenergic Transporters : 뇌 전체에 널리 분포되어 있는noradrenergic neuronal plasma membranes 내의 solute carrier family 6 (SLC6) 중 sodium- 및 chloride-의존적인 transporter입니다. 아드레날린과 노르아드레날린의 재흡수를 담당합니다.Cannabinoid Transporters : Anandamide membrane transporters (AMTs) 또는 endocannabinoid membrane transporters (EMTs)라고도 불리며, Endocannabinoids의 세포로의 재흡수를 촉진하는 것으로 알려져 있습니다. 그러나, 신경전달물질 수송체로서의 존재는 논란의 여지가 있으며 막관통 단백질 수송체 또는 수송체를 코딩하는 유전자는 아직 확인되지 않았습니다.Dopamine Transporters : Striatum와 substantia nigra 등 뇌 전역의 도파민 활성과 관련된 영역에 널리 분포된 solute carrier family 6 (SLC6)이며, sodium- 및 chloride에 의존적입니다. 신속하게 도파민을 제거합니다.GABA Transporters : 신속하게 GABA를 제거하도록 매개하며 세포 외 GABA level을 낮게 유지하도록 하는 solute carrier family 6 (SLC6)이며, sodium- 및 chloride에 의존적입니다. 4개의 12-TM 도메인 수송체가 확인되었고 뉴런 및 신경교세포에 국한되었습니다.Glutamate (EAAT) Transporters : 뇌 전역에 분포된 solute carrier family 6 (SLC1)이며, sodium- 및 chloride에 의존적입니다. 5개의 subtype이 존재하며, 각각이 특정 영역에 특이적으로 분포합니다.Glycine Transporters : High affinity Sodium- 및 chloride에 의존적인 neurotransmitter transporter 단백질입니다. GlyT1 및 GlyT2의 두 종류의 subtype이 존재하는데, GlyT1은 caudal brain areas의 glia에 주로 위치합니다.Nucleoside Transporters : Na+-dependent solute carrier family 28 (SLC28) 와 the equilibrative solute carrier family 29 (SLC29)의 두 family 로 존재합니다. SLC28(CNT1,2, 및 3)은 조직에 따라 다른 subtype의 발현 패턴을 보입니다.Vesicular Monoamine Transporters(VMAT) : 도파민과 같은 생체 아민을 모노아민 함유 뉴런 내의 소포로 수송하며, 이는 신경 전달을 돕고 cytoplasmic neurotransmitter concentrations를 유지하는 데 도움이 됩니다. 종류 5-HT Transporters Cat. No. Product Name Activity 5-HT Transporter Inhibitors 4456 Amitriptyline hydrochloride 5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist 1427 Citalopram hydrobromide Highly potent and selective 5-HT uptake inhibitor 4358 Dapoxetine hydrochloride Selective serotonin reuptake inhibitor (SSRI) 2695 Dexfenfluramine hydrochloride 5-HT reuptake inhibitor; also stimulates 5-HT release 4798 (S)-Duloxetine hydrochloride Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake 4796 Escitalopram oxalate Selective serotonin reuptake inhibitor (SSRI) 0927 Fluoxetine hydrochloride 5-HT reuptake inhibitor 1033 Fluvoxamine maleate 5-HT reuptake inhibitor 1588 Indatraline hydrochloride Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake 2545 Lofepramine 5-HT and NA reuptake inhibitor (SNRI) 3286 Milnacipran hydrochloride 5-HT and NA reuptake inhibitor (SNRI) 2141 Paroxetine maleate Highly potent and selective 5-HT uptake inhibitor 2395 Sertraline hydrochloride 5-HT reuptake inhibitor 2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport; depletes 5-HT stores 2917 Venlafaxine hydrochloride 5-HT and NA reuptake inhibitor (SNRI) 6202 Vilazodone hydrochloride Potent SSRI and 5-HT1A partial agonist; antidepressant Other 5763 (R)-Citalopram oxalate Enantiomer of escitalopram oxalate (Cat. No. 1427) 3547 Serotonin hydrochloride Endogenous substrate Acetylcholine Transporters Cat. No. Product Name Activity Acetylcholine Transporter Inhibitors 0653 (±)-Vesamicol hydrochloride Inhibits ACh transport Adrenergic Transporters Cat. No. Product Name Activity Adrenergic Transporter Inhibitors 4456 Amitriptyline hydrochloride 5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist 2831 Bupropion hydrochloride Non-selective inhibitor of dopamine and noradrenalin transporters 3067 Desipramine hydrochloride Selective inhibitor of noradrenalin transporters 4798 (S)-Duloxetine hydrochloride Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake 1588 Indatraline hydrochloride Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake 2545 Lofepramine 5-HT and NA reuptake inhibitor (SNRI) 1812 Threo-methylphenidate hydrochloride Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant 3286 Milnacipran hydrochloride 5-HT and NA reuptake inhibitor (SNRI) 1025 Nisoxetine hydrochloride Noradrenalin re-uptake inhibitor 1992 Nomifensine Potent noradrenalin and dopamine uptake inhibitor. Antidepressant 1982 Reboxetine mesylate Potent and selective noradrenalin uptake inhibitor; orally active 2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores 2011 Tomoxetine hydrochloride Potent and selective noradrenalin re-uptake inhibitor 2917 Venlafaxine hydrochloride 5-HT and NA reuptake inhibitor (SNRI) Substrates 5169 Noradrenaline bitartrate Endogenous adrenergic hormone and neurotransmitter Other 6717 FFN 270 Fluorescent substrate for NET and VMAT2 Cannabinoid Transporters Cat. No. Product Name Activity Cannabinoid Transporter Inhibitors 1116 AM 404 Anandamide transport inhibitor 1570 (-)-Cannabidiol AMT inhibitor; also GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist; natural cannabinoid Dopamine Transporters Cat. No. Product Name Activity Dopamine Transporter Inhibitors 2831 Bupropion hydrochloride Non-selective inhibitor of dopamine and noradrenalin transporters 4798 (S)-Duloxetine hydrochloride Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake 0513 GBR 12783 dihydrochloride Potent and selective DA uptake inhibitor 0421 GBR 12909 dihydrochloride Selective DA uptake inhibitor; also σ ligand 1588 Indatraline hydrochloride Potent dopamine uptake inhibitor; also inhibits 5-HT and noradrenalin uptake 4351 JHW 007 hydrochloride High affinity dopamine uptake inhibitor 1812 Threo-methylphenidate hydrochloride Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant 1992 Nomifensine Potent noradrenalin and dopamine uptake inhibitor. Antidepressant 2742 Reserpine Inhibitor of vesicular monoamine transport 1497 Rimcazole dihydrochloride DAT inhibitor. Also σ2 antagonist 2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport; depletes dopamine stores Other 4946 AIM 100 Promotes endocytosis and oligomerization of DAT; also Ack1 inhibitor 5200 FFN 102 mesylate Selective fluorescent substrate of DAT and VMAT2 GABA Transporters Cat. No. Product Name Activity GABA Inhibitors 1296 CI 966 hydrochloride Selective inhibitor of GAT-1 1779 NNC 711 Selective GAT-1 inhibitor 0768 Riluzole hydrochloride GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels 1081 SKF 89976A hydrochloride Potent GAT-1 inhibitor; brain penetrant 1561 (S)-SNAP 5114 GABA uptake inhibitor 0181 TACA GABA uptake inhibitor; also GABAA agonist and substrate for GABA-T 4256 Tiagabine hydrochloride Selective GAT-1 inhibitor; anticonvulsant Glutamate (EAAT) Transporters Cat. No. Product Name Activity Glutamate Transporter Modulators 6578 GT 949 Potent and selective positive allosteric modulator of EAAT2 Glutamate Transporter Inhibitors 0846 Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF 3697 7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237) 0237 7-Chlorokynurenic acid Potent competitive inhibitor of L-glutamate uptake 0111 Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake 0845 Evans Blue tetrasodium salt Potent inhibitor of L-glutamate uptake into synaptic vesicles; also non-NMDA iGluR antagonist; P2X antagonist 0183 L-(-)-threo-3-Hydroxyaspartic acid Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 0298 L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor 1223 DL-TBOA Selective non-transportable inhibitor of EAATs 2532 TFB-TBOA High affinity EAAT1 and EAAT2 blocker 3490 UCPH 101 Selective non-substrate EAAT1 inhibitor 2652 WAY 213613 Potent, non-substrate EAAT2 inhibitor Other 5082 LDN 212320 Increases EAAT2 expression; neuroprotective Glycine Transporters Cat. No. Product Name Activity Glycine Transporter Inhibitors 1757 ALX 5407 hydrochloride Selective non-transportable GlyT1 inhibitor 5308 ASP 2535 Potent and selective GlyT1 inhibitor 3397 LY 2365109 hydrochloride Potent and selective GlyT1 inhibitor 2789 NFPS Selective non-transportable GlyT1 inhibitor 4447 Org 24598 Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo 4782 Org 25543 hydrochloride Potent and selective GlyT2 inhibitor Nucleoside Transporters Cat. No. Product Name Activity Nucleoside Transporter Inhibitors 4588 8MDP Potent equilibrative nucleoside transporter (ENT) inhibitor 1692 Cilostazol Adenosine uptake inhibitor. Also PDE3A inhibitor 0481 Dilazep dihydrochloride Adenosine uptake inhibitor 0691 Dipyridamole Adenosine transport inhibitor 1745 5-Iodotubercidin Nucleoside transporter inhibitor; also a broad spectrum kinase inhibitor 2924 NBMPR Equilibrative nucleoside transporter 1 (ENT1) inhibitor 6864 Ticagrelor High affinity equilibrative nucleoside transporter (ENT1) inhibitor; also potent P2Y12 antagonist Vesicular Monoamine Transporters Cat. No. Product Name Activity Vesicular Monoamine Transporter Inhibitors 2742 Reserpine Inhibitor of vesicular monoamine transport 5168 Rose Bengal Potent VGlut and VMAT inhibitor; cell permeable 2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport Other 5200 FFN 102 mesylate Selective fluorescent substrate of VMAT2 and DAT 5911 FFN 200 dihydrochloride Selective fluorescent VMAT2 substrate 5043 FFN 206 dihydrochloride Fluorescent VMAT2 substrate 6717 FFN 270 Fluorescent substrate for NET and VMAT2 3878 FFN 511 Fluorescent substrate for VMAT2 주문정보 견적문의 제품담기 주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다. Product Cat.No. Size Maker Qty Data Sheet MSDS 전체보기 추천제품 관련제품 견적문의 제품담기 주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다. Product Cat.No. Size Maker Qty Data Sheet MSDS 전체보기 자료 웨비나/Video