Neurotransmitter Transporter | 고마바이오텍

특징

5-HT Transporters : 뇌 전체에 널리 분포되어 있는 solute carrier family 6 (SLC6) 중 sodium- 및 chloride-의존적인 transporter입니다. 5-HT의 재흡수를 담당하며 분자의 이동을 위해 구조적 변화를 거칩니다.
Acetylcholine Transporters : vesicular monoamine transporters (VMAT) 1와 VMAT2를 포함하는 ATP 의존 수송체이며, solute carrier family 18 (SLC18) 중 하나 입니다.
Adrenergic Transporters : 뇌 전체에 널리 분포되어 있는noradrenergic neuronal plasma membranes 내의 solute carrier family 6 (SLC6) 중 sodium- 및 chloride-의존적인 transporter입니다. 아드레날린과 노르아드레날린의 재흡수를 담당합니다.
Cannabinoid Transporters : Anandamide membrane transporters (AMTs) 또는 endocannabinoid membrane transporters (EMTs)라고도 불리며, Endocannabinoids의 세포로의 재흡수를 촉진하는 것으로 알려져 있습니다. 그러나, 신경전달물질 수송체로서의 존재는 논란의 여지가 있으며 막관통 단백질 수송체 또는 수송체를 코딩하는 유전자는 아직 확인되지 않았습니다.
Dopamine Transporters : Striatum와 substantia nigra 등 뇌 전역의 도파민 활성과 관련된 영역에 널리 분포된 solute carrier family 6 (SLC6)이며, sodium- 및 chloride에 의존적입니다. 신속하게 도파민을 제거합니다.
GABA Transporters : 신속하게 GABA를 제거하도록 매개하며 세포 외 GABA level을 낮게 유지하도록 하는 solute carrier family 6 (SLC6)이며, sodium- 및 chloride에 의존적입니다. 4개의 12-TM 도메인 수송체가 확인되었고 뉴런 및 신경교세포에 국한되었습니다.
Glutamate (EAAT) Transporters : 뇌 전역에 분포된 solute carrier family 6 (SLC1)이며, sodium- 및 chloride에 의존적입니다. 5개의 subtype이 존재하며, 각각이 특정 영역에 특이적으로 분포합니다.
Glycine Transporters : High affinity Sodium- 및 chloride에 의존적인 neurotransmitter transporter 단백질입니다. GlyT1 및 GlyT2의 두 종류의 subtype이 존재하는데, GlyT1은 caudal brain areas의 glia에 주로 위치합니다.
Nucleoside Transporters : Na+-dependent solute carrier family 28 (SLC28) 와 the equilibrative solute carrier family 29 (SLC29)의 두 family 로 존재합니다. SLC28(CNT1,2, 및 3)은 조직에 따라 다른 subtype의 발현 패턴을 보입니다.
Vesicular Monoamine Transporters(VMAT) : 도파민과 같은 생체 아민을 모노아민 함유 뉴런 내의 소포로 수송하며, 이는 신경 전달을 돕고 cytoplasmic neurotransmitter concentrations를 유지하는 데 도움이 됩니다.

주요 제품

5-HT Transporters

Group	Cat. No.	Product	Activity
5-HT Transporter Inhibitors	4456	Amitriptyline hydrochloride	5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
	1427	Citalopram hydrobromide	Highly potent and selective 5-HT uptake inhibitor
	4358	Dapoxetine hydrochloride	Selective serotonin reuptake inhibitor (SSRI)
	2695	Dexfenfluramine hydrochloride	5-HT reuptake inhibitor; also stimulates 5-HT release
	4798	(S)-Duloxetine hydrochloride	Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake
	4796	Escitalopram oxalate	Selective serotonin reuptake inhibitor (SSRI)
	0927	Fluoxetine hydrochloride	5-HT reuptake inhibitor
	1033	Fluvoxamine maleate	5-HT reuptake inhibitor
	1588	Indatraline hydrochloride	Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
	2545	Lofepramine	5-HT and NA reuptake inhibitor (SNRI)
	3286	Milnacipran hydrochloride	5-HT and NA reuptake inhibitor (SNRI)
	2141	Paroxetine maleate	Highly potent and selective 5-HT uptake inhibitor
	2395	Sertraline hydrochloride	5-HT reuptake inhibitor
	2175	Tetrabenazine	Potent inhibitor of vesicular monoamine transport; depletes 5-HT stores
	2917	Venlafaxine hydrochloride	5-HT and NA reuptake inhibitor (SNRI)
	6202	Vilazodone hydrochloride	Potent SSRI and 5-HT1A partial agonist; antidepressant
Other	5763	(R)-Citalopram oxalate	Enantiomer of escitalopram oxalate (Cat. No. 1427)
Other	3547	Serotonin hydrochloride	Endogenous substrate

Acetylcholine Transporters

Group	Cat. No.	Product	Activity
Acetylcholine Transporter Inhibitors	0653	(±)-Vesamicol hydrochloride	Inhibits ACh transport

Adrenergic Transporters

Group	Cat. No.	Product	Activity
Adrenergic Transporter Inhibitors	4456	Amitriptyline hydrochloride	5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist
	2831	Bupropion hydrochloride	Non-selective inhibitor of dopamine and noradrenalin transporters
	3067	Desipramine hydrochloride	Selective inhibitor of noradrenalin transporters
	4798	(S)-Duloxetine hydrochloride	Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
	1588	Indatraline hydrochloride	Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake
	2545	Lofepramine	5-HT and NA reuptake inhibitor (SNRI)
	1812	Threo-methylphenidate hydrochloride	Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
	3286	Milnacipran hydrochloride	5-HT and NA reuptake inhibitor (SNRI)
	1025	Nisoxetine hydrochloride	Noradrenalin re-uptake inhibitor
	1992	Nomifensine	Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
	1982	Reboxetine mesylate	Potent and selective noradrenalin uptake inhibitor; orally active
	2175	Tetrabenazine	Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores
	2011	Tomoxetine hydrochloride	Potent and selective noradrenalin re-uptake inhibitor
	2917	Venlafaxine hydrochloride	5-HT and NA reuptake inhibitor (SNRI)
Substrates	5169	Noradrenaline bitartrate	Endogenous adrenergic hormone and neurotransmitter
Other	6717	FFN 270	Fluorescent substrate for NET and VMAT2

Cannabinoid Transporters

Group	Cat. No.	Product	Activity
Cannabinoid Transporter Inhibitors	1116	AM 404	Anandamide transport inhibitor
Cannabinoid Transporter Inhibitors	1570	(-)-Cannabidiol	AMT inhibitor; also GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist; natural cannabinoid

Dopamine Transporters

Group	Cat. No.	Product	Activity
Dopamine Transporter Inhibitors	2831	Bupropion hydrochloride	Non-selective inhibitor of dopamine and noradrenalin transporters
	4798	(S)-Duloxetine hydrochloride	Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
	0513	GBR 12783 dihydrochloride	Potent and selective DA uptake inhibitor
	0421	GBR 12909 dihydrochloride	Selective DA uptake inhibitor; also σ ligand
	1588	Indatraline hydrochloride	Potent dopamine uptake inhibitor; also inhibits 5-HT and noradrenalin uptake
	4351	JHW 007 hydrochloride	High affinity dopamine uptake inhibitor
	1812	Threo-methylphenidate hydrochloride	Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
	1992	Nomifensine	Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
	2742	Reserpine	Inhibitor of vesicular monoamine transport
	1497	Rimcazole dihydrochloride	DAT inhibitor. Also σ2 antagonist
	2175	Tetrabenazine	Potent inhibitor of vesicular monoamine transport; depletes dopamine stores
Other	4946	AIM 100	Promotes endocytosis and oligomerization of DAT; also Ack1 inhibitor
Other	5200	FFN 102 mesylate	Selective fluorescent substrate of DAT and VMAT2

GABA Transporters

Group	Cat. No.	Product	Activity
GABA Inhibitors	1296	CI 966 hydrochloride	Selective inhibitor of GAT-1
	1779	NNC 711	Selective GAT-1 inhibitor
	0768	Riluzole hydrochloride	GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
	1081	SKF 89976A hydrochloride	Potent GAT-1 inhibitor; brain penetrant
	1561	(S)-SNAP 5114	GABA uptake inhibitor
	0181	TACA	GABA uptake inhibitor; also GABAA agonist and substrate for GABA-T
	4256	Tiagabine hydrochloride	Selective GAT-1 inhibitor; anticonvulsant

Glutamate (EAAT) Transporters

Group	Cat. No.	Product	Activity
Glutamate Transporter Modulators	6578	GT 949	Potent and selective positive allosteric modulator of EAAT2
Glutamate Transporter Inhibitors	0846	Chicago Sky Blue 6B	Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
	3697	7-Chlorokynurenic acid sodium salt	Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
	0237	7-Chlorokynurenic acid	Potent competitive inhibitor of L-glutamate uptake
	0111	Dihydrokainic acid	EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
	0845	Evans Blue tetrasodium salt	Potent inhibitor of L-glutamate uptake into synaptic vesicles; also non-NMDA iGluR antagonist; P2X antagonist
	0183	L-(-)-threo-3-Hydroxyaspartic acid	Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
	0298	L-trans-2,4-PDC	Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
	1223	DL-TBOA	Selective non-transportable inhibitor of EAATs
	2532	TFB-TBOA	High affinity EAAT1 and EAAT2 blocker
	3490	UCPH 101	Selective non-substrate EAAT1 inhibitor
	2652	WAY 213613	Potent, non-substrate EAAT2 inhibitor
Other	5082	LDN 212320	Increases EAAT2 expression; neuroprotective

Glycine Transporters

Group	Cat. No.	Product	Activity
Glycine Transporter Inhibitors	1757	ALX 5407 hydrochloride	Selective non-transportable GlyT1 inhibitor
	5308	ASP 2535	Potent and selective GlyT1 inhibitor
	3397	LY 2365109 hydrochloride	Potent and selective GlyT1 inhibitor
	2789	NFPS	Selective non-transportable GlyT1 inhibitor
	4447	Org 24598	Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
	4782	Org 25543 hydrochloride	Potent and selective GlyT2 inhibitor

Nucleoside Transporters

Group	Cat. No.	Product	Activity
Nucleoside Transporter Inhibitors	4588	8MDP	Potent equilibrative nucleoside transporter (ENT) inhibitor
	1692	Cilostazol	Adenosine uptake inhibitor. Also PDE3A inhibitor
	0481	Dilazep dihydrochloride	Adenosine uptake inhibitor
	0691	Dipyridamole	Adenosine transport inhibitor
	1745	5-Iodotubercidin	Nucleoside transporter inhibitor; also a broad spectrum kinase inhibitor
	2924	NBMPR	Equilibrative nucleoside transporter 1 (ENT1) inhibitor
	6864	Ticagrelor	High affinity equilibrative nucleoside transporter (ENT1) inhibitor; also potent P2Y12 antagonist

Vesicular Monoamine Transporters

Group	Cat. No.	Product	Activity
Vesicular Monoamine Transporter Inhibitors	2742	Reserpine	Inhibitor of vesicular monoamine transport
	5168	Rose Bengal	Potent VGlut and VMAT inhibitor; cell permeable
	2175	Tetrabenazine	Potent inhibitor of vesicular monoamine transport
Other	5200	FFN 102 mesylate	Selective fluorescent substrate of VMAT2 and DAT
	5911	FFN 200 dihydrochloride	Selective fluorescent VMAT2 substrate
	5043	FFN 206 dihydrochloride	Fluorescent VMAT2 substrate
	6717	FFN 270	Fluorescent substrate for NET and VMAT2
	3878	FFN 511	Fluorescent substrate for VMAT2

주문정보

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	Product	Cat.No.	Size	Maker	Qty	Data Sheet	MSDS

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