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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

프린트 제품 문의

배경

 

Neurotransmitter transporter는 biological membrane을 가로질러 특정 세포 및 subcelluar 위치로 신경 전달 물질을 운반하는 막횡단 단백질 그룹입니다. 이들은 뉴런과  glia의 원형질막에서 발견되며 대부분이 나트륨 의존적입니다. 종종 신경 전달 물질 수송을 위한 에너지를 제공하기 위해 막을 가로지르는 전기화학적 gradient에 의존하는데, 예를 들어 Na + cotransport는 글루타메이트 수송에 필요한 에너지를 제공합니다. 신경 전달 물질 수송체는 신경 전달 물질을 틈새에서 제거함으로써 신경전달 물질의 효과를 종료시키는 작용을 하는 시냅스 갈라진 틈에서 고농도로 발견됩니다. 

 

신경 전달 물질 수송체는 우울증, 간질 및 정신분열증 등의 치료에서 약물의 표적으로 삼고 있습니다. 또한 코카인 등의 마약도 이러한 수송체에 대한 작용을 통해 효과를 냅니다.

 

 

 

타겟 

 

  • 5-HT Transporters :  뇌 전체에 널리 분포되어 있는 solute carrier family 6 (SLC6) 중 sodium- 및 chloride-의존적인 transporter입니다. 5-HT의 재흡수를 담당하며 분자의 이동을 위해 구조적 변화를 거칩니다.
  • Acetylcholine Transporters : vesicular monoamine transporters (VMAT) 1와 VMAT2를 포함하는 ATP 의존 수송체이며, solute carrier family 18 (SLC18) 중 하나 입니다.
  • Adrenergic Transporters : 뇌 전체에 널리 분포되어 있는noradrenergic neuronal plasma membranes 내의 solute carrier family 6 (SLC6) 중 sodium- 및 chloride-의존적인 transporter입니다. 아드레날린과 노르아드레날린의 재흡수를 담당합니다.
  • Cannabinoid Transporters : Anandamide membrane transporters (AMTs) 또는 endocannabinoid membrane transporters (EMTs)라고도 불리며, Endocannabinoids의 세포로의 재흡수를 촉진하는 것으로 알려져 있습니다. 그러나, 신경전달물질 수송체로서의 존재는 논란의 여지가 있으며 막관통 단백질 수송체 또는 수송체를 코딩하는 유전자는 아직 확인되지 않았습니다.
  • Dopamine Transporters : Striatum와 substantia nigra 등 뇌 전역의 도파민 활성과 관련된 영역에 널리 분포된 solute carrier family 6 (SLC6)이며, sodium- 및 chloride에 의존적입니다. 신속하게 도파민을 제거합니다.
  • GABA Transporters : 신속하게 GABA를 제거하도록 매개하며 세포 외 GABA level을 낮게 유지하도록 하는 solute carrier family 6 (SLC6)이며, sodium- 및 chloride에 의존적입니다. 4개의 12-TM 도메인 수송체가 확인되었고 뉴런 및 신경교세포에 국한되었습니다.
  • Glutamate (EAAT) Transporters : 뇌 전역에 분포된 solute carrier family 6 (SLC1)이며, sodium- 및 chloride에 의존적입니다. 5개의 subtype이 존재하며, 각각이 특정 영역에 특이적으로 분포합니다.
  • Glycine Transporters : High affinity Sodium- 및 chloride에 의존적인 neurotransmitter transporter 단백질입니다. GlyT1 및 GlyT2의 두 종류의 subtype이 존재하는데, GlyT1은 caudal brain areas의 glia에 주로 위치합니다.
  • Nucleoside Transporters : Na+-dependent solute carrier family 28 (SLC28) 와 the equilibrative solute carrier family 29 (SLC29)의 두 family 로 존재합니다. SLC28(CNT1,2, 및 3)은 조직에 따라 다른 subtype의 발현 패턴을 보입니다.
  • Vesicular Monoamine Transporters(VMAT) :  도파민과 같은 생체 아민을 모노아민 함유 뉴런 내의 소포로 수송하며, 이는 신경 전달을 돕고 cytoplasmic neurotransmitter concentrations를 유지하는 데 도움이 됩니다.

 

 

 

종류 

 

  • 5-HT Transporters

 

　 Cat. No. Product Name Activity
5-HT Transporter Inhibitors 4456 Amitriptyline hydrochloride 5-HT and NA reuptake inhibitor (SNRI); also TrkA/B agonist
1427 Citalopram hydrobromide Highly potent and selective 5-HT uptake inhibitor
4358 Dapoxetine hydrochloride Selective serotonin reuptake inhibitor (SSRI)
2695 Dexfenfluramine hydrochloride 5-HT reuptake inhibitor; also stimulates 5-HT release
4798 (S)-Duloxetine hydrochloride Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake
4796 Escitalopram oxalate Selective serotonin reuptake inhibitor (SSRI)
0927 Fluoxetine hydrochloride 5-HT reuptake inhibitor
1033 Fluvoxamine maleate 5-HT reuptake inhibitor
1588 Indatraline hydrochloride Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake
2545 Lofepramine 5-HT and NA reuptake inhibitor (SNRI)
3286 Milnacipran hydrochloride 5-HT and NA reuptake inhibitor (SNRI)
2141 Paroxetine maleate Highly potent and selective 5-HT uptake inhibitor
2395 Sertraline hydrochloride 5-HT reuptake inhibitor
2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport; depletes 5-HT stores
2917 Venlafaxine hydrochloride 5-HT and NA reuptake inhibitor (SNRI)
6202 Vilazodone hydrochloride Potent SSRI and 5-HT1A partial agonist; antidepressant
Other 5763 (R)-Citalopram oxalate Enantiomer of escitalopram oxalate (Cat. No. 1427)
3547 Serotonin hydrochloride Endogenous substrate

 

 

  • Acetylcholine Transporters

 

　 Cat. No. Product Name Activity
Acetylcholine Transporter Inhibitors 0653 (±)-Vesamicol hydrochloride Inhibits ACh transport

  

  • Adrenergic Transporters

 

 

　 Cat. No. Product Name Activity
Adrenergic Transporter Inhibitors 4456 Amitriptyline hydrochloride 5-HT and noradrenalin re-uptake inhibitor; also TrkA/B agonist
2831 Bupropion hydrochloride Non-selective inhibitor of dopamine and noradrenalin transporters
3067 Desipramine hydrochloride Selective inhibitor of noradrenalin transporters
4798 (S)-Duloxetine hydrochloride Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
1588 Indatraline hydrochloride Potent noradrenalin uptake inhibitor; also inhibits 5-HT and dopamine uptake
2545 Lofepramine 5-HT and NA reuptake inhibitor (SNRI)
1812 Threo-methylphenidate hydrochloride Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
3286 Milnacipran hydrochloride 5-HT and NA reuptake inhibitor (SNRI)
1025 Nisoxetine hydrochloride Noradrenalin re-uptake inhibitor
1992 Nomifensine Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
1982 Reboxetine mesylate Potent and selective noradrenalin uptake inhibitor; orally active
2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport; depletes noradrenalin stores
2011 Tomoxetine hydrochloride Potent and selective noradrenalin re-uptake inhibitor
2917 Venlafaxine hydrochloride 5-HT and NA reuptake inhibitor (SNRI)
Substrates 5169 Noradrenaline bitartrate Endogenous adrenergic hormone and neurotransmitter
Other 6717 FFN 270 Fluorescent substrate for NET and VMAT2

 

 

  • Cannabinoid Transporters

 

 

　 Cat. No. Product Name Activity
Cannabinoid Transporter Inhibitors 1116 AM 404 Anandamide transport inhibitor
1570 (-)-Cannabidiol AMT inhibitor; also GPR55 antagonist, weak CB1 antagonist, CB2 inverse agonist; natural cannabinoid

 

 

  • Dopamine Transporters

 

 

　 Cat. No. Product Name Activity
Dopamine Transporter Inhibitors 2831 Bupropion hydrochloride Non-selective inhibitor of dopamine and noradrenalin transporters
4798 (S)-Duloxetine hydrochloride Potent 5-HT and NA reuptake inhibitor; also blocks dopamine reuptake
0513 GBR 12783 dihydrochloride Potent and selective DA uptake inhibitor
0421 GBR 12909 dihydrochloride Selective DA uptake inhibitor; also σ ligand
1588 Indatraline hydrochloride Potent dopamine uptake inhibitor; also inhibits 5-HT and noradrenalin uptake
4351 JHW 007 hydrochloride High affinity dopamine uptake inhibitor
1812 Threo-methylphenidate hydrochloride Inhibitor of dopamine and noradrenalin transporters. Psychomotor stimulant
1992 Nomifensine Potent noradrenalin and dopamine uptake inhibitor. Antidepressant
2742 Reserpine Inhibitor of vesicular monoamine transport
1497 Rimcazole dihydrochloride DAT inhibitor. Also σ2 antagonist
2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport; depletes dopamine stores
Other 4946 AIM 100 Promotes endocytosis and oligomerization of DAT; also Ack1 inhibitor
5200 FFN 102 mesylate Selective fluorescent substrate of DAT and VMAT2

 

 

  • GABA Transporters

 

 

　 Cat. No. Product Name Activity
GABA Inhibitors 1296 CI 966 hydrochloride Selective inhibitor of GAT-1
1779 NNC 711 Selective GAT-1 inhibitor
0768 Riluzole hydrochloride GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels
1081 SKF 89976A hydrochloride Potent GAT-1 inhibitor; brain penetrant
1561 (S)-SNAP 5114 GABA uptake inhibitor
0181 TACA GABA uptake inhibitor; also GABAA agonist and substrate for GABA-T
4256 Tiagabine hydrochloride Selective GAT-1 inhibitor; anticonvulsant

 

 

  • Glutamate (EAAT) Transporters

 

 

　 Cat. No. Product Name Activity
Glutamate Transporter Modulators 6578 GT 949 Potent and selective positive allosteric modulator of EAAT2
Glutamate Transporter Inhibitors 0846 Chicago Sky Blue 6B Potent inhibitor of L-glutamate uptake into synaptic vesicles; also inhibits MIF
3697 7-Chlorokynurenic acid sodium salt Potent competitive inhibitor of L-glutamate uptake. Sodium salt of 7-Chlorokynurenic acid (Cat. No. 0237)
0237 7-Chlorokynurenic acid Potent competitive inhibitor of L-glutamate uptake
0111 Dihydrokainic acid EAAT2 (GLT-1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
0845 Evans Blue tetrasodium salt Potent inhibitor of L-glutamate uptake into synaptic vesicles; also non-NMDA iGluR antagonist; P2X antagonist
0183 L-(-)-threo-3-Hydroxyaspartic acid Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
0298 L-trans-2,4-PDC Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
1223 DL-TBOA Selective non-transportable inhibitor of EAATs
2532 TFB-TBOA High affinity EAAT1 and EAAT2 blocker
3490 UCPH 101 Selective non-substrate EAAT1 inhibitor
2652 WAY 213613 Potent, non-substrate EAAT2 inhibitor
Other 5082 LDN 212320 Increases EAAT2 expression; neuroprotective

 

 

  • Glycine Transporters

 

 

　 Cat. No. Product Name Activity
Glycine Transporter Inhibitors 1757 ALX 5407 hydrochloride Selective non-transportable GlyT1 inhibitor
5308 ASP 2535 Potent and selective GlyT1 inhibitor
3397 LY 2365109 hydrochloride Potent and selective GlyT1 inhibitor
2789 NFPS Selective non-transportable GlyT1 inhibitor
4447 Org 24598 Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
4782 Org 25543 hydrochloride Potent and selective GlyT2 inhibitor

 

 

  • Nucleoside Transporters

 

 

　 Cat. No. Product Name Activity
Nucleoside Transporter Inhibitors 4588 8MDP Potent equilibrative nucleoside transporter (ENT) inhibitor
1692 Cilostazol Adenosine uptake inhibitor. Also PDE3A inhibitor
0481 Dilazep dihydrochloride Adenosine uptake inhibitor
0691 Dipyridamole Adenosine transport inhibitor
1745 5-Iodotubercidin Nucleoside transporter inhibitor; also a broad spectrum kinase inhibitor
2924 NBMPR Equilibrative nucleoside transporter 1 (ENT1) inhibitor
6864 Ticagrelor High affinity equilibrative nucleoside transporter (ENT1) inhibitor; also potent P2Y12 antagonist

 

 

  •  Vesicular Monoamine Transporters

 

 

　 Cat. No. Product Name Activity
Vesicular Monoamine Transporter Inhibitors 2742 Reserpine Inhibitor of vesicular monoamine transport
5168 Rose Bengal Potent VGlut and VMAT inhibitor; cell permeable
2175 Tetrabenazine Potent inhibitor of vesicular monoamine transport
Other 5200 FFN 102 mesylate Selective fluorescent substrate of VMAT2 and DAT
5911 FFN 200 dihydrochloride Selective fluorescent VMAT2 substrate
5043 FFN 206 dihydrochloride Fluorescent VMAT2 substrate
6717 FFN 270 Fluorescent substrate for NET and VMAT2
3878 FFN 511 Fluorescent substrate for VMAT2

 

주문정보

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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