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Ubiquitin
E3 Ligase Inhibitors |
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Cat. No. |
Product Name |
Activity |
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0652 |
Thalidomide |
Binds cereblon; also TNF-α synthesis inhibitor |
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2443 |
RITA |
MDM2-p53 interaction inhibitor |
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3503 |
HLI
373 |
Hdm2 inhibitor; activates p53-dependent transcription |
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3984 |
Nutlin-3 |
MDM2 antagonist; inhibits MDM2-p53 interaction |
| |
4375 |
SMER
3 |
Selective inhibitor of E3 ubiquitin ligase |
| |
5047 |
PRT
4165 |
Inhibitor of Bmi1/Ring1A; blocks histone H2A
ubiquitination |
| |
5076 |
SZL
P1-41 |
Selective Skp2 inhibitor; suppresses E3 ligase
activity |
| |
5191 |
PTC
209 |
Bmi-1 inhibitor; antitumor |
| |
5332 |
SP
141 |
High affinity MDM2 inhibitor |
| |
5397 |
A01 |
High affinity Smurf1 inhibitor; enhances BMP
signaling |
| |
5433 |
Heclin |
HECT E3 ubiquitin ligase inhibitor |
| |
5636 |
GS
143 |
β-TrCP1 ligase inhibitor |
| |
5747 |
Apcin |
Cdc20 inhibitor; inhibits Cdc20-substrate interaction |
| |
6075 |
Nutlin
3a |
MDM2 antagonist; active enantiomer
of Nutlin-3 (Cat. No. 3984) |
| |
6156 |
VH
298 |
High-affinity inhibitor of VHL |
| |
6719 |
YH
239-EE |
MDM2 inhibitor; disrupts MDM2-p53 interaction |
| |
6904 |
Idasanutlin |
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction |
| |
7055 |
WS
383 |
Potent, selective and reversible DCN1-UBC12
interaction inhibitor |
| |
7089 |
CSN5i-3 |
Potent and selective CSN5 (COP9 signalosome)
inhibitor |
| |
7192 |
SMIP
004 |
SKP2 (S-phase kinase-associated protein 2) inhibitor;
upregulates p27 and arrests cell cycle in G1 phase |
| |
7289 |
Nimbolide |
RNF114 inhibitor |
| |
7498 |
SPOP-i-6lc |
SPOP E3 ubiquitin ligase inhibitor |
| |
7542 |
SJ
1008066 |
MAGE-A11 inhibitor disrupts MAGE-A11:PCF11
interaction |
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Ligands |
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Cat. No. |
Product Name |
Activity |
| |
7476 |
EN
219 |
Covalent RNF114 ligand |
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Degraders |
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Cat. No. |
Product Name |
Activity |
| |
6416 |
CM
11 |
Homo-PROTAC® for self-degradation of pVHL30 |
| |
7219 |
CRBN
PROTAC® 14a |
Cereblon Degrader (PROTAC®) |
| |
6948 |
CRBN-6-5-5-VHL |
Potent and selective cereblon Degrader;
cell-permeable |
| |
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Controls |
|
|
| |
Cat. No. |
Product Name |
Activity |
| |
6157 |
cis VH
298 |
Negative control for VH 298 |
| |
7532 |
CSN5i-3-NEG |
Negative control for CSN5i-3 (Cat. No.
7089) |
| |
7716 |
N-methylated
pomalidomide |
Pomalidomide negative control; also functionalized
cereblon ligand for generating Degrader negative controls |
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Others |
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Cat. No. |
Product Name |
Activity |
| |
7662 |
Azurin p28 peptide |
Binds
p53 and inhibits COP1-mediated ubiquitination of p53 |
| |
7483 |
BDY FL VH032 |
High-affinity VHL fluorescent probe for TR-FRET and
FP assays |
| |
7287 |
FAM-DEALA-Hyp-YIPD |
Fluorescent HIF-1α peptide; can be used to evaluate
the effect of VHL binding on degradation activity |
| |
7452 |
FAM-DEALAHypYIPMDDDFQLRSF |
Fluorescent HIF-1α peptide; can be used to evaluate
the effect of VHL binding on degradation activity |
| |
7627 |
FITC-labelled Keap1-Nrf2
probe |
Fluorescent Keap1-Nrf2 peptide |
| |
6782 |
Indisulam |
Molecular glue; pre-mRNA splicing modulator |
| |
6305 |
Lenalidomide |
Cereblon binder; induces ubiquitination and
degradation of CK1α by E3 ubiquitin ligase |
| |
5131 |
NAB 2 |
Protects against α-synuclein toxicity; promotes
Rsp5/Nedd4-dependent endosomal transport |
| |
6302 |
Pomalidomide |
Cereblon binder; also TNF-α inhibitor and
antiangiogenic |
| |
7288 |
Thalidomide-Cyanine 5 |
High affinity cereblon fluorescent probe |