제품 상세 Antibody 6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며, 최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다. 프린트 제품 문의 특징 Human iPSC-derived neural stem cell은 알츠하이머 환자로부터 fibroblast 혹은 PBMC를 채취하여 episomal vector 방법을 통해 iPSC로 리프로그래밍 후 chemically defined cortical neural induction을 이용하여 neural stem cell(NSC)로 분화시켜 만든 신경 줄기 세포 입니다. ApoE 혹은 Presenilin 1 유전자 형을 갖도록 엔지니어링되었습니다. 배양 21일차 정도에 spontaneous synaptic activity가 감지되며, 35일차에 synchronized burst firing이 발생합니다.Astrocyte와 함께 co-culture를 함으로써 LTP(long-term potentiation)이나 LTD(long-term depression)을 유도할 수 있습니다. 종류 Product Cat. No. Primary Cell Type Gene Type Source Human iPSC-Derived Neural Stem Cells ax0111 Fibroblast (87 Yr Female) APOE4 homozygous Alzheimer's Disease Patient Human iPSC-Derived Neural Stem Cells ax0112 Fibroblast (38 Yr Female) Presenilin 1 (PSEN1) L286V Alzheimer's Disease Patient Human iPSC-Derived Neural Stem Cells ax0113 Fibroblast (53 Yr Male) Presenilin 1 (PSEN1) M146L Alzheimer's Disease Patient Human iPSC-Derived Neural Stem Cells ax0114 Fibroblast (31 Yr Female) Presenilin 1 (PSEN1) A246E Alzheimer's Disease Patient Alzheimer’s Disease Cells CENSOi070-A PBMCs (59 Yr Female) ApoE Alzheimer's Disease Patient Alzheimer’s Disease Cells CENSOi074-A PBMCs (60 Yr Male) ApoE Alzheimer's Disease Patient Alzheimer’s Disease Cells CENSOi077-A PBMCs (52 Yr Female) ApoE Alzheimer's Disease Patient 사용 논문 Xia, Y., Wang, Zh., Zhang, J. et al. C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer’s disease. Mol Psychiatry 26, 6002–6022 (2021). https://doi.org/10.1038/s41380-020-00956-4Koroleva, A. et al. In Vitro Development of Human iPSC-Derived Functional Neuronal Networks on Laser-Fabricated 3D Scaffolds. ACS Appl. Mater. Interfaces, 13, 7, 7839–7853(2021). https://pubs.acs.org/doi/10.1021/acsami.0c16616Jones, V. et al. Aberrant iPSC-derived human astrocytes in Alzheimer's disease. Cell Death Dis 8, e2696 (2017). https://doi.org/10.1038/cddis.2017.89Zollo, A. et al. Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer’s Disease Patients Carrying the APOE Epsilon 4 Allele, Neural Plasticity, vol. 2017, Article ID 1892612, 10 pages, 2017. https://doi.org/10.1155/2017/1892612 주문정보 견적문의 제품담기 주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다. Product Cat.No. Size Maker Qty Data Sheet MSDS 전체보기 추천제품 관련제품 견적문의 제품담기 주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다. Product Cat.No. Size Maker Qty Data Sheet MSDS 전체보기 자료 웨비나/Video