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의약품 안전성과 유효성 평가서비스 | Safety and Efficacy Service 이미지

의약품 안전성과 유효성 평가서비스 | Safety and Efficacy Service

Eurofins Discovery의 Spectrum Screen, BioPrint, Safety Screen 87, Safety Screen Functional, Safety Screen 44 스크리닝 서비스를 통해 약물의 유효성, 부작용, 안전성을 측정해 드립니다.

특징

 

  • 개발된 의약품의 안전성과 유효성을 측정합니다.
  • off-target related adverse drug reactions (ADRs)을 조기에 식별하여 unsafe compounds를 탐지하거나 더 효과적인 약물을 디자인 하는데 유용합니다.
  • GPCR, Ion channel, Transporter, Kinase등 다양한 family 및 target에 대해 스크리닝을 진행합니다.
  • Drug Discovery 단계에 따른 Tier 1, 2, 3 별로 포괄적인 panel을 제공합니다.
    • Tier 1  Safety Panel : Safety Screen 44 Panels & SAFETYscan47 Functional Panel
    • Tier 2  Safety Panel : Safety Screen 87 Panels
    • Tier 3  Safety Panel : Spectrum Screen Panels & BioPrint Profile Panel




종류 

 

FAMILY Service Spectrum Screen BioPrint Safety Screen 87 Safety Screen Functional  Safety Screen 44
Cat. No. PP16 P22-p  PP223 P347 PP241
No. of Targets 174 132 87 64 44
Cell Surface  GHB         
Cell Surface IL-6 Human        
Cell Surface  Interleukin IL-1 R1        
Cell Surface  TNF-alpha        
Cytosolic QR2 / MT3        
Cytoskeleton Tubulin         
GPCR 5-HT1A Ⅴ*
GPCR 5-HT1B  Ⅴ*
GPCR 5-HT1D        
GPCR 5-HT2A   Ⅴ*
GPCR 5-HT2B  Ⅴ*
GPCR 5-HT2C     
GPCR 5-HT3A        
GPCR 5-HT4       
GPCR 5-HT5A         
GPCR 5-HT6       
GPCR 5-HT7       
GPCR A1     
GPCR A2A  Ⅴ*
GPCR A2B       
GPCR A3       
GPCR alpha1A  Ⅴ*
GPCR alpha1B     
GPCR alpha1D       
GPCR alpha2A Ⅴ*
GPCR alpha2B     
GPCR alpha2C       
GPCR APJ       
GPCR AT1     
GPCR AT2       
GPCR B1         
GPCR B2     
GPCR BB1         
GPCR BB2        
GPCR BB3       
GPCR beta1 Ⅴ*
GPCR beta2  Ⅴ*
GPCR beta3       
GPCR BLT1 (LTB4)        
GPCR CB1  Ⅴ*
GPCR CB2  Ⅴ*
GPCR CCK1 (CCKA)  Ⅴ*
GPCR CCK2 (CCKB)     
GPCR CCR1       
GPCR CCR2       
GPCR CCR5         
GPCR CGRP (CLR/RAMP1)        
GPCR CRF1       
GPCR CT         
GPCR CX3CR1         
GPCR CXCR1 (IL-8RA)         
GPCR CXCR2 (IL-8RB)       
GPCR CXCR3         
GPCR CXCR4         
GPCR CysLT1     
GPCR CysLT2         
GPCR D1  Ⅴ*
GPCR D2L     Ⅴ*  
GPCR D2S   
GPCR D3       
GPCR D4        
GPCR D5         
GPCR delta (DOP)  Ⅴ*
GPCR DP1        
GPCR DP2        
GPCR EP1        
GPCR EP2      
GPCR EP3        
GPCR EP4        
GPCR ETA Ⅴ*
GPCR ETB      
GPCR FP      
GPCR GABAB (B1a/B2)      
GPCR GABAB (B1b/B2)        
GPCR GHSR        
GPCR Glucagon      
GPCR GnRH        
GPCR H1 Ⅴ*
GPCR H2 Ⅴ*
GPCR H3      
GPCR H4R      
GPCR IP      
GPCR kappa (KOP) Ⅴ*
GPCR M1 Ⅴ*
GPCR M2 Ⅴ*
GPCR M3 Ⅴ*
GPCR M4    
GPCR M5        
GPCR MC1    
GPCR MC3      
GPCR MC4    
GPCR MC5        
GPCR MCH1      
GPCR mGlu2        
GPCR mGlu5      
GPCR Motilin      
GPCR MT1      
GPCR MT2        
GPCR mu (MOP) Ⅴ*
GPCR NK1    
GPCR NK2      
GPCR NK3        
GPCR Acetylcholine (Muscarinic), Non-Selective        
GPCR P2Y, Non-Selective        
GPCR NOP (ORL1)      
GPCR NT1        
GPCR OT        
GPCR OX1        
GPCR OX2        
GPCR PAF    
GPCR sst1      
GPCR sst2        
GPCR sst3        
GPCR sst4      
GPCR sst5        
GPCR TRH        
GPCR UT (GPR14)      
GPCR V1A Ⅴ*
GPCR V1B        
GPCR V2      
GPCR VIP1 (VPAC1)      
GPCR VIP2 (VPAC2)        
GPCR Y1    
GPCR Y2        
Ion Channel 5-HT3A    
Ion Channel Cav1.2 (L-type) (Dihydropyridine Site)  
Ion Channel Cav1.2 (L-type) (Diltiazem Site)    
Ion Channel Cav1.2 (L-type) (Verapamil Site)    
Ion Channel Cav1.2 (L-type)        
Ion Channel Cav2.2 (N-type)    
Ion Channel Glutamate (AMPA, Non-Selective)    
Ion Channel Glutamate (Kainate, Non-Selective)     
Ion Channel Glutamate (NMDA, Non-Selective)   
Ion Channel Glutamate (NMDA, Non-Selective)     
Ion Channel Glutamate (Non-Selective)     
Ion Channel Glutamate, NMDA      
Ion Channel hERG  
Ion Channel IP3R1        
Ion Channel KATP      
Ion Channel KCNQ1        
Ion Channel KV (Non-Selective)       
Ion Channel nAChR (alpha1)       
Ion Channel nAChR (alpha3/beta4)       
Ion Channel nAChR (alpha4/beta2)   
Ion Channel nAChR (alpha7) Human        
Ion Channel nAChR (alpha7) Rat        
Ion Channel nAChR (Muscle-Type)         
Ion Channel Nav1.5        
Ion Channel GABAA (alpha1/beta2/gamma2)       
Ion Channel GABAA [3H]  Non-Selective      
Ion Channel GABAA [3H]         
Ion Channel GABAA [3H]     
Ion Channel GABAA [3H]        
Ion Channel GABAA [3H]         
Ion Channel Glycine [3H]       
Ion Channel P2X, Non-Selective        
Ion Channel Sodium Ion Channel [3H],Non-Selective,  
Ion Channel Gabapentin        
Ion Channel RY3        
Ion Channel SKCa (Non-Selective)      
Kinase Abl        
Kinase CaMK2alpha        
Kinase CDK2 / cyclinA        
Kinase EGFR        
Kinase ERK2 (MAPK1)        
Kinase Flt-1 (VEGFR1)        
Kinase Fyn        
Kinase IR    
Kinase lck    
Kinase LYN        
Kinase PKCalpha        
Kinase PDGFR (Non-Selective)         
Kinase SAPK2A (p38alpha)        
Kinase TGFbeta (Non-Selective)         
Kinase ZAP70        
Lipid Metabolism COX1  
Lipid Metabolism COX2  
Nitrogen Metabolism iNOS        
NHR AR  
NHR ERalpha    
NHR ERbeta        
NHR GR  
NHR LXRbeta        
NHR MCR        
NHR PPARgamma      
NHR PR      
NHR RARalpha        
NHR RXRalpha        
NHR TR (Non-Selective)         
NHR VDR        
Nucleotide Signaling Atrial Natriuretic Factor (ANF, Non-Selective)         
Nucleotide Signaling Guanylyl Cyclase        
Neurotransmitter Metabolism Acetylcholinesterase  
Neurotransmitter Metabolism Monoamine Oxidase A (MAO-A)  
Neurotransmitter Metabolism Monoamine Oxidase B (MAO-B)        
Other Phorbol Ester         
PDE PDE2A        
PDE PDE3A      
PDE PDE3B      
PDE PDE4D  
PDE PDE5        
PDE PDE6        
PDE Rolipram         
Protease ACE      
Protease ACE2        
Protease beta-Secretase 1        
Protease Caspase 3        
Protease Cathepsin G        
Protease HIV-1        
Protease MMP1        
Protease MMP2        
Protease MMP9        
Steroid Metabolism Xanthine Oxidase        
Transmembrane Imidazoline I2        
Transmembrane sigma1       
Transmembrane  sigma2         
Transporter Adenosine       
Transporter ATPase      
Transporter CHT1       
Transporter DAT
Transporter GABA (Non-Selective)     
Transporter GLYT1         
Transporter NET 
Transporter SET
Transporter VMAT (Non-Selective)         

  *cell-based 타겟중 agonist &antagonist 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet
Safety and Efficacy 분석서비스 . . EUROFINS DISCOVERY
Maker
EUROFINS DISCOVERY
Cat.No.
.
Product
Safety and Efficacy 분석서비스
Size
.
Qty

추천제품

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    분석실험/제작서비스 Vol.2 이미지

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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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