Transcription Factors Inhibitor & Activator | 고마바이오텍

특징 

  

• 진핵세포에서 유전자 전사를 시작하거나 조절하는 데에 필요한 단백질입니다.
• 일반적인 전사인자는 유전자의 기초 전사에 필요하며 전사 개시 복합체의 형성에 참여합니다.  
• 대부분의 전사인자는 RNA 중합효소와 직접적으로 상호작용합니다.
• 특정 전사인자는 개별 RNA 중합효소의 결합을 증진/차단하는 조정 조절 서열에 결합하는 것을 촉진하거나 차단하여 특정 유전자의 전사를 자극하거나 억제합니다.

 

  

주요 제품

AP-1
	Cat. No.	Product Name	Activity
AP-1 Inhibitors	1989	c-JUN peptide	JNK/c-Jun interaction inhibitor
	5309	SP 100030	NF-κB and AP-1 dual inhibitor
	2476	SR 11302	AP-1 inhibitor; antitumor agent
	7317	T 5224	Selective inhibitor of c-Fos/activator protein (AP)-1
Aryl Hydrocarbon Receptor
	Cat. No.	Product Name	Activity
Aryl Hydrocarbon Receptor Agonists	6321	10-Cl-BBQ	Potent aryl hydrocarbon receptor (AhR) agonist; orally bioavailable
	5304	FICZ	High affinity aryl hydrocarbon receptor (AhR) agonist
	1803	ITE	Endogenous agonist for the transcription factor aryl hydrocarbon receptor
	3873	MeBIO	AhR agonist. Inactive analog of BIO (Cat. No. 3194)
	1267	Pifithrin-α hydrobromide	Aryl hydrocarbon receptor agonist. Also p53 inhibitor
Aryl Hydrocarbon Receptor Antagonists	3858	CH 223191	Potent aryl hydrocarbon receptor (AhR) antagonist
	7086	StemRegenin 1	Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
Ligands	4393	L-Kynurenine	Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand
Other	4995	Phortress	Prodrug of the antitumor agent 5F 203
Hypoxia Inducible Factor
	Cat. No.	Product Name	Activity
Hypoxia Inducible Factor (HIF) Inhibitors	5953	Adaptaquin	HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
	5582	TAT-cyclo-CLLFVY	Selective HIF-1 dimerization inhibitor
	4408	DMOG	Inhibitor of hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH)
	5520	Echinomycin	Highly potent and selective HIF-1α inhibitor
	6653	FM19G11	HIF α-subunit inhibitor
	5655	GN 44028	Potent HIF-1α inhibitor
	4451	IOX 2	Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
	4324	KC7F2	HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
	6322	LW 6	HIF-1α inhibitor; inhibits cellular accumulation of HIF-1α; also malate dehydrogenase-2 inhibitor
	2954	PX 12	Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
	5243	TC-S 7009	High affinity and selective HIF-2α inhibitor
	6156	VH 298	High-affinity inhibitor of VHL; blocks interaction of VHL and HIF-α
Hypoxia Inducible Factor (HIF) Activators	4565	ML 228	HIF pathway activator
Other	4705	Chetomin	Blocks interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300
	6157	cis VH 298	Negative control for VH 298
	5764	Deferoxamine mesylate	Hypoxia mimetic; also iron chelator
	7287	FAM-DEALA-Hyp-YIPD	Fluorescent HIF-1α peptide
	7452	FAM-DEALAHypYIPMDDDFQLRSF	Fluorescent HIF-1α peptide
MYC
	Cat. No.	Product Name	Activity
MYC Inhibitors	4406	10058-F4	Inhibits c-Myc-Max dimerization
	5306	KJ Pyr 9	High affinity Myc inhibitor
NF-κB and IκB
	Cat. No.	Product Name	Activity
NF-κB and IκB Inhibitors	4547	ACHP	Selective IKKα and IKKβ inhibitor; blocks NF-κB-DNA binding
	4857	Amlexanox	Inhibitor of TBK1 and IKKε; antiallergic agent
	1777	Arctigenin	Inhibitor of IκBα phosphorylation. Also inhibits MEK1
	1743	Bay 11-7085	Irreversible inhibitor of TNF-α-induced IκBα phosphorylation
	1744	Bay 11-7821	Indirect inhibitor of IκBα phosphorylation
	5273	Bengamide B	Potent inhibitor of NF-κB activation
	5300	BI 605906	Selective IKKβ inhibitor
	4806	BMS 345541	Selective allosteric inhibitor of IKK; anti-inflammatory
	5821	C-DIM 12	Inhibits NF-κB-dependent gene expression; Nurr1 activator
	2743	Caffeic acid phenethyl ester	Specific inhibitor of NF-κB activation
	2509	Cardamonin	Inhibitor of NF-κB activation; anti-inflammatory
	6646	CDDO-Me	NF-κB pathway inhibitor; inhibits IKKβ; also Nrf2 pathway activator
	3203	Celastrol	Inhibits TNF-α-induced NF-κB activation
	6237	FPS ZM1	High affinity antagonist of the receptor for advanced glycation end products (RAGE)
	2637	Gliotoxin	Immunosuppressant; inhibits NF-κB and cytokine production
	5672	GSK 319347A	Potent and selective IKKε inhibitor
	4590	Honokiol	Blocks NF-κB activation; also anti-inflammatory and antioxidant
	2539	IKK 16	Selective inhibitor of IKK
	2611	IMD 0354	Inhibitor of IKKβ
	5699	IP7e	Blocks NF-κB pathway; also potent Nurr1 activator
	5846	IT 901	NF-κB c-Rel subunit inhibitor
	2874	Luteolin	Blocks NF-κB activation
	1748	MG 132	Inhibits NF-κB activation; proteasome and calpain inhibitor
	4899	ML 120B dihydrochloride	Novel IKK2-selective inhibitor
	4354	ML 130	Inhibits NOD1-induced NF-κB activation
	0610	Parthenolide	NF-κB inhibitor; also 5-HT release inhibitor
	4238	PF 184	Potent and selective IKKβ inhibitor
	1554	Piceatannol	Inhibits TNF-induced NF-κB activation
	1947	PR 39 (porcine)	IκBα inhibitor
	3731	Pristimerin	Suppresses NF-κB activation
	4569	PS 1145 dihydrochloride	Selective IKK inhibitor; orally active
	0727	Pyrrolidinedithiocarbamate ammonium	Inhibits NF-κB, prevents increase in NOS mRNA
	6259	RAGE antagonist peptide	Receptor for advanced glycation end products (RAGE) antagonist
	3318	SC 514	IKKβ inhibitor; attenuates NF-κB-induced gene expression
	6829	(R)-Shikonin	Blocks TNF-α and NF-κB signaling; induces necroptosis; anti-inflammatory
	5309	SP 100030	NF-κB and AP-1 dual inhibitor
	4935	Sulfasalazine	Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
	4426	Tanshinone IIA	Inhibits NF-κB and AP-1 DNA binding. Displays antioxidant properties
	2559	TPCA-1	Potent, selective inhibitor of IKKβ
	2816	Withaferin A	Inhibits NF-κB activation
	6111	Zoledronic Acid	NF-κB signaling inhibitor; also potent farnesyl diphosphate (FPP) synthase inhibitor
NF-κB and IκB Activators	3906	Betulinic acid	Activates NF-κB; antitumor and anti-HIV agent. Also TGR5 agonist
	6124	(R)-2-Hydroxyglutaric acid disodium salt	NF-κB activator; also KDM4A inhibitor
	5739	Prostratin	NF-κB activator; also PKC activator
Other	1126	Dexamethasone	Reduces levels of activated NF-κB in immature dendritic cells; anti-inflammatory glucocorticoid
NFAT
	Cat. No.	Product Name	Activity
NFAT Inhibitors	3930	NFAT Inhibitor	Inhibitor of calcineurin-mediated NFAT activation
	5710	NFAT inhibitor, Cell Permeable	Cell permeable NFAT inhibitor
Other	4210	Ascomycin	Calcineurin phosphatase inhibitor; analog of FK 506 (Cat. No. 3631)
	1101	Cyclosporin A	Calcineurin inhibitor
	3631	FK 506	Potent calcineurin inhibitor; immunosuppressant
	2162	INCA-6	Inhibitor of calcineurin-NFAT association
Nrf2
	Cat. No.	Product Name	Activity
Nrf2 Inhibitors	6243	ML 385	Nrf2 inhibitor; phenotypically lethal
Nrf2 Activators	5145	AI-3	ARE activator; induces Nrf2-ARE-dependent transcription
	4737	CDDO Im	Nrf2 signaling activator
	6646	CDDO-Me	Nrf2 pathway activator; also NF-κB pathway inhibitor; inhibits IKKβ
	4512	DMF	Activator of Nrf2 pathway; neuroprotective
	7199	(±)-Eriodictyol	Activates Nrf2/ARE signaling; antioxidant; also potent TRPV1 antagonist
	6172	INF 4E	Activates Keap1-Nrf2 pathway; also caspase-1 and NLRP3 inflammasome inhibitor
	5625	ML 334	Inhibitor of Keap1- Nrf2 interaction
	4511	MMF	Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
	5293	NK 252	Nrf2 activator
	6662	4-Octyl itaconate	Nrf2 activator; cell permeable
	5294	Oltipraz	Nrf2 activator
	5707	RA 839	Nrf2 activator; inhibits Nrf2/Keap1 interaction
	4811	TAT 14	Nrf2 pathway activator; blocks Nrf2/Keap1 interaction
p53
	Cat. No.	Product Name	Activity
p53 Inhibitors	1267	Pifithrin-α hydrobromide	p53 inhibitor. Also aryl hydrocarbon receptor agonist
	3843	Cyclic Pifithrin-α hydrobromide	p53 inhibitor
	2653	Pifithrin-μ	Inhibitor of p53-mitochondrial binding
p53 Activators	3503	HLI 373	Hdm2 inhibitor; activates p53-dependent transcription
	6904	Idasanutlin	Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
	6615	KCC 07	BAI1/p53 signaling activator; inhibits MBD2 (Methyl-CpG-binding domain protein 2)
	2185	NSC 146109 hydrochloride	Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
	5065	NSC 319726	Reactivator of mutant p53
	3984	Nutlin-3	MDM2 antagonist; inhibits MDM2-p53 interaction
	6075	Nutlin 3a	MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
	2443	RITA	p53-MDM2 interaction inhibitor; antitumor
	5332	SP 141	High affinity MDM2 inhibitor
	3365	Tenovin-1	Activates p53 transcriptional activity
	3356	WR 1065 dihydrochloride	p53 activator. Also ROS scavenger
Other	5417	BMH 21	p53 pathway activator; also RNA polymerase 1 inhibitor
	3362	MIRA-1	Restores mutant p53 activity; proapoptotic
	4326	PhiKan 083	p53 stabilizing agent
	4396	Piperlongumine	Induces apoptosis; increases p53 and ROS levels in cancer cells
	1862	PRIMA-1	Restores mutant p53 activity; induces apoptosis
	3710	PRIMA-1MET	Restores mutant p53 activity
	3214	RETRA hydrochloride	Antitumor agent; suppresses mutant p53-bearing cancer cells
	4240	SCH 529074	Restores mutant p53 activity
SREBP
	Cat. No.	Product Name	Activity
SREBP Inhibitors	4444	Fatostatin A	Cell permeable inhibitor of SREBP activation
	3354	PF 429242 dihydrochloride	Competitive inhibitor of SREBP site 1 protease
STAT
	Cat. No.	Product Name	Activity
STAT Inhibitors	1571	Cucurbitacin I	Selective inhibitor of STAT3/JAK2 signaling
	6218	Galiellalactone	STAT3 inhibitor; active in vivo
	6110	HJC 0416 hydrochloride	STAT3 inhibitor
	5522	Napabucasin	STAT3 inhibitor; also blocks cancer stem cell self-renewal
	4079	Niclosamide	STAT3 inhibitor; also inhibits mTORC1 signaling
	4655	NSC 74859	Selective STAT3 inhibitor
	3918	Pyrimethamine	STAT3 inhibitor; also potent inhibitor of multidrug and toxin extrusion (MATE) transporters and DHFR inhibitor
	5138	RSVA 405	STAT3 inhibitor; also AMPK activator
	3035	SD 1008	JAK2/STAT3 signaling pathway inhibitor
	2798	Stattic	Selective STAT3 inhibitor
STAT Activators	3945	Colivelin	STAT3 activator; also protects against β-amyloid neurotoxicity
Other	3495	Fludarabine	Purine analog; inhibits cytokine-induced STAT1 activation
	6994	HODHBt	STAT5-SUMO protein-protein interaction inhibitor

주문정보

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