Receptor Tyrosine Kinases (RTKs) Inhibitors

시약 및 기기 상세

Receptor Tyrosine Kinases (RTKs) Inhibitors

ALK, EGFR, Eph Receptors, FGFR, FLT3, Insulin and Insulin-like Receptors, MET Receptors, PDGFR, Trk Receptors, VEGFR등 tyrosine kinase 활성을 유도하는 수용체에 대한 inhibitor, activator, agonist, antagonist를 소개합니다.

프린트 제품 문의

특징

Receptor Tyrosine Kinases (RTK)는 효소 연결 수용체중 하나로, 리간드가 붙으면 tyrosine kinase 활성을 유도합니다.
세포외부의 리간드 결합 도메인, 단일 membrane-spanning 도메인, 세포내부의 tyrosine kinase 도메인의 3구성으로 이루어 집니다.
리간드는 일반적으로 유기체의 다른 곳에서 생성되는 확산성 펩타이드나 작은 단백질이며, 일반적으로 growth factor, cytokine, hormone등이 해당됩니다.

타겟

ALK
EGFR
Eph Receptors
FGFR
FLT3
Insulin and Insulin-like Receptors
MET Receptors
PDGFR
Trk Receptors
VEGFR

주요 제품

ALK
Cat. No.	Product	Activity
5310	ASP 3026	Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
6905	Ceritinib	Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3
4368	Crizotinib	Potent c-MET/ALK inhibitor
5111	GSK 1838705	Potent ALK inhibitor; also IR and IGF1R inhibitor
5098	KRCA 0008	Potent Ack1 and ALK dual inhibitor; orally bioavailable
1614	SB 431542	Potent, selective inhibitor of TGF-βRI, ALK4 and ALK7
3263	SB 505124	Selective inhibitor of TGF-βRI, ALK4 and ALK7

EGFR
Cat. No.	Product	Activity
5318	AEE 788	Potent EGFR and VEGFR inhibitor
6812	Afatinib dimaleate	Potent dual specificity EGFR/HER2 inhibitor; active in vivo
1276	AG 1478 hydrochloride	Highly potent EGFR-kinase inhibitor
414	AG 490	EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor
1555	AG 825	Selective ErbB2 inhibitor
2416	BIBX 1382 dihydrochloride	Highly selective EGFR-kinase inhibitor
5022	BMS 599626 dihydrochloride	Potent, selective EGFR and ErbB2 inhibitor
5916	Canertinib dihydrochloride	Potent EGFR kinase inhibitor
3360	CGP 52411	EGFR inhibitor. Also inhibits Aβ42 fibril formation
6231	Dacomitinib	Potent irreversible pan ErbB inhibitor
4502	DIM	Inhibits EGFR activation; also induces apoptosis
7424	EMI 48	Inhibitor of EGFR mutants
7194	Erlotinib Hydrochloride	Potent, reversible EGFR tyrosine kinase inhibitor
1110	Genistein	EGFR kinase inhibitor. Also estrogen and PPARγ ligand
2239	GW 583340 dihydrochloride	Potent dual EGFR/ErbB2 inhibitor; orally active
3580	HKI 357	Dual irreversible inhibitor of ErbB2 and EGFR
3000	Iressa	Orally active, selective EGFR inhibitor
6962	JBJ-03-142-02	Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors
3352	JNJ 28871063 hydrochloride	Potent ErbB receptor family inhibitor
6811	Lapatinib	Potent and selective dual ErbB2 (HER-2) and EGFR inhibitor
1331	Lavendustin A	EGFR, p60c-src inhibitor
7371	Neratinib	Potent HER2 receptor tyrosine kinase and EGFR kinase inhibitor
1037	PD 153035 hydrochloride	EGFR-kinase inhibitor
2615	PD 158780	Potent ErbB receptor family inhibitor
6349	Pelitinib	Potent and irreversible EGFR inhibitor; orally bioavailable
4941	PKI 166 hydrochloride	Potent EGFR-kinase inhibitor
2794	PP 3	EGFR-kinase inhibitor. Also Src kinase negative control
3599	TAK 165	Potent and selective ErbB2 inhibitor
3115	WHI-P 154	Potent EGFR inhibitor. Also inhibits JAK3

Eph Receptors
Cat. No.	Product	Activity
5290	KYL	EphA4 kinase inhibitor; neuroprotective

FGFR
Cat. No.	Product	Activity
4274	AP 24534	Potent multi-kinase and pan-Bcr-Abl inhibitor
7454	Cediranib	Potent inhibitor of VEGFR, PDGFR and FGFR
4002	FIIN 1 hydrochloride	Potent, irreversible FGFR inhibitor
7049	Nintedanib	Potent VEGFR, PDGFR and FGFR inhibitor
3724	PD 161570	Selective FGFR inhibitor
3785	PD 166285 dihydrochloride	FGFR, PDGFRβ and Src inhibitor; also inhibits Wee1
3044	PD 173074	FGFR1 and -3 inhibitor
3300	SU 5402	Potent FGFR and VEGFR inhibitor
3335	SU 6668	FGFR, VEGFR and PDGFR inhibitor

FMS-like receptor tyrosine kinase-3 (FLT3)
Cat. No.	Product	Activity
5013	AC 710	Potent FLT3 inhibitor; also inhibits other PDGFR family members
6905	Ceritinib	Potent FLT3 inhibitor; also potently inhibits ALK, IR, IGF1R and STK22D
6056	GSK 1363089	Potent FLT3 inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
5260	KG 5	PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
3395	Lestaurtinib	FLT3, JAK2 and TrkA inhibitor; also inhibits AurA and AurB
6788	Quizartinib	Highly potent FLT3 inhibitor
6814	Sorafenib	Flt-3 inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, PDGFR-β and cKIT
3037	SU 5416	Inhbitor of VEGFR, KIT, RET, MET and FLT3
2591	TCS 359	Potent FLT3 inhibitor
5422	XL 184	Potent FLT3 inhibitor; also inhibits other RTKs

Insulin and Insulin-like Receptors
Cat. No.	Product	Activity
4774	BMS 536924	Dual IR/IGF1R inhibitor
6905	Ceritinib	Potent IR and IGF1R inhibitor; also potently inhibits ALK, STK22D and FLT3
1819	Demethylasterriquinone B1	Selective insulin RTK activator
5111	GSK 1838705	Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
3435	Insulin (human) recombinant	expressed in yeast
5247	NVP ADW 742	ATP-competitive inhibitor of IGF1R
2956	Picropodophyllotoxin	Selective IGF1R inhibitor
2768	PQ 401	IGF1R inhibitor

MET Receptor
Cat. No.	Product	Activity
4368	Crizotinib	Potent c-MET/ALK inhibitor
6056	GSK 1363089	Potent inhibitor of MET, VEGFR2, Ron and AXL
1683	K 252a	Receptor tyrosine kinase inhibitor, inhibits MET
4239	PF 04217903 mesylate	Highly selective MET inhibitor
2693	PHA 665752	Potent and selective MET inhibitor
5356	SGX 523	Selective and potent c-MET kinase inhibitor
3037	SU 5416	MET inhibitor. Also inhibits KIT, RET, VEGFR and FLT3
5422	XL 184	Potent c-MET inhibitor; also inhibits other RTKs

PDGFR
Cat. No.	Product	Activity
5013	AC 710	Potent and selective PDGFR family inhibitor
4274	AP 24534	Potent multi-kinase and pan-Bcr-Abl inhibitor
7454	Cediranib	Potent inhibitor of VEGFR, PDGFR and FGFR
5993	CP 673451	Potent and selective PDGFR inhibitor
1222	DMPQ dihydrochloride	Potent, selective inhibitor of PDGFRβ
6056	GSK 1363089	Potent PDGFR inhibtor; also inhibits of MET, VEGFR2, Ron and AXL
5906	Imatinib mesylate	PDGFR inhibitor; also inhibits v-Abl tyrosine kinase and c-kit
6976	JNJ 10198409	Potent PDGFRα and PDGFRβ inhbitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
5260	KG 5	PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor; antiangiogenic
7049	Nintedanib	Potent VEGFR, PDGFR and FGFR inhibitor
3785	PD 166285 dihydrochloride	PDGFRβ, FGFR and Src inhibitor; also inhibits Wee1
6814	Sorafenib	PDGFR-β inhibitor; also inhibits Raf-1, VEGFR-2, VEGFR-3, Flt-3 and cKIT
3304	SU 16f	Potent and selective PDGFRβ inhibitor
3335	SU 6668	PDGFR, VEGFR and FGFR inhibitor
3768	Sunitinib malate	Potent VEGFR, PDGFRβ and KIT inhibitor

Trk Receptors
Cat. No.	Product	Activity
3826	7,8-Dihydroxyflavone	TrkB agonist
4456	Amitriptyline hydrochloride	TrkA/B agonist; also a serotonin and noradrenaline uptake inhibitor
4781	ANA 12	TrkB receptor antagonist
2837	BDNF (human)	Activates TrkB and p75 receptors
5062	Cyclotraxin B	TrkB receptor antagonist
1819	Demethylasterriquinone B1	Trk receptor activator; also selective insulin RTK activator
4559	GNF 5837	Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC
2238	GW 441756	Potent, selective TrkA inhibitor
5961	HIOC	Selective TrkB receptor agonist; neuroprotectant
3395	Lestaurtinib	TrkA, JAK2 and FLT3 inhibitor; also inhibits AurA and AurB
4607	LM 22A4	Potent TrkB agonist
6037	LM22B 10	TrkB and TrkC agonist; brain penetrant
6115	PF 06273340	Potent and selective pan-Trk inhibitor; peripherally restricted

VEGFR
Cat. No.	Product	Activity
5318	AEE 788	Potent VEGFR and EGFR inhibitor
4274	AP 24534	Potent multi-kinase and pan-Bcr-Abl inhibitor
4350	Axitinib	Potent VEGFR-1, -2 and -3 inhibitor
6069	BMS 605541	Potent VEGFR-2 inhibitor
7454	Cediranib	Potent inhibitor of VEGFR, PDGFR and FGFR
6056	GSK 1363089	Potent inhibitor of MET, VEGFR2, Ron and AXL
2542	Ki 8751	Potent, selective VEGFR-2 inhibitor
7049	Nintedanib	Potent VEGFR, PDGFR and FGFR inhibitor
6015	RAF 265	VEGFR-2 and Raf kinase inhibitor
6814	Sorafenib	VEGFR-2 and VEGFR-3 inhibitor; also inhibits Raf-1, PDGFR-β, Flt-3 and cKIT
3300	SU 5402	Potent VEGFR and FGFR inhibitor
3037	SU 5416	VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
3335	SU 6668	VEGFR, PDGFR and FGFR inhibitor
3768	Sunitinib malate	Potent VEGFR, PDGFRβ and KIT inhibitor
5680	Vatalanib succinate	Potent VEGFR inhibitor; also aromatase inhibitor
5422	XL 184	Potent VEGFR inhibitor; also inhibits other RTKs
2475	ZM 323881 hydrochloride	Potent, selective inhibitor of VEGFR-2

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
Product	Cat.No.	Size	Maker
Selpercatinib	7696/50	50 mg	TOCRIS
Selpercatinib	7696/10	10 mg	TOCRIS
Vandetanib	7497	50 mg	TOCRIS
Vandetanib	7497	10 mg	TOCRIS
7,8-Dihydroxyflavone (10 mg)	3826	10 mg	TOCRIS
7,8-Dihydroxyflavone (50 mg)	3826	50 mg	TOCRIS
AC 710 (10 mg)	5013	10 mg	TOCRIS
AC 710 (50 mg)	5013	50 mg	TOCRIS
AEE 788 (10 mg)	5318	10 mg	TOCRIS
AEE 788 (50 mg)	5318	50 mg	TOCRIS
Afatinib dimaleate (10 MG)	6812	10 mg	TOCRIS
Afatinib dimaleate (50 MG)	6812	50 mg	TOCRIS
AG 1478 hydrochloride (10 mg)	1276	10 mg	TOCRIS
AG 1478 hydrochloride (50 mg)	1276	50 mg	TOCRIS
AG 490 (10 mg)	0414	10 mg	TOCRIS
AG 490 (50 mg)	0414	50 mg	TOCRIS
ANA 12 (10 mg)	4781	10 mg	TOCRIS
ANA 12 (50 mg)	4781	50 mg	TOCRIS
AP 24534 (10 mg)	4274	10 mg	TOCRIS
ASP 3026 (10 mg)	5310	10 mg	TOCRIS
ASP 3026 (50 mg)	5310	50 mg	TOCRIS
Axitinib (10 mg)	4350	10 mg	TOCRIS
Axitinib (50 mg)	4350	50 mg	TOCRIS
AZ 14145845	8023	50 mg	TOCRIS
AZ 14145845	8023	10 mg	TOCRIS
AZD 4547	7823	10 mg	TOCRIS
AZD 4547	7823	50 mg	TOCRIS
BMS 536924 (10 mg)	4774	10 mg	TOCRIS
BMS 536924 (50 mg)	4774	50 mg	TOCRIS
Canertinib dihydrochloride (25 MG)	5916	25 mg	TOCRIS
Canertinib dihydrochloride (5 MG)	5916	5 mg	TOCRIS
Cediranib	7454	50 mg	TOCRIS
Cediranib	7454	10 mg	TOCRIS
Ceritinib (10 MG)	6905	10 mg	TOCRIS
Ceritinib (50 MG)	6905	50 mg	TOCRIS
CP 673451 (10 mg)	5993	10 mg	TOCRIS
Crizotinib (10 mg)	4368	10 mg	TOCRIS
Crizotinib (50 mg)	4368	50 mg	TOCRIS
Cyclotraxin B (1 mg)	5062	1 mg	TOCRIS
Dacomitinib (10 MG)	6231	10 mg	TOCRIS
Dacomitinib (50 MG)	6231	50 mg	TOCRIS
Demethylasterriquinone B1 (5 mg)	1819	5 mg	TOCRIS
EMI 48	7424	10 mg	TOCRIS
Erlotinib Hydrochloride	7194	50 mg	TOCRIS
Genistein (50 mg)	1110	50 mg	TOCRIS
Gilteritinib	7891	50 mg	TOCRIS
Gilteritinib	7891	10 mg	TOCRIS
GNF 5837 (10 mg)	4559	10 mg	TOCRIS
GNF 5837 (50 mg)	4559	50 mg	TOCRIS
GSK 1838705 (10 mg)	5111	10 mg	TOCRIS

전체보기

1
Maker	TOCRIS
Cat.No.	7696/50
Product	Selpercatinib
Size	50 mg
Qty
Data Sheet
MSDS

2
Maker	TOCRIS
Cat.No.	7696/10
Product	Selpercatinib
Size	10 mg
Qty
Data Sheet
MSDS

3
Maker	TOCRIS
Cat.No.	7497
Product	Vandetanib
Size	50 mg
Qty
Data Sheet
MSDS

4
Maker	TOCRIS
Cat.No.	7497
Product	Vandetanib
Size	10 mg
Qty
Data Sheet
MSDS

5
Maker	TOCRIS
Cat.No.	3826
Product	7,8-Dihydroxyflavone (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

6
Maker	TOCRIS
Cat.No.	3826
Product	7,8-Dihydroxyflavone (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

7
Maker	TOCRIS
Cat.No.	5013
Product	AC 710 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

8
Maker	TOCRIS
Cat.No.	5013
Product	AC 710 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

9
Maker	TOCRIS
Cat.No.	5318
Product	AEE 788 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

10
Maker	TOCRIS
Cat.No.	5318
Product	AEE 788 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

11
Maker	TOCRIS
Cat.No.	6812
Product	Afatinib dimaleate (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

12
Maker	TOCRIS
Cat.No.	6812
Product	Afatinib dimaleate (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

13
Maker	TOCRIS
Cat.No.	1276
Product	AG 1478 hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

14
Maker	TOCRIS
Cat.No.	1276
Product	AG 1478 hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

15
Maker	TOCRIS
Cat.No.	0414
Product	AG 490 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

16
Maker	TOCRIS
Cat.No.	0414
Product	AG 490 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

17
Maker	TOCRIS
Cat.No.	4781
Product	ANA 12 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

18
Maker	TOCRIS
Cat.No.	4781
Product	ANA 12 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

19
Maker	TOCRIS
Cat.No.	4274
Product	AP 24534 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

20
Maker	TOCRIS
Cat.No.	5310
Product	ASP 3026 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

21
Maker	TOCRIS
Cat.No.	5310
Product	ASP 3026 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

22
Maker	TOCRIS
Cat.No.	4350
Product	Axitinib (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

23
Maker	TOCRIS
Cat.No.	4350
Product	Axitinib (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

24
Maker	TOCRIS
Cat.No.	8023
Product	AZ 14145845
Size	50 mg
Qty
Data Sheet
MSDS

25
Maker	TOCRIS
Cat.No.	8023
Product	AZ 14145845
Size	10 mg
Qty
Data Sheet
MSDS

26
Maker	TOCRIS
Cat.No.	7823
Product	AZD 4547
Size	10 mg
Qty
Data Sheet
MSDS

27
Maker	TOCRIS
Cat.No.	7823
Product	AZD 4547
Size	50 mg
Qty
Data Sheet
MSDS

28
Maker	TOCRIS
Cat.No.	4774
Product	BMS 536924 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

29
Maker	TOCRIS
Cat.No.	4774
Product	BMS 536924 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

30
Maker	TOCRIS
Cat.No.	5916
Product	Canertinib dihydrochloride (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

31
Maker	TOCRIS
Cat.No.	5916
Product	Canertinib dihydrochloride (5 MG)
Size	5 mg
Qty
Data Sheet
MSDS

32
Maker	TOCRIS
Cat.No.	7454
Product	Cediranib
Size	50 mg
Qty
Data Sheet
MSDS

33
Maker	TOCRIS
Cat.No.	7454
Product	Cediranib
Size	10 mg
Qty
Data Sheet
MSDS

34
Maker	TOCRIS
Cat.No.	6905
Product	Ceritinib (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

35
Maker	TOCRIS
Cat.No.	6905
Product	Ceritinib (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

36
Maker	TOCRIS
Cat.No.	5993
Product	CP 673451 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

37
Maker	TOCRIS
Cat.No.	4368
Product	Crizotinib (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

38
Maker	TOCRIS
Cat.No.	4368
Product	Crizotinib (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

39
Maker	TOCRIS
Cat.No.	5062
Product	Cyclotraxin B (1 mg)
Size	1 mg
Qty
Data Sheet
MSDS

40
Maker	TOCRIS
Cat.No.	6231
Product	Dacomitinib (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

41
Maker	TOCRIS
Cat.No.	6231
Product	Dacomitinib (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

42
Maker	TOCRIS
Cat.No.	1819
Product	Demethylasterriquinone B1 (5 mg)
Size	5 mg
Qty
Data Sheet
MSDS

43
Maker	TOCRIS
Cat.No.	7424
Product	EMI 48
Size	10 mg
Qty
Data Sheet
MSDS

44
Maker	TOCRIS
Cat.No.	7194
Product	Erlotinib Hydrochloride
Size	50 mg
Qty
Data Sheet
MSDS

45
Maker	TOCRIS
Cat.No.	1110
Product	Genistein (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

46
Maker	TOCRIS
Cat.No.	7891
Product	Gilteritinib
Size	50 mg
Qty
Data Sheet
MSDS

47
Maker	TOCRIS
Cat.No.	7891
Product	Gilteritinib
Size	10 mg
Qty
Data Sheet
MSDS

48
Maker	TOCRIS
Cat.No.	4559
Product	GNF 5837 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

전체보기

Receptor Tyrosine Kinases (RTKs) Inhibitors | 고마바이오텍

Receptor Tyrosine Kinases (RTKs) Inhibitors

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