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제품 상세
비임상 독성 시험서비스 | In Vitro Toxicology Services 이미지

비임상 독성 시험서비스 | In Vitro Toxicology Services

Eurofins Discovery사는 Hepatotoxicity, Cardiotoxicity, Genotoxicity, Cytotoxicity, Nephrotoxicity등 in vitro drug-induced toxicity를 측정해 드립니다.

프린트 제품 문의

특징

  

  • 약물의 독성으로 인한 부작용에 대한 분석은 임상개발 후반에 진행될 경우 비용이 많이 들고 프로젝트 일정에 상당한 영향을 줄수 있으므로, 발견과정 초기에 포괄적인 in vitro toxicology 분석을 통해 drug safety profile을 평가하는 것이 필요합니다.
  • Hepatoxocity (간독성), Cardiotoxicity (심장독성), Genotoxicity (유전독성), Cytotoxicity (세포독성), Nephrotoxicity (신장독성)에 대한 분석을 진행해 드립니다.
  • Panel service 를 통해 다양한 관련 분석을 진행할 수 있으며, 개별 서비스로도 선택할 수 있습니다.

 


서비스 패널 종류



IN VITRO TOXICOLOGY PANEL (#PSC375)
  • Ames fluctuation test
  • Micronucleus Panel
  • Cell viability (human hepatocytes)
  • CardiacProfiler Ion Channel Core Panel - Qube APC (6 Conc.)
  • Cytotoxicity (HepG2; 5 endpoints; HCA)
  • Cell viability (HRPTEpiC)

DRUG-INDUCED LIVER INJURY (DILI) PANELS - DILI Screening Panel (#P385)
  • Cell Viability (HepG2, 72-hour, CellTiter-Glo)
  • Mitotox - Cell Viability (HepG2, Galactose Medium, CellTiter-Glo)
  • Mitotox - Cell Viability (HepG2, Glucose Medium, CellTiter-Glo)

DRUG-INDUCED LIVER INJURY (DILI) PANELS - DILI Mechanistic Panel (#P385M)
  • Cell viability (human hepatocytes)
  • High Content Cytotoxicity (HepG2) - Cell number (cytotox)
  • High Content Cytotoxicity (HepG2) - Nuclear size
  • High Content Cytotoxicity (HepG2) - Mitochondrial membrane potential
  • High Content Cytotoxicity (HepG2) - Intracellular free calcium
  • High Content Cytotoxicity (HepG2) - Membrane permeability
  • BSEP inhibition (MV, 3H-taurocholic acid substrate)
  • Mitotox - Cell Viability (HepG2, Galactose Medium, CellTiter-Glo)
  • Mitotox - Cell Viability (HepG2, Glucose Medium, CellTiter-Glo)
  • FXR Functional Agonist & Antagonist activation assay
  • Phospholipidosis (HepG2, HCA)
  • Glutathione conjugate detection (liver S9, human)

Ames Test and Fluctuation Assays (#G175)
  • Ames fluctuation test (TA98 - S9)
  • Ames fluctuation test (TA98 + S9)
  • Ames fluctuation test (TA100 - S9)
  • Ames fluctuation test (TA100 + S9)
  • Ames fluctuation test (TA1535 - S9)
  • Ames fluctuation test (TA1535 + S9)
  • Ames fluctuation test (TA1537-S9)
  • Ames fluctuation test (TA1537 + S9)

In Vitro Micronucleus Assays (#G344)
  • Micronucleus Panel
  • Micronucleus (CHO - S9, HCA)
  • Micronucleus (CHO + S9, HCA)

Hepatotoxicity Assays
  • Cellular Stress (PHH; Cell Viability; HSP27; Apoptosis) (#970010)
  • Cytotoxicity (PHH; Cell Viability; ROS; MMP) (#970011)
  • Cytotoxicity (PHH; Cell Viability; Apoptosis) (#970012)
  • Cell viability (human hepatocytes) (#533)
  • BSEP Human Transporter Cell Based Assay (#3745)
  • MRP Human Transporter Inhibition Assay (#3879)

Cardiotoxicity Assays
  • CardiacProfiler Ion Channel Core Panel - Qube APC (1 Conc.)
  • CardiacProfiler Ion Channel Core Panel - Qube APC (6 Conc.)
  • CardiacProfiler Ion Channel Full Panel - Qube APC (1 Conc.)
  • CardiacProfiler Ion Channel Full Panel - Qube APC (6 Conc.)
  • hERG Potassium Channel Assay - Qube APC (1 Conc.)
  • hERG Potassium Channel Assay - Qube APC (6 Conc.)
  • hCav1.2 (L-type) Calcium Channel Assay - Qube APC (1 Conc.)
  • hCav1.2 (L-type) Calcium Channel Assay - Qube APC (6 Conc.)
  • hNav1.5 Sodium Channel Assay - Qube APC (1 Conc.)
  • hNav1.5 Sodium Channel Assay - Qube APC (6 Conc.)
  • hNav1.5 Late Current Sodium Channel Assay - Qube APC (1 Conc.)
  • hNav1.5 Late Current Sodium Channel Assay - Qube APC (6 Conc.)
  • hKCNQ1 /hminK Potassium Channel Assay - Qube APC (1 Conc.)
  • hKCNQ1 /hminK Potassium Channel Assay - Qube APC (6 Conc.)
  • hKir2.1 Potassium Channel Assay - Qube APC (1 Conc.)
  • hKir2.1 Potassium Channel Assay - Qube APC (6 Conc.)
  • hKv4.3 /hKChIP2 Potassium Channel Assay - Qube APC (1 Conc.)
  • hKv4.3 /hKChIP2 Potassium Channel Assay - Qube APC (6 Conc.)

Cytotoxicity Assays 
  • Cytotoxicity Panel (HepG2; 5 endpoints; HCA) (#G202)
  • Cytotoxicity (NHDF-neo; Cell Viability; Apoptosis; Cell Cycle) (#970021)
  • Cellular Stress (NHDF-neo; Cell Viability; HSP27) (#970020)
  • Cytotoxicity (HUVEC; Cell Viability; Apoptosis; Cell Cycle) (#970520)
  • Cellular Stress (HUVEC; Cell Viability; HSP27) (#970040)
  • Cytotoxicity (HUMSC; Cell Viability; Apoptosis; Cell Cycle) (#970041)
  • Cellular Stress (HUMSC; Cell Viability; HSP27) (#970050)
  • Cytotoxicity (custom) (#1537)
  • Cytotoxicity Panel (#P213)
  • Cell Viability (HUMSC) (#4574)
  • Cell Viability (HUVEC) (#4575)
  • Cell Viability (NHDF-neo) (#4576)

Nephrotoxicity Assays 
  • Cellular Stress (HRPTEpiC; Cell Viability; HSP27; KIM1) (#970030)
  • Cytotoxicity (HRPTEpiC; Cell Viability; Apoptosis; Cell Cycle) (#970031)
  • Cell Viability (#4573)


주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
독성 분석서비스 (In Vitro Toxicology Services) . . EUROFINS DISCOVERY
Maker
EUROFINS DISCOVERY
Cat.No.
.
Product
독성 분석서비스 (In Vitro Toxicology Services)
Size
.
Qty

추천제품

관련제품

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

자료

  • Eurofins 신약개발 분석서비스

    Eurofins 신약개발 분석서비스 이미지

    고마뉴스 자료신청 [KOMA]

    신약개발 과정에 필요한 분석 및 제작서비스가 수록된 종합 카탈로그입니다.

  • Drug Candidate Assessment Resource Guide

    Drug Candidate Assessment Resource Guide 이미지

    [EUROFINS DISCOVERX]

    후보 약물의 독성에 대한 안전성 평가 패키지 안내입니다.

웨비나/Video

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제품 문의

 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet
MSDS

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