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전기영동 > 단백질 전기영동 전기영동 > 헥산 전기영동
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제품 상세
PathHunter Pharmacotrafficking Assay (Pharmacochaperone 분석) 이미지

PathHunter Pharmacotrafficking Assay (Pharmacochaperone 분석)

Eurofins DiscoverX PathHunter® cell-based pharmacotrafficking assay는 Pharmacochaperone 역할을 하는 소분자 화합물을 식별하고 최적화하기 위한 실험에 이용되는 세포주를 제공합니다.

프린트 제품 문의

특징

  

  • PathHunter cell-based pharmacotrafficking assay는 단백질의 misfolding에 의한 내재화와 protein trafficking에 관련된 질병 과정에서의 약리학적 특성화와 화합물의 기능을 조사하기 위한 cell line을 제공합니다.
  • 잘못 접힌 단백질의 적절한 folding을 촉진하고 의도한 위치로의 수송을 지원하여 pharmacochaperone으로 기능하는 화합물의 식별 및 최적화를 지원합니다.

  

 

원리

  

세포주는 ER에 있는 misfolded PK-tagged transmembrane protein과 cell membrane에 있는 EA-tag을 공동발현합니다. Pharmacochaperone이 misfolded PK-tagged protein에 결합하면 단백질이 골지체를 거쳐 세포막으로 이동하고 EA-PK를 형성하여 fuctional enzyme은 substrate를 가수분해하여 chemiluminescent signal을 생성하며, misfolded protein은 endosome으로 내재화 됩니다. 

 


 

 

  

구성

  

  • cell line 2 vials

 

 

 

종류

 

Target PRODUCT TYPE Item Number PRODUCT DESCRIPTION Size
ADRB2(W158A) Cell Lines 93-0986C3 PathHunter U2OS ADRB2(W158A) ENDO-EA Pharmacotrafficking Assay 2 vials
ADRB2(W158A) Consumables 493-0986C3 PathHunter U2OS ADRB2(W158A) ENDO-EA Pharmacotrafficking Assay Starter Pack Pack
AVPR2(S167T) Cell Lines 93-0992C3 PathHunter U2OS AVPR2(S167T) ENDO-EA Pharmacotrafficking Assay 2 vials
AVPR2(S167T) Consumables 493-0992C3 PathHunter U2OS AVPR2(S167T) ENDO-EA Pharmacotrafficking Assay Starter Pack Pack
CFTR-ΔF508 Cell Lines 93-0987C3 PathHunter U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay 2 vials
CFTR-ΔF508 Consumables 493-0987C3 PathHunter U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay Starter Pack Pack
KCNH2(G601S) Cell Lines 93-1064C3 PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay 2 vials
KCNH2(G601S) Consumables 493-1064C3 PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay Starter Pack Pack
MC4R(T162I) Cell Lines 93-1004C3 PathHunter U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay 2 vials
MC4R(T162I) Consumables 493-1004C3 PathHunter U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay Starter Pack Pack
mRHO(P23H) Cell Lines 93-0990C3 PathHunter U2OS mRHO(P23H) ENDO-EA Pharmacotrafficking Assay 2 vials
mRHO(P23H) Cell Lines 93-1077C3 PathHunter U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay 2 vials
mRHO(P23H) Consumables 493-0990C3 PathHunter U2OS mRHO(P23H) ENDO-EA Pharmacotrafficking Assay Starter Pack Pack
mRHO(P23H) Consumables 493-1077C3 PathHunter U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay Starter Pack Pack
SMO(W535L) Cell Lines 93-0991C3 PathHunter U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay 2 vials
SMO(W535L) Consumables 493-0991C3 PathHunter U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay Starter Pack Pack

 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
PathHunter® U2OS ADRB2(W158A) ENDO-EA Pharmacotrafficking Assay 93-0986C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS AVPR2(S167T) ENDO-EA Pharmacotrafficking Assay 93-0992C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay 93-0987C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay 93-1064C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay 93-1004C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS mRHO(P23H) ENDO-EA Pharmacotrafficking Assay 93-0990C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay 93-1077C3 1 PK EUROFINS DISCOVERX
PathHunter® U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay 93-0991C3 1 PK EUROFINS DISCOVERX
PathHunter U2OS ADRB2(W158A) ENDO-EA Pharmacotrafficking Assay Starter Pack 493-0986C3 Pack EUROFINS DISCOVERX
PathHunter U2OS AVPR2(S167T) ENDO-EA Pharmacotrafficking Assay Starter Pack 493-0992C3 Pack EUROFINS DISCOVERX
PathHunter U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay Starter Pack 493-0987C3 Pack EUROFINS DISCOVERX
PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay Starter Pack 493-1064C3 Pack EUROFINS DISCOVERX
PathHunter U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay Starter Pack 493-1004C3 Pack EUROFINS DISCOVERX
PathHunter U2OS mRHO(P23H) ENDO-EA Pharmacotrafficking Assay Starter Pack 493-0990C3 Pack EUROFINS DISCOVERX
PathHunter U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay Starter Pack 493-1077C3 Pack EUROFINS DISCOVERX
PathHunter U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay Starter Pack 493-0991C3 Pack EUROFINS DISCOVERX
전체보기
Maker
EUROFINS DISCOVERX
Cat.No.
93-0986C3
Product
PathHunter® U2OS ADRB2(W158A) ENDO-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-0992C3
Product
PathHunter® U2OS AVPR2(S167T) ENDO-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-0987C3
Product
PathHunter® U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-1064C3
Product
PathHunter® U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-1004C3
Product
PathHunter® U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-0990C3
Product
PathHunter® U2OS mRHO(P23H) ENDO-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-1077C3
Product
PathHunter® U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
93-0991C3
Product
PathHunter® U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay
Size
1 PK
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-0986C3
Product
PathHunter U2OS ADRB2(W158A) ENDO-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-0992C3
Product
PathHunter U2OS AVPR2(S167T) ENDO-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-0987C3
Product
PathHunter U2OS CFTR-ΔF508 MEM-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-1064C3
Product
PathHunter U2OS KCNH2(G601S) MEM-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-1004C3
Product
PathHunter U2OS MC4R(T162I) ENDO-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-0990C3
Product
PathHunter U2OS mRHO(P23H) ENDO-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-1077C3
Product
PathHunter U2OS mRHO(P23H) MEM-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
Maker
EUROFINS DISCOVERX
Cat.No.
493-0991C3
Product
PathHunter U2OS SMO(W535L) MEM-EA Pharmacotrafficking Assay Starter Pack
Size
Pack
Qty
Data Sheet
전체보기

추천제품

관련제품

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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