| Cancer Stem Cell Differentiation |
|
| Cat. No. |
Product |
Activity |
| 1803 |
ITE |
Induces
stem-like cancer cell differentiation; also inhibits TGF-β-induced human
myofibroblast differentiation |
| 3070 |
Thioridazine hydrochloride |
Selective inducer of CSC differentiation; anticancer agent |
|
|
|
| Cardiomyocyte
Stem Cells |
|
| Cat. No. |
Product |
Activity |
| 1041 |
1-EBIO |
KCa activator; promotes ESC
differentiation into cardiomyocytes |
| 3842 |
5-Azacytidine |
DNA methyltransferase inhibitor; induces differentiation of MSCs
into cardiomyocytes |
| 3084 |
Anacardic acid |
Promotes cardiomyocyte differentiation from mESCs; also histone
acetyltransferase (HAT) inhibitor |
| 3851 |
Cardiogenol C hydrochloride |
Induces cardiomyocyte differentiation in ESCs |
| 4475 |
Cardionogen 1 |
Inhibitor of Wnt/β -catenin signaling; induces ES cell cardiac
differentiation |
| 3093 |
Dorsomorphin dihydrochloride |
Promotes cardiomyocyte differentiation in mouse ESCs; BMP type I
receptor inhibitor |
| 4439 |
ISX 9 |
Neurogenic agent; induces neuronal differentiation of SVZ
progenitors and also induces cardiomyogenic differentiation |
| 5068 |
ITD 1 |
Selective inhibitor of TGF-beta signaling; induces cardiomyocyte
differentiation in ESCs |
| 3533 |
IWP 2 |
Promotes promotes cardiomyocyte differentiation from hPSCs;
PORCN inhibitor |
| 5214 |
IWP 4 |
Potent inhibitor of Wnt/β-catenin signaling; induces
cardiomyocyte differentiation of human ESCs and iPSCs |
| 4731 |
KY 02111 |
Inhibits canonical Wnt signaling. Promotes differentiation of
human ESCs and iPSCs into cardiomyocytes |
| 4287 |
Poly(I:C) |
Accelerates maturation of hPSC-derived cardiomyocytes; synthetic
double-stranded RNA (dsRNA) |
| 6577 |
Pyridone 6 |
Promotes cardiac differentiation; potent pan-JAK inhibitor |
| 3304 |
SU 16f |
Component of 9C cocktail for conversion of fibroblasts to
cardiomyocytes; potent and selective PDGFRβ inhibitor |
| 6666 |
T3 |
Promotes maturation of hPSC-derived cardiomyocytes; thyroid
hormone. |
| 5148 |
Wnt-C59 |
Wnt signaling inhibitor; induces differentiation of iPSCs to
cardiomyocytes |
| 2293 |
Zebularine |
DNA methyltransferase inhibitor; induces cardiomyocyte
differentiation in MSCs |
|
|
|
| ESCs
and iPSCs |
|
| Cat. No. |
Product |
Activity |
| 1041 |
1-EBIO |
KCa activator; promotes ESC
differentiation into cardiomyocytes |
| 4845 |
A 939572 |
Induces cell death of undifferentiated human ESCs; SCD1
inhibitor |
| 3851 |
Cardiogenol C hydrochloride |
Induces cardiomyocyte differentiation in ESCs |
| 4475 |
Cardionogen 1 |
Inhibitor of Wnt/β -catenin signaling; induces ES cell cardiac
differentiation |
| 5233 |
CCG 1423 |
Induces intermediate mesoderm differentiation from ESCs; Rho/SRF
pathway inhibitor |
| 5687 |
Centrinone |
Selective PLK4 inhihibtor; induces differentiation in PSCs |
| 5329 |
CKI 7 dihydrochloride |
CK1 inhibitor; induces retinal cell differentiation from human
ESCs and iPSCs |
| 1623 |
Cyclopamine |
Inhibitor of Hedgehog (Hh) signaling; induces differentiation of
hESCs into hormone expressing endocrine cells |
| 6873 |
DC 271 |
Fluorescent retinoic acid analog; solvochromatic probe |
| 1141 |
Dibutyryl-cAMP, sodium salt |
Promotes differentiation of hPSCs to dopaminergic neurons;
cell-permeable cAMP analog |
| 4126 |
DMH-1 |
BMP receptor ALK2 inhibitor; promotes iPSC neurogenesis in
combination with SB 431542 (Cat. No. 1614) |
| 3176 |
DMSO, sterile filtered |
Improves responsiveness of hESCs and hiPSCs to differentiation
signals |
| 3093 |
Dorsomorphin dihydrochloride |
BMP type I receptor inhibitor; promotes cardiomyocyte
differentiation in mouse ESCs |
| 4011 |
EC 23 |
Synthetic retinoid; induces neural differentiation of hESCs |
| 6291 |
ELA-32 (human) |
Apelin receptor agonist; promotes self-renewal and primes hESCs
toward endoderm lineage |
| 5254 |
FH 1 |
Enhances iPSC-derived hepatocyte differentiation and maturation |
| 6790 |
GSK 126 |
Promotes the transition of ESCs to feeder-free extended
pluripotent stem (EPS) cells |
| 4650 |
I-BET 151 dihydrochloride |
BET bromodomain inhibitor; also promotes differentiation of
hiPSCs into megakaryocytes |
| 4015 |
IDE 1 |
Induces definitive endoderm formation in mouse and human ESCs |
| 4016 |
IDE 2 |
Induces definitive endoderm formation in mouse and human ESCs |
| 5068 |
ITD 1 |
Selective inhibitor of TGF-β signaling; induces cardiomyocyte
differentiation in ESCs |
| 5214 |
IWP 4 |
Potent inhibitor of Wnt/β-catenin signaling; induces
cardiomyocyte differentiation of human ESCs and iPSCs |
| 4731 |
KY 02111 |
Inhibits canonical Wnt signaling. Promotes differentiation of
human ESCs and iPSCs into cardiomyocytes |
| 6053 |
LDN 193189 dihydrochloride |
Potent and selective ALK2 and ALK3 inhibitor; promotes neural
induction of hPSCs |
| 6068 |
Lin28 1632 |
RNA binding protein Lin28 inhibitor; promotes mESC
differentiation |
| 2694 |
PD 407824 |
Sensitizes hESCs to BMP4 to induce differentiation; also potent
and selective inhibitor of Chk1 and Wee1 |
| 4847 |
PluriSln 1 |
Inhibitor of SCD1; selectively eliminates undifferentiated hPSCs
from culture |
| 6577 |
Pyridone 6 |
Induces intermediate mesoderm; cell permeable JAK inhibitor |
| 1292 |
Rapamycin |
mTOR inhibitor; also drives hPSC differentiation to mesendoderm
and blood progenitor cells |
| 0695 |
Retinoic acid |
Endogenous retinoic acid receptor agonist; promotes ESC
differentiation |
| 4366 |
SAG |
Enhances neuronal differentiation of iPSCs into dopaminergic
neurons; Smo agonist |
| 6881 |
SB 4 |
Potent BMP4 agonist; activates canonical BMP signaling |
| 6424 |
Sodium Cromoglicate |
Promotes ESCs/iPSCs differentiation into pancreatic endocrine
islet cells |
| 4484 |
STF 31 |
Eliminates undifferentiated hPSCs from culture; also NAMPT and
GLUT1 inhibitor |
| 3835 |
TWS 119 |
GSK-3β inhibitor; induces neuronal differentiation in ESCs |
| 5148 |
Wnt-C59 |
Wnt signaling inhibitor; induces differentiation of iPSCs to
cardiomyocytes |
|
|
|
| Hepatocyte
Stem Cells |
|
| Cat. No. |
Product |
Activity |
| 2952 |
CI 994 |
Increases
efficiency of hPSCs hepatocyte differentiation; Class I HDAC inhibitor |
| 5254 |
FH 1 |
Enhances iPSC-derived hepatocyte differentiation and maturation |
| 3850 |
Sodium butyrate |
Directs differentiation of mESCs into hepatocytes; HDAC
inhibitor |
|
|
|
| Mesenchymal
Stem Cells |
|
| Cat. No. |
Product |
Activity |
| 5778 |
2-Phospho-L-ascorbic
acid trisodium salt |
Ascorbic acid
derivative; maintains differentiation potential in bone marrow-derived MSCs |
| 3842 |
5-Azacytidine |
DNA methyltransferase inhibitor; induces differentiation of MSCs
into cardiomyocytes |
| 2840 |
AICAR |
AMPK activator; promotes osteogenic differentiation of bone
marrow-derived MSCs |
| 1126 |
Dexamethasone |
Anti-inflammatory glucocorticoid; induces differentiation of
human MSCs |
| 4918 |
GSA 10 |
Smo receptor agonist; induces differentiation of mesenchymal
progenitor cells into osteoblasts |
| 4513 |
Kartogenin |
Potently induces chondrogenesis in MSCs |
| 6787 |
KI-7 |
Potentiates osteoblast differentiation from MSCs; A2B receptor positive allosteric
modulator |
| 4106 |
Nicotinamide |
Promotes MSC differentiation; anti-inflammatory agent |
| 4551 |
Purmorphamine |
Smo receptor agonist; induces differentiation of mesenchymal
progenitor cells into osteoblasts |
| 6187 |
SK 216 |
Attenuates TGF-β-dependent epithelial-mesenchymal transition;
Also PAI-1 inhibitor |
| 1496 |
SP 600125 |
JNK inhibitor; prevents BMP9-induced osteogenic differentiation
of MSCs |
| 3877 |
TCS 2210 |
Inducer of neuronal differentiation in MSCs |
| 2293 |
Zebularine |
DNA methyltransferase inhibitor; induces cardiomyocyte
differentiation in MSCs |
|
|
|
| Neural
Stem Cells |
|
| Cat. No. |
Product |
Activity |
| 3854 |
1-Oleoyl
lysophosphatidic acid sodium salt |
LPA1 and LPA2 agonist; inhibits
differentiation of neural stem cells into neurons |
| 2939 |
A 83-01 |
Promotes neural differentiation of hPSCs; selective inhibitor of
TGF-βRI, ALK4 and ALK7 |
| 7163 |
Chroman 1 |
Highly potent and selective ROCK 2 inhibitor; improves cell
survival after cryogeneisis |
| 6476 |
Compound E |
Induces neuronal differentiation; γ-secretase inhibitor |
| 2634 |
DAPT |
Gamma γ-secretase inhibitor; induces neuronal differentiation;
blocks Notch signaling |
| 5566 |
DG 172 dihydrochloride |
Augments GM-CSF/IL-4-induced differentiation of mature dendritic
cells from bone marrow cells; PPARβ/δ inverse agonist |
| 1141 |
Dibutyryl-cAMP, sodium salt |
Promotes differentiation of hPSCs to dopaminergic neurons;
cell-permeable cAMP analog |
| 3093 |
Dorsomorphin dihydrochloride |
Promotes neural differentiation of hPSCs; also BMP type I
receptor inhibitor |
| 0927 |
Fluoxetine hydrochloride |
5-HT reuptake inhibitor; induces differentiation of neuronal
precursors |
| 1099 |
Forskolin |
Adenylyl cyclase activator; induces neuronal differentiation |
| 2845 |
IBMX |
PDE inhibitor; facilitates differentiation of neural progenitor
cells |
| 4439 |
ISX 9 |
Neurogenic agent; induces neuronal differentiation of SVZ
progenitors and also induces cardiomyogenic differentiation |
| 4888 |
KHS 101 hydrochloride |
Selective inducer of neuronal differentiation in hippocampal
neural progenitors |
| 6053 |
LDN 193189 dihydrochloride |
Potent and selective ALK2 and ALK3 inhibitor; promotes neural
induction of hPSCs |
| 2864 |
Metformin hydrochloride |
Activator of LKB1/AMPK; enhances neurogenesis |
| 6668 |
ML 184 |
Promotes NSC proliferation and differentiation; also selective
GPR55 agonist |
| 5186 |
Neuropathiazol |
Selective inducer of neuronal differentiation in hippocampal
neural progenitors |
| 4076 |
P7C3 |
Neuroprotective compound; enhances neurogenesis in vivo |
| 3044 |
PD 173074 |
Selective FGFR1 and -3 inhibitor; inhibits proliferation and
differentiation of oligodendrocyte progenitors |
| 6385 |
Phenanthroline |
Enhances hPSC differentiation into cranial placode cells |
| 3534 |
PNU 74654 |
Promotes neural differentiation of hPSCs; inhibits Wnt signaling |
| 4366 |
SAG |
Enhances neuronal differentiation of iPSCs into dopaminergic
neurons; Smo agonist |
| 6390 |
SAG dihydrochloride |
Dihydrochloride salt of SAG; Smo receptor agonist |
| 3300 |
SU 5402 |
Potent FGFR and VEGFR inhibitor; attenuates integrin β4-induced
differentiation of neural stem cells |
| 3877 |
TCS 2210 |
Inducer of neuronal differentiation in MSCs |
| 6336 |
Trazodone hydrochloride |
Enhances neural differentiation; also 5-HT2A and α1adrenoceptor antagonist; antidepressant and neuroprotectant |
| 3835 |
TWS 119 |
GSK-3β inhibitor; induces neuronal differentiation in ESCs |
| 3115 |
WHI-P 154 |
JAK3 kinase inhibitor; also induces differentiation of neural
progenitor cells |
| 1254 |
Y-27632 dihydrochloride |
Selective ROCK inhibitor; part of cocktail used to induce
neurons from fibroblasts |
|
|
|
| Osteogenic
Stem Cells |
|
| Cat. No. |
Product |
Activity |
| 2840 |
AICAR |
AMPK
activator; promotes osteogenic differentiation of bone marrow-derived MSCs |
| 4504 |
Chaetocin |
Promotes osteogenic differentiation in MSCs |
| 5495 |
CW 008 |
PKA signaling activator; promotes osteogenesis from hMSCs |
| 4918 |
GSA 10 |
Smo receptor agonist; induces differentiation of mesenchymal
progenitor cells into osteoblasts |
| 4551 |
Purmorphamine |
Smo receptor agonist; induces differentiation of mesenchymal
progenitor cells into osteoblasts |
| 7066 |
RCGD 423 |
gp130 modulator; promotes chondrocyte activation |
|
|
|
| Other
Differentiation Products |
|
| Cat. No. |
Product |
Activity |
| 4265 |
AS 1842856 |
Suppresses
differentiation of adipocytes; Foxo1 inhibitor |
| 4200 |
C 646 |
Represses pluripotency genes in mouse embryonic stem cells;
histone acetyltransferase (HAT) inhibitor |
| 3858 |
CH 223191 |
AhR antagonist; attenuates Th17 differentiation of naive CD4 T
cells |
| 1453 |
Clemastine fumarate |
Promotes differentiation of oligodendrocytes from progenitors; H1 antagonist |
| 6653 |
FM19G11 |
Inhibits transcriptional activity of pluripotency markers; HIF
α-subunit inhibitor |
| 1103 |
Ketoconazole |
Promotes differentiation of oligodendrocytes from progenitors;
Cytochrome P450c17 inhibitor |
| 3016 |
Miconazole nitrate |
Promotes differentiation of oligodendrocytes from progenitors;
antifungal agent |
| 6900 |
NNMTi |
Promotes myoblast differentiation; enhances proliferation and
regenerative capacity of muSCs |
| 5325 |
Rosiglitazone |
Promotes differentiation of adipocytes; also potent and
selective PPARγ agonist |
| 1614 |
SB 431542 |
Promotes stem cell proliferation, differentiation and sheet
formation |
| 5291 |
SIS3 |
Selective Smad3 inhibitor; inhibits TGF-β-induced myofibroblast
differentiation |
| 6666 |
T3 |
Promotes differentiation of oligodendroglial precursor cells;
thyroid hormone |
| 5343 |
TPPB |
Induces differentiation of hESC to pancreatic progenitors; also
high affinity PKC activator and APP modulator |
|
|
|
| Retinal
Stem Cells |
|
| Cat. No. |
Product |
Activity |
| 5329 |
CKI 7
dihydrochloride |
CK1
inhibitor; induces retinal cell differentiation from human ESCs and iPSCs |
| 2634 |
DAPT |
Preferentially induces cone photoreceptor subtype in retinal
cell differentiation |
| 5849 |
EC 19 |
Synthetic retinoid; induces differentiation of stem cells |
| 4011 |
EC 23 |
Synthetic retinoid; induces neural differentiation of hESCs |
| 6666 |
T3 |
Specifies cone cell subtype in retinal cell differentiation |
|
|
|
| Stem
Cell Proliferation |
|
| Cat. No. |
Product |
Activity |
| 4027 |
16,16-Dimethyl
Prostaglandin E2 |
Induces stem
cell proliferation |
| 3336 |
A 769662 |
Potent AMPK activator; inhibits MSC proliferation |
| 2939 |
A 83-01 |
Maintains self-renewal of human iPSCs; selective inhibitor of
TGF-βRI, ALK4 and ALK7 |
| 4095 |
Amiodarone hydrochloride |
Selectively eliminates NSCs in hESC-derived cell populations;
also broad-spectrum ion channel blocker |
| 7001 |
AT 7867 |
Induces proliferation of iPSC-derived pancreatic progenitor
cells; pan-Akt and PKA inhibitor |
| 3194 |
BIO |
Maintains self-renewal and pluripotency of ESCs; potent
inhibitor of GSK-3; also inhibits cdks |
| 7372 |
CDK8/19i |
Potent and selective CDK8 and CDK19 inhibitor; maintains
pluripotency of mouse PSCs in culture |
| 3858 |
CH 223191 |
AhR antagonist; promotes expansion of human hematopoietic stem
cells |
| 7163 |
Chroman 1 |
Highly potent and selective ROCK 2 inhibitor; improves cell
survival after cryogeneisis |
| 6019 |
Diprotin A |
Increases number of viable HSC during harvesting; DPP-IV
inhibitor |
| 1261 |
EHNA hydrochloride |
Suppresses spontaneous differentiation of human ESCs; adenosine
deaminase inhibitor |
| 6291 |
ELA-32 (human) |
Apelin receptor agonist; promotes self-renewal and primes hESCs
toward endoderm lineage |
| 6340 |
Epiblastin A |
Converts epiblast stem cells to ESCs and promotes ESC
self-renewal; CK1 inhibitor |
| 6961 |
FzM1.8 |
Preserves stemness and promotes proliferation of
undifferentiated cells; Frizzled 4 allosteric agonist |
| 2285 |
Go 6983 |
Optimizes naïve human pluripotent stem cell growth and
viability; PKC inhibitor |
| 2910 |
H 89 dihydrochloride |
Improves survival and clonogenicity of dissociated human ESCs;
PKA inhibitor |
| 5283 |
HLM 006474 |
E2F transcription factor inhibitor; attenuates hESC
proliferation |
| 3853 |
ID 8 |
Sustains self-renewal and pluripotency of ESCs |
| 4997 |
INDY |
Dyrk1A/B inhibitor; impairs self-renewal of NSCs |
| 4713 |
IQ 1 |
Enables Wnt/β-catenin-driven expansion of ESCs; prevents
spontaneous differentiation |
| 3533 |
IWP 2 |
PORCN inhibitor; suppresses self-renewal in R1 ESCs |
| 1130 |
LY 294002 hydrochloride |
Prototypical PI 3-kinase inhibitor; suppresses proliferation of
mESCs |
| 6618 |
MB 05032 |
Promotes HSC expansion; also FBPase inhibitor |
| 5779 |
NSC 23005 sodium |
Potently promotes HSC expansion ; p18INK inhibitor |
| 1671 |
PD 102807 |
Promotes expansion of erythroid progenitors |
| 3044 |
PD 173074 |
Selective FGFR1 and -3 inhibitor; inhibits proliferation and
differentiation of oligodendrocyte progenitors |
| 1213 |
PD 98059 |
MEK inhibitor; enhances ESC self-renewal |
| 4124 |
Pioglitazone hydrochloride |
Acts synergistically with Y-27632 (Cat.No. 1254) to
improve PSC cloning efficiency; PPARγ agonist |
| 4433 |
Pluripotin |
Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal |
| 6991 |
Poly Vinyl Alcohol |
Carrier molecule for stem cell culture; replaces serum albumin
for ex vivo stem
cell expansion |
| 2296 |
Prostaglandin E2 |
Induces hematopoietic stem cell proliferation |
| 4978 |
Pyrintegrin |
Enhances survival of human ESCs following enzymatic dissociation |
| 1264 |
SB 202190 |
Promotes stability of human PSCs; potent, selective inhibitor of
p38 MAPK |
| 1202 |
SB 203580 |
Selective inhibitor of p38 MAPK; stimulates neural stem cell
proliferation |
| 1616 |
SB 216763 |
GSK-3 inhibitor; maintains mouse ESCs in a pluripotent state |
| 1614 |
SB 431542 |
Induces proliferation, differentiation and sheet formation of
ESC-derived endothelial cells |
| 1496 |
SP 600125 |
Used for maintaining stem cells in naive pluripotent state;
selective JNK inhibitor |
| 3300 |
SU 5402 |
Supports mESC self-renewal; potent FGFR and VEGFR inhibitor |
| 6634 |
Surfen |
Maintains pluripotency of hESCs; heparin sulfate antagonist |
| 5759 |
SW 033291 |
High affinity 15-PGDH inhibitor; promotes hematopoiesis and
hepatocyte proliferation |
| 3845 |
Thiazovivin |
Improves survival of hESCs; ROCK inhibitor |
| 7340 |
Tocriscreen Stem Cell Library |
A library of 120 stem cell compounds (100 μL 10 mM DMSO
solutions) to explore stem cell reprogramming, differentiation, proliferation
and signaling |
| 5284 |
trans-ISRIB |
Promotes survival of hPSCs in combination with other small
molecules; also integrated stress response (ISR) inhibitor |
| 3114 |
Troglitazone |
Selective PPARγ agonist; inhibits growth of hematopoietic cell
lines |
| 1144 |
U0126 |
Regulates hPSCs self-renewal; also potent, selective inhibitor
of MEK1 and 2 |
| 5413 |
WH-4-023 |
Supports self-renewal of naive hESCs |
| 1254 |
Y-27632 dihydrochloride |
Selective ROCK inhibitor; increases survival rate of human
embryonic stem cells undergoing cryopreservation |
| 6719 |
YH 239-EE |
Promotes survival of muscle stem cells (MuSCs); MDM2 inhibitor;
activates p53 activity |
| 6599 |
Yhhu 3792 |
Enhances the self-renewal capability of NSCs; notch signaling
pathway activator; active in vivo |