고마바이오텍(주)
Category 전체보기
전기영동 > 단백질 전기영동 전기영동 > 헥산 전기영동
Cat. No.전체보기

검색 결과가 없습니다.

Product전체보기

검색 결과가 없습니다.

Brand전체보기

검색 결과가 없습니다.

제품 상세
Apoptosis Inhibitors & Activators 이미지

Apoptosis Inhibitors & Activators

Apoptosis pathway에 관련된 inhibitor & activator를 안내합니다.

14.3.3 Protein Inhibitors 

 

14.3.3 단백질은 대사, 단백질 trafficking, 신호 전달, 세포 사멸 및 세포 주기 조절과 같은 많은 중요한 세포 과정에 관여하는 고도로 보존된 단백질 그룹입니다. 14.3.3 단백질은 phospho-serine/-threonine binding protein 입니다.  

 

Cat. No. Product  Activity
2144 R18 Inhibitor of 14.3.3 proteins

  

 

Apoptosis Inducers

 

아폽토시스를 유도하는 inducer는 DNA cross-linking, anti-apoptosis 단백질 억제 및 caspase의 활성화를 포함한 다양한 메커니즘을 통해 pro-apoptosis 효과를 나타냅니다. 이러한 유도제는 antitumor 또는 antineoplastic effect를 유도하기 위해 특정 세포 과정을 표적으로 할 수 있습니다. 

 

Cat. No. Product  Activity
0789 (±)-Anatoxin A fumarate nAChR agonist; apoptosis inducer
2137 2,3-DCPE hydrochloride Selectively induces cancer cell apoptosis
1229 Actinomycin D Antineoplastic antibiotic
2098 Apoptosis Activator 2 Selectively induces tumor cell apoptosis
3367 AT 101 Downregulates Bcl-2 and Mcl-1; pro-apoptotic
3681 Bendamustine hydrochloride Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906 Betulinic acid Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5791 Bz 423 ATP synthase inhibitor; proapoptotic
2489 C 75 Induces apoptosis and exhibits anti-tumor activity
2626 Carboplatin DNA cross-linking antitumor agent
5804 Chaetoglobosin A Selectively induces apoptosis of CLL cells; antibiotic
2251 Cisplatin DNA-alkylating antitumor agent
5292 Cladribine Deoxyadenosine analog; pro-apoptotic
4091 Cyclophosphamide Alkylating agent; chemotherapeutic
2252 Doxorubicin hydrochloride Antitumor antibiotic agent; induces apoptosis
7507 Evofosfamide Hypoxia-activated DNA alkylating agent prodrug
4808 FK 866 hydrochloride Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
3495 Fludarabine Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
6776 G5 Activates apoptosis in an apoptosome-independent pathway; ubiquitin isopeptidase inhibitor
3603 Kaempferol Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
6617 LYN 1604 dihydrochloride Induces apoptosis; ULK1 agonist
3258 Mitomycin C DNA cross-linking antitumor agent
5231 MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor
3715 Narciclasine Antiproliferative agent; exhibits pro-apoptotic effects
3427 Oncrasin 1 Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623 Oxaliplatin DNA cross-linking antitumor agent
4643 PCI 34051 Potent and selective histone deacetylase 8 inhibitor; induces apoptosis in T cell-derived cell lines
5359 Rifaximin Apoptosis inducer; pregnane X receptor agonist and antibiotic
5314 SMBA 1 High affinity and selective activator of Bax
1621 Streptozocin DNA alkylator; antitumor and induces diabetes
2706 Temozolomide DNA-methylating antitumor agent

  

 

ASK1 Inhibitors

 

Apoptosis signal-regulated kinase 1 (ASK1)은 serine/threonine kinase, MAP3K family member로 JNK와 p38의 활성을 통해 apoptosis를 유도합니다. ASK1은 신경퇴행성 질환과 산화스트레스 관련 질병의 병리학적인 부분에 관여합니다.  

 

Cat. No. Product Activity
5641 MSC 2032964A Potent and selective ASK1 inhibitor; orally bioavailable
4825 TC ASK 10 Potent and selective ASK1 inhibitor; orally bioavailable

 

  

Bcl-2 Family Inhibitors & Activators

 

Bcl-2 Family는 apoptosis의 programmed cell death에 관여하며 모든 구성요소들은 4개의 Bcl-2 homology domain 중 적어도 하나를 갖고 있습니다. Bcl-2, Bcl-XL, Mcl-1과 같은 요소들은 anti-apoptotic 역할을, Bax, Bak, Bok등은 proapoptotic 역할을 합니다.  

 

Cat. No. Product  Activity
6409 A 1210477 Selective, high affinity Mcl-1 inhibitor; proapoptotic
7661 A 1331852 Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
6960 ABT 199 Selective, high affinity Bcl-2 inhibitor; orally bioavailable
7680 ABT 263 High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
6835 ABT 737 Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
4676 ARRY 520 trifluoroacetate Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
2160 Bax channel blocker Allosteric inhibitor of Bax channel activation
6323 FX 1 Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
3794 iMAC2 Inhibitor of Bid-induced Bax cytochrome c release
4819 Methylprednisolone Anti-apoptotic; upregulates expression of Bcl-xL after injury
5733 ML 311 Inhibits Mcl-1-BIM interaction
6539 Obatoclax mesylate Inhibitor of Bcl-2 family members; antiapoptotic
5314 SMBA 1 High affinity and selective activator of Bax

  

 

Calpain Inhibitors 

 

Calpain은 calcium-sensitive cysteine proteases 그룹에 속하며 포유류에서 어느곳에서나 발현합니다. 구조적으로 80kDa catalytic subunit와 28kDa regulatory subunit를 가집니다.  

 

Cat. No. Product  Activity
2950 Acetyl-Calpastatin (184-210) (human) Selective calpain inhibitor
0448 Calpeptin Calpain and cathepsin L inhibitor
5208 E 64 Potent and irreversible cysteine protease inhibitor
1748 MG 132 Proteasome and calpain inhibitor. Inhibits NF-κB activation
1269 PD 150606 Cell permeable calpain inhibitor

 

  

Caspase Inhibitors & Activators 

 

Caspases (cysteinyl aspartate proteases)는 apoptosis, necrosis, inflammation의 시그널링에 관여하는 효소로 initiator와 effector로 구분됩니다. Initiator isoform은 upstream adaptor molecule에 의해 활성화되고 반응합니다.   

 

Cat. No. Product  Activity
7242 Ac-FLTD-CMK Potent and selective inhibitor of caspases 1, 5 and 4
2251 Cisplatin Potent pro-apoptotic anticancer agent; activates caspase-3
7310 Emricasan Potent pan-caspase inhibitor
6172 INF 4E Caspase-1 and NLRP3 inflammasome inhibitor
2581 PAC 1 Activator of procaspase-3; pro-apoptotic
7143 VX 765 High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
2166 Z-DEVD-FMK Cell-permeable, irreversible caspase-3 inhibitor
2163 Z-VAD-FMK Cell-permeable, irreversible caspase inhibitor

  

 

Inhibitor of Apoptosis Inhibitors

 

The inhibitor of apoptosis (IAP) family는 apoptosis caspase를 유도하는 인자들과 함께 apoptosis의 대표 regulator 입니다. 

  

Cat. No. Product  Activity
6470 A 410099.1 High affinity XIAP antagonist; active in vivo
5141 AZD 5582 dihydrochloride Dimeric Smac mimetic; potent IAP inhibitor
5251 UC 112 IAP and XIAP inhibitor; antitumor
6491 YM 155 Survivin suppressor

  

 

 p53 Inhibitors & Activators

 

p53은 단백질 레벨과 post-translational modification state가 세포스트레스 (예, 저산소증, DNA 및 spindle 손상 등..)에 반응하여 변경되는 전사인자 입니다. p53의 활성화는 ATM, ATR, Chk1, MAPK에 의한 인산화를 포함한 여러 메커니즘에 의해 발생합니다.  

 

Cat. No. Product  Activity
3843 Cyclic Pifithrin-α hydrobromide p53 inhibitor
3503 HLI 373 Hdm2 inhibitor; activates p53-dependent transcription
6904 Idasanutlin Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
6615 KCC 07 BAI1/p53 signaling activator; inhibits MBD2 (Methyl-CpG-binding domain protein 2)
2185 NSC 146109 hydrochloride Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
5065 NSC 319726 Reactivator of mutant p53
6075 Nutlin 3a MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
3984 Nutlin-3 MDM2 antagonist; inhibits MDM2-p53 interaction
1267 Pifithrin-α hydrobromide p53 inhibitor. Also aryl hydrocarbon receptor agonist
2653 Pifithrin-μ Inhibitor of p53-mitochondrial binding
2443 RITA p53-MDM2 interaction inhibitor; antitumor
5332 SP 141 High affinity MDM2 inhibitor
3356 WR 1065 dihydrochloride p53 activator. Also ROS scavenger

 

  

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
2,3-DCPE hydrochloride (10 mg) 2137 10 mg TOCRIS
2,3-DCPE hydrochloride (50 mg) 2137 50 mg TOCRIS
A 1331852 7661 10 mg TOCRIS
A 410099.1 (10 MG) 6470 10 mg TOCRIS
A 410099.1 (50 MG) 6470 50 mg TOCRIS
ABT 199 (10 MG) 6960 10 mg TOCRIS
ABT 199 (50 MG) 6960 50 mg TOCRIS
ABT 263 7680 10 mg TOCRIS
ABT 263 7680 50 mg TOCRIS
ABT 737 (10 MG) 6835 10 mg TOCRIS
ABT 737 (50 MG) 6835 50 mg TOCRIS
Apoptosis Activator 2 (10 mg) 2098 10 mg TOCRIS
Apoptosis Activator 2 (50 mg) 2098 50 mg TOCRIS
ARRY 520 trifluoroacetate (10 mg) 4676 10 mg TOCRIS
AT 101 (10 mg) 3367 10 mg TOCRIS
AT 101 (50 mg) 3367 50 mg TOCRIS
AZD 5582 dihydrochloride (10 mg) 5141 10 mg TOCRIS
Bax channel blocker (10 mg) 2160 10 mg TOCRIS
Bax channel blocker (50 mg) 2160 50 mg TOCRIS
Bendamustine hydrochloride (10 mg) 3681 10 mg TOCRIS
Bendamustine hydrochloride (50 mg) 3681 50 mg TOCRIS
Betulinic acid (10 mg) 3906 10 mg TOCRIS
Betulinic acid (50 mg) 3906 50 mg TOCRIS
Bz 423 (10 mg) 5791 10 mg TOCRIS
Bz 423 (50 mg) 5791 50 mg TOCRIS
C 75 (10 mg) 2489 10 mg TOCRIS
C 75 (50 mg) 2489 50 mg TOCRIS
Caffeic acid phenethyl ester (10 mg) 2743 10 mg TOCRIS
Caffeic acid phenethyl ester (50 mg) 2743 50 mg TOCRIS
Carboplatin (50 mg) 2626 50 mg TOCRIS
Cisplatin (50 mg) 2251 50 mg TOCRIS
Cladribine (10 mg) 5292 10 mg TOCRIS
Cladribine (50 mg) 5292 50 mg TOCRIS
Cyclic Pifithrin-a hydrobromide (10 mg) 3843 10 mg TOCRIS
Cyclic Pifithrin-a hydrobromide (50 mg) 3843 50 mg TOCRIS
Cyclophosphamide (50 mg) 4091 50 mg TOCRIS
Doxorubicin hydrochloride (10 mg) 2252 10 mg TOCRIS
Doxorubicin hydrochloride (50 mg) 2252 50 mg TOCRIS
E 64 (10 mg) 5208 10 mg TOCRIS
E 64 (50 mg) 5208 50 mg TOCRIS
Embelin (10 mg) 2156 10 mg TOCRIS
Embelin (50 mg) 2156 50 mg TOCRIS
Evofosfamide 7507 50 mg TOCRIS
Evofosfamide 7507 10 mg TOCRIS
Fludarabine (10 mg) 3495 10 mg TOCRIS
Fludarabine (50 mg) 3495 50 mg TOCRIS
FX 1 (25 MG) 6323 25 mg TOCRIS
FX 1 (5 MG) 6323 5 mg TOCRIS
HLI 373 (10 mg) 3503 10 mg TOCRIS
HLI 373 (50 mg) 3503 50 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
2137
Product
2,3-DCPE hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2137
Product
2,3-DCPE hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7661
Product
A 1331852
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6470
Product
A 410099.1 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6470
Product
A 410099.1 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6960
Product
ABT 199 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6960
Product
ABT 199 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7680
Product
ABT 263
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7680
Product
ABT 263
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6835
Product
ABT 737 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6835
Product
ABT 737 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2098
Product
Apoptosis Activator 2 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2098
Product
Apoptosis Activator 2 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4676
Product
ARRY 520 trifluoroacetate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3367
Product
AT 101 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3367
Product
AT 101 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5141
Product
AZD 5582 dihydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2160
Product
Bax channel blocker (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2160
Product
Bax channel blocker (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3681
Product
Bendamustine hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3681
Product
Bendamustine hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3906
Product
Betulinic acid (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3906
Product
Betulinic acid (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5791
Product
Bz 423 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5791
Product
Bz 423 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2489
Product
C 75 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2489
Product
C 75 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2743
Product
Caffeic acid phenethyl ester (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2743
Product
Caffeic acid phenethyl ester (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2626
Product
Carboplatin (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2251
Product
Cisplatin (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5292
Product
Cladribine (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5292
Product
Cladribine (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3843
Product
Cyclic Pifithrin-a hydrobromide (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3843
Product
Cyclic Pifithrin-a hydrobromide (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4091
Product
Cyclophosphamide (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2252
Product
Doxorubicin hydrochloride (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2252
Product
Doxorubicin hydrochloride (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5208
Product
E 64 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5208
Product
E 64 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2156
Product
Embelin (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
2156
Product
Embelin (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7507
Product
Evofosfamide
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7507
Product
Evofosfamide
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3495
Product
Fludarabine (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3495
Product
Fludarabine (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6323
Product
FX 1 (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6323
Product
FX 1 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3503
Product
HLI 373 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3503
Product
HLI 373 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
전체보기

추천제품

자료

  • Programmed Cell Death Poster

    Programmed Cell Death Poster 이미지

    [TOCRIS]

    Programmed Cell Death pathway poster 입니다.

  • Programmed Cell Death

    Programmed Cell Death 이미지

    [ARIGO]

    Apoptosis, Necroptosis, Pyroptosis pathway에 대한 포스터 입니다.

  • Inhibitor Book Vol.4

    Inhibitor Book Vol.4 이미지

    고마뉴스 자료신청 [KOMA]

    다양한 Disease 및 pathway 에 관련된 inhibitor 자료 입니다.

웨비나/Video

TOP

제품 문의

0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet
MSDS

로그인

로그인