Apoptosis Inhibitors & Activators

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Apoptosis Inhibitors & Activators

Apoptosis pathway에 관련된 inhibitor & activator를 안내합니다.

프린트 제품 문의

14.3.3 Protein Inhibitors

14.3.3 단백질은 대사, 단백질 trafficking, 신호 전달, 세포 사멸 및 세포 주기 조절과 같은 많은 중요한 세포 과정에 관여하는 고도로 보존된 단백질 그룹입니다. 14.3.3 단백질은 phospho-serine/-threonine binding protein 입니다.

Cat. No.	Product	Activity
2144	R18	Inhibitor of 14.3.3 proteins

Apoptosis Inducers

아폽토시스를 유도하는 inducer는 DNA cross-linking, anti-apoptosis 단백질 억제 및 caspase의 활성화를 포함한 다양한 메커니즘을 통해 pro-apoptosis 효과를 나타냅니다. 이러한 유도제는 antitumor 또는 antineoplastic effect를 유도하기 위해 특정 세포 과정을 표적으로 할 수 있습니다.

Cat. No.	Product	Activity
0789	(±)-Anatoxin A fumarate	nAChR agonist; apoptosis inducer
2137	2,3-DCPE hydrochloride	Selectively induces cancer cell apoptosis
1229	Actinomycin D	Antineoplastic antibiotic
2098	Apoptosis Activator 2	Selectively induces tumor cell apoptosis
3367	AT 101	Downregulates Bcl-2 and Mcl-1; pro-apoptotic
3681	Bendamustine hydrochloride	Cytostatic agent; exhibits DNA alkylating and purine analog properties
3906	Betulinic acid	Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
5791	Bz 423	ATP synthase inhibitor; proapoptotic
2489	C 75	Induces apoptosis and exhibits anti-tumor activity
2626	Carboplatin	DNA cross-linking antitumor agent
5804	Chaetoglobosin A	Selectively induces apoptosis of CLL cells; antibiotic
2251	Cisplatin	DNA-alkylating antitumor agent
5292	Cladribine	Deoxyadenosine analog; pro-apoptotic
4091	Cyclophosphamide	Alkylating agent; chemotherapeutic
2252	Doxorubicin hydrochloride	Antitumor antibiotic agent; induces apoptosis
7507	Evofosfamide	Hypoxia-activated DNA alkylating agent prodrug
4808	FK 866 hydrochloride	Potent and non-competitive NAMPT inhibitor; induces apoptosis and autophagy
3495	Fludarabine	Proapoptotic; increases Bax and decreases Bid, XIAP and survivin expression
6776	G5	Activates apoptosis in an apoptosome-independent pathway; ubiquitin isopeptidase inhibitor
3603	Kaempferol	Proapoptotic; downregulates PLK1 expression and activates mitochondrial Ca2+ uniporter
6617	LYN 1604 dihydrochloride	Induces apoptosis; ULK1 agonist
3258	Mitomycin C	DNA cross-linking antitumor agent
5231	MPC 6827 hydrochloride	Inhibitor of microtubule polymerization; antimitotic and antitumor
3715	Narciclasine	Antiproliferative agent; exhibits pro-apoptotic effects
3427	Oncrasin 1	Proapoptotic; induces abnormal nuclear accumulation of PKCι
2623	Oxaliplatin	DNA cross-linking antitumor agent
4643	PCI 34051	Potent and selective histone deacetylase 8 inhibitor; induces apoptosis in T cell-derived cell lines
5359	Rifaximin	Apoptosis inducer; pregnane X receptor agonist and antibiotic
5314	SMBA 1	High affinity and selective activator of Bax
1621	Streptozocin	DNA alkylator; antitumor and induces diabetes
2706	Temozolomide	DNA-methylating antitumor agent

ASK1 Inhibitors

Apoptosis signal-regulated kinase 1 (ASK1)은 serine/threonine kinase, MAP3K family member로 JNK와 p38의 활성을 통해 apoptosis를 유도합니다. ASK1은 신경퇴행성 질환과 산화스트레스 관련 질병의 병리학적인 부분에 관여합니다.

Cat. No.	Product	Activity
5641	MSC 2032964A	Potent and selective ASK1 inhibitor; orally bioavailable
4825	TC ASK 10	Potent and selective ASK1 inhibitor; orally bioavailable

Bcl-2 Family Inhibitors & Activators

Bcl-2 Family는 apoptosis의 programmed cell death에 관여하며 모든 구성요소들은 4개의 Bcl-2 homology domain 중 적어도 하나를 갖고 있습니다. Bcl-2, Bcl-XL, Mcl-1과 같은 요소들은 anti-apoptotic 역할을, Bax, Bak, Bok등은 proapoptotic 역할을 합니다.

Cat. No.	Product	Activity
6409	A 1210477	Selective, high affinity Mcl-1 inhibitor; proapoptotic
7661	A 1331852	Potent and selective Bcl-xL inhibitor; antitumor and inducer of apoptosis
6960	ABT 199	Selective, high affinity Bcl-2 inhibitor; orally bioavailable
7680	ABT 263	High affinity Bcl-2 family inhibitor; proapoptotic, senolytic and antitumor
6835	ABT 737	Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines
4676	ARRY 520 trifluoroacetate	Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
2160	Bax channel blocker	Allosteric inhibitor of Bax channel activation
6323	FX 1	Bcl-6 inhibitor; 10-fold more potent than endogenous Bcl-6 corepressors
3794	iMAC2	Inhibitor of Bid-induced Bax cytochrome c release
4819	Methylprednisolone	Anti-apoptotic; upregulates expression of Bcl-xL after injury
5733	ML 311	Inhibits Mcl-1-BIM interaction
6539	Obatoclax mesylate	Inhibitor of Bcl-2 family members; antiapoptotic
5314	SMBA 1	High affinity and selective activator of Bax

Calpain Inhibitors

Calpain은 calcium-sensitive cysteine proteases 그룹에 속하며 포유류에서 어느곳에서나 발현합니다. 구조적으로 80kDa catalytic subunit와 28kDa regulatory subunit를 가집니다.

Cat. No.	Product	Activity
2950	Acetyl-Calpastatin (184-210) (human)	Selective calpain inhibitor
0448	Calpeptin	Calpain and cathepsin L inhibitor
5208	E 64	Potent and irreversible cysteine protease inhibitor
1748	MG 132	Proteasome and calpain inhibitor. Inhibits NF-κB activation
1269	PD 150606	Cell permeable calpain inhibitor

Caspase Inhibitors & Activators

Caspases (cysteinyl aspartate proteases)는 apoptosis, necrosis, inflammation의 시그널링에 관여하는 효소로 initiator와 effector로 구분됩니다. Initiator isoform은 upstream adaptor molecule에 의해 활성화되고 반응합니다.

Cat. No.	Product	Activity
7242	Ac-FLTD-CMK	Potent and selective inhibitor of caspases 1, 5 and 4
2251	Cisplatin	Potent pro-apoptotic anticancer agent; activates caspase-3
7310	Emricasan	Potent pan-caspase inhibitor
6172	INF 4E	Caspase-1 and NLRP3 inflammasome inhibitor
2581	PAC 1	Activator of procaspase-3; pro-apoptotic
7143	VX 765	High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable
2166	Z-DEVD-FMK	Cell-permeable, irreversible caspase-3 inhibitor
2163	Z-VAD-FMK	Cell-permeable, irreversible caspase inhibitor

Inhibitor of Apoptosis Inhibitors

The inhibitor of apoptosis (IAP) family는 apoptosis caspase를 유도하는 인자들과 함께 apoptosis의 대표 regulator 입니다.

Cat. No.	Product	Activity
6470	A 410099.1	High affinity XIAP antagonist; active in vivo
5141	AZD 5582 dihydrochloride	Dimeric Smac mimetic; potent IAP inhibitor
5251	UC 112	IAP and XIAP inhibitor; antitumor
6491	YM 155	Survivin suppressor

p53 Inhibitors & Activators

p53은 단백질 레벨과 post-translational modification state가 세포스트레스 (예, 저산소증, DNA 및 spindle 손상 등..)에 반응하여 변경되는 전사인자 입니다. p53의 활성화는 ATM, ATR, Chk1, MAPK에 의한 인산화를 포함한 여러 메커니즘에 의해 발생합니다.

Cat. No.	Product	Activity
3843	Cyclic Pifithrin-α hydrobromide	p53 inhibitor
3503	HLI 373	Hdm2 inhibitor; activates p53-dependent transcription
6904	Idasanutlin	Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
6615	KCC 07	BAI1/p53 signaling activator; inhibits MBD2 (Methyl-CpG-binding domain protein 2)
2185	NSC 146109 hydrochloride	Cell-permeable, genotype-selective antitumor agent; activates p53-dependent transcription
5065	NSC 319726	Reactivator of mutant p53
6075	Nutlin 3a	MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
3984	Nutlin-3	MDM2 antagonist; inhibits MDM2-p53 interaction
1267	Pifithrin-α hydrobromide	p53 inhibitor. Also aryl hydrocarbon receptor agonist
2653	Pifithrin-μ	Inhibitor of p53-mitochondrial binding
2443	RITA	p53-MDM2 interaction inhibitor; antitumor
5332	SP 141	High affinity MDM2 inhibitor
3356	WR 1065 dihydrochloride	p53 activator. Also ROS scavenger

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
Product	Cat.No.	Size	Maker
A 1331852	7661	10 mg	TOCRIS
A 410099.1 (10 MG)	6470	10 mg	TOCRIS
A 410099.1 (50 MG)	6470	50 mg	TOCRIS
ABT 199 (10 MG)	6960	10 mg	TOCRIS
ABT 199 (50 MG)	6960	50 mg	TOCRIS
ABT 263	7680	10 mg	TOCRIS
ABT 263	7680	50 mg	TOCRIS
ABT 737 (10 MG)	6835	10 mg	TOCRIS
ABT 737 (50 MG)	6835	50 mg	TOCRIS
Apoptosis Activator 2 (10 mg)	2098	10 mg	TOCRIS
Apoptosis Activator 2 (50 mg)	2098	50 mg	TOCRIS
ARRY 520 trifluoroacetate (10 mg)	4676	10 mg	TOCRIS
AT 101 (10 mg)	3367	10 mg	TOCRIS
AT 101 (50 mg)	3367	50 mg	TOCRIS
AZD 5582 dihydrochloride (10 mg)	5141	10 mg	TOCRIS
Bax channel blocker (10 mg)	2160	10 mg	TOCRIS
Bax channel blocker (50 mg)	2160	50 mg	TOCRIS
Betulinic acid (10 mg)	3906	10 mg	TOCRIS
Betulinic acid (50 mg)	3906	50 mg	TOCRIS
Bz 423 (10 mg)	5791	10 mg	TOCRIS
Bz 423 (50 mg)	5791	50 mg	TOCRIS
C 75 (10 mg)	2489	10 mg	TOCRIS
C 75 (50 mg)	2489	50 mg	TOCRIS
Caffeic acid phenethyl ester (10 mg)	2743	10 mg	TOCRIS
Caffeic acid phenethyl ester (50 mg)	2743	50 mg	TOCRIS
Carboplatin (50 mg)	2626	50 mg	TOCRIS
Cisplatin (50 mg)	2251	50 mg	TOCRIS
Cyclic Pifithrin-a hydrobromide (10 mg)	3843	10 mg	TOCRIS
Cyclic Pifithrin-a hydrobromide (50 mg)	3843	50 mg	TOCRIS
Cyclophosphamide (50 mg)	4091	50 mg	TOCRIS
Doxorubicin hydrochloride (10 mg)	2252	10 mg	TOCRIS
Doxorubicin hydrochloride (50 mg)	2252	50 mg	TOCRIS
E 64 (10 mg)	5208	10 mg	TOCRIS
E 64 (50 mg)	5208	50 mg	TOCRIS
Embelin (10 mg)	2156	10 mg	TOCRIS
Embelin (50 mg)	2156	50 mg	TOCRIS
Evofosfamide	7507	50 mg	TOCRIS
Evofosfamide	7507	10 mg	TOCRIS
Fludarabine (10 mg)	3495	10 mg	TOCRIS
Fludarabine (50 mg)	3495	50 mg	TOCRIS
FX 1 (25 MG)	6323	25 mg	TOCRIS
FX 1 (5 MG)	6323	5 mg	TOCRIS
HLI 373 (10 mg)	3503	10 mg	TOCRIS
HLI 373 (50 mg)	3503	50 mg	TOCRIS
Idasanutlin (10 MG)	6904	10 mg	TOCRIS
Idasanutlin (50 MG)	6904	50 mg	TOCRIS
IKK 16 (10 mg)	2539	10 mg	TOCRIS
IKK 16 (50 mg)	2539	50 mg	TOCRIS
IMD 0354 (10 mg)	2611	10 mg	TOCRIS
IMD 0354 (50 mg)	2611	50 mg	TOCRIS

전체보기

1
Maker	TOCRIS
Cat.No.	7661
Product	A 1331852
Size	10 mg
Qty
Data Sheet
MSDS

2
Maker	TOCRIS
Cat.No.	6470
Product	A 410099.1 (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

3
Maker	TOCRIS
Cat.No.	6470
Product	A 410099.1 (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

4
Maker	TOCRIS
Cat.No.	6960
Product	ABT 199 (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

5
Maker	TOCRIS
Cat.No.	6960
Product	ABT 199 (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

6
Maker	TOCRIS
Cat.No.	7680
Product	ABT 263
Size	10 mg
Qty
Data Sheet
MSDS

7
Maker	TOCRIS
Cat.No.	7680
Product	ABT 263
Size	50 mg
Qty
Data Sheet
MSDS

8
Maker	TOCRIS
Cat.No.	6835
Product	ABT 737 (10 MG)
Size	10 mg
Qty
Data Sheet
MSDS

9
Maker	TOCRIS
Cat.No.	6835
Product	ABT 737 (50 MG)
Size	50 mg
Qty
Data Sheet
MSDS

10
Maker	TOCRIS
Cat.No.	2098
Product	Apoptosis Activator 2 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

11
Maker	TOCRIS
Cat.No.	2098
Product	Apoptosis Activator 2 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

12
Maker	TOCRIS
Cat.No.	4676
Product	ARRY 520 trifluoroacetate (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

13
Maker	TOCRIS
Cat.No.	3367
Product	AT 101 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

14
Maker	TOCRIS
Cat.No.	3367
Product	AT 101 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

15
Maker	TOCRIS
Cat.No.	5141
Product	AZD 5582 dihydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

16
Maker	TOCRIS
Cat.No.	2160
Product	Bax channel blocker (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

17
Maker	TOCRIS
Cat.No.	2160
Product	Bax channel blocker (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

18
Maker	TOCRIS
Cat.No.	3906
Product	Betulinic acid (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

19
Maker	TOCRIS
Cat.No.	3906
Product	Betulinic acid (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

20
Maker	TOCRIS
Cat.No.	5791
Product	Bz 423 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

21
Maker	TOCRIS
Cat.No.	5791
Product	Bz 423 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

22
Maker	TOCRIS
Cat.No.	2489
Product	C 75 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

23
Maker	TOCRIS
Cat.No.	2489
Product	C 75 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

24
Maker	TOCRIS
Cat.No.	2743
Product	Caffeic acid phenethyl ester (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

25
Maker	TOCRIS
Cat.No.	2743
Product	Caffeic acid phenethyl ester (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

26
Maker	TOCRIS
Cat.No.	2626
Product	Carboplatin (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

27
Maker	TOCRIS
Cat.No.	2251
Product	Cisplatin (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

28
Maker	TOCRIS
Cat.No.	3843
Product	Cyclic Pifithrin-a hydrobromide (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

29
Maker	TOCRIS
Cat.No.	3843
Product	Cyclic Pifithrin-a hydrobromide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

30
Maker	TOCRIS
Cat.No.	4091
Product	Cyclophosphamide (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

31
Maker	TOCRIS
Cat.No.	2252
Product	Doxorubicin hydrochloride (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

32
Maker	TOCRIS
Cat.No.	2252
Product	Doxorubicin hydrochloride (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

33
Maker	TOCRIS
Cat.No.	5208
Product	E 64 (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

34
Maker	TOCRIS
Cat.No.	5208
Product	E 64 (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

35
Maker	TOCRIS
Cat.No.	2156
Product	Embelin (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

36
Maker	TOCRIS
Cat.No.	2156
Product	Embelin (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

37
Maker	TOCRIS
Cat.No.	7507
Product	Evofosfamide
Size	50 mg
Qty
Data Sheet
MSDS

38
Maker	TOCRIS
Cat.No.	7507
Product	Evofosfamide
Size	10 mg
Qty
Data Sheet
MSDS

39
Maker	TOCRIS
Cat.No.	3495
Product	Fludarabine (10 mg)
Size	10 mg
Qty
Data Sheet
MSDS

40
Maker	TOCRIS
Cat.No.	3495
Product	Fludarabine (50 mg)
Size	50 mg
Qty
Data Sheet
MSDS

41
Maker	TOCRIS
Cat.No.	6323
Product	FX 1 (25 MG)
Size	25 mg
Qty
Data Sheet
MSDS

전체보기

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