|
Autophagy Inhibitors |
|
|
Cat. No. |
Product Name |
Activity |
|
1544 |
(±)-Bay
K 8644 |
L-type Ca2+ channel activator; inhibits
autophagy |
|
3977 |
3-Methyladenine |
Class III PI 3-kinase inhibitor; also inhibits
autophagy |
|
4265 |
AS
1842856 |
Potent and selective Foxo1 inhibitor; suppresses
autophagy |
|
6324 |
Autophinib |
Potent VPS34 inhibitor |
|
3771 |
Azithromycin |
Autophagy
inhibitor; antibiotic |
|
1334 |
Bafilomycin
A1 |
H+-ATPase (vacuolar) inhibitor; also inhibits
autophagy |
|
4109 |
Chloroquine
diphosphate |
Inhibits apoptosis and autophagy |
|
2656 |
Concanamycin
A |
H+-ATPase (vacuolar) inhibitor |
|
4417 |
DBeQ |
Selective p97 ATPase inhibitor; blocks autophagosome
maturation |
|
4545 |
E
64d |
Cathepsin inhibitor; interferes with autolysosomal
digestion |
|
0786 |
Edaravone |
Autophagy inhibitor; also anti-ischemic and
antioxidant |
|
2473 |
GW
4064 |
Selective farnesoid X receptor (FXR) agonist;
suppresses autophagy in nutrient-deprived hepatocytes |
|
5648 |
Hydroxychloroquine
sulfate |
Autophagy inhibitor; also TLR9 inhibitor |
|
1130 |
LY
294002 hydrochloride |
Prototypical PI 3-kinase inhibitor; inhibits
autophagic sequestration |
|
3982 |
Mdivi
1 |
Autophagy inhibitor; also selective dynamin inhibitor |
|
5153 |
ML
240 |
ATP-competitive inhibitor of p97 ATPase; impairs
autophagosome maturation |
|
5134 |
MRT
67307 dihydrochloride |
Autophagy inhibitor; also salt inducible kinase (SIK)
inhibitor |
|
5067 |
MRT
68601 hydrochloride |
Potent TBK1 inhibitor; also inhibits autophagy |
|
5780 |
MRT
68921 dihydrochloride |
Autophagy inhibitor; potent ULK inhibitor |
|
6180 |
NMS
873 |
Potent and selective p97 ATPase (VCP) allosteric
inhibitor |
|
1228 |
Nocodazole |
Microtubule inhibitor; inhibits
autophagosome-lysosome fusion |
|
1190 |
Pepstatin
A |
Protease inhibitor; interferes with autolysosomal
digestion |
|
5197 |
Spautin
1 |
Inhibits autophagy; USP10 and USP13 inhibitor |
|
1097 |
Taxol |
Promotes assembly and inhibits disassembly of
microtubules |
|
1256 |
Vinblastine
sulfate |
Disrupts microtubules; inhibits autophagosome
maturation |
|
1232 |
Wortmannin |
Potent, irreversible inhibitor of PI 3-kinase. Also
inhibitor of PLK1 |
|
4686 |
Xanthohumol |
p97 ATPase (VCP) inhibitor; impairs autophagosome
maturation |
|
|
|
|
|
Autophagy Activators |
|
|
Cat. No. |
Product Name |
Activity |
|
3336 |
A
769662 |
Autophagy activator; potent AMPK activator |
|
1234 |
A23187,
free acid |
Causes ER stress; can be used to induce autophagy in
mammalian cells |
|
4095 |
Amiodarone
hydrochloride |
Causes mitochondrial fragmentation and cell death;
stimulates autophagy |
|
1231 |
Brefeldin
A |
Causes ER stress; induces autophagy in mammalian
cells |
|
4098 |
Carbamazepine |
Induces autophagy by inhibiting inositol synthesis;
Inhibits neuronal NaV channels |
|
0690 |
Clonidine
hydrochloride |
α2 agonist and I1 ligand; thought to
enhance autophagy |
|
1126 |
Dexamethasone |
Anti-inflammatory glucocorticoid; also induces
autophagy in ALL cell lines |
|
3093 |
Dorsomorphin
dihydrochloride |
Induces autophagy via an AMPK inhibition-independent
mechanism |
|
3993 |
EB
1089 |
Vitamin D receptor agonist; induces autophagy in
MCF-7 cells |
|
7474 |
EN6 |
Activator of autophagy; inactivates mTORC1 signaling |
|
6188 |
Everolimus |
Autophagy activator; mTOR inhibitor |
|
4808 |
FK
866 hydrochloride |
Non-competitive and potent NAMPT inhibitor; induces
apoptosis and autophagy |
|
6494 |
Galangin |
Autophagy inducer; also TRPC5 inhibitor |
|
0741 |
GF
109203X |
Protein kinase C inhibitor |
|
0681 |
L-690,330 |
Inositol monophosphatase inhibitor; induces autophagy
independently of mTOR inhibition |
|
2864 |
Metformin
hydrochloride |
Activator of LKB1/AMPK; activates autophagy |
|
1391 |
NF
449 |
Highly selective P2X1 antagonist; Gsα-selective
antagonist |
|
4079 |
Niclosamide |
STAT3 inhibitor; also inhibits mTORC1 signaling.
Stimulates autophagy in vitro |
|
0600 |
Nimodipine |
Induces autophagy; Ca2+ channel blocker (L-type) |
|
0601 |
Nitrendipine |
Induces autophagy; Ca2+ channel blocker (L-type) |
|
6087 |
Perifosine |
PKB/Akt inhibitor; induces autophagy |
|
2930 |
PI
103 hydrochloride |
Inhibitor of PI 3-kinase, mTOR and DNA-PK |
|
1267 |
Pifithrin-α hydrobromide |
p53 inhibitor |
|
1292 |
Rapamycin |
mTOR inhibitor; induces autophagy |
|
1418 |
Resveratrol |
Autophagy activator; also cyclooxygenase inhibitor |
|
0695 |
Retinoic
acid |
Autophagy activator; also endogenous retinoic acid
receptor agonist |
|
0790 |
Rilmenidine
hemifumarate |
α2 agonist and I1 ligand; thought to
enhance autophagy |
|
1610 |
Rottlerin |
Stimulates autophagy |
|
4652 |
SAHA |
Autophagy activator; also Class I and II HDAC
inhibitor |
|
4989 |
Salirasib |
Ras inhibitor; also induces autophagy |
|
4297 |
SMER
28 |
Positive regulator of autophagy |
|
2706 |
Temozolomide |
DNA-methylating antitumor agent; also induces
autophagy |
|
5264 |
Temsirolimus |
Autophagy activator; mTOR inhibitor |
|
1138 |
Thapsigargin |
Causes ER stress; can be used to induce autophagy in
mammalian cells |
|
4247 |
Torin
1 |
Potent and selective mTOR inhibitor; induces
autophagy in HeLa cells |
|
4248 |
Torin
2 |
Autophagy activator; also potent and selective mTOR
inhibitor |
|
1406 |
Trichostatin
A |
Autophagy activator; potent histone deacetylase
inhibitor |
|
3516 |
Tunicamycin |
Causes ER stress; can be used to induce autophagy |
|
2815 |
Valproic
acid, sodium salt |
Reduces inositol levels; induces autophagy |
|
0654 |
Verapamil
hydrochloride |
Ca2+ channel blocker (L-type); induces autophagy |