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293 Cell Lines for AAV, Adenovirus, Lentivirus, Retrovirus Production 이미지

293 Cell Lines for AAV, Adenovirus, Lentivirus, Retrovirus Production

293AAV Cell Line, 293AD Cell Line, 293LTV Cell Line, 293RTV Cell Line은 각각 AAV, Adenovirus, Lentivirus, Retrovirus 생산에 이용되는 293 host cell line 입니다.

프린트 제품 문의

특징  


    • Parental HEK293 cell에서 유래된 cell line으로, virus가 잘 도입되도록 평평한 형태와 높은 부착성을 제공합니다.
    • 종류 
      • AAV : 293AAV Cell Line (#AAV-100)
      • Adenovirus : 293AD Cell Line (#AD-100)
      • Lentivirus : 293LTV Cell Line (#LTV-100)
      • Retrovirus : 293RTV Cell Line (#RV-100)

     

     

     

     

    사용 논문

     

    AAV-100 　
      1. Yun, T. et al. (2021). Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin. Cell Death Discov. 7(1):257. doi: 10.1038/s41420-021-00652-4.
      2. Chao, G. et al. (2021). Measurement of Large Serine Integrase Enzymatic Characteristics in HEK293 Cells Reveals Variability and Influence on Downstream Reporter Expression. FEBS J. doi: 10.1111/febs.16037.
      3. Sveidahl Johansen, O. et al. (2021). Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. doi: 10.1016/j.cell.2021.04.037.
      4. Hu, J. et al. (2021). Co-opting regulation bypass repair as a gene correction strategy for monogenic diseases. Mol Ther. doi: 10.1016/j.ymthe.2021.04.017.
      5. Motori, E. et al. (2020). Larsson, Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction. Sci. Adv. 6(35). doi: 10.1126/sciadv.aba8271.
      6. Gӧbel, J. et al. (2020). Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling. Cell Metab. pii: S1550-4131(20)30120-0. doi: 10.1016/j.cmet.2020.03.005.
      7. Lin, Y.H. et al. (2020). Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurochem Int. doi: 10.1016/j.neuint.2020.104935.
      8. Siegrist, C.M. et al. (2020). CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector. Sci Rep. 10(1):19307. doi: 10.1038/s41598-020-76449-9.
      9. Sun, W. et al. (2020). snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature. 587(7832):98-102. doi: 10.1038/s41586-020-2856-x.
      10. Bougioukli, S. et al. (2020). Limited potential of AAV-mediated gene therapy in transducing human mesenchymal stem cells for bone repair applications. Gene Ther. doi: 10.1038/s41434-020-0182-4.
      11. Chen, S.H. et al. (2020). A Simple, Two-Step, Small-Scale Purification of Recombinant Adeno-Associated Viruses. J Virol Methods. doi: 10.1016/j.jviromet.2020.113863.
      12. Wu, Z. et al. (2020). Gene therapy conversion of striatal astrocytes into GABAergic neurons in mouse models of Huntington's disease. Nat Commun. 11(1):1105. doi: 10.1038/s41467-020-14855-3.
      13. Miyawaki, T. et al. (2020). Visualization and molecular characterization of whole-brain vascular networks with capillary resolution. Nat Commun. 11(1):1104. doi: 10.1038/s41467-020-14786-z.
      14. Funahashi, Y. et al. (2019). Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors. Cell Rep. 29(10):3235-3252.e9. doi: 10.1016/j.celrep.2019.10.116.
      15. Nakano, R. et al . (2019). Auxin-mediated rapid degradation of target proteins in hippocampal neurons. Neuroreport. 30(13):908-913. doi: 10.1097/WNR.0000000000001299.
      16. Kuzumaki, N. et al. (2019). Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease. Brain. doi: 10.1093/brain/awz084.
      17. Ao, H. et al. (2019). Egr1 mediates retinal vascular dysfunction in diabetes mellitus via promoting p53 transcription. J Cell Mol Med. doi: 10.1111/jcmm.14225.
      18. Nakamura, M. et al. (2019). Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab. pii: S1550-4131(19)30005-1. doi: 10.1016/j.cmet.2019.01.005.
      19. Iwasawa, C. et al. (2019). Regional and temporal regulation and role of somatostatin receptor subtypes in the mouse brain following systemic kainate-induced acute seizures. Neurosci Res. pii: S0168-0102(18)30670-9. doi: 10.1016/j.neures.2019.01.004.
      20. Hashimoto, H. et al. (2016). Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans. Biochem Biophys Res Commun. doi:10.1016/j.bbrc.2016.08.104.
      21. Lee, S. E. et al. (2016). nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1600944113.
      22. Lutz, D. et al. (2014).  Myelin Basic Protein Cleaves Cell Adhesion Molecule L1 and Promotes Neuritogenesis and Cell Survival. J Biol Chem. 289:13503-13518.
    AD-100 　
      1. Wade, M. et al. (2021). In vivo generation of collagen specific Tregs with AAV8 suppresses autoimmune responses and arthritis in DBA1 mice through IL10 production. Sci Rep. 11(1):18204. doi: 10.1038/s41598-021-97739-w.
      2. Light, T.P. et al. (2021). A Cancer Mutation Promotes EphA4 Oligomerization and Signaling by Altering the Conformation of the SAM Domain. J Biol Chem. doi: 10.1016/j.jbc.2021.100876.
      3. Koduri, V. et al. (2021). Targeting oncoproteins with a positive selection assay for protein degraders. Sci Adv. 7(6):eabd6263. doi: 10.1126/sciadv.abd6263.
      4. Tanaka, N. et al. (2020). Vacuum microcasting of 2-methacryloyloxyethyl phosphorylcholine polymer for stable cell patterning. Biotechniques. doi: 10.2144/btn-2020-0052.
      5. Gehring, M.P. et al. (2020). Protein kinase C phosphorylates the EphA2 receptor on serine 892 in the regulatory linker connecting the kinase and SAM domains. Cell Signal. doi: 10.1016/j.cellsig.2020.109668.
      6. Cho, J.H. et al. (2020). CD9 induces cellular senescence and aggravates atherosclerotic plaque formation. Cell Death Differ. doi: 10.1038/s41418-020-0537-9.
      7. Hu, Z. (2020). Tissue factor as a new target for CAR-NK cell immunotherapy of triple-negative breast cancer. Sci Rep. 10(1):2815. doi: 10.1038/s41598-020-59736-3.
      8. Watanabe, H. et al. (2018). Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein. Nat Commun. 9(1):30. doi: 10.1038/s41467-017-02537-6.
      9. Wu, B. et al. (2018). Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate. J Neuroinflammation. 15(1):79. doi: 10.1186/s12974-018-1120-x.
      10. Dai, C.Y. et al. (2018). The IL-6/STAT3 pathway upregulates microRNA-125b expression in hepatitis C virus infection. Oncotarget. 9(13):11291-11302. doi: 10.18632/oncotarget.24129.
      11. Lin, G.Z. et al. (2018). Immunogenicity of recombinant Adenovirus co-expressing the L7/L12 and BCSP31 proteins of Brucella abortus. Kafkas Univ Vet Fak Derg. 24 (2): 211-217. doi: 10.9775/kvfd.2017.18644.
      12. Zaric, M. et al. (2017). Long-lived tissue resident HIV-1 specific memory CD8+ T cells are generated by skin immunization with live virus vectored microneedle arrays. J Control Release. 268:166-175. doi: 10.1016/j.jconrel.2017.10.026.
      13. Ravindran, D. et al. (2017). Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. PLoS One. 12(3):e0173224. doi: 10.1371/journal.pone.0173224.
      14. Ridiandries, A. et al. (2017). Broad-Spectrum Inhibition of the CC-Chemokine Class Improves Wound Healing and Wound Angiogenesis. Int J Mol Sci. doi: 10.3390/ijms18010155.
      15. Bae, E. J. et al. (2015). Cell models to study cell-to-cell transmission of α-synuclein. Methods Mol Biol. 1345:291-298.
      16. Strathearn, K. E. & Pardo, A. M. P. (2015). Parameters to Consider When Expanding Cells on Corning® Microcarriers. Corning Application Note.
      17. Sugiyama, K. et al. (2014). Expression of the miR200 family of microRNAs in mesothelial cells suppresses the dissemination of ovarian cancer cells. Mol Cancer Ther. 13:2081-2091.
      18. Peng, D. et al. (2014). Glutathione peroxidase 7 has potential tumour suppressor functions that are silenced by location-specific methylation in oesophageal adenocarcinoma. Gut 63:540-551.
      19. Peng, D. et al. (2011). Glutathione Peroxidase 7 Protects Against Oxidative DNA Damage in Oesophageal Cells. Gut. 61:1250-1260.
      20. Kothari, H. el at. (2010) Cystine 186-cystine 209 disulfide bond is not essential for the procoagulant activity of tissue factor or for its de-encryption. Blood 115:4273-4283.
      21. Fang, S. et al. (2007). Coordinated recruitment of histone methyltransferase G9a and other chromatin modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism. Mol. Cell. Biol. 27:1407-1424.
      22. Ponugoti, B. et al. (2007). Functional interaction of HNF-4 and PGC-1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, SREBP-1c. Mol. Endocrinol. 21:2698-2712.
    LTV-100 　
      1. Wade, M. et al. (2021). In vivo generation of collagen specific Tregs with AAV8 suppresses autoimmune responses and arthritis in DBA1 mice through IL10 production. Sci Rep. 11(1):18204. doi: 10.1038/s41598-021-97739-w.
      2. Smith, C.M. et al. (2021). Phosphatidylserine binding directly regulates TIM-3 function. Biochem J. 478(17):3331-3349. doi: 10.1042/BCJ20210425.
      3. Kiss, E. et al. (2021). Artesunate restores the levels of inhibitory synapse proteins and reduces amyloid-β and C-terminal fragments (CTFs) of the amyloid precursor protein in an AD-mouse model. Mol Cell Neurosci. doi: 10.1016/j.mcn.2021.103624.
      4. Kiss, E. et al. (2021). Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density. Biol Chem. doi: 10.1515/hsz-2021-0153.
      5. Jeong, J. et al. (2021). Combination of cell signaling molecules can facilitate MYOD1-mediated myogenic transdifferentiation of pig fibroblasts. J Anim Sci Biotechnol. 12(1):64. doi: 10.1186/s40104-021-00583-1.
      6. Martin-Jaular, L. et al. (2021). Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. EMBO J. doi: 10.15252/embj.2020105492.
      7. Xie, W. et al. (2021). Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor β suppression in hematopoietic stem cells. Burns Trauma. doi: 10.1093/burnst/tkaa045.
      8. Sinha, A. et al. (2020). RAD51-Mediated DNA Homologous Recombination Is Independent of PTEN Mutational Status. Cancers (Basel). 12(11):E3178. doi: 10.3390/cancers12113178.
      9. Sun, W. et al. (2020). snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis. Nature. 587(7832):98-102. doi: 10.1038/s41586-020-2856-x.
      10. Yoshihara, E. et al. (2020). Immune-evasive human islet-like organoids ameliorate diabetes. Nature. doi: 10.1038/s41586-020-2631-z.
      11. Baci, D. et al. (2020). Extracellular Vesicles from Skeletal Muscle Cells Efficiently Promote Myogenesis in Induced Pluripotent Stem Cells. Cells. 9(6):E1527. doi: 10.3390/cells9061527.
      12. Smolková, K. et al. (2020). SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2. Sci Rep. 10(1):8677. doi: 10.1038/s41598-020-65351-z.
      13. Lucchini, F.C. et al. (2020). ASK1 inhibits browning of white adipose tissue in obesity. Nat Commun. 11(1):1642. doi: 10.1038/s41467-020-15483-7.
      14. Hsu, W.L. et al. (2020). Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome. Sci Rep. 10(1):1074. doi: 10.1038/s41598-020-57745-w.
      15. Harten, I.A. et al. (2020). The Synthesis and Secretion of Versican Isoform V3 by Mammalian Cells: A Role for N-linked Glycosylation. Matrix Biol. pii: S0945-053X(20)30008-1. doi: 10.1016/j.matbio.2020.01.002.
      16. Yanai, M. et al. (2019). ADAR2 is involved in self and nonself recognition of Borna disease virus genomic RNA in the nucleus. J Virol. pii: JVI.01513-19. doi: 10.1128/JVI.01513-19.
      17. Rubio, R.M. et al. (2019). Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Proc Natl Acad Sci U S A. pii: 201915139. doi: 10.1073/pnas.1915139116.
      18. Madan, E. et al. (2019). HIF-transcribed p53 chaperones HIF-1α. Nucleic Acids Res. pii: gkz766. doi: 10.1093/nar/gkz766.
      19. Zhou, Y. et al. (2019). Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming. Cell Stem Cell. pii: S1934-5909(19)30224-3. doi: 10.1016/j.stem.2019.05.020.
      20. Kobayashi, M. et al. (2019). AGO CLIP Reveals an Activated Network for Acute Regulation of Brain Glutamate Homeostasis in Ischemic Stroke. Cell Rep. 28(4):979-991.e6. doi: 10.1016/j.celrep.2019.06.075.
      21. Peng, D. et al. (2019). NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells. Cancer Lett. pii: S0304-3835(19)30326-X. doi: 10.1016/j.canlet.2019.05.031.
      22. Lau, M.T. et al. (2019). Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote. Nat Commun. 10(1):1655. doi: 10.1038/s41467-019-09681-1.
      23. Bhattacharya, S. et al. (2019). Lentiviral-mediated delivery of classical swine fever virus Erns gene into porcine kidney-15 cells for production of recombinant ELISA diagnostic antigen. Mol Biol Rep. doi: 10.1007/s11033-019-04829-0.
      24. Navinés-Ferrer, A. et al. (2018). MRGPRX2-mediated mast cell response to drugs used in perioperative procedures and anaesthesia. Sci Rep. 8(1):11628. doi: 10.1038/s41598-018-29965-8.
      25. Meier, S. et al. (2018). Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart. Sci Rep. 8(1):4638. doi: 10.1038/s41598-018-22993-4.
      26. Ghosh, N. & Banerjee, E.R. (2017). A Review on Various Tissue Engineering Techniques to Induce Differentiation of Pluripotent Stem Cells. Medical Glory. 1(2):130-149.
      27. Agudelo, D. et al. (2017). Marker-free coselection for CRISPR-driven genome editing in human cells. Nat Methods. 14(6):615–620. doi:10.1038/nmeth.4265.
      28. Zheng, L. et al. (2017). Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma. Int J Mol Sci. 18(12). pii: E2773. doi: 10.3390/ijms18122773.
      29. Hsu, W.L. et al. (2017). Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2. BMC Biol. 15(1):112. doi: 10.1186/s12915-017-0452-9.
      30. Tao, C.C. et al. (2017). Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ. doi: 10.1038/cdd.2016.161.

     

    주문정보

    주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
      Product Cat.No. Size Maker Qty Data Sheet MSDS
    		293AAV Cell Line AAV-100 1 vial CELL BIOLABS
    		293AD Cell Line AD-100 1 vial CELL BIOLABS
    		293LTV Cell Line LTV-100 1 vial CELL BIOLABS
    		293RTV Cell Line RV-100 1 vial CELL BIOLABS
    Maker
    CELL BIOLABS
    Cat.No.
    AAV-100
    Product
    293AAV Cell Line
    Size
    1 vial
    Qty
    Data Sheet
    MSDS
    Maker
    CELL BIOLABS
    Cat.No.
    AD-100
    Product
    293AD Cell Line
    Size
    1 vial
    Qty
    Data Sheet
    MSDS
    Maker
    CELL BIOLABS
    Cat.No.
    LTV-100
    Product
    293LTV Cell Line
    Size
    1 vial
    Qty
    Data Sheet
    MSDS
    Maker
    CELL BIOLABS
    Cat.No.
    RV-100
    Product
    293RTV Cell Line
    Size
    1 vial
    Qty
    Data Sheet
    MSDS

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    		 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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