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[R&D Systems] Fc gamma receptor (FcγR) proteins 이미지

[R&D Systems] Fc gamma receptor (FcγR) proteins

Maker : R&D SYSTEMS

Fc 감마 수용체 (Fc gamma receptor, FcγR) 단백질은 항체의 Fc 영역과 FcγR 간의 결합 친화도를 측정하기 위해 이용됩니다.

특징 

 

  • Fc 감마 수용체 (Fc gamma receptor, FcγR) 단백질은 항체의 Fc 영역에 결합하는 수용체로, 면역 반응을 활성화하거나 억제를 매개합니다. 
  • 항체-수용체 상호작용을 분석하는 데 사용되어, 항체의 Fc 영역이 Fcγ 수용체와 어떻게 결합하는지 평가하는 역할을 합니다.
  • 면역 세포의 활성화 기전을 규명하는 데 활용되어, Fcγ 수용체가 항체에 결합함으로써 대식세포, 수지상세포, NK 세포 등의 면역 반응을 유도하는 과정을 모사하는 역할을 합니다.
  • 항체 치료제의 효능을 평가하고 개발하는 데 사용되어, Fc 영역의 변형이 수용체와의 결합력 및 ADCC 기능에 미치는 영향을 파악하는 역할을 합니다.
  • 약물 스크리닝 및 후보 물질 발굴 실험에서, FcγR과 상호작용할 수 있는 항체나 저분자 화합물을 선별하는 데 역할을 합니다.
  • ELISA, SPR, BLI 등의 분석 플랫폼에서 리간드 또는 캡처 단백질로 사용되어, 항체의 Fc 부분과의 결합력을 정량화하는 데 역할을 합니다.

  

 

Fc 감마 수용체 종류별 기능 

 

아형 CD명 결합 친화도 주요 발현 세포 역할
FcγRI CD64 고친화성 (High affinity) 대식세포, 수지상세포, 호중구, 단핵구 • IgG 항체의 Fc 부분을 높은 친화도로 결합하여, 항체-항원 복합체의 포식작용(phagocytosis) 및 항원 제시에 관여
FcγRIIA CD32A 중간 친화도 호중구, 대식세포, 혈소판 등 • IgG와 결합하여 세포 독성 반응, 염증 반응 유도, 면역 복합체 제거에 관여
• 항체 치료제의 작용 메커니즘 분석에도 사용
FcγRIIB CD32B 억제성 수용체 (Inhibitory) B 세포, 대식세포, 수지상세포 등 • 유일한 억제성 Fcγ 수용체로, 면역 반응을 억제하여 자가면역 반응을 조절
• 항체 치료제의 부작용 최소화 전략에 중요한 표적
FcγRIIIA CD16A 낮은~중간 친화도 NK 세포, 대식세포, 일부 단핵구 • NK 세포에 발현되어 ADCC (항체 의존 세포 독성 작용) 유도
• 항암 항체 치료제 효능 평가에서 매우 중요한 수용체
FcγRIIIB CD16B 낮은 친화도 호중구 전용 • 글리코실포스파티딜이노시톨(GPI) 앵커를 통해 세포막에 부착
• 면역 복합체의 청소, 호중구 활성화 등에 관여

 

 

주요 제품 

 

  Human Mouse Rat Cynomolgus
Fc gamma RI/CD64 Protein 1257-FC-050 2074-FC-050 9558-FC-100 9239-FC-100
Fc gamma RIIA His AFG1330-020 (Alexa Fluor® 488)
AFR1330-020 (Alexa Fluor® 647)
     
Fc gamma RIIA/CD32a     9696-CD-100 9240-CD-100
Fc gamma RIIA/CD32a (H167)  9595-CD-050
1330-CD-050
     
Fc gamma RIIA/CD32a Avi His  AVI1330-050      
Fc gamma RIIB/C (CD32b/c)  1875-CD-050      
Fc gamma RIIB/CD32b   1460-CD-050 9666-CD-100  
Fc gamma RIIB/CD32b Avi-tag  AVI1875-050      
Fc gamma RIII/CD16   1960-FC-050   9224-FC-050
Fc gamma RIIIA AFG4325-020 (Alexa Fluor® 488)
AFR4325-020 (Alexa Fluor® 647)
     
Fc gamma RIIIA (F176) His Avi  AVI8894-050      
Fc gamma RIIIA/CD16a 4325-FC-050   9596-CD-100  
Fc gamma RIIIA/CD16a (V176F)  8894-FC-050      
Fc gamma RIIIA/CD16a His Avi  AVI10468-050      
Fc gamma RIIIB/CD16b 1597-FC-050/CF      
Fc gamma RIIIB/CD16b (aa18-200)  9948-FC-100      
Fc gamma RIIIB/CD16b His Avi AVI11507-050      
Fc gamma RIIIB/CD16b/NA1 His 11652-FC-050      
Fc gamma RIIIB/CD16b/SH His  11709-FC-050      

 

 

데이터

 

 

A. Recombinant Human Fc gamma RIIIA/CD16a Protein SEC-MALS.

Recombinant Human Fc gamma RIIIA/CD16a Protein (Catalog # 4325-FC) has a molecular weight (MW) of 33.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a monomer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

 

B. Recombinant Human Fc gamma RIIIA/CD16a Protein Binding Activity

Recombinant Human Fc gamma RIIIA/CD16a (Catalog # 4325-FC) binds human IgG with an estimated Kd<50 nM.

 

C. Recombinant Human Fc gamma RIIIA/CD16a Protein SDS-PAGE

1 μg/lane of Recombinant Human Fc gamma RIIIA/CD16a was resolved with SDS‑PAGE under reducing (R) conditions and visualized by silver staining, showing bands at 40-50 kDa.

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
Recombinant Cynomolgus Fc gamma RIII/CD16 Protein, CF (50 ug) 9224-FC-050 50 ug R&D SYSTEMS
Recombinant Cynomolgus Monkey Fc gamma RI/CD64 Protein, CF (100 ug) 9239-FC-100 100 ug R&D SYSTEMS
Recombinant Cynomolgus Monkey Fc gamma RIIA/CD32a Protein (100 ug) 9240-CD-100 100 ug R&D SYSTEMS
Recombinant Cynomolgus Monkey Fc gamma RIIB Protein, CF (100 ug) 9246-CD-100 100 ug R&D SYSTEMS
Recombinant Human Fc gamma RI/CD64 Protein, CF (50 ug) 1257-FC-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIA/CD32a (H167) Protein, CF (50 ug) 9595-CD-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein (50 ug) 1330-CD-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF (1 MG) 1330-CD-01M/CF 1 MG R&D SYSTEMS
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF (50 ug) 1330-CD-050/CF 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIA/CD32a Avi His Protein, CF (50 ug) AVI1330-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF (50 ug) 1875-CD-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIA (F176) His Avi Protein, CF (50 ug) AVI8894-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein, CF (50 ug) 8894-FC-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIA/CD16a His Avi Protein, CF (50 ug) AVI10468-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIA/CD16a Protein, CF (50 ug) 4325-FC-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIB/CD16b (aa18-200) Protein (100 ug) 9948-FC-100 100 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIB/CD16b His Avi Protein, CF (50 ug) AVI11507-050 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIB/CD16b Protein, CF (50 ug) 1597-FC-050/CF 50 ug R&D SYSTEMS
Recombinant Human Fc gamma RIIIB/CD16b/NA1 His Protein, CF 11652-FC-050 50 µg R&D SYSTEMS
Recombinant Human Fc gamma RIIIB/CD16b/SH His Protein, CF 11709-FC-050 50 µg R&D SYSTEMS
Recombinant Mouse Fc gamma RI/CD64 Protein, CF (50 ug) 2074-FC-050 50 ug R&D SYSTEMS
Recombinant Mouse Fc gamma RIIB/CD32b Protein, CF (50 ug) 1460-CD-050 50 ug R&D SYSTEMS
Recombinant Mouse Fc gamma RIII/CD16 Protein, CF (50 ug) 1960-FC-050 50 ug R&D SYSTEMS
Recombinant Rat Fc gamma RI/CD64 Protein, CF (100 ug) 9558-FC-100 100 ug R&D SYSTEMS
Recombinant Rat Fc gamma RIIA/CD32a Protein, CF (100 ug) 9696-CD-100 100 ug R&D SYSTEMS
Recombinant Rat Fc gamma RIIB/CD32b Protein, CF (100 ug) 9666-CD-100 100 ug R&D SYSTEMS
Recombinant Rat Fc gamma RIIIA/CD16a Protein, CF (100 ug) 9596-CD-100 100 ug R&D SYSTEMS
전체보기
Maker
R&D SYSTEMS
Cat.No.
9224-FC-050
Product
Recombinant Cynomolgus Fc gamma RIII/CD16 Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9239-FC-100
Product
Recombinant Cynomolgus Monkey Fc gamma RI/CD64 Protein, CF (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9240-CD-100
Product
Recombinant Cynomolgus Monkey Fc gamma RIIA/CD32a Protein (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9246-CD-100
Product
Recombinant Cynomolgus Monkey Fc gamma RIIB Protein, CF (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1257-FC-050
Product
Recombinant Human Fc gamma RI/CD64 Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9595-CD-050
Product
Recombinant Human Fc gamma RIIA/CD32a (H167) Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1330-CD-050
Product
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1330-CD-01M/CF
Product
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF (1 MG)
Size
1 MG
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1330-CD-050/CF
Product
Recombinant Human Fc gamma RIIA/CD32a (R167) Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
AVI1330-050
Product
Recombinant Human Fc gamma RIIA/CD32a Avi His Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1875-CD-050
Product
Recombinant Human Fc gamma RIIB/C (CD32b/c) Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
AVI8894-050
Product
Recombinant Human Fc gamma RIIIA (F176) His Avi Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
8894-FC-050
Product
Recombinant Human Fc gamma RIIIA/CD16a (V176F) Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
AVI10468-050
Product
Recombinant Human Fc gamma RIIIA/CD16a His Avi Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
4325-FC-050
Product
Recombinant Human Fc gamma RIIIA/CD16a Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9948-FC-100
Product
Recombinant Human Fc gamma RIIIB/CD16b (aa18-200) Protein (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
AVI11507-050
Product
Recombinant Human Fc gamma RIIIB/CD16b His Avi Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1597-FC-050/CF
Product
Recombinant Human Fc gamma RIIIB/CD16b Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
11652-FC-050
Product
Recombinant Human Fc gamma RIIIB/CD16b/NA1 His Protein, CF
Size
50 µg
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
11709-FC-050
Product
Recombinant Human Fc gamma RIIIB/CD16b/SH His Protein, CF
Size
50 µg
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
2074-FC-050
Product
Recombinant Mouse Fc gamma RI/CD64 Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1460-CD-050
Product
Recombinant Mouse Fc gamma RIIB/CD32b Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
1960-FC-050
Product
Recombinant Mouse Fc gamma RIII/CD16 Protein, CF (50 ug)
Size
50 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9558-FC-100
Product
Recombinant Rat Fc gamma RI/CD64 Protein, CF (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9696-CD-100
Product
Recombinant Rat Fc gamma RIIA/CD32a Protein, CF (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9666-CD-100
Product
Recombinant Rat Fc gamma RIIB/CD32b Protein, CF (100 ug)
Size
100 ug
Qty
Data Sheet
Maker
R&D SYSTEMS
Cat.No.
9596-CD-100
Product
Recombinant Rat Fc gamma RIIIA/CD16a Protein, CF (100 ug)
Size
100 ug
Qty
Data Sheet
전체보기

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