항체치료제 제작 서비스 | Therapeutic Antibody Production Service | 고마바이오텍

제작 과정

1. Antigen Preparation (타겟 설정 및 항원 제작)

• Antigen & Assay design: DNA / Peptide / Protein 
• 표적단백질에 대한 신중하고 철저한 분석
  

2. Immunization (면역 반응)

• DNA / Peptide / Protein / Stable Cell line immunization 서비스 제공 가능
• 다양한 species immunization 가능: Mouse / Rat / Rabbit / Chicken / Sheep / Bovine / Llama and transgenic animals

3. Lead Generation (항체 제작 및 스크리닝) 

• Hybridoma generation
• B cell select 
• In-House display library: Human Naive / Human Patient / Llama Naive library screening 서비스
• Custom display library: Mouse / Chicken / Llama / Rabbit  library screening 서비스

4. Lead Selection & Characterization (효과 높은 항체 선별)

• Target reactivity and functionality studies
• Off-rate ranking and affinity 
• Epitope binning and mapping

 5. Engineering (최적화)

• Antibody Humanization
• Antibody affinity Maturation
• Bispecific antibody generation

6. Manufacturing (대량 생산) 

• Recombinant Antibody production for pre-clinical applications
• Stable cell line development