Lipid Nanoparticle (LNP) 패키징 서비스 | 고마바이오텍

특징

• 다양한 ionizable lipid formulation으로 높은 encapsulation 효율을 제공합니다.
• in vitro delivery와 expression 효과가 입증되었습니다.
• in vivo expression에도 테스트 되었습니다. 

 

서비스 옵션

1. Characterization 

• Ionizable lipid formulations (MC3-LNP / SM102-LNP/ ALC0315-LNP/ LP01-LNP)
• Final concentration can be customized <0.4 mg/mL
• Liquid, ships frozen on dry ice, one time freeze/thaw cycle

2. QC Testing  

• Encapsulation Efficiency: >85%
• Size Distribution: POI ±20 nm
• Polydispersity Index: <0.2
• Zeta potential: ± 15 mV
• pH: 7.4 ± 0.5
• Endotoxin : <4 EU/ml 

3. Size/Scale Options 

• Load 20nt ~ 10kb mRNA
• Load  1- 30 mg mRNA

4. Administration 

• Intramuscular (I.M.) for animal use only
• Intravenous (I.V.) for animal use only
• For in vitro studies

Manufacturing Workflow 

Quality Control and Specification