세포 유전자치료제 (CGT) 스크리닝 서비스

제품 상세

개발된 세포치료제의 IND 승인을 위한 평가 서비스를 제공합니다.

프린트 제품 문의

Cell banking 제작

Small 스케일에서 large 스케일에 이르는 단백질 labeling, reagent generation, cell banking 서비스 및 Performance qualification을 제공합니다.

Custom Cell Banking	Master Cell Banks (MCB)	Mycoplasma, sterility (bacterial and fungal contamination), and stability testing; cloning
	Research Cell Banks (RCB)

Phenotypic and Safety 평가 서비스

Functional in vitro 평가를 통해 바이오 의약품의 clinical에서의 평가를 예측합니다.

Cellular Apoptosis	Primary Cells	Assessment of biotherapeutic impact on cell death
	Cell Lines
Cellular Proliferation	ATP	Assessment of biotherapeutic impact on cell growth
	Redox
Cellular Signaling Assay	PathHunter	Assessment of biotherapeutic impact on downstream signaling on various platforms
	Phosphorylation
	Second Massenger (cAMP)
Cytotoxicity (ADCC, CDC, ADCP) Cell Viability	Commercially Available Tumor Cell Lines	Assessment of biotherapeutics to induce cell death in target cell lines of interest. Different assay formats available (LDH, CellTiter Glo, Live/Dead, Flow Cytometry) and subpopulation phenotyping
	Target-Specific KILR Cell Lines
	Primary Cells (PBMCs)
Custom Cell Line Generation	CRISPR	Insertion of gene into cell line to express protein of interest; high-, medium-, low expression, receptor quantitation
	Lentivirus
Custom Cell Line Cloning		Single-cell flow cytometry sorting for creation of clonal cell lines

Cell-based Assays 서비스

Cell physiology와 signaling pathway 활성화/억제성을 평가합니다.

Cell Physiology Assessment	Early Apoptosis : Annexin V Binding
	Mid-Stage Apoptosis : Caspase Activation, Bcl-2
	Late-Stage Apoptosis : Mitochondrial depolarization, ATM, H2A.X, DNA Fragmentation
	Apoptotic Degradation of DNA : ATM, H2A.X
	Autophagic Cell Death
	DNA Replication During Proliferation
	Cellular Proliferation (Cell-by-Cell)
	Cell Cycle Progressions during Drug Treatment
Cell Signaling Pathway Activation/ Deactivation Assessment	BTK
	EGF Receptor
	eIFα
	ErbB Receptor
	GPCR (IP-1 Production)
	JNK
	MAPK (ERK1/2, MEK1)
	mTOR
	NFκB
	Nitric Oxide Production in Cells
	p38
	P53 (Phosphorylation, Acetylation)
	P70 S6K
	PI3K
	PI3K MAPK (pAKt, pERK1/2)
	STAT3
	STAT5
	SYK Kinase

Viral Therapy AAV 서비스

AAV 바이러스 벡터 생산과 테스트 서비스를 제공합니다.

Leukocyte & MSC 서비스

세포 평가 서비스를 제공합니다.

Leukocyte Services	Population Dissection
	CD4 and CD8 Lymphocyte Population Assessment
	Detection and Assessment of Memory T-Cells
	B-Cell Population Assessment (Flow)
	Memory B Cell Assessment (Flow)
	NK Cell Assessment (Flow)
	CAR Lymphocyte Cell-Killing Assays
	Isolation and Expansion of Cell Populations from Patient Samples
	Immunophenotyping
Mesenchymal Stem Cell Services	Secretome Profiling
	Exosome Isolation and Characterization
	Verification of MSC Cell Lines

Biotherapeutic 특성화 서비스

바이오치료제의 특성화 분석서비스를 제공합니다.

Activity/Function (Flow, ELISA, SPR)
Immunophenotyping (Flow)
Size and Purity (FPLC, PAGE, aSEC)
Manufacturability (Stability, agitation, time, temp, pH) (SLS/DLS, aSEC)
Stability (Rebuffering, Concentration) (LS/DLS, aSEC)
Cross-Reactivity (Dog, Human, Monkey, Mouse, Pig, Rat, Macaque, more..) (ELISA, Flow, SPR)