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피부암 연구 | Skin Cancer Antibody 이미지

피부암 연구 | Skin Cancer Antibody

대표적인 피부암인 Melanoma 연구를 위한 항체를 소개합니다.

배경 

 

Melanoma gp100은 melanocyte-specific type I transmembrane glycoprotein 코딩합니다. 이 단백질은 melanocyte에서 멜라닌 생성 소기관인 melanosome에 많이 발현되며, premelanosome의 구조 형성에서 주요한 역할을 합니다. 이 단백질은 흑색종(melanoma)에 특이적인 혈청 마커로 사용될 수 있습니다. 

 

MART1 / Melan A는 Melanoma antigen recognized by T-cells 1이라고도 불리며, GPR143의 안정성을 확보하여 melanosome 생합성에 관여합니다. Stage II melanosome의 형성에 중요한 melanocyte 단백질 PMEL의 발현, 안정성, 트래피킹 및 처리에 중요한 역할을 합니다

 

CD146은 Melanoma-associated antigen MUC18으로도 불리며, 세포 부착 및 혈관 조직의 intercellular junction에서 내피 monolayer의 응집에 역할을 합니다. 이 단백질이 발현되면 melanoma 세포가 혈관 시스템의 세포 요소와 상호 작용하도록 하여 hematogeneous tumor의 확산을 증가시킬 수 있습니다.


PRAME 유전자는 human melanoma에 우선적으로 발현되며 cytolytic T lymphocyte에 의해 인식되는 항원을 코딩합니다. 발현된 단백질은 retinoic acid 수용체의 억제제로 작용하여 암세포가 성장 advantage를 갖도록 합니다. 

MIA(Melanoma Inhibitory Activity)는 melanoma에는 발현되지만, melanocyte에는 발현되지 않습니다. MIA는 melanoma에서 autocrine growth-regulatory factors으로 분비되므로, melanoma의 serological marker로 이용됩니다. 


 

주요 제품

 

anti-Melanoma gp100 antibody (#ARG41406)
Product Description Rabbit Polyclonal antibody recognizes Melanoma gp100
Tested Reactivity Hu
Tested Application IHC-P, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name Melanoma gp100
Antigen Species Human
Immunogen Synthetic peptide derived from Human Melanoma gp100.
Conjugation Un-conjugated
Alternate Names Premelanosome protein; SILV; ME20; Melanocyte protein Pmel 17; ME20-M; Secreted melanoma-associated ME20 antigen; 95 kDa melanocyte-specific secreted glycoprotein; Silver locus protein homolog; ME20S; D12S53E; SIL; P1; Melanocyte protein PMEL; PMEL17; ME20-S; Melanoma-associated ME20 antigen; gp100; ME20M; P100; SI; P26; Melanocytes lineage-specific antigen GP100
   
anti-MART1 / Melan A antibody [M2-9E3] (#ARG55951)
Product Description Mouse Monoclonal antibody [M2-9E3] recognizes MART1 / Melan A
Tested Reactivity Hu, Ms, Rat
Tested Application FACS, ICC/IF, IHC-P, WB
Host Mouse
Clonality Monoclonal
Clone M2-9E3
Isotype IgG2b, kappa
Target Name MART1 / Melan A
Antigen Species Human
Immunogen Recombinant Human MART-1 protein.
Conjugation Un-conjugated
Alternate Names MART-1; MART1; Protein Melan-A; Antigen SK29-AA; Antigen LB39-AA; Melanoma antigen recognized by T-cells 1
   
anti-CD146 antibody [C264] (#ARG21220)
Product Description Mouse Monoclonal antibody [C264] recognizes CD146
Tested Reactivity Chk, Turkey
Tested Application FACS, ICC/IF, IP
Specificity Chicken/Turkey MCAM.
Host Mouse
Clonality Monoclonal
Clone C264
Isotype IgG2b, kappa
Target Name CD146
Antigen Species Chicken
Immunogen Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos
Conjugation Un-conjugated
Alternate Names Cell surface glycoprotein P1H12; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; Cell surface glycoprotein MUC18; Melanoma cell adhesion molecule; CD146; MUC18; CD antigen CD146; S-endo 1 endothelial-associated antigen
   
anti-PRAME antibody (#ARG40092)
Product Description Rabbit Polyclonal antibody recognizes PRAME
Tested Reactivity Hu, Ms, Rat
Tested Application WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name PRAME
Antigen Species Human
Immunogen Recombinant fusion protein corresponding to aa. 1-200 of Human PRAME (NP_006106.1).
Conjugation Un-conjugated
Alternate Names OIP4; MAPE; Melanoma antigen preferentially expressed in tumors; CT130; OIP-4; Preferentially expressed antigen of melanoma; Opa-interacting protein 4
   
anti-MIA antibody (#ARG66108)
Product Description Rabbit Polyclonal antibody recognizes MIA
Tested Reactivity Hu
Tested Application ELISA, WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Target Name MIA
Antigen Species Human
Immunogen E. coli derived recombinant Human MIA.
  (MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ)
Conjugation Un-conjugated
Alternate Names CD-RAP; Melanoma inhibitory activity protein; Melanoma-derived growth regulatory protein

  

 

 

실험 결과

 

 

    


  

 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
anti-MART1 / Melan A antibody [M2-9E3] ARG55951 50 ug ARIGO
anti-Melanoma antibody [PNL2] ARG56111 50 ug ARIGO
anti-Melanoma gp100 antibody ARG41406 100 ul ARIGO
gp100 Antibody [SPM142] 34-163 100 ug PROSCI
Melan-A Antibody [MLANA/788] 33-360 100 ug PROSCI
SILV Antibody 30-232 100 ul PROSCI
MART-1 Antibody [M2-7C10] 33-130 100 ug PROSCI
Melanoma Antibody [PNL2] 33-528 100 ug PROSCI
S100A Antibody [S1-61] 33-750 100 ug PROSCI
Genorise® Human Ki67 Monoclonal Antibody GR126069 100 ug GENORISE
Anti-Human Human Ki67 (Proliferation Marker) peptide IgG KI672-M 100 ul ALPHA DIAGNOSTICS
Anti-Human Human Ki67 (Proliferation Marker) peptide IgG KI671-A 100 ul ALPHA DIAGNOSTICS
anti-MART1 / Melan A antibody ARG55397 100 ul ARIGO
anti-MART1 / Melan A antibody [A103] ARG55952 50 ug ARIGO
anti-MART1 / Melan A antibody [M2-7C10] ARG62540 0.5 ml ARIGO
anti-Melanoma Associated Antigen antibody [KBA.62] ARG56112 50 ug ARIGO
anti-Melanoma gp100 antibody ARG64008 100 ug ARIGO
anti-Melanoma gp100 antibody [NKI-beteb] ARG55978 50 ug ARIGO
anti-Melanoma gp100 antibody [P14-V] ARG10577 100 ul ARIGO
anti-MIA antibody ARG66108 50 ug ARIGO
anti-MIA antibody (Biotin) ARG66109 50 ug ARIGO
anti-PRAME antibody ARG40092 100 ul ARIGO
anti-Pramef20 antibody ARG59817 100 ul ARIGO
anti-S100A10 antibody ARG57881 100 ul ARIGO
anti-S100A10 antibody ARG57445 100 ul ARIGO
anti-S100A11 antibody ARG59513 100 ul ARIGO
anti-S100A11 antibody [20D11] ARG57078 50 ul ARIGO
anti-S100A4 antibody ARG64101 100 ug ARIGO
anti-S100A4 antibody ARG41964 100 ul ARIGO
anti-S100A4 antibody ARG55904 50 ul ARIGO
anti-S100A4 antibody ARG66507 100 ul ARIGO
anti-S100A4 antibody ARG55904 100 ul ARIGO
anti-S100A4 antibody [1C3] ARG57154 50 ul ARIGO
anti-S100A4 antibody [S100A4/1481] ARG41966 50 ug ARIGO
anti-S100A4 antibody [S100A4/1482] ARG41965 50 ug ARIGO
anti-S100A6 antibody ARG57885 100 ul ARIGO
anti-S100A6 antibody ARG57447 100 ul ARIGO
anti-S100A6 antibody ARG66520 100 ul ARIGO
anti-S100A6 antibody ARG41665 100 ul ARIGO
anti-S100A7 / Psoriasin antibody [2A3] ARG11050 100 ug ARIGO
anti-S100A8 antibody ARG40311 50 ug ARIGO
anti-S100A9 antibody ARG40994 50 ug ARIGO
anti-S100A9 antibody ARG40310 50 ug ARIGO
anti-S100A9 antibody ARG64813 100 ug ARIGO
anti-S100A9 antibody [47-8D3] ARG56075 50 ug ARIGO
anti-Tyrosinase antibody [T311] ARG55988 50 ug ARIGO
gp100 Antibody [HMB45] 33-201 100 ug PROSCI
gp100 Antibody [SPM286] 34-164 100 ug PROSCI
MART-1 Antibody [SPM540] 34-108 100 ug PROSCI
MCAM Recombinant Protein 96-125 0.1 mg PROSCI
전체보기
Maker
ARIGO
Cat.No.
ARG55951
Product
anti-MART1 / Melan A antibody [M2-9E3]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG56111
Product
anti-Melanoma antibody [PNL2]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG41406
Product
anti-Melanoma gp100 antibody
Size
100 ul
Qty
Data Sheet
Maker
PROSCI
Cat.No.
34-163
Product
gp100 Antibody [SPM142]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
33-360
Product
Melan-A Antibody [MLANA/788]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
30-232
Product
SILV Antibody
Size
100 ul
Qty
Data Sheet
Maker
PROSCI
Cat.No.
33-130
Product
MART-1 Antibody [M2-7C10]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
33-528
Product
Melanoma Antibody [PNL2]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
33-750
Product
S100A Antibody [S1-61]
Size
100 ug
Qty
Data Sheet
Maker
GENORISE
Cat.No.
GR126069
Product
Genorise® Human Ki67 Monoclonal Antibody
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
KI672-M
Product
Anti-Human Human Ki67 (Proliferation Marker) peptide IgG
Size
100 ul
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
KI671-A
Product
Anti-Human Human Ki67 (Proliferation Marker) peptide IgG
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG55397
Product
anti-MART1 / Melan A antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG55952
Product
anti-MART1 / Melan A antibody [A103]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG62540
Product
anti-MART1 / Melan A antibody [M2-7C10]
Size
0.5 ml
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG56112
Product
anti-Melanoma Associated Antigen antibody [KBA.62]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG64008
Product
anti-Melanoma gp100 antibody
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG55978
Product
anti-Melanoma gp100 antibody [NKI-beteb]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG10577
Product
anti-Melanoma gp100 antibody [P14-V]
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG66108
Product
anti-MIA antibody
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG66109
Product
anti-MIA antibody (Biotin)
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG40092
Product
anti-PRAME antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG59817
Product
anti-Pramef20 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57881
Product
anti-S100A10 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57445
Product
anti-S100A10 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG59513
Product
anti-S100A11 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57078
Product
anti-S100A11 antibody [20D11]
Size
50 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG64101
Product
anti-S100A4 antibody
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG41964
Product
anti-S100A4 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG55904
Product
anti-S100A4 antibody
Size
50 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG66507
Product
anti-S100A4 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG55904
Product
anti-S100A4 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57154
Product
anti-S100A4 antibody [1C3]
Size
50 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG41966
Product
anti-S100A4 antibody [S100A4/1481]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG41965
Product
anti-S100A4 antibody [S100A4/1482]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57885
Product
anti-S100A6 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG57447
Product
anti-S100A6 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG66520
Product
anti-S100A6 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG41665
Product
anti-S100A6 antibody
Size
100 ul
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG11050
Product
anti-S100A7 / Psoriasin antibody [2A3]
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG40311
Product
anti-S100A8 antibody
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG40994
Product
anti-S100A9 antibody
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG40310
Product
anti-S100A9 antibody
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG64813
Product
anti-S100A9 antibody
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG56075
Product
anti-S100A9 antibody [47-8D3]
Size
50 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG55988
Product
anti-Tyrosinase antibody [T311]
Size
50 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
33-201
Product
gp100 Antibody [HMB45]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
34-164
Product
gp100 Antibody [SPM286]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
34-108
Product
MART-1 Antibody [SPM540]
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-125
Product
MCAM Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
전체보기

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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Size
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