| TRPA1 Activator/Blocker/Antagonist/Modulators |
|
| Cat. No. |
Product |
Activity |
| 4716 |
A
967079 |
Selective
TRPA1 channel blocker |
| 5914 |
AM
0902 |
Potent
and selective TRPA1 antagonist |
| 3296 |
AP
18 |
Reversible
TRPA1 channel blocker |
| 5178 |
ASP
7663 |
Selective
TRPA1 activator |
| 6497 |
GSK 2833503A |
Potent and
selective TRPC6 and TRPC3 antagonist |
| 2896 |
HC
030031 |
Selective
TRPA1 blocker |
| 1531 |
Icilin |
Activates
a novel cold receptor. Cooling agent |
| 6269 |
JT010 |
Potent
and selective TRPA1 channel activator |
| 4901 |
Optovin |
Reversible
photoactive TRPA1 activator |
| 3197 |
Polygodial |
TRPA1
channel activator; analgesic and antifungal |
| 1418 |
Resveratrol |
TRPA1
activator: also cyclooxygenase inhibitor |
| 3938 |
TCS
5861528 |
TRPA1
blocker |
| 6875 |
TRPC6-PAM-C20 |
Selective positive
allosteric modulator (PAM) of TRPC6 |
|
|
|
| TRPC
Channel Inhibitors/Activators |
|
| Cat. No. |
Product |
Activity |
| 6766 |
AC 1903 |
Selective TRPC5
inhibitor |
| 6495 |
AM 12 |
TRPC5 inhibitor |
| 6940 |
BTD |
Selective TRPC5
activator |
| 7170 |
D-GsMTx4 |
TRPC1/6 and Piezo2
inhibitor; resistant to proteolytic digestion |
| 4522 |
Flufenamic acid |
Activates TRPC6;
NSAID |
| 6508 |
GSK 1702934A |
Potent and
selective TRPC3/6 activator |
| 6497 |
GSK 2833503A |
Potent and
selective TRPC6 and TRPC3 antagonist |
| 4912 |
GsMTx4 |
TRPC1 and TRPC6
inhibitor; inhibits mechanosensitive ion channels |
| 5807 |
M 084 hydrochloride |
TRPC4 and TRPC5
inhibitor; antidepressant and anxiolytic |
| 4732 |
ML 204 |
Selective TRPC4
inhibitor |
| 6941 |
Pyr 10 |
Selective TRPC3
inhibitor |
| 3751 |
Pyr3 |
Selective TRPC3
inhibitor |
| 0768 |
Riluzole
hydrochloride |
TRPC5 activator;
also inhibits GABA uptake and glutamate release and blocks NaV channels |
| 5831 |
SAR 7334 |
Potent TRPC6
inhibitor |
| 1147 |
SKF 96365
hydrochloride |
TRPC channel
inhibitor; also inhibits store-operated Ca2+ entry |
| 6875 |
TRPC6-PAM-C20 |
Selective positive
allosteric modulator (PAM) of TRPC6 |
|
|
|
| TRPM
Channel Agonists/Antagonists/Activators/Blockers |
| Cat. No. |
Product |
Activity |
| 4999 |
9-Phenanthrol |
Selective TRPM4
blocker |
| 6874 |
AMG 333 |
Potent and
selective TRPM8 antagonist; active in vivo |
| 3989 |
AMTB hydrochloride |
TRPM8 blocker |
| 6724 |
CBA |
Selective TRPM4
blocker |
| 5521 |
CIM 0216 |
Selective TRPM3
agonist |
| 1531 |
Icilin |
Activates a novel
cold receptor. Cooling agent |
| 5324 |
M8 B hydrochloride |
Potent and
selective TRPM8 channel blocker |
| 5143 |
Ononetin |
TRPM3 blocker |
| 5376 |
Pregnenolone
sulfate sodium salt |
TRPM3 activator;
also NMDA potentiator and inhibitor of GABAA receptors |
| 5388 |
RQ 00203078 |
Potent and
selective TRPM8 antagonist; orally active |
| 4632 |
TC-I 2000 |
TRPM8 blocker |
| 5410 |
TC-I 2014 |
Potent TRPM8
antagonist |
| 1268 |
U 73122 |
TRPM4 activator and
TRPM3 blocker; also phospholipase C inhibitor |
| 3040 |
WS 12 |
TRPM8 agonist;
cooling agent |
|
|
|
| TRPML
Channel Activators & Blockers |
|
| Cat. No. |
Product |
Activity |
| 4741 |
Gadolinium chloride |
TRPML3 blocker;
stretch-activated calcium channel blocker |
| 5547 |
MK6-83 |
TRPML channel
activator |
| 4746 |
ML SA1 |
Activator of TRPML
channels |
| 4907 |
SN 2 |
Selective TRPML3
channel activator |
|
|
|
| TRPP
Channel Blockers |
|
| Cat. No. |
Product |
Activity |
| 0890 |
Amiloride
hydrochloride |
Na+ channel
blocker; inhibits TRPP3 channel |
| 3380 |
Benzamil |
NCX inhibitor;
inhibits TRPP3 channel activity |
| 3378 |
EIPA |
Inhibits
TRPP3-mediated currents; also inhibits the Na+/H+ exchanger (NHE) |
| 3379 |
Phenamil |
Inhibits
TRPP3-mediated currents; also inhibits epithelial Na+ channels |
|
|
|
| TRPV
Channel Agonists/Antagonists/Inhibitors/Activators |
| Cat. No. |
Product |
Activity |
| 7199 |
(±)-Eriodictyol |
Potent TRPV1
antagonist; also antioxidant; activates Nrf2/ARE signaling |
| 0462 |
(E)-Capsaicin |
TRPV agonist |
| 5781 |
A 425619 |
Potent TRPV1
antagonist |
| 4319 |
A 784168 |
Potent and
selective TRPV1 antagonist |
| 1116 |
AM 404 |
TRPV agonist; also
anandamide transport inhibitor |
| 4330 |
AMG 21629 |
Potent and
selective TRPV1 antagonist |
| 5995 |
AMG 517 |
Potent TRPV1
antagonist |
| 2316 |
AMG 9810 |
Potent and
selective TRPV1 competitive antagonist |
| 1339 |
Anandamide |
Endogenous TRPV1
agonist; also cannabinoid agonist |
| 3875 |
BCTC |
TRPV1 antagonist |
| 0464 |
Capsazepine |
TRPV antagonist;
also activator of ENaCδ |
| 7118 |
cis-22a |
TRPV6 inhibitor |
| 4876 |
Eact |
TRPV1 activator;
also TMEM16A activator |
| 6433 |
GSK 1016790A |
Potent TRPV4
agonist; active in vivo |
| 5106 |
GSK 2193874 |
Potent and
selective TRPV4 antagonist; orally active |
| 4100 |
HC 067047 |
Potent and
selective TRPV4 antagonist |
| 3361 |
JNJ 17203212 |
Reversible,
competitive and potent TRPV1 antagonist |
| 1641 |
OLDA |
Potent and
selective endogenous TRPV1 agonist |
| 0934 |
Olvanil |
Potent TRPV agonist |
| 3746 |
RN 1734 |
Selective TRPV4
antagonist |
| 3745 |
RN 1747 |
Selective TRPV4
agonist |
| 5678 |
RN 9893
hydrochloride |
Potent and
selective TRPV4 antagonist |
| 1439 |
Ruthenium Red |
Blocks
capsaicin-activated cation channels |
| 1615 |
SB 366791 |
Potent and
selective TRPV1 competitive antagonist |
| 6990 |
SET 2 |
Selective TRPV2
antagonist |
| 1098 |
Tranilast |
Antiallergic;
inhibits TRPV2-mediated responses |
| 6831 |
TRPV3 74a |
Selective TRPV3
antagonist; brain penetrant |