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면역계 연구 | Toll-like Receptors inhibitors 이미지

면역계 연구 | Toll-like Receptors inhibitors

Toll-like receptors(TLRs)는 선천성 면역계에서 중요한 역할을 하는 single transmembrane cell-surface receptors입니다. TLR에 대한 agonist, antagonist, inhibitor 등을 소개합니다.

특징​  

 

  • Toll-like receptors(TLRs)는 선천성 면역계에서 중요한 역할을 하는 single transmembrane cell-surface receptors입니다. TLR은 대식세포, B 림포구 및 비만 세포와 같은 면역 세포에서 발견되며, 주로 homodimer로 존재하고 TLR2-TLR6 heterodimer도 보고 되었습니다.  
  • TLR은 면역 질환, 크론병, 유방암, 신경 질환, 신장 질환 등 다양한 분야에서 중요한 연구 타겟으로 관심받고 있습니다.
  • TLR에 대한 agonist, antagonist, inhibitor를 제공합니다.

  

 

주요 제품 

 

Toll-like Receptor Agonists & Antagonist
Cat. No. Product Activity
6142 CL 075 TLR8 agonist
5414 CU-T12-9 Potent TLR1/2 agonist
4809 DSR 6434 Potent TLR7 agonist
3700 Imiquimod Toll-like receptor 7 (TLR7) agonist
6858 MMG 11 TLR2 antagonist
4637 Pam2CSK4 TLR2/6 agonist; induces TNF-α production
4633 Pam3CSK4 TLR1/2 agonist; induces cytokine production
4287 Poly(I:C) TLR3 agonist
4536 Resiquimod Toll-like receptor 7 (TLR7) agonist
5445 SM 324405 Potent TLR7 agonist
Toll-like Receptor Inhibitors
Cat. No. Product Activity
5373 C34 TLR4 inhibitor
4884 CU CPT 22 Selective TLR1/2 inhibitor
4883 CU CPT 4a Selective TLR3 inhibitor
6479 CU CPT 9a Highly potent TLR8 inhibitor
5648 Hydroxychloroquine sulfate TLR9 inhibitor; also Autophagy inhibitor
5705 M62812 TLR-4 inhibitor
6587 TAK 242 TLR4 signaling inhibitor
Others
Cat. No. Product Activity
7414 DSRM-3716 Potent and reversible SARM1 NAD hydrolase inhibitor
3270 GIT 27 Interferes with TLR4, TLR2/6 signaling

 

 

Toll-like receptors (TLRs) Pathway 

 


 

그림 1. The toll-like receptors (TLRs) act in response to molecular patterns found in microbes such as bacteria and viruses that pose a biological threat. The signaling pathway leads to the activation of innate and acquired immunity along with an inflammatory response and the upregulation of cytokines.

 

 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
C34 (10 mg) 5373 10 mg TOCRIS
C34 (50 mg) 5373 50 mg TOCRIS
CU CPT 22 (10 mg) 4884 10 mg TOCRIS
CU CPT 22 (50 mg) 4884 50 mg TOCRIS
CU CPT 4a (10 mg) 4883 10 mg TOCRIS
CU CPT 4a (50 mg) 4883 50 mg TOCRIS
CU CPT 9a (25 MG) 6479 25 mg TOCRIS
CU CPT 9a (5 MG) 6479 5 mg TOCRIS
CU-T12-9 (10 mg) 5414 10 mg TOCRIS
CU-T12-9 (50 mg) 5414 50 mg TOCRIS
DSR 6434 (10 mg) 4809 10 mg TOCRIS
DSR 6434 (50 mg) 4809 50 mg TOCRIS
DSRM-3716 7414 50 mg TOCRIS
GIT 27 (10 mg) 3270 10 mg TOCRIS
GIT 27 (50 mg) 3270 50 mg TOCRIS
Hydroxychloroquine sulfate (10 mg) 5648 10 mg TOCRIS
Hydroxychloroquine sulfate (50 mg) 5648 50 mg TOCRIS
Imiquimod (50 mg) 3700 50 mg TOCRIS
MMG 11 (10 MG) 6858 10 mg TOCRIS
MMG 11 (50 MG) 6858 50 mg TOCRIS
Pam2CSK4 (1 mg) 4637 1 mg TOCRIS
Pam3CSK4 (1 mg) 4633 1 mg TOCRIS
Poly(I:C) (10 mg) 4287 10 mg TOCRIS
Poly(I:C) (50 mg) 4287 50 mg TOCRIS
Resiquimod (10 mg) 4536 10 mg TOCRIS
Resiquimod (50 mg) 4536 50 mg TOCRIS
SM 324405 (10 mg) 5445 10 mg TOCRIS
SM 324405 (50 mg) 5445 50 mg TOCRIS
TAK 242 (5 MG) 6587 5 mg TOCRIS
전체보기
Maker
TOCRIS
Cat.No.
5373
Product
C34 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5373
Product
C34 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4884
Product
CU CPT 22 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4884
Product
CU CPT 22 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4883
Product
CU CPT 4a (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4883
Product
CU CPT 4a (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6479
Product
CU CPT 9a (25 MG)
Size
25 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6479
Product
CU CPT 9a (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5414
Product
CU-T12-9 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5414
Product
CU-T12-9 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4809
Product
DSR 6434 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4809
Product
DSR 6434 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
7414
Product
DSRM-3716
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3270
Product
GIT 27 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3270
Product
GIT 27 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5648
Product
Hydroxychloroquine sulfate (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5648
Product
Hydroxychloroquine sulfate (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
3700
Product
Imiquimod (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6858
Product
MMG 11 (10 MG)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6858
Product
MMG 11 (50 MG)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4637
Product
Pam2CSK4 (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4633
Product
Pam3CSK4 (1 mg)
Size
1 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4287
Product
Poly(I:C) (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4287
Product
Poly(I:C) (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4536
Product
Resiquimod (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
4536
Product
Resiquimod (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5445
Product
SM 324405 (10 mg)
Size
10 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
5445
Product
SM 324405 (50 mg)
Size
50 mg
Qty
Data Sheet
MSDS
Maker
TOCRIS
Cat.No.
6587
Product
TAK 242 (5 MG)
Size
5 mg
Qty
Data Sheet
MSDS
전체보기

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