고마바이오텍(주)

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제품 상세
Immune Checkpoint Proteins 이미지

Immune Checkpoint Proteins

Immune Checkpoint의 recombinant protein을 소개합니다.

프린트 제품 문의

배경

 

PD-1은 T세포 표면에서 발현되는 immune checkpoint protein입니다. PD-1이 자신의 리간드인 PD-L1에 결합하면 억제 신호가 전달되어 T 세포의 세포 독성을 억제합니다. 다양한 유형의 암세포는 T 세포 면역을 회피하기 위해 PD-L1을 과발현합니다. 최신 암 연구는 PD-1/PD-L1의 분자 기전을 더욱 이해하는 데 초점을 맞춥니다.

 

막 결합 형태 외에도 soluble PD-1 및 PD-L1(sPD-L1 및 sPD-1)이 밝혀졌습니다. Soluble 형태는 PD-1/PD-L1 신호 전달의 복잡성을 증가시킵니다. sPD-L1은 종양 세포에서 생성되며 T 세포 활동을 억제할 수 있습니다. 예후가 좋지 않으면 sPD-L1 수치가 상승됩니다. 반면, sPD-1은 alternative splicing을 통해 생산되며 PD-L1의 억제 효과를 antigonize하여 anti-tumor 면역성을 향상시킬 수 있습니다. sPD-1 및 sPD-L1의 수준은 예후 및 치료 반응 예측을 위한 잠재적인 표지 인자로 고려되고 있습니다.

 

 

 

종류

  

Human CD279 / PD-1 recombinant protein (ECD) (His-tagged, C-ter) (#ARG70235)
Product Description HEK293 expressed, His-tagged (C-ter) Human CD279 / PD-1 recombinant protein (ECD).
Tested Reactivity Hu
Tested Application Binding, SDS-PAGE
Target Name CD279 / PD-1 (ECD)
Species Human
A.A. Sequence Leu25 - Thr168 of Human CD279 / PD-1 (NP_005009.2) with 6X His tag at the C-terminus.
Expression System HEK293
Alternate Names hPD-l; CD279; PD-1; Protein PD-1; CD antigen CD279; PD1; hSLE1; SLEB2; Programmed cell death protein 1; hPD-1
　 　
Human TIM3 recombinant protein (ECD) (His-tagged, C-ter) (#ARG70236)
Product Description HEK293 expressed, His-tagged (C-ter) Human TIM3 recombinant protein (ECD).
Tested Reactivity Hu
Tested Application Binding, SDS-PAGE
Target Name TIM3 (ECD)
Species Human
A.A. Sequence Ser22 - Arg200 of Human TIM3 (NP_116171.3) with 6X His tag at the C-terminus.
Expression System HEK293
Alternate Names KIM-3; TIM3; TIMD-3; Tim-3; TIM-3; CD366; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD3; T-cell membrane protein 3; HAVcr-2; T-cell immunoglobulin mucin receptor 3; Hepatitis A virus cellular receptor 2
　 　
Human HVEM / TR2 recombinant protein (ECD) (Fc-His-tagged, C-ter) (#ARG70237)
Product Description HEK293 expressed, Fc-His-tagged (C-ter) Human HVEM / TR2 recombinant protein (ECD).
Tested Reactivity Hu
Tested Application Binding, SDS-PAGE
Target Name HVEM / TR2 (ECD)
Species Human
A.A. Sequence Leu39 - Val202 of Human HVEM / TR2 (NP_003811.2) with an Fc-6X His tag at the C-terminus.
Expression System HEK293
Alternate Names Herpes virus entry mediator A; HVEM; Tumor necrosis factor receptor-like 2; HVEA; CD antigen CD270; CD270; Tumor necrosis factor receptor superfamily member 14; LIGHTR; HveA; Herpesvirus entry mediator A; ATAR; TR2
　 　
Human CD48 recombinant protein (ECD) (His-tagged, C-ter) (#ARG70286)
Product Description HEK293 expressed, His-tagged (C-ter) Human CD48 recombinant protein (ECD).
Tested Reactivity Hu
Tested Application Binding, SDS-PAGE
Target Name CD48 (ECD)
Species Human
A.A. Sequence Gln27 - Ser220 of Human CD48 (NP_001769.2) with 6X His tag at the C-terminus.
Expression System HEK293
Alternate Names Leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen; BCM1 surface antigen; CD antigen CD48; TCT.1; BLAST1; BCM1; MEM-102; mCD48; Signaling lymphocytic activation molecule 2; BLAST; hCD48; SLAMF2; SLAM family member 2

 

 

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
Mouse CD274 / PD-L1 recombinant protein (His-tagged, C-ter) ARG70229 100 ug ARIGO
CTLA 4 Recombinant Protein RF16010-01 0.1 mg PROSCI
Human CD279 / PD-1 recombinant protein (ECD) (His-tagged, C-ter) ARG70235 100μg ARIGO
Human CD48 recombinant protein (ECD) (His-tagged, C-ter) ARG70286 100μg ARIGO
Human CD80 recombinant protein (ECD) (His-tagged, C-ter) ARG70233 100μg ARIGO
Human HVEM / TR2 recombinant protein (ECD) (Fc-His-tagged, C-ter) ARG70237 100μg ARIGO
Human TIM3 recombinant protein (ECD) (His-tagged, C-ter) ARG70236 100μg ARIGO
Mouse CD274 / PD-L1 recombinant protein (Fc-His-tagged, C-ter) ARG70230 100 ug ARIGO
Mouse CD80 recombinant protein (ECD) (Fc-His-tagged, C-ter) ARG70337 100μg ARIGO
Mouse CD86 recombinant protein (ECD) (Fc-tagged, C-ter) ARG70339 100μg ARIGO
Mouse CD86 recombinant protein (ECD) (His-tagged, C-ter) ARG70338 100μg ARIGO
B7-H2 / ICOSLG Recombinant Protein 11-311 0.1 mg PROSCI
B7-H2 / ICOSLG Recombinant Protein 11-276 0.1 mg PROSCI
B7-H2 / ICOSLG Recombinant Protein 11-310 0.1 mg PROSCI
B7-H2 / ICOSLG Recombinant Protein 11-409 0.1 mg PROSCI
B7-H2 / ICOSLG Recombinant Protein 11-280 0.1 mg PROSCI
CD273 [PD-L2] non-lytic Recombinant Protein 90-426 100 ug PROSCI
CD273 [PD-L2] Recombinant Protein 90-427 100 ug PROSCI
CD273 [PD-L2] Recombinant Protein 90-425 100 ug PROSCI
CD273 [PD-L2] Recombinant Protein 90-428 100 ug PROSCI
CD80 Recombinant Protein 96-044 0.1 mg PROSCI
CD80 Recombinant Protein 90-401 100 ug PROSCI
CD80 Recombinant Protein 96-085 0.1 mg PROSCI
CD80 Recombinant Protein 90-400 100 ug PROSCI
CD80 Recombinant Protein 96-045 0.1 mg PROSCI
CD80 Recombinant Protein 90-399 100 ug PROSCI
CD86 Recombinant Protein 96-127 0.2 mg PROSCI
CD86 Recombinant Protein 96-119 0.1 mg PROSCI
CD86 Recombinant Protein 96-122 0.1 mg PROSCI
CD86 Recombinant Protein 91-371 0.05 mg PROSCI
CD86 Recombinant Protein 96-120 0.1 mg PROSCI
CD86 Recombinant Protein 90-406 100 ug PROSCI
CTLA 4 Recombinant Protein 96-216 0.2 mg PROSCI
CTLA 4 Recombinant Protein 96-215 0.2 mg PROSCI
CTLA 4 Recombinant Protein 96-219 0.2 mg PROSCI
CTLA 4 Recombinant Protein 96-218 0.1 mg PROSCI
CTLA-4 Fc Recombinant Protein 40-692 50 ug PROSCI
CTLA-4 Recombinant Protein 97-040 100 ug PROSCI
CTLA-4 Recombinant Protein 96-987 200 ug PROSCI
CTLA-4 Recombinant Protein 92-722 0.05 mg PROSCI
CTLA-4 Recombinant Protein 97-033 100 ug PROSCI
CTLA-4 Recombinant Protein 96-858 100 ug PROSCI
CTLA-4 Recombinant Protein 96-988 200 ug PROSCI
CTLA-4 Recombinant Protein 92-723 0.05 mg PROSCI
Human BTN1A1 recombinant protein (Active) (ECD) (Fc-His-tagged, C-ter) ARG70292 50μg ARIGO
Human CD137L / TNFSF9 recombinant protein (Active) (His-tagged, C-ter) ARG70103 20 ug ARIGO
Human CD137L / TNFSF9 recombinant protein (Active) (His-tagged, C-ter) ARG70103 100 ug ARIGO
Human CD172a / SIRP alpha recombinant protein (ECD) (Fc-His-tagged, C-ter) ARG70267 100μg ARIGO
Human CD273 / PD-L2 recombinant protein (ECD) (Fc-His-tagged, C-ter) ARG70299 100μg ARIGO
Human CD273 / PD-L2 recombinant protein (ECD) (His-tagged, C-ter) ARG70260 100μg ARIGO
전체보기
Maker
ARIGO
Cat.No.
ARG70229
Product
Mouse CD274 / PD-L1 recombinant protein (His-tagged, C-ter)
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
RF16010-01
Product
CTLA 4 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70235
Product
Human CD279 / PD-1 recombinant protein (ECD) (His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70286
Product
Human CD48 recombinant protein (ECD) (His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70233
Product
Human CD80 recombinant protein (ECD) (His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70237
Product
Human HVEM / TR2 recombinant protein (ECD) (Fc-His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70236
Product
Human TIM3 recombinant protein (ECD) (His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70230
Product
Mouse CD274 / PD-L1 recombinant protein (Fc-His-tagged, C-ter)
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70337
Product
Mouse CD80 recombinant protein (ECD) (Fc-His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70339
Product
Mouse CD86 recombinant protein (ECD) (Fc-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70338
Product
Mouse CD86 recombinant protein (ECD) (His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
11-311
Product
B7-H2 / ICOSLG Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
11-276
Product
B7-H2 / ICOSLG Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
11-310
Product
B7-H2 / ICOSLG Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
11-409
Product
B7-H2 / ICOSLG Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
11-280
Product
B7-H2 / ICOSLG Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-426
Product
CD273 [PD-L2] non-lytic Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-427
Product
CD273 [PD-L2] Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-425
Product
CD273 [PD-L2] Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-428
Product
CD273 [PD-L2] Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-044
Product
CD80 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-401
Product
CD80 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-085
Product
CD80 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-400
Product
CD80 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-045
Product
CD80 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-399
Product
CD80 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-127
Product
CD86 Recombinant Protein
Size
0.2 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-119
Product
CD86 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-122
Product
CD86 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
91-371
Product
CD86 Recombinant Protein
Size
0.05 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-120
Product
CD86 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
90-406
Product
CD86 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-216
Product
CTLA 4 Recombinant Protein
Size
0.2 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-215
Product
CTLA 4 Recombinant Protein
Size
0.2 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-219
Product
CTLA 4 Recombinant Protein
Size
0.2 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-218
Product
CTLA 4 Recombinant Protein
Size
0.1 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
40-692
Product
CTLA-4 Fc Recombinant Protein
Size
50 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
97-040
Product
CTLA-4 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-987
Product
CTLA-4 Recombinant Protein
Size
200 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
92-722
Product
CTLA-4 Recombinant Protein
Size
0.05 mg
Qty
Data Sheet
Maker
PROSCI
Cat.No.
97-033
Product
CTLA-4 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-858
Product
CTLA-4 Recombinant Protein
Size
100 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
96-988
Product
CTLA-4 Recombinant Protein
Size
200 ug
Qty
Data Sheet
Maker
PROSCI
Cat.No.
92-723
Product
CTLA-4 Recombinant Protein
Size
0.05 mg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70292
Product
Human BTN1A1 recombinant protein (Active) (ECD) (Fc-His-tagged, C-ter)
Size
50μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70103
Product
Human CD137L / TNFSF9 recombinant protein (Active) (His-tagged, C-ter)
Size
20 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70103
Product
Human CD137L / TNFSF9 recombinant protein (Active) (His-tagged, C-ter)
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70267
Product
Human CD172a / SIRP alpha recombinant protein (ECD) (Fc-His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70299
Product
Human CD273 / PD-L2 recombinant protein (ECD) (Fc-His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG70260
Product
Human CD273 / PD-L2 recombinant protein (ECD) (His-tagged, C-ter)
Size
100μg
Qty
Data Sheet
전체보기

추천제품

관련제품

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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제품 문의

 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet
MSDS

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