Immune checkpoint Single Domain Antibody (sdAb) | 고마바이오텍

LAG-3 Immune Checkpoint sdAb

• ​Host Species: Llama
• Species Reactivity: Human
• Immunogen : LAG3 antibody was raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.
• 종류 : SD8837, SD8839, SD8841, SD8842, SD8843

•  Fig.1 : Titration ELISA analysis of LAG-3 sdAbs to detect recombinant LAG-3 (extracellular domain) coated at 1 ug/mL. sdAbs are detected with a mouse mAb against a C-terminal myc-tag followed by a goat anti-mouse IgG-HRP conjugate.
• Fig.2 : Immunohistochemistry of LAG-3 in human lymph node tissue with LAG-3 single domain antibody at 1 μg/mL.
• Fig.3 : Flow cytometry analysis of LAG-3 overexpressing HEK293 cells using LAG-3 single domain antibody at 1 μg/ml. Blue: Untransfected HEK293 cells. Yellow: LAG-3 overexpressing HEK293 cells.
• Fig.4 : Immunofluorescence of LAG-3 in transfected HEK293 cells with LAG-3 single domain antibody at 5 μg/mL.

PD-1 Immune Checkpoint sdAb

• ​Host Species: Llama
• Species Reactivity: Human
• Immunogen : PD-1 antibody was raised against a recombinant protein corresponding to amino acids 25 - 167 of human PD-1.
• 종류 : SD8643, SD8645, SD8647, SD8649 

• Fig.1 : Titration ELISA of PD-1
• Fig.2 : Flow cytometry analysis of PD-1 transfected 293 cells using PD-1 [F2-5F4] antibody at 10 μg/ml. Blue: untransfected cells, Yellow: PD-1 transfected cells.

PDL-1 Immune Checkpoint sdAb 

• ​Host Species: Llama
• Species Reactivity: Human
• Immunogen : PD-L1 antibody was raised against a recombinant protein corresponding to amino acids 19 - 239 of human PD-L1.
• 종류 : SD8639, SD8641

• Fig.1 : Immunofluorescence of PD-L1 in transfected 293 cells with PD-L1 antibody at 10 μg/ml. (Green: PD-L1 Antibody [F2G2] (SD8641) / Blue: DAPI staining)
• Fig.2 : Immunocytochemistry of PD-L1 in transfected 293 cells with PD-L1 antibody at 10 μg/ml.
• Fig.3 : Flow cytometry analysis of PD-L1 transfected 293 cells using PD-L1 [F6A9] antibody at 10 μg/ml. Blue: untransfected cells, Yellow: PD-L1 transfected cells.

TIGIT Immune Checkpoint sdAb 

• ​Host Species: Llama
• Species Reactivity: Human
• Immunogen : TIGIT antibody was raised against a recombinant protein corresponding to amino acids 22-141 of human TIGIT.
• 종류 : SD8824, SD8827, SD8828, SD8829, SD8830