고마바이오텍(주)
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제품 상세
세포 유전자치료제 (CGT) 스크리닝 서비스 이미지

세포 유전자치료제 (CGT) 스크리닝 서비스

개발된 세포치료제의 IND 승인을 위한 평가 서비스를 제공합니다.

Cell banking 제작 

Small 스케일에서 large 스케일에 이르는 단백질 labeling, reagent generation, cell banking 서비스 및 Performance qualification을 제공합니다.

 

Custom Cell Banking Master Cell Banks (MCB) Mycoplasma, sterility (bacterial and fungal contamination),
and stability testing; cloning
Research Cell Banks (RCB)

 

 

Phenotypic and Safety 평가 서비스 

Functional in vitro 평가를 통해 바이오 의약품의 clinical에서의 평가를 예측합니다.  

 

Cellular Apoptosis Primary Cells Assessment of biotherapeutic impact on cell death
Cell Lines
Cellular Proliferation ATP Assessment of biotherapeutic impact on cell growth
Redox
Cellular Signaling Assay PathHunter Assessment of biotherapeutic impact on downstream signaling on various platforms
Phosphorylation
Second Massenger (cAMP)
Cytotoxicity (ADCC, CDC, ADCP) Cell Viability Commercially Available Tumor Cell Lines Assessment of biotherapeutics to induce cell death in target cell lines of interest.
Different assay formats available (LDH, CellTiter Glo, Live/Dead, Flow Cytometry) and subpopulation phenotyping
Target-Specific KILR Cell Lines
Primary Cells (PBMCs)
Custom Cell Line Generation CRISPR Insertion of gene into cell line to express protein of interest;
high-, medium-, low expression, receptor quantitation
Lentivirus
Custom Cell Line Cloning   Single-cell flow cytometry sorting for creation of clonal cell lines

  

  

Cell-based Assays 서비스 

Cell physiology와 signaling pathway 활성화/억제성을 평가합니다.  

 

Cell Physiology Assessment Early Apoptosis : Annexin V Binding
Mid-Stage Apoptosis : Caspase Activation, Bcl-2
Late-Stage Apoptosis : Mitochondrial depolarization, ATM, H2A.X, DNA Fragmentation
Apoptotic Degradation of DNA : ATM, H2A.X
Autophagic Cell Death 
DNA Replication During Proliferation
Cellular Proliferation (Cell-by-Cell) 
Cell Cycle Progressions during Drug Treatment
Cell Signaling Pathway Activation/
Deactivation Assessment
BTK 
EGF Receptor 
eIFα 
ErbB Receptor 
GPCR (IP-1 Production)
JNK 
MAPK (ERK1/2, MEK1)
mTOR 
NFκB 
Nitric Oxide Production in Cells 
p38 
P53 (Phosphorylation, Acetylation) 
P70 S6K 
PI3K 
PI3K MAPK (pAKt, pERK1/2) 
STAT3
STAT5
SYK Kinase 

 

 

Viral Therapy AAV 서비스

AAV 바이러스 벡터 생산과 테스트 서비스를 제공합니다. 

 

  • Plasmid Transfection
  • mRNA Vaccine Transfection and Assessment of Effects
  • Lab-Scale Production and Harvesting of AAV Particles
  • Viral particle Aggregation Assessment
  • Analysis of AAV Capsid Size
  • Analysis of Empty vs Full Capsids for AAV Particles
  • Titering of AAV Viral Particles
  • Buffer Exchange During AAV Viral Particle Preparation
  • Viral Targeting of Relevant Cell Types

  


Leukocyte & MSC 서비스

세포 평가 서비스를 제공합니다.  

 

Leukocyte Services Population Dissection
CD4 and CD8 Lymphocyte Population Assessment
Detection and Assessment of Memory T-Cells
B-Cell Population Assessment (Flow)
Memory B Cell Assessment (Flow)
NK Cell Assessment (Flow)
CAR Lymphocyte Cell-Killing Assays
Isolation and Expansion of Cell Populations from Patient Samples
Immunophenotyping
Mesenchymal Stem Cell Services Secretome Profiling
Exosome Isolation and Characterization
Verification of MSC Cell Lines

 

  

Biotherapeutic 특성화 서비스

바이오치료제의 특성화 분석서비스를 제공합니다.

  • Activity/Function (Flow, ELISA, SPR)
  • Immunophenotyping (Flow)
  • Size and Purity (FPLC, PAGE, aSEC)
  • Manufacturability (Stability, agitation, time, temp, pH) (SLS/DLS, aSEC)
  • Stability (Rebuffering, Concentration) (LS/DLS, aSEC)
  • Cross-Reactivity (Dog, Human, Monkey, Mouse, Pig, Rat, Macaque, more..) (ELISA, Flow, SPR)

 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet
유전자세포치료제 (CGT) 스크리닝 서비스 . . EUROFINS DISCOVERY
Maker
EUROFINS DISCOVERY
Cat.No.
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Product
유전자세포치료제 (CGT) 스크리닝 서비스
Size
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Qty

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0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Cat.No.
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Data Sheet

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