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발암원성 평가 | Carcinogenicity Risk Assessment SafetyScreen Panel 이미지

발암원성 평가 | Carcinogenicity Risk Assessment SafetyScreen Panel

개발중인 약물의 발암성 위험 평가를 위한 Carcinogenicity Risk Assessment SafetyScreen Panel 분석서비스를 제공합니다.

특징 

 

  • 인간 발암성 평가를 위한 ICH 지침 S1B(R1)에서 주요 원칙 중 하나는 2년간의 쥐 연구가 인간 발암성 평가에 가치를 더하는지 결정하기 위해 증거의 가중치(WoE)를 사용하는 것입니다. WoE에서 고려해야 할 한 가지 중요한 요소는 Selectivity와 Off-Target 가능성, 특히 발암성 위험 (예: nuclear receptor에 대한 결합)을 알려주는 모화합물과 주요 대사산물에 대한 2차 약리학 검사 결과입니다. 
  • Carcinogenicity Risk Assessment SafetyScreen Panel은 enzyme, kinase, GPCR, cytokine, nuclear hormone receptor를 포함하는 30가지의 assay panel을 통해 화합물의 활성을 스크리닝하고, 발암성에 대한 안전성 평가를 제공합니다.
  • No. of Assays on Panel: 30
  • Test Sample Requirements: 180 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)


Panel  종류

Family
Name
Item
Protein
Organism
Assay Type
CYP450 CYP1A2 Human CYP450 Enzymatic LeadHunter Assay - TW 118050 CYP1A2 Human Enzymatic
CYP450 CYP3A4 Human CYP450 Enzymatic LeadHunter Assay - TW 118090 CYP3A4 Human Enzymatic
Kinase SAPK2A (p38alpha) Human CMGC Kinase Enzymatic Radiometric LeadHunter Assay [10 uM ATP] - TW 176610 p38alpha (SAPK2A) Human Enzymatic
NHR AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - TW 206000 AR Human Binding
NHR ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - TW 226010 ERalpha Human Binding
NHR ERbeta Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - TW 226050 ERbeta Human Binding
Cell Surface (Other) IL-6 Human Interleukin Binding Agonist Radioligand LeadHunter Assay - TW 244100   Human Binding
Other Phorbol Ester Binding LeadHunter Assay - TW 264500   Mouse Binding
NHR PPARgamma Human NHR Binding Agonist Radioligand LeadHunter Assay - TW 267500 PPARgamma Human Binding
NHR PR Human Progesterone NHR Binding Agonist Radioligand LeadHunter Assay - TW 299005 PR Human Binding
Protease Caspase 3 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW 163200 Caspase 3 Human Enzymatic
Protease Caspase 9 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW 163600 Caspase 9 Human Enzymatic
Free Radical Scavenger Free Radical Scavenger Bovine SOD Mimetic Enzymatic LeadHunter Assay - TW 193500   Bovine Enzymatic
GPCR beta (Non-Selective) Rat Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW 204300   Rat Binding
GPCR AT1 Human Angiotensin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW 210030 AT1 Human Binding
GPCR ETA Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - TW 224010 ETA Human Binding
GPCR ETB Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - TW 224110 ETB Human Binding
Kinase EGFR Human RTK Kinase Binding Radiometric LeadHunter Assay [10 uM ] - TW 225510 EGFR Human Binding
GPCR GnRH Human Gonadotrophin-Releasing Hormone GPCR Binding Agonist Radioligand LeadHunter Assay - TW 239200 GnRH Human Binding
GPCR CXCR1 (IL-8RA) Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW 244420 CXCR1 (IL-8RA) Human Binding
GPCR CXCR2 (IL-8RB) Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW 244500 CXCR2 (IL-8RB) Human Binding
GPCR MC1 Human Melanocortin GPCR Binding Agonist Radioligand LeadHunter Assay - TW 251100 MC1 Human Binding
GPCR M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW 252610 M1 Human Binding
GPCR M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW 252810 M3 Human Binding
Kinase PDGFR (Non-Selective) Mouse RTK Kinase Binding Agonist Radioligand LeadHunter Assay - TW 265200   Mouse Binding
GPCR EP1 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW 268110 EP1 Human Binding
GPCR EP2 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW 268200 EP2 Human Binding
GPCR sst2 Human Somatostatin GPCR Binding Agonist Radioligand LeadHunter Assay - TW 282700 sst2 Human Binding
Kinase TGFbeta (Non-Selective) Mouse TKL Kinase Binding Agonist Radioligand LeadHunter Assay - TW 286200   Mouse Binding
Cell Surface (Other) IL-1 R1 Human Interleukin Binding Agonist Radioligand LeadHunter Assay - TW 243530 IL-1R-1 Human Binding


 

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet
발암원성 평가서비스 (Carcinogenicity Risk Assessment SafetyScreen Panel) PP294 . EUROFINS DISCOVERY
Maker
EUROFINS DISCOVERY
Cat.No.
PP294
Product
발암원성 평가서비스 (Carcinogenicity Risk Assessment SafetyScreen Panel)
Size
.
Qty

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제품 문의

0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
Maker
Cat.No.
Product
Size
Qty
Data Sheet

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