발암원성 평가 | Carcinogenicity Risk Assessment SafetyScreen Panel

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발암원성 평가 | Carcinogenicity Risk Assessment SafetyScreen Panel

개발중인 약물의 발암성 위험 평가를 위한 Carcinogenicity Risk Assessment SafetyScreen Panel 분석서비스를 제공합니다.

프린트 제품 문의

특징

인간 발암성 평가를 위한 ICH 지침 S1B(R1)에서 주요 원칙 중 하나는 2년간의 쥐 연구가 인간 발암성 평가에 가치를 더하는지 결정하기 위해 증거의 가중치(WoE)를 사용하는 것입니다. WoE에서 고려해야 할 한 가지 중요한 요소는 Selectivity와 Off-Target 가능성, 특히 발암성 위험 (예: nuclear receptor에 대한 결합)을 알려주는 모화합물과 주요 대사산물에 대한 2차 약리학 검사 결과입니다.
Carcinogenicity Risk Assessment SafetyScreen Panel은 enzyme, kinase, GPCR, cytokine, nuclear hormone receptor를 포함하는 30가지의 assay panel을 통해 화합물의 활성을 스크리닝하고, 발암성에 대한 안전성 평가를 제공합니다.
No. of Assays on Panel: 30
Test Sample Requirements: 180 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)

Panel 종류

Family	Name	Item	Protein	Organism	Assay Type
CYP450	CYP1A2 Human CYP450 Enzymatic LeadHunter Assay - TW	118050	CYP1A2	Human	Enzymatic
CYP450	CYP3A4 Human CYP450 Enzymatic LeadHunter Assay - TW	118090	CYP3A4	Human	Enzymatic
Kinase	SAPK2A (p38alpha) Human CMGC Kinase Enzymatic Radiometric LeadHunter Assay [10 uM ATP] - TW	176610	p38alpha (SAPK2A)	Human	Enzymatic
NHR	AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - TW	206000	AR	Human	Binding
NHR	ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - TW	226010	ERalpha	Human	Binding
NHR	ERbeta Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - TW	226050	ERbeta	Human	Binding
Cell Surface (Other)	IL-6 Human Interleukin Binding Agonist Radioligand LeadHunter Assay - TW	244100		Human	Binding
Other	Phorbol Ester Binding LeadHunter Assay - TW	264500		Mouse	Binding
NHR	PPARgamma Human NHR Binding Agonist Radioligand LeadHunter Assay - TW	267500	PPARgamma	Human	Binding
NHR	PR Human Progesterone NHR Binding Agonist Radioligand LeadHunter Assay - TW	299005	PR	Human	Binding
Protease	Caspase 3 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW	163200	Caspase 3	Human	Enzymatic
Protease	Caspase 9 Human Caspase Cysteine Peptidase Enzymatic LeadHunter Assay - TW	163600	Caspase 9	Human	Enzymatic
Free Radical Scavenger	Free Radical Scavenger Bovine SOD Mimetic Enzymatic LeadHunter Assay - TW	193500		Bovine	Enzymatic
GPCR	beta (Non-Selective) Rat Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW	204300		Rat	Binding
GPCR	AT1 Human Angiotensin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW	210030	AT1	Human	Binding
GPCR	ETA Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - TW	224010	ETA	Human	Binding
GPCR	ETB Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - TW	224110	ETB	Human	Binding
Kinase	EGFR Human RTK Kinase Binding Radiometric LeadHunter Assay [10 uM ] - TW	225510	EGFR	Human	Binding
GPCR	GnRH Human Gonadotrophin-Releasing Hormone GPCR Binding Agonist Radioligand LeadHunter Assay - TW	239200	GnRH	Human	Binding
GPCR	CXCR1 (IL-8RA) Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW	244420	CXCR1 (IL-8RA)	Human	Binding
GPCR	CXCR2 (IL-8RB) Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW	244500	CXCR2 (IL-8RB)	Human	Binding
GPCR	MC1 Human Melanocortin GPCR Binding Agonist Radioligand LeadHunter Assay - TW	251100	MC1	Human	Binding
GPCR	M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW	252610	M1	Human	Binding
GPCR	M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW	252810	M3	Human	Binding
Kinase	PDGFR (Non-Selective) Mouse RTK Kinase Binding Agonist Radioligand LeadHunter Assay - TW	265200		Mouse	Binding
GPCR	EP1 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW	268110	EP1	Human	Binding
GPCR	EP2 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW	268200	EP2	Human	Binding
GPCR	sst2 Human Somatostatin GPCR Binding Agonist Radioligand LeadHunter Assay - TW	282700	sst2	Human	Binding
Kinase	TGFbeta (Non-Selective) Mouse TKL Kinase Binding Agonist Radioligand LeadHunter Assay - TW	286200		Mouse	Binding
Cell Surface (Other)	IL-1 R1 Human Interleukin Binding Agonist Radioligand LeadHunter Assay - TW	243530	IL-1R-1	Human	Binding

주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
	Product	Cat.No.	Size	Maker	Qty	Data Sheet
	발암원성 평가서비스 (Carcinogenicity Risk Assessment SafetyScreen Panel)	PP294	.	EUROFINS DISCOVERY

1
Maker	EUROFINS DISCOVERY
Cat.No.	PP294
Product	발암원성 평가서비스 (Carcinogenicity Risk Assessment SafetyScreen Panel)
Size	.
Qty