| Androgen Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product |
Activity |
|
Androgen
Receptor Agonists |
5274 |
BMS
564929 |
Highly
potent and muscle-selective androgen receptor (AR) agonist |
|
3812 |
Cl-4AS-1 |
Steroidal
androgen receptor agonist |
|
2822 |
Testosterone |
Endogenous
androgen receptor agonist |
|
Androgen
Receptor Antagonists |
3389 |
Bicalutamide |
Non-steroidal
androgen receptor antagonist |
|
6158 |
(S)-Equol |
Dihydrotestosterone
antagonist; potent estrogen receptor β (ERβ) agonist |
|
4094 |
Flutamide |
Non-steroidal
androgen receptor antagonist |
|
6108 |
Galeterone |
Androgen
receptor antagonist; also CYP17 inhibitor |
|
Androgen Receptor
Modulators |
3813 |
TFM-4AS-1 |
Selective
androgen receptor modulator (SARM) |
|
Androgen Receptor
Inhibitors |
5842 |
MK
386 |
Potent,
selective human type 1 5α-reductase inhibitor |
|
Degraders |
7254 |
ARCC
4 |
Potent
and selective androgen receptor degrader |
|
Other |
4946 |
AIM
100 |
Potent
and selective Ack1 inhibitor |
|
3293 |
Finasteride |
Type
II 5α-reductase inhibitor |
|
3572 |
GSK
650394 |
Serum-
and glucocorticoid-regulated kinase (SGK) inhibitor |
|
4396 |
Piperlongumine |
Induces
apoptosis; depletes androgen receptors in prostate cancer cells |
|
2968 |
Spironolactone |
Antiandrogen;
inhibits steroid hormone biosynthesis. Also MR antagonist |
|
6223 |
XY
018 |
Inhibits
AR expression; RORγ antagonist |
|
|
|
|
|
|
|
|
|
|
|
PPAR |
|
|
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|
퍼옥시좀 증식자
활성화 수용체(PPAR) 는 유전자 발현을 조절하기 위해 레티노이드 X 수용체(RXR) 동형과 이종 이량체화하는 리간드 활성화 전사 인자의
핵 수용체 패밀리의 구성원입니다. PPAR의 세가지 하위유형(α, δ(β라고도 함) 및 γ)이 확인 및 복제되었습니다. 많은 내인성
리간드가 PPAR에 대해 분리되었는데, 프로스타사이클린, 지방산, 리소포스파티딘산 및 류코트리엔 B4가 포함됩니다. PPAR은 지질
항상성, 세포 증식, 분화, 지방 생성 및 면역 기능을 포함하여 세포에서 많은 중요한 역할을 하며 대사 질환의 치료에 유용합니다. |
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|
PPARα |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
PPARα
Agonists |
4190 |
CP
775146 |
Selective,
high affinity PPARα agonist |
|
4113 |
Fenofibrate |
PPARα
agonist |
|
1677 |
GW
7647 |
Highly
selective, potent PPARα agonist. Orally active |
|
1484 |
Oleylethanolamide |
PPARα
agonist; also GPR55 agonist |
|
0879 |
Palmitoylethanolamide |
Endogenous
lipid with PPARα agonist activity |
|
1312 |
WY
14643 |
Selective
PPARα agonist |
|
PPARα
Antagonists |
4618 |
GW
6471 |
PPARα
antagonist |
|
1311 |
MK
886 |
PPARα
antagonist. Also FLAP inhibitor |
|
|
|
|
|
|
PPARγ |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
PPARγ
Agonists |
1307 |
Ciglitazone |
Selective
PPARγ agonist |
|
4784 |
Edaglitazone |
Potent
and selective PPARγ agonist; antidiabetic |
|
1664 |
GW
1929 hydrochloride |
Selective
PPARγ agonist. Orally active |
|
2150 |
nTZDpa |
Potent,
selective PPARγ partial agonist |
|
4124 |
Pioglitazone
hydrochloride |
Selective
PPARγ agonist; antidiabetic agent |
|
2306 |
15-deoxy-Δ-12,14-Prostaglandin
J2 |
Endogenous
PPARγ agonist |
|
5325 |
Rosiglitazone |
Potent
and selective PPARγ agonist; antidiabetic agent |
|
5139 |
Telmisartan |
PPARγ
partial agonist; AT1 antagonist |
|
3114 |
Troglitazone |
Selective
PPARγ agonist; antidiabetic agent |
|
PPARγ
Antagonists |
4344 |
FH
535 |
PPARγ/δ
antagonist; also inhibits Wnt/β-catenin signaling |
|
1508 |
GW
9662 |
Selective
covalent PPARγ antagonist |
|
6383 |
SR
16832 |
Dual
site PPARγ inhibitor |
|
2022 |
SR
202 |
Selective
PPARγ antagonist; antidiabetic and antiobesity agent |
|
2301 |
T
0070907 |
Highly
potent and selective covalent PPARγ antagonist |
|
Other |
1110 |
Genistein |
PPARγ
ligand. Also estrogen receptor ligand and EGFR inhibitor |
|
5920 |
LG
100268 |
Activates
RXR/PPARγ heterodimers; potent and selective RXR agonist |
|
4409 |
SR
1664 |
High
affinity PPARγ ligand; blocks Cdk5-dependent PPARγ phosphorylation |
|
|
|
|
|
|
PPARδ |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
PPARδ
Agonists |
2229 |
GW
0742 |
Highly
selective, potent PPARδ agonist |
|
5674 |
GW
501516 |
Potent
and selective PPARδ agonist |
|
1856 |
L-165,041 |
Potent
PPARδ agonist |
|
PPARδ
Antagonists |
4344 |
FH
535 |
PPARγ/δ
antagonist; also inhibits Wnt/β-catenin signaling |
|
3433 |
GSK
0660 |
Selective
PPARδ antagonist |
|
3961 |
GSK
3787 |
Potent
and selective PPARδ antagonist |
|
|
|
|
|
|
Aryl Hydrocarbon Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product |
Activity |
|
Aryl
Hydrocarbon Receptor Agonists |
6321 |
10-Cl-BBQ |
Potent
aryl hydrocarbon receptor (AhR) agonist; orally bioavailable |
|
5304 |
FICZ |
High
affinity aryl hydrocarbon receptor (AhR) agonist |
|
1803 |
ITE |
Endogenous
agonist for the transcription factor aryl hydrocarbon receptor |
|
3873 |
MeBIO |
AhR
agonist. Inactive analog of BIO (Cat. No. 3194) |
|
1267 |
Pifithrin-α
hydrobromide |
Aryl
hydrocarbon receptor agonist. Also p53 inhibitor |
|
Aryl
Hydrocarbon Receptor Antagonists |
3858 |
CH
223191 |
Potent
aryl hydrocarbon receptor (AhR) antagonist |
|
7086 |
StemRegenin
1 |
Aryl
hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment |
|
Ligands |
4393 |
L-Kynurenine |
Tryptophan
catabolite; endogenous aryl hydrocarbon receptor ligand |
|
Other |
4995 |
Phortress |
Prodrug
of the antitumor agent 5F 203 |
|
|
|
|
|
|
Pregnane X Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Pregnane
X Receptor Agonists |
4245 |
Meclizine
dihydrochloride |
Human
pregnane X receptor agonist; H1 antagonist |
|
4121 |
Rifampicin |
Pregnane
X receptor agonist; antibiotic |
|
5359 |
Rifaximin |
Pregnane
X receptor agonist; antibiotic |
|
2969 |
SR
12813 |
Pregnane
X receptor agonist |
|
|
|
|
|
|
Constitutive Androstane Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Constitutive
Androstane Receptor Agonists |
3683 |
CITCO |
Selective
CAR agonist |
|
1225 |
TCPOBOP |
Constitutive
androstane receptor agonist |
|
Constitutive
Androstane Receptor Inverse Agonists |
4096 |
Clotrimazole |
CAR
inverse agonist; Also Cytochrome P450 inhibitor |
|
5188 |
S
07662 |
Constitutive
androstane receptor (CAR) inverse agonist |
|
2373 |
T
0901317 |
CAR
inverse agonist; Also potent LXR agonist |
|
Constitutive
Androstane Receptor Antagonists |
5605 |
CINPA
1 |
Potent
CAR antagonist |
|
670 |
PK
11195 |
CAR
antagonist. Also peripheral benzodiazepine receptor antagonist |
|
|
|
|
|
|
Progesterone Receptors |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Progesterone
Receptor Agonists |
4833 |
Levonorgestrel |
Synthetic
progesterone analog |
|
6285 |
Megestrol
Acetate |
Synthetic
progesterone analog |
|
4115 |
Mometasone
furoate |
Synthetic
corticosteroid; anti-inflammatory agent |
|
2835 |
Progesterone |
Endogenous
progesterone receptor agonist |
|
Progesterone
Receptor Antagonists |
1479 |
Mifepristone |
Progesterone
and glucocorticoid receptor antagonist |
|
Other |
6242 |
AG
205 |
Progesterone
receptor membrane component 1 (Pgrmc1) ligand |
|
|
|
|
|
|
Estrogen and Related Receptors |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Estrogen
and Related Receptor Agonists |
5053 |
AC
186 |
Potent
and selective ERβ agonist; neuroprotective |
|
1417 |
Daidzein |
Estrogen
receptor agonist. Also induces cell cycle arrest |
|
1494 |
DPN |
Highly
potent ERβ agonist |
|
4494 |
(R)-DPN |
Enantiomer
of DPN (Cat. No. 1494) |
|
2266 |
DY131 |
Agonist
selective for estrogen-related receptors ERRβ and ERRγ |
|
6158 |
(S)-Equol |
Potent
estrogen receptor β (ERβ) agonist; dihydrotestosterone antagonist |
|
4276 |
ERB
041 |
Potent
ERβ agonist |
|
2823 |
α-Estradiol |
Endogenous
estrogen receptor agonist |
|
2824 |
β-Estradiol |
Endogenous
ER agonist |
|
3523 |
FERb
033 |
Potent
and selective ERβ agonist |
|
3075 |
GSK
4716 |
Selective
ERRγ and ERRβ agonist |
|
3907 |
27-Hydroxycholesterol |
ER
partial agonist; also LXR agonist |
|
1426 |
PPT |
Subtype-selective
ERα agonist |
|
3366 |
WAY
200070 |
Selective
ERβ agonist |
|
Estrogen and
Related Receptor Inverse Agonists |
3928 |
XCT
790 |
Selective
ERRα inverse agonist |
|
Estrogen
and Related Receptor Antagonists |
1047 |
ICI
182,780 |
Estrogen
receptor antagonist |
|
1991 |
MPP
dihydrochloride |
Highly
selective ERα antagonist |
|
2662 |
PHTPP |
Selective
ERβ antagonist |
|
2183 |
ZK
164015 |
Potent
estrogen receptor antagonist |
|
Estrogen
and Related Receptor Modulators |
5263 |
Bazedoxifene
acetate |
Potent
and selective estrogen receptor modulator (SERM) |
|
3412 |
(Z)-4-Hydroxytamoxifen |
Metabolite
of tamoxifen (Cat. No. 0999) |
|
2280 |
Raloxifene
hydrochloride |
Selective estrogen
receptor modulator (SERM) |
|
6342 |
Tamoxifen |
Estrogen receptor
partial agonist/antagonist |
|
0999 |
Tamoxifen citrate |
Estrogen receptor
partial agonist/antagonist |
|
2676 |
Y 134 |
Selective estrogen
receptor modulator (SERM), selective for ERα |
|
Estrogen and
Related Receptor Inhibitors |
4382 |
Letrozole |
Potent, reversible
non-steroidal aromatase inhibitor |
|
Degraders |
7120 |
SNIPER(ER)-87 |
Potent and selective
ERα Degrader (SNIPER) |
|
Other |
3388 |
Anastrozole |
Potent aromatase
(CYP19) inhibitor |
|
3705 |
Endoxifen |
Potent antiestrogen;
ERα ligand |
|
1110 |
Genistein |
Estrogen receptor
ligand. Also tyrosine kinase inhibitor |
|
1990 |
(R,R)-THC |
Potent
subtype-selective ligand; ERα agonist/ERβ antagonist |
|
3975 |
Zearalenone |
Estrogen receptor
ligand; mycotoxin |
|
|
|
|
|
|
Retinoic Acid Receptors |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Retinoic
Acid Receptor Agonists |
4046 |
AC 261066 |
RARβ2 agonist |
|
2436 |
AC 55649 |
Selective RARβ2
agonist |
|
2852 |
Adapalene |
RARβ and RARγ agonist |
|
0760 |
AM 580 |
Retinoic acid analog;
RARα agonist |
|
3507 |
AM 80 |
RARα agonist;
anticancer agent |
|
3505 |
BMS 753 |
RARα-selective
agonist |
|
3410 |
BMS 961 |
Selective RARγ
agonist |
|
2554 |
CD 1530 |
Potent and selective
RARγ agonist |
|
3824 |
CD 2314 |
Selective RARβ
agonist |
|
1549 |
CD 437 |
RARγ-selective
agonist |
|
2020 |
Ch 55 |
Potent RAR agonist |
|
6873 |
DC 271 |
Fluorescent retinoic
acid analog; solvochromatic probe |
|
0695 |
Retinoic acid |
Endogenous retinoic
acid receptor agonist |
|
0761 |
TTNPB |
Retinoic acid analog;
RAR agonist |
|
Retinoic Acid
Receptor Inverse Agonists |
3509 |
BMS 493 |
Pan-RAR inverse
agonist |
|
Retinoic
Acid Receptor Antagonists |
5758 |
AGN 193109 |
High affinity pan-RAR
antagonist |
|
3660 |
BMS 195614 |
Selective RARα
antagonist |
|
3800 |
CD 2665 |
Selective RARβ/γ
antagonist |
|
3823 |
ER 50891 |
Selective RARα
antagonist |
|
2021 |
LE 135 |
Selective RARβ
antagonist |
|
5984 |
LY 2955303 |
High affinity and
selective RARγ antagonist |
|
3822 |
MM 11253 |
RARγ-selective
antagonist |
|
Other |
3409 |
BMS 453 |
Synthetic retinoid
and RARβ agonist; also RARα and RARγ antagonist |
|
4011 |
EC 23 |
Synthetic retinoid;
induces differentiation of stem cells |
|
1396 |
Fenretinide |
Synthetic retinoid;
antiproliferative and antioxidant |
|
2705 |
Liarozole
dihydrochloride |
Blocks retinoic acid
metabolism |
|
|
|
|
|
|
Glucocorticoid Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Glucocorticoid
Receptor Agonists |
3685 |
Corticosterone |
Endogenous
glucocorticoid |
|
2007 |
Fluticasone
propionate |
Selective high
affinity glucocorticoid receptor agonist |
|
4116 |
GSK 9027 |
Glucocorticoid
receptor agonist |
|
4819 |
Methylprednisolone |
Glucocorticoid
receptor agonist |
|
4115 |
Mometasone furoate |
Synthetic
corticosteroid; anti-inflammatory agent |
|
Glucocorticoid
Receptor Antagonists |
1479 |
Mifepristone |
Glucocorticoid and
progesterone receptor antagonist |
|
Glucocorticoid
Receptor Inhibitors |
6400 |
Alsterpaullone |
Glucocorticoid
receptor inhibitor; also inhibits CDK1/2, GSK-3β and Lck |
|
Other |
2671 |
Budesonide |
Synthetic
glucocorticoid; anti-inflammatory and chemopreventive |
|
6357 |
Ciclesonide |
Glucocorticoid
antiasthmatic prodrug |
|
1126 |
Dexamethasone |
Anti-inflammatory
glucocorticoid |
|
4093 |
Hydrocortisone |
Adrenal
glucocorticoid; immunosuppressant |
|
|
|
|
|
|
Retinoic Acid-related Orphan Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Retinoic Acid-related Orphan Receptor Agonists |
6873 |
DC 271 |
Fluorescent retinoic
acid analog; solvochromatic probe |
|
5868 |
SR 0987 |
T cell-specific RORγ
(RORγt) agonist |
|
4874 |
SR 1078 |
RORα/γ agonist |
|
Retinoic Acid-related Orphan Receptor Inverse
Agonists |
5987 |
(±)-ML 209 |
RORγt inverse
agonist; suppresses Th17 cell differentiation |
|
4869 |
SR 2211 |
Selective RORγ
inverse agonist |
|
Retinoic
Acid-related Orphan Receptor Antagonists |
6223 |
XY 018 |
RORγ antagonist;
inhibits AR expression |
|
Other |
0695 |
Retinoic acid |
Endogenous retinoic
acid receptor agonist; proposed RORβ ligand |
|
|
|
|
|
|
LXR-like Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
LXR-like
Receptor Agonists |
2563 |
Fexaramine |
Potent, selective
farnesoid X receptor (FXR) agonist |
|
2474 |
GW 3965 hydrochloride |
Orally active liver X
receptor (LXR) agonist |
|
2473 |
GW 4064 |
Selective farnesoid X
receptor (FXR) agonist |
|
3907 |
27-Hydroxycholesterol |
LXR agonist; also ER
partial agonist |
|
2373 |
T 0901317 |
Potent liver X
receptor (LXR) agonist; also CAR inverse agonist |
|
5951 |
WAY 252623 |
Potent LXR agonist |
|
LXR-like
Receptor Inverse Agonists |
5854 |
SR 9238 |
Potent and selective
LXR inverse agonist |
|
6138 |
SR 9243 |
Selective LXR inverse
agonist |
|
LXR-like
Receptor Antagonists |
5656 |
DY 268 |
Potent FXR antagonist |
|
6669 |
Gly MCA |
FXR antagonist;
selectively active in intestines; orally bioavailable |
|
5694 |
GSK 2033 |
Potent LXR antagonist |
|
|
|
|
|
|
Retinoid X Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Retinoid
X Receptor Agonists |
5819 |
Bexarotene |
Potent and selective
RXR agonist |
|
3302 |
CD 3254 |
Potent and selective
RXRα agonist |
|
6873 |
DC 271 |
Fluorescent retinoic
acid analog; solvochromatic probe |
|
3687 |
Docosahexaenoic acid |
RXR agonist |
|
5920 |
LG 100268 |
Potent and selective
RXR agonist; also activates RXR/PPARγ heterodimers |
|
0695 |
Retinoic acid |
Endogenous retinoic
acid receptor agonist |
|
3411 |
SR 11237 |
Pan RXR agonist |
|
Retinoid
X Receptor Antagonists |
3912 |
HX 531 |
Potent RXR antagonist |
|
5086 |
PA 452 |
RXR antagonist |
|
3303 |
UVI 3003 |
RXR antagonist |
|
Retinoid X
Receptor Modulators |
3508 |
LG 101506 |
Selective RXR
modulator |
|
Other |
1396 |
Fenretinide |
Synthetic retinoid;
antiproliferative and antioxidant |
|
3913 |
HX 630 |
RXR synergist |
|
2705 |
Liarozole
dihydrochloride |
Blocks retinoic acid
metabolism |
|
|
|
|
|
|
Mineralocorticoid Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Mineralocorticoid
Receptor Agonists |
3685 |
Corticosterone |
Endogenous
glucocorticoid |
|
Mineralocorticoid
Receptor Antagonists |
2397 |
Eplerenone |
Selective
mineralocorticoid receptor antagonist |
|
1672 |
RU 28318, potassium
salt |
Potent, selective
mineralocorticoid receptor antagonist |
|
2968 |
Spironolactone |
Mineralocorticoid
receptor antagonist |
|
|
|
|
|
|
Rev-Erb Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Rev-Erb
Receptor Agonists |
3663 |
GSK 4112 |
Selective Rev-Erbα
agonist |
|
6038 |
SR 10067 |
Selective Rev-Erbα/β
agonist; anxiolytic |
|
5855 |
SR 9009 |
Rev-Erbα/β agonist |
|
Rev-Erb Receptor
Antagonists |
4463 |
SR 8278 |
Rev-Erbα antagonist |
|
|
|
|
|
|
Nerve Growth Factor IB-like Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Nerve
Growth Factor IB-like Receptor Agonists |
5459 |
Cytosporone B |
High affinity Nur77
agonist |
|
6376 |
DIM-C-pPhOCH3 |
Nur77 agonist |
|
6017 |
THPN |
Nur77 agonist;
induces autophagy in melanoma cell lines |
|
Nerve Growth
Factor IB-like Receptor Antagonists |
6377 |
DIM-C-pPhOH |
Nur77 antagonist |
|
Nerve
Growth Factor IB-like Receptor Activators |
5821 |
C-DIM 12 |
Nurr1 activator;
inhibits NF-κB-dependent gene expression |
|
5699 |
IP7e |
Potent Nurr1
activator |
|
|
|
|
|
|
Vitamin D Receptor |
|
|
|
|
|
|
|
|
Cat. No. |
Product Name |
Activity |
|
Vitamin
D Receptor Agonists |
2551 |
Calcitriol |
Vitamin D receptor
(VDR) agonist |
|
3993 |
EB 1089 |
Vitamin D receptor
(VDR) agonist |
|
Other |
4036 |
Calcifediol |
Prohormone of
calcitriol (Cat. No. 2551). Major circulating form of vitamin D |
|
2700 |
Calcipotriol |
Vitamin D3 analog |
|
4146 |
Ercalcidiol |
Metabolite of vitamin
D2 |
|
4160 |
22-Oxacalcitriol |
Non-calcemic vitamin
D3 (Cat. No. 4156) analog |
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4161 |
Paricalcitol |
Analog of the active
form of vitamin D2 |
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Other Nuclear Receptor |
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Cat. No. |
Product Name |
Activity |
|
Other Nuclear
Receptor Agonists |
4554 |
GC 1 |
High
affinity thyroid receptor α (TRα) and TRβ agonist; thyromimetic |
|
Other Nuclear
Receptor Inverse Agonists |
4957 |
ML 179 |
Selective
liver receptor homolog 1 (LRH1) inverse agonist |
|
Other Nuclear
Receptor Antagonists |
3440 |
SID 7969543 |
Selective
steroidogenic factor-1 (SF-1, NR5A1) inhibitor |
|
Degraders |
7388 |
ND1-YL2 |
SRC-1
peptide-based Degrader; active in vivo |
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Other |
2013 |
Guggulsterone |
Broad
spectrum steroid receptor ligand. Antagonizes FXR and displays hypolipidemic
activity |
|
3570 |
Z-Guggulsterone |
Broad
spectrum steroid receptor ligand. More active isomer of guggulsterone (Cat.
No. 2013) |
|
5964 |
SI-2 hydrochloride |
Steroid
receptor coactivator 3 (SRC-3) inhibitor |
|
6666 |
T3 |
Thyroid
hormone; also promotes differentiation of oligodendroglial precursor cells |
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