| Antiangiogenic Inhibitors |
|
| Cat. No. |
Product |
Activity |
| 5121 |
3PO |
PFKFB3 inhibitor;
antiangiogenic |
| 5617 |
AZD 1480 |
Potent and
selective JAK2 inhibitor; antiangiogenic |
| 4706 |
Borrelidin |
Antiangiogenic;
inhibits threonyl-tRNA synthetase |
| 5029 |
CHC |
Monocarboxylic acid
transport (MCT) inhibitor; displays anti-angiogenic activities |
| 1629 |
Herbimycin A |
Antiangiogenic.
Inhibits Src family kinases and Hsp90 |
| 5981 |
Itraconazole |
SMO antagonist;
antiangiogenic |
| 5260 |
KG 5 |
Antiangiogenic;
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor |
| 6305 |
Lenalidomide |
Angiogenesis
inhibitor; also TNF-α inhibitor and cereblon binder |
| 4664 |
Obtustatin |
Potent and
selective α1β1 inhibitor; antiangiogenic |
| 2710 |
OGT 2115 |
Antiangiogenic.
Heparanase inhibitor |
| 6302 |
Pomalidomide |
Antiangiogenic;
also TNF-α inhibitor and cereblon ubiquitination inhibitor |
| 2954 |
PX 12 |
Thioredoxin-1
inhibitor; attenuates expression of HIF-1α |
| 1418 |
Resveratrol |
Cyclooxygenase
inhbitor |
| 6187 |
SK 216 |
Angiogenesis
inhibitor; Also PAI-1 inhibitor |
| 6498 |
TASP 0277308 |
Potent and
selective S1P1 receptor antagonist; inhibits angiogenesis |
| 0652 |
Thalidomide |
Antiangiogenic;
also inhibits TNF-α synthesis |
| 1098 |
Tranilast |
Antiangiogenic |
|
|
|
| Matrix
Metalloprotease Inhibitors |
|
| Cat. No. |
Product |
Activity |
| 2622 |
ARP 101 |
Inhibitor of MMP-2 |
| 2961 |
Batimastat |
Potent, broad
spectrum MMP inhibitor |
| 2632 |
CL 82198
hydrochloride |
Selective inhibitor
of MMP-13 |
| 3807 |
Disulfiram |
Inhibits expression
of MMP-2 and MMP-9; displays a range of other activities |
| 4090 |
Doxycycline hyclate |
Broad-spectrum MMP
inhibitor; tetracycline derivative |
| 2983 |
GM 6001 |
Broad spectrum MMP
inhibitor |
| 7030 |
GW 280264X |
Potent ADAM10 and
ADAM17 endopeptidase nhibitor |
| 6439 |
JNJ 0966 |
Pro-MMP9 activation
inhibitor |
| 2631 |
Marimastat |
Broad spectrum MMP
inhibitor |
| 3268 |
Minocycline
hydrochloride |
Inhibitor of MMP
activity |
| 4902 |
NSC 405020 |
Inhibitor of
MT1-MMP; antitumor |
| 2520 |
PD 166793 |
Broad spectrum MMP
inhibitor |
| 6088 |
SB 3CT |
High affinity and
selective MMP2 inhibitor |
| 4775 |
SD 2590
hydrochloride |
Potent MMP
inhibitor |
| 6134 |
T 26c disodium salt |
Highly potent and
selective MMP13 inhibitor |
| 5523 |
TAPI 0 |
ADAM-17 (TACE) and
MMP inhibitor |
| 6162 |
TAPI 1 |
ADAM-17 (TACE) and
MMP inhibitor |
| 6013 |
TAPI 2 |
ADAM-17 (TACE) and
MMP inhibitor |
| 2900 |
UK 370106 |
Highly selective
MMP-3 and MMP-12 inhibitor |
| 4188 |
UK 383367 |
Potent and
selective BMP-1 (PCP) inhibitor |
| 2633 |
WAY 170523 |
Potent and
selective inhibitor of MMP-13 |
|
|
|
| Hypoxia Inducible
Factor (HIF) Inhibitors |
|
| Cat. No. |
Product |
Activity |
| 5953 |
Adaptaquin |
HIF-prolyl
hydroxylase-2 (PHD2) inhibitor; antioxidant |
| 4705 |
Chetomin |
Blocks interaction
of HIF-1α, HIF-2α and STAT2 with CBP/p300 |
| 6157 |
cis VH 298 |
Negative control
for VH 298 |
| 5764 |
Deferoxamine
mesylate |
Hypoxia mimetic;
also iron chelator |
| 4408 |
DMOG |
Inhibitor of
hypoxia-inducible factor α (HIF-α) prolyl hydroxylase (HIF-PH) |
| 5520 |
Echinomycin |
Highly potent and
selective HIF-1α inhibitor |
| 7287 |
FAM-DEALA-Hyp-YIPD |
Fluorescent HIF-1α
peptide |
| 7452 |
FAM-DEALAHypYIPMDDDFQLRSF |
Fluorescent HIF-1α
peptide |
| 6653 |
FM19G11 |
HIF α-subunit
inhibitor |
| 5655 |
GN 44028 |
Potent HIF-1α
inhibitor |
| 4451 |
IOX 2 |
Potent, selective
HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor |
| 4324 |
KC7F2 |
HIF-1α inhibitor;
down-regulates HIF-1α protein synthesis |
| 6322 |
LW 6 |
HIF-1α inhibitor;
inhibits cellular accumulation of HIF-1α; also malate dehydrogenase-2
inhibitor |
| 2954 |
PX 12 |
Thioredoxin-1
inhibitor; attenuates expression of HIF-1α |
| 5582 |
TAT-cyclo-CLLFVY |
Selective HIF-1
dimerization inhibitor |
| 5243 |
TC-S 7009 |
High affinity and
selective HIF-2α inhibitor |
| 7774 |
VH 032 |
Inhibitor of VHL;
blocks interaction of VHL and HIF-α |
| 6156 |
VH 298 |
High-affinity
inhibitor of VHL; blocks interaction of VHL and HIF-α |