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제품 상세
HIV Antibody & Protein 이미지

HIV Antibody & Protein

Human immunodeficiency virus (HIV) 연구를 위한 항원, 항체를 안내합니다.

프린트 제품 문의

Human immunodeficiency virus (HIV)란? 

  

  • Human immunodeficiency virus (HIV)는 retrovirus과의 일부인 Lentivirus 속으로 분류되고, 주로 helper T cell (CD4+), macrophage, dendritic cell등의 면역체계에 중요한 세포를 감염시킵니다.
  • 감염 메카니즘은 1) 감염된 세포 사멸, 2) 감염된 세포에서 apoptosis 증가, 3) 감염된 세포를 인식하는 CD8 cytotoxic lymphocyte에 의해 감염된 CD4+ T cell 사멸로 이어집니다. 
  • CD4+ T cell의 수가 일정 기준 이하로 감소하게 되면 세포 매개 면역이 상실되고, 신체는 점진적으로 감염에 더 취약해 집니다. 



구조

  • 9개의 바이러스 유전인자를 암호화하고 있는 2벌의 양성 single strand RNA로 구성되어 있으며 RNA는 바이러스 단백질 p24와 capsid로 구성되어 있습니다. 
  • gp41은 gp120에 비공유 결합된 당단백질이며, 원래 바이러스 외피에 묻혀 있지만 gp120이 CD4 수용체에 결합하면 gp120이 구조를 변경하여 gp41이 노출되면서 숙주 세포와의 융합을 돕게됩니다. 
  • Env 유전자는 gp41과 gp120의 전구체인 gp160을 코딩하며, HIV가 번식하는 동안 숙주세포내 존재하는 효소에 의해 gp160이 절단되어 gp41과 gp120을 생성합니다.
  • pol 유전자는 reverse transcriptase (RT)와 RNase H, integrase (IN), HIV protease (PR)을 코딩합니다. HIV protease는 Gag polyprotein 전구물질로 부터 structural protein을 생성하는데 필요하고, RT는 RNA template로부터 DNA로 전사하는데 이용되며, IN은 double-stranded DNA가 host genome내로 융합되는데 필요합니다. 
  • gag (group-specific antigen)은 성숙기 동안 viral protease에 의해 precursor gag polyprotein을 코딩하여 MA (matrix protein, p17), CA (capsid protein, p24), SP (spacer peptide 1, p2), NC (nucleocapsid protein, p7), SP2 (spacer peptide 2, p1), P6 단백질을 생성합니다. 
  • tat (HIV trans-activator) 유전자는 viral mRNA의 합성, infected cell로부터의 virion release등 viral genome RNA의 reverse transcription 조절에 중요한 역할을 합니다. 





*이미지출처: 위키피디아


주요 제품

anti-HIV1 p24 antibody [473] (#ARG10061)
Product Description Mouse Monoclonal antibody [473] recognizes HIV1 p24
Tested Reactivity HIV
Tested Application ELISA, WB
Specificity No cross activity with HIV-1 GP41 and HIV-2 GP36 was found.
Host Mouse
Clonality Monoclonal
Clone 473
Isotype IgG1, kappa
Target Name HIV1 p24
Antigen Species HIV
Immunogen Purified recombinant HIV-1 p24 (core protein)
Conjugation Un-conjugated
　 　 　
　 anti-HIV protease antibody [1696] (#ARG63002)
Product Description Mouse Monoclonal antibody [1696] recognizes HIV protease
Tested Reactivity HIV
Tested Application ELISA, FuncSt, WB
Specificity The clone 1696 recognizes free N-terminus of mature HIV protease (HIV-1 and HIV-2), an enzyme that hydrolyzes polyproteins of HIV viruses into functional proteins. 1696 does not react with the precursor.
Host Mouse
Clonality Monoclonal
Clone 1696
Isotype IgG1
Target Name HIV protease
Antigen Species HIV
Immunogen Bacterially expressed full-length HIV-1 protease
Conjugation Un-conjugated
　 　 　
　 Goat anti-HIV gp120 IgG (poly) IgG (# AB-16150)
Antigen purified native gp120 from strain IIIB
Antibody Host/Type Goat IgG, Aff pure IgG (cat # AB-16150) in PBS, pH 7.5, 0.05% azide
Specificity gp120 (predominate gp120 band in WB)
Titer > 1:1,000 by western blot immunoassay
Cross reactivity Antiserum does not cross-react with human T or B cells.
Application By direct ELISA (against recombinant gp120), 1:5000-10,000 dilution will yield 0.4 O. D using alkaline phosphatase conjugated rabbit anti-mouse Ig.
　 　 　
　 Rabbit Anti HIV-1 gp41 IgG (#AB-16010)
Antigen E. coli derived recombinant HIV-I protein, DEV-I (contains the C- terminus of gp120 and most of gp41).
Application Immunoreactive with HIV-I gp41. Generates a Strong positive control spot on HIVSav 1+2. Generates 1 OD (410nm) at a dilution of 1: 250 on AS 1001 (DEV-1) ELISA. 
　 　 　
　 Recombinant (E. coli) HIV-1 gp41/gp120, protein (soluble) (#HGP412-R)
Antigen Cat# HGP412-R Contains all the immunogenic determinants found in gp41 and a small portion of gp120.
rHIV 1 is a nonglycosylated 233aa polypeptide chain with a molecular mass of 27275.88
Type It is supplied in 0.5X PBS with 0.05% PBS with 0.05% SDS, pH 9.7 in liquid at 0.5-1 mg/ml (see lot sp concn on the vial) or in powder form. Reconstitute powder in water.
Application Western Blotting (100-500 ng/lane)
ELISA (0.1-1 ug/ml indirect ELISA or to at 1-10 ug/ml in ELISA.








주문정보

주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS
Anti-HIV gp120 IgG (poly) IgG AB-16150 100 ul ALPHA DIAGNOSTICS
Anti-HIV gp41 IgG (poly) AB-16160 100 ul ALPHA DIAGNOSTICS
Anti-HIV p24 IgG (poly) AB-16140 100 ul ALPHA DIAGNOSTICS
anti-HIV protease antibody [1696] ARG63002 100 ug ARIGO
anti-HIV protease antibody [1696] (azide free) ARG63001 100 ug ARIGO
Anti-HIV Virus/Virion IgG (poly) AB-16130 100 ul ALPHA DIAGNOSTICS
Anti-HIV-1 gp41 IgG AB-16010 1 ml ALPHA DIAGNOSTICS
Anti-HIV-2 gp39 IgG AB-16110 1 ml ALPHA DIAGNOSTICS
anti-HIV1 p24 antibody ARG22688 1 ml ARIGO
anti-HIV1 p24 antibody [473] ARG10061 100 ug ARIGO
anti-HIV1 p24 antibody [473] (HRP) ARG10168 0.2 ml ARIGO
anti-HIV1 P24 Core Protein antibody [340] ARG10167 500 ug ARIGO
Mouse Anti- HIV-1 p24 IgG AB-15210 100 ug ALPHA DIAGNOSTICS
Mouse Anti-HIV-1 gp120 (PND, principal neutralizing domain) IgG AB-15110 100 ug ALPHA DIAGNOSTICS
Mouse Anti-HIV-1 gp41 IgG AB-15910 100 ug ALPHA DIAGNOSTICS
Mouse Anti-HIV-2 gp39 IgG AB-15310 100 ug ALPHA DIAGNOSTICS
Rabbit anti-HIV-1 nef antibody HIV11-S 100 ul ALPHA DIAGNOSTICS
Rabbit anti-HIV-1 p24 antibody HIV21-S 100 ul ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV gp13 protein (HIV-gp13 Subtype O), soluble HGP13-R 100 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV gp36 protein (soluble) HGP362-R 100 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV Protease Protein (9-aa, His-tag, ~12 kda, <95%) RP-1633 5 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 gp41 protein (gp41 epitopes+gp120 CT, soluble) HGP412-R 100 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 gp41 protein (insoluble) HGP410-R 100 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 gp41, protein (soluble) HGP411-R 100 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p120 protein (C-terminus of gp120 and most of gp41) (soluble ~16 kda) HP1201-R 100 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 core (full length, GST at the NT, >90%, His-Tag) RP-583-7 25 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (155-321aa, His-tag at the NT, >95%) RP-583-8 20 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype B, strain 92418, 133-363 aa) (27 kda, >95%, His-Tag) RP-583-1 50 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype B, strain HXB2, 133-363 aa) (27 kda, >95%, His-Tag) RP-583-2 50 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype C, strain 92BR025, 131-363 aa) (27 kda, >95%, His-Tag) RP-583-5 50 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype D, strain NDK, 131-363 aa) (27 kda, >95%, His-Tag) RP-583-4 50 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (group N, strain 06CM-U14296, 131-363 aa) (27 kda, >95%, His-Tag) RP-583-6 50 ug ALPHA DIAGNOSTICS
Recombinant (E. coli) HIV-1 p24 gag (group O, strain BCF06, 131-362 aa) (27 kda, >95%, His Tag) RP-583-3 50 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV Type-O Envelope RP-565 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV Type-O gp41 RP-567 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 Envelope ( 233) RP-533 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 Envelope conjugated to HIV-2 gp39 RP-564 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gag p17, p24, gp120 proteins, GST at the NT (>95%) RP-543 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gag p17-p24, gp41-gp120 (>95%) RP-542 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gp41 (HIV gp41, 288 aa, 466-753-betal gal fusion protein) RP-544 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gp41 Long (444-833 aa gp41+Beta-Gal at NT, 114 Kda) RP-545 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gp41 Long, Biotin Labeled RP-552 50 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gp41 Long, Horseradish peroxidase Labeled RP-553 50 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gp41, Biotin Labeled RP-550 50 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 gp41, Horseradish Peroxidase Labeled RP-551 50 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 nef RP-557 100 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 p24 immunodominant regions (>95%) , HRP Labeled RP-541 50 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 TAT RP-562 10 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 TAT Clade-C RP-549 10 ug ALPHA DIAGNOSTICS
Recombinant (E.Coli) HIV-1 TAT, Biotin Labeled RP-561 1 ug ALPHA DIAGNOSTICS
전체보기
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-16150
Product
Anti-HIV gp120 IgG (poly) IgG
Size
100 ul
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-16160
Product
Anti-HIV gp41 IgG (poly)
Size
100 ul
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-16140
Product
Anti-HIV p24 IgG (poly)
Size
100 ul
Qty
Maker
ARIGO
Cat.No.
ARG63002
Product
anti-HIV protease antibody [1696]
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG63001
Product
anti-HIV protease antibody [1696] (azide free)
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-16130
Product
Anti-HIV Virus/Virion IgG (poly)
Size
100 ul
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-16010
Product
Anti-HIV-1 gp41 IgG
Size
1 ml
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-16110
Product
Anti-HIV-2 gp39 IgG
Size
1 ml
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG22688
Product
anti-HIV1 p24 antibody
Size
1 ml
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG10061
Product
anti-HIV1 p24 antibody [473]
Size
100 ug
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG10168
Product
anti-HIV1 p24 antibody [473] (HRP)
Size
0.2 ml
Qty
Data Sheet
Maker
ARIGO
Cat.No.
ARG10167
Product
anti-HIV1 P24 Core Protein antibody [340]
Size
500 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-15210
Product
Mouse Anti- HIV-1 p24 IgG
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-15110
Product
Mouse Anti-HIV-1 gp120 (PND, principal neutralizing domain) IgG
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-15910
Product
Mouse Anti-HIV-1 gp41 IgG
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
AB-15310
Product
Mouse Anti-HIV-2 gp39 IgG
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
HIV11-S
Product
Rabbit anti-HIV-1 nef antibody
Size
100 ul
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
HIV21-S
Product
Rabbit anti-HIV-1 p24 antibody
Size
100 ul
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
HGP13-R
Product
Recombinant (E. coli) HIV gp13 protein (HIV-gp13 Subtype O), soluble
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
HGP362-R
Product
Recombinant (E. coli) HIV gp36 protein (soluble)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-1633
Product
Recombinant (E. coli) HIV Protease Protein (9-aa, His-tag, ~12 kda, <95%)
Size
5 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
HGP412-R
Product
Recombinant (E. coli) HIV-1 gp41 protein (gp41 epitopes+gp120 CT, soluble)
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
HGP410-R
Product
Recombinant (E. coli) HIV-1 gp41 protein (insoluble)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
HGP411-R
Product
Recombinant (E. coli) HIV-1 gp41, protein (soluble)
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
HP1201-R
Product
Recombinant (E. coli) HIV-1 p120 protein (C-terminus of gp120 and most of gp41) (soluble ~16 kda)
Size
100 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-7
Product
Recombinant (E. coli) HIV-1 p24 core (full length, GST at the NT, >90%, His-Tag)
Size
25 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-8
Product
Recombinant (E. coli) HIV-1 p24 gag (155-321aa, His-tag at the NT, >95%)
Size
20 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-1
Product
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype B, strain 92418, 133-363 aa) (27 kda, >95%, His-Tag)
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-2
Product
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype B, strain HXB2, 133-363 aa) (27 kda, >95%, His-Tag)
Size
50 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-5
Product
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype C, strain 92BR025, 131-363 aa) (27 kda, >95%, His-Tag)
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-4
Product
Recombinant (E. coli) HIV-1 p24 gag (group M, subtype D, strain NDK, 131-363 aa) (27 kda, >95%, His-Tag)
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-6
Product
Recombinant (E. coli) HIV-1 p24 gag (group N, strain 06CM-U14296, 131-363 aa) (27 kda, >95%, His-Tag)
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-583-3
Product
Recombinant (E. coli) HIV-1 p24 gag (group O, strain BCF06, 131-362 aa) (27 kda, >95%, His Tag)
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-565
Product
Recombinant (E.Coli) HIV Type-O Envelope
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-567
Product
Recombinant (E.Coli) HIV Type-O gp41
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-533
Product
Recombinant (E.Coli) HIV-1 Envelope ( 233)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-564
Product
Recombinant (E.Coli) HIV-1 Envelope conjugated to HIV-2 gp39
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-543
Product
Recombinant (E.Coli) HIV-1 gag p17, p24, gp120 proteins, GST at the NT (>95%)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-542
Product
Recombinant (E.Coli) HIV-1 gag p17-p24, gp41-gp120 (>95%)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-544
Product
Recombinant (E.Coli) HIV-1 gp41 (HIV gp41, 288 aa, 466-753-betal gal fusion protein)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-545
Product
Recombinant (E.Coli) HIV-1 gp41 Long (444-833 aa gp41+Beta-Gal at NT, 114 Kda)
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-552
Product
Recombinant (E.Coli) HIV-1 gp41 Long, Biotin Labeled
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-553
Product
Recombinant (E.Coli) HIV-1 gp41 Long, Horseradish peroxidase Labeled
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-550
Product
Recombinant (E.Coli) HIV-1 gp41, Biotin Labeled
Size
50 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-551
Product
Recombinant (E.Coli) HIV-1 gp41, Horseradish Peroxidase Labeled
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-557
Product
Recombinant (E.Coli) HIV-1 nef
Size
100 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-541
Product
Recombinant (E.Coli) HIV-1 p24 immunodominant regions (>95%) , HRP Labeled
Size
50 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-562
Product
Recombinant (E.Coli) HIV-1 TAT
Size
10 ug
Qty
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-549
Product
Recombinant (E.Coli) HIV-1 TAT Clade-C
Size
10 ug
Qty
Data Sheet
Maker
ALPHA DIAGNOSTICS
Cat.No.
RP-561
Product
Recombinant (E.Coli) HIV-1 TAT, Biotin Labeled
Size
1 ug
Qty
전체보기

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주문정보 - Cat No, PRODUCT, SIZE, 수량 등 항목으로 구성되어있습니다.
  Product Cat.No. Size Maker Qty Data Sheet MSDS

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 0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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Cat.No.
Product
Size
Qty
Data Sheet
MSDS

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