iPSC 유래 망막상피세포 | Retinal Pigment Epithelial cells | 고마바이오텍

Human iPSC-derived RPE cells demonstrate typical cobblestone morphology and pigmentation on microscopy.

RPE cells express key markers MITF, ZO-1 and PMEL17 on ICC.

We utilize chronic N-retinylidene-N-retinylethanolamine (A2E) treatment combined with blue light irradiation to induce apoptosis, oxidative stress and inflammation. This helps to better reproduce pathological AMD conditions to produce more human-relevant AMD models.

A2E treatment combined with blue light can reproduce AMD conditions. A: Images demonstrating enhanced cell death with combination treatment (A2E and blue light) versus vehicle control and blue light. B: Increasing A2E concentrations produce a significant increase in cell death. This assay was used to guide the most appropriate concentration of A2E for chronic treatment. Ns: P > 0.05, **** P ≤ 0.0001.