ATPases Inhibitors | 고마바이오텍

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	Ca2+-ATPase
	Cat. No.	Product Name	Activity
	1235	Cyclopiazonic acid	Inhibitor of SERCA ATPase
	1138	Thapsigargin	Potent inhibitor of SERCA ATPase
	5869	CDN 1163	SERCA2 allosteric activator
	3807	Disulfiram	Reversibly stimulates SERCA Ca2+-ATPase; displays a range of other activities
	2006	Paxilline	SERCA ATPase blocker. Also potent BKCa channel blocker
	H+,K+-ATPase
	Cat. No.	Product Name	Activity
	2583	Omeprazole	H+,K+-ATPase inhibitor
	1690	SCH 28080	H+,K+-ATPase inhibitor
	H+-ATPase
	Cat. No.	Product Name	Activity
	1334	Bafilomycin A1	H+-ATPase (vacuolar) inhibitor
	2656	Concanamycin A	H+-ATPase (vacuolar) inhibitor
	3807	Disulfiram	Inhibitor of V-ATPase; displays a range of other activities
	7474	EN6	H+ ATPase activator; activates autophagy; inactivates mTORC1 signaling
	Kinesin
	Cat. No.	Product Name	Activity
	6664	Kinesore	Kinesin-1 modulator; cell permeable
	4676	ARRY 520 trifluoroacetate	Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
	5399	BTB1	Selective and ATP-competitive Kif18A inhibitor
	5261	Dimethylenastron	Inhibitor of mitotic motor kinesin Eg5
	6837	GSK 923295A	Potent and selective centromere associated protein E (CENP-E) allosteric inhibitor
	5408	Ispinesib	High affinity and selective allosteric KSP inhibitor
	1305	Monastrol	Selective inhibitor of mitotic kinesin Eg5
	2191	S-Trityl-L-cysteine	Potent, selective inhibitor of mitotic kinesin Eg5
	Myosin
	Cat. No.	Product Name	Activity
	1760	(±)-Blebbistatin	Selective inhibitor of myosin II ATPase activity
	1853	(R)-(+)-Blebbistatin	Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (±)-blebbistatin
	1852	(S)-(-)-Blebbistatin	Selective inhibitor of myosin II ATPase activity. Active enantiomer of (±)-blebbistatin
	1870	BTS	Selective inhibitor of skeletal muscle myosin II ATPase activity
	Na+/K+ ATPase
	Cat. No.	Product Name	Activity
	4583	Digoxin	Na+/K+ ATPase inhibitor
	4740	Lithium carbonate	Mood stabilizer; inhibits Na+/K+ ATPase pump activity
	1076	Ouabain	Na+/K+ ATPase inhibitor
	5315	Rostafuroxin	Na+/K+ ATPase modulator; antihypertensive agent
	NTPDase
	Cat. No.	Product Name	Activity
	3633	Adenosine 5'-(α,β-methylene)diphosphate sodium salt	Ecto-5'-nucleotidase (CD73) inhibitor
	1283	ARL 67156 trisodium salt	NTPDase inhibitor
	2689	POM 1	Inhibitor of E-NTPDases
	2574	PSB 06126	NTPDase 3 inhibitor
	2573	PSB 069	Non-selective NTPDase inhibitor
	6083	PSB 12379	Ecto-5'-nucleotidase (CD73) inhibitor
	p97 ATPase
	Cat. No.	Product Name	Activity
	7379	CB 5083	Potent p97 ATPase inhibitor
	4417	DBeQ	Selective and reversible p97 ATPase inhibitor
	5153	ML 240	ATP-competitive inhibitor of p97 ATPase
	6180	NMS 873	Potent and selective p97 ATPase (VCP) allosteric inhibitor
	4686	Xanthohumol	p97 ATPase (VCP) inhibitor

 

 

 

Properties of ATPases

Type	P	F	V
Substances Transported	H+, Na+, K+, Ca2+	H+ only	H+ only
Structural and Functional Features	Large catalytic α-subunits become phosphorylated during solute transport. β-subunits regulate transport	Multiple TM and cytosolic subunits synthesize ATP on β-subunits, powered by movement of H+ down an electrochemical gradient	Multiple TM and cytosolic subunits use energy released from ATP hydrolysis to pump H+ from cytosol to organelle lumen
Localization	H+ pump: plasma membrane of plants, fungi, bacteria Na+/K+ pump: plasma membrane of higher eukaryotes H+/K+ pump: plasma membrane of gastric chief cells Ca2+ pump: plasma membrane of eukaryotic cells Ca2+ pump: sarcoplasmic reticulum membrane in muscle cells	Bacterial plasma membranes Inner mitochondrial membrane Thylakoid membrane of chloroplast	Vacuolar membranes in plants, yeast and other fungi Endosomal and lyosomal membranes in eukaryotic cells Plasma membrane of acid-secreting cells (e.g. osteoclasts)

 

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