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제품 상세

Antibody

6.5 - 270 kDa 범위를 커버하는 3가지 컬러 밴드를 포함하며,
최대 100%까지의 transfer 효과를 개런티하는 Prestained protein ladder를 소개합니다.

특징


  • GPCR β-arrestin, second messenger assay, dimerization assay로 구성된 Obesity screening panel입니다.
  • Hit to Lead나 Lead Optimization 단계에서 약물의 specificity 와 selectivity를 측정하는데 유용합니다.
  • 25개의 panel로 구성되어 있으며, 각각의 assay는 개별로 진행할 수 있습니다. 
  • Eurofins DiscoverX의 PathHunter GPCR cell line과 분석방법을 이용하여  functional assay 결과를 제공합니다.
  • Format: Small molecule and Biologics Profiling in 10-point dose response curve format with 3-fold dilutions in replicates 
  • Test Sample Requirements: 75uL of a 1000X stock based on the final concentration being tested



종류 

 

Family
Name
Item
Protein
Organism
Assay Type
GPCR GIP Human Glucagon GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2059AG GIP Human Cell Based
GPCR CT Human Calcitonin GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2114AG CT Human Cell Based
GPCR AMY3 (CT/RAMP3) Human Calcitonin GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2116AG CT Human Cell Based
GPCR CT Human Calcitonin GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2245AG CT Human Cell Based
GPCR AMY3 (CT/RAMP3) Human Calcitonin GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2276AG CT Human Cell Based
GPCR Glucagon Human Glucagon GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2306AG Glucagon Human Cell Based
GPCR GIP Human Glucagon GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2308AG GIP Human Cell Based
GPCR GLP-1 Human Glucagon GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2309AG GLP-1 Human Cell Based
GPCR CCK1 (CCKA) Human Cholecystokinin GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2138AG CCK1 (CCKA) Human Cell Based
GPCR GHSR Human Ghrelin GPCR Cell Based Antagonist Arrestin LeadHunter Assay - US 86-0001P-2164AN GHSR Human Cell Based
GPCR Glucagon Human Glucagon GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2165AG Glucagon Human Cell Based
GPCR GLP-1 Human Glucagon GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2166AG GLP-1 Human Cell Based
GPCR MC4 Human Melanocortin GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2189AG MC4 Human Cell Based
GPCR Y2 Human Neuropeptide Y GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2198AG Y2 Human Cell Based
GPCR Y4 Human Neuropeptide Y GPCR Cell Based Agonist Arrestin LeadHunter Assay - US 86-0001P-2199AG Y4 Human Cell Based
GPCR OX1 Human Orexin GPCR Cell Based Antagonist Arrestin LeadHunter Assay - US 86-0001P-2205AN OX1 Human Cell Based
GPCR OX2 Human Orexin GPCR Cell Based Antagonist Arrestin LeadHunter Assay - US 86-0001P-2206AN OX2 Human Cell Based
GPCR MC4 Human Melanocortin GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2326AG MC4 Human Cell Based
GPCR Y2 Human Neuropeptide Y GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2337AG Y2 Human Cell Based
GPCR Y4 Human Neuropeptide Y GPCR Cell Based Agonist cAMP LeadHunter Assay - US 86-0007P-2338AG Y4 Human Cell Based
GPCR CCK1 (CCKA) Human Cholecystokinin GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - US 86-0030P-2138AG CCK1 (CCKA) Human Cell Based
GPCR GHSR Human Ghrelin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - US 86-0030P-2164AN GHSR Human Cell Based
GPCR OX1 Human Orexin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - US 86-0030P-2205AN OX1 Human Cell Based
GPCR OX2 Human Orexin GPCR Cell Based Antagonist Calcium Flux LeadHunter Assay - US 86-0030P-2206AN OX2 Human Cell Based
Cell Surface (Other) LEPR/LEPR Human Cytokine Cell Based Agonist Dimerization LeadHunter Assay - US 86-0020P-2661AG LEPR Human Cell Based

 

 

Counterscreen Assays

 

  • 상기 Obesity panel과 함께, 혹은 후에 수행하여 후보 화합물에 대한 추가적인 검증을 제공합니다. 
  • 약물의 특이성을 측정하고 이상반응 (Adverse Effect) 우려를 해결하기 위한 추가 정보를 제공합니다. 

 

Neuropeptide Y Agonist Program Counterscreens
86-0001P-2197AG    Y1 Human Neuropeptide Y GPCR Cell Based Agonist Arrestin LeadHunter Assay
Melanocortin Agonist Program Counterscreens
86-0001P-2188AG MC1 Human Melanocortin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2324AG MC1 Human Melanocortin GPCR Cell Based Agonist cAMP LeadHunter Assay
86-0001P-2069AG MC3 Human Melanocortin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2325AG MC3 Human Melanocortin GPCR Cell Based Agonist cAMP LeadHunter Assay
86-0001P-2190AG MC5 Human Melanocortin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2327AG MC5 Human Melanocortin GPCR Cell Based Agonist cAMP LeadHunter Assay
Amylin/Calcitonin Agonist Program Counterscreens
86-0001P-2118AG AM1 (CLR/RAMP2) Human Calcitonin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0001P-2119AG AM2 (CLR/RAMP3) Human Calcitonin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2249AG AM2 (CLR/RAMP3) Human Calcitonin GPCR Cell Based Agonist cAMP LeadHunter Assay
86-0001P-2115AG AMY2 (CT/RAMP2) Human Calcitonin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0001P-2117AG CGRP (CLR/RAMP1) Human Calcitonin GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2248AG CGRP (CLR/RAMP1) Human Calcitonin GPCR Cell Based Agonist cAMP LeadHunter Assay
Alternate Target Counterscreens
86-0001P-2243AG VIP1 (VPAC1) Human VIP and PACAP GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2361AG VIP1 (VPAC1) Human VIP and PACAP GPCR Cell Based Agonist cAMP LeadHunter Assay
86-0001P-2244AG VIP2 (VPAC2) Human VIP and PACAP GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0007P-2362AG VIP2 (VPAC2) Human VIP and PACAP GPCR Cell Based Agonist cAMP LeadHunter Assay
86-0001P-2076AG FFA1 (GPR40) Human Free Fatty Acid GPCR Cell Based Agonist Arrestin LeadHunter Assay
86-0011P-2416AG FFA1 (GPR40) Human Free Fatty Acid GPCR Cell Based Agonist Calcium Flux LeadHunter Assay
86-0001P-2070AN CB1 Human Cannabinoid GPCR Cell Based Antagonist Arrestin LeadHunter Assay
86-0007P-2277AN CB1 Human Cannabinoid GPCR Cell Based Antagonist cAMP LeadHunter Assay
86-0024P-2678AG TGFBR1/ActR2B (ACVR2B) Human TKL Kinase Cell Based Agonist Dimerization LeadHunter Assay

 

주문정보

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제품 문의

0.5 ml Elite Pre-stained Protein Ladder (2 x 0.25 ml) PAL-EPL-500 0.5ml 500
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